AIM: To evaluate the outcome of laser iridotomy using532-nm Nd: YAG laser(PASCAL) with short pulse duration and Nd: YAG laser compared to conventional combined laser iridotomy.METHODS: Retrospective, nonrandomized, co...AIM: To evaluate the outcome of laser iridotomy using532-nm Nd: YAG laser(PASCAL) with short pulse duration and Nd: YAG laser compared to conventional combined laser iridotomy.METHODS: Retrospective, nonrandomized, comparative case series. Forty-five eyes of 34 patients underwent laser iridotomy. Twenty-two eyes underwent iridotomy using short duration PASCAL and Nd: YAG laser, and 23 eyes underwent iridotomy using conventional combined laser method. The average settings of PASCAL were60 μm and 700-900 m W with a short duration of 0.01 s to reduce the total applied energy. The conventional laser was 50 μm and 700-900 m W for 0.1s. After photocoagulation with these laser, the Nd: YAG laser was added in each group. Endothelial cell counts of preiridotomy and 2mo after iridotomy were measured and compared.RESULTS: All eyes completed iridotomy successfully.The total energy used in the PASCAL group was 1.85 ±1.17 J. Compared to conventional laser 13.25 ±1.67 J, the energy used was very small due to the short exposure time of PASCAL. Endothelial cell counts were reduced by0.88% in the PASCAL group and 6.72% in the conventional laser group(P =0.044). The change in corneal endothelial cell counts before and after iridotomy was significant in conventional combined laser iridotomy group(P =0.004).CONCLUSION: Combined PASCAL and Nd:YAG laseriridotomy is an effective and safe technique in the dark brown irides of Asians. Furthermore, the short duration of exposure in PASCAL offers the advantages of reducing the total energy used and minimizing the corneal damage.展开更多
目的研究超皮秒双波长1064 nm联合532 nm点阵激光治疗黄褐斑的疗效与安全性。方法回顾性分析于2019年1月至2022年12月来广州市皮肤病防治所激光科就诊的黄褐斑患者45例,均为女性,年龄(40.6±2.4)岁,采用超皮秒双波长1064 nm联合532...目的研究超皮秒双波长1064 nm联合532 nm点阵激光治疗黄褐斑的疗效与安全性。方法回顾性分析于2019年1月至2022年12月来广州市皮肤病防治所激光科就诊的黄褐斑患者45例,均为女性,年龄(40.6±2.4)岁,采用超皮秒双波长1064 nm联合532 nm点阵激光治疗,每4周治疗1次,共治疗3次,采用黄褐斑面积和严重指数(Melasma Area and Severity Index,MASI)评分,VISIA检测正面紫外线斑、棕色斑、斑点、红斑计数分值,医生整体评价法(Physician Global Assessment,PGA)观察疗效,评估不良反应。采用重复测量设计的方差分析、配对t检验。结果治疗3次后PGA评分显示完全清除2例(4.4%),基本清除2例(4.4%),明显改善5例(11.1%),中度改善19例(42.2%),轻度改善15例(33.3%),无改善1例(2.2%),较治疗前加重1例(2.2%),改善率达95.6%。治疗前及治疗1次、2次、3次后MASI评分差异有统计学意义(F=7.2870,P=0.0002);与基线值[(19.32±10.36)分]相比,治疗2次后[(12.13±7.27)分,t=2.9190,P=0.0049]、治疗3次后MASI评分[(9.49±6.65)分,t=4.3720,P<0.0001]均明显下降。VISIA棕色斑分值治疗前后差异有统计学意义(F=5.3610,P=0.0005);在3次治疗后[(22.24±7.84)分]较基线值[(29.06±8.72)分]出现下降(t=3.5790,P=0.0007);红色斑分值治疗前后差异有统计学意义(F=5.0720,P=0.0007),与基线值[(18.80±9.51)分]比较,在治疗2次[(14.09±7.18)分,t=3.1640,P=0.0022]、3次后[(13.26±8.49)分,t=3.2290,P=0.0019]均明显下降。患者术中出现轻度疼痛,术后出现轻度红斑、水肿、色素沉着,均在2~7 d内消退,无水疱疤痕。结论超皮秒双波长点阵激光治疗黄褐斑疗效确切,安全性好。展开更多
文摘AIM: To evaluate the outcome of laser iridotomy using532-nm Nd: YAG laser(PASCAL) with short pulse duration and Nd: YAG laser compared to conventional combined laser iridotomy.METHODS: Retrospective, nonrandomized, comparative case series. Forty-five eyes of 34 patients underwent laser iridotomy. Twenty-two eyes underwent iridotomy using short duration PASCAL and Nd: YAG laser, and 23 eyes underwent iridotomy using conventional combined laser method. The average settings of PASCAL were60 μm and 700-900 m W with a short duration of 0.01 s to reduce the total applied energy. The conventional laser was 50 μm and 700-900 m W for 0.1s. After photocoagulation with these laser, the Nd: YAG laser was added in each group. Endothelial cell counts of preiridotomy and 2mo after iridotomy were measured and compared.RESULTS: All eyes completed iridotomy successfully.The total energy used in the PASCAL group was 1.85 ±1.17 J. Compared to conventional laser 13.25 ±1.67 J, the energy used was very small due to the short exposure time of PASCAL. Endothelial cell counts were reduced by0.88% in the PASCAL group and 6.72% in the conventional laser group(P =0.044). The change in corneal endothelial cell counts before and after iridotomy was significant in conventional combined laser iridotomy group(P =0.004).CONCLUSION: Combined PASCAL and Nd:YAG laseriridotomy is an effective and safe technique in the dark brown irides of Asians. Furthermore, the short duration of exposure in PASCAL offers the advantages of reducing the total energy used and minimizing the corneal damage.
文摘目的研究超皮秒双波长1064 nm联合532 nm点阵激光治疗黄褐斑的疗效与安全性。方法回顾性分析于2019年1月至2022年12月来广州市皮肤病防治所激光科就诊的黄褐斑患者45例,均为女性,年龄(40.6±2.4)岁,采用超皮秒双波长1064 nm联合532 nm点阵激光治疗,每4周治疗1次,共治疗3次,采用黄褐斑面积和严重指数(Melasma Area and Severity Index,MASI)评分,VISIA检测正面紫外线斑、棕色斑、斑点、红斑计数分值,医生整体评价法(Physician Global Assessment,PGA)观察疗效,评估不良反应。采用重复测量设计的方差分析、配对t检验。结果治疗3次后PGA评分显示完全清除2例(4.4%),基本清除2例(4.4%),明显改善5例(11.1%),中度改善19例(42.2%),轻度改善15例(33.3%),无改善1例(2.2%),较治疗前加重1例(2.2%),改善率达95.6%。治疗前及治疗1次、2次、3次后MASI评分差异有统计学意义(F=7.2870,P=0.0002);与基线值[(19.32±10.36)分]相比,治疗2次后[(12.13±7.27)分,t=2.9190,P=0.0049]、治疗3次后MASI评分[(9.49±6.65)分,t=4.3720,P<0.0001]均明显下降。VISIA棕色斑分值治疗前后差异有统计学意义(F=5.3610,P=0.0005);在3次治疗后[(22.24±7.84)分]较基线值[(29.06±8.72)分]出现下降(t=3.5790,P=0.0007);红色斑分值治疗前后差异有统计学意义(F=5.0720,P=0.0007),与基线值[(18.80±9.51)分]比较,在治疗2次[(14.09±7.18)分,t=3.1640,P=0.0022]、3次后[(13.26±8.49)分,t=3.2290,P=0.0019]均明显下降。患者术中出现轻度疼痛,术后出现轻度红斑、水肿、色素沉着,均在2~7 d内消退,无水疱疤痕。结论超皮秒双波长点阵激光治疗黄褐斑疗效确切,安全性好。
