Objective To evaluate the safety of 6% hydroxyethyl starch(200/0.5) for expand plasma volume during operation. Methods multiple centers, random and double blind procedure. 144 adault patients, ASA gradeⅠ-Ⅱ, schedule...Objective To evaluate the safety of 6% hydroxyethyl starch(200/0.5) for expand plasma volume during operation. Methods multiple centers, random and double blind procedure. 144 adault patients, ASA gradeⅠ-Ⅱ, scheduled for selective surgery. Both the test group(6% hydroxyethyl starch group)and the control group(HES group) are all 72 patients. The liver functions, renal functions, acid-base changes and coagulation variables were observed after administration. Results There are no significant difference between test group and control group in liver functions, renal functions, acid-base changes and coagulation variables (P> 0.05 ), with significant difference only in FⅧ:C activity between test group and control group (P<0.05) after volume treatment. but the numerical value of FⅧ:C in both groups are all in normal range in clinic. Conclusion 6% hydroxyethyl starch (200/0.5) is safe for expand plasma volume during operation.展开更多
文摘目的:探讨6%羟乙基淀粉(HES)130/0.4对骨折创伤兔子血清白蛋白、微血管白蛋白渗漏、炎性因子的影响。方法:将20只健康雌性大白兔随机分为模型组和HES组,各10只,均采用钝器敲打后肢造成后肢骨折,行骨折切开内固定术。术后,模型组注射10 m L/kg生理盐水,HES组注射10 m L/kg 6%HES 130/0.4,连续3 d。比较两组血清白蛋白水平、微血管白蛋白渗漏情况以及白细胞介素-6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)水平。结果:术后72 h,两组血清白蛋白水平低于术前,但HES组高于模型组,差异有统计学意义(P<0.05);HES组肠系膜微血管白蛋白渗漏率低于模型组,差异有统计学意义(P<0.05);两组血清IL-6、CRP以及PCT水平高于术前,但HES组低于模型组,差异有统计学意义(P<0.05)。结论:骨折创伤兔子术后存在血清白蛋白水平下降、炎性因子水平升高情况,给予6%HES 130/0.4治疗可以减小血清白蛋白降低幅度,下调IL-6、CRP以及PCT水平,改善白蛋白渗漏情况。
文摘Objective To evaluate the safety of 6% hydroxyethyl starch(200/0.5) for expand plasma volume during operation. Methods multiple centers, random and double blind procedure. 144 adault patients, ASA gradeⅠ-Ⅱ, scheduled for selective surgery. Both the test group(6% hydroxyethyl starch group)and the control group(HES group) are all 72 patients. The liver functions, renal functions, acid-base changes and coagulation variables were observed after administration. Results There are no significant difference between test group and control group in liver functions, renal functions, acid-base changes and coagulation variables (P> 0.05 ), with significant difference only in FⅧ:C activity between test group and control group (P<0.05) after volume treatment. but the numerical value of FⅧ:C in both groups are all in normal range in clinic. Conclusion 6% hydroxyethyl starch (200/0.5) is safe for expand plasma volume during operation.