Novel Bi_(2)MoO_(6) nanocrystals with tunable oxygen vacancies have been developed via a facile low-cost approach with the assistance of a glyoxal reductant under solvothermal conditions.With the introduction of oxyge...Novel Bi_(2)MoO_(6) nanocrystals with tunable oxygen vacancies have been developed via a facile low-cost approach with the assistance of a glyoxal reductant under solvothermal conditions.With the introduction of oxygen vacancies,the optical absorption of Bi_(2)MoO_(6) is extended and its bandgap narrowed.Oxygen vacancies not only lead to the appearance of a defect band level in the forbidden band but can also result in a minor up-shift of the valence band maximum,promoting the mobility of photogenerated holes.Moreover,oxygen vacancies can act as electron acceptors,temporarily capturing electrons excited by light and reducing the recombination of electrons and holes.At the same time,oxygen vacancies help to capture oxygen,which reacts with the captured photogenerated electrons to generate more superoxide radicals(·O_(2)-)to participate in the reaction,thereby significantly promoting the redox performance of the photocatalyst.From Bi_(2)MoO_(6) containing these oxygen vacancies(OVBMO),excellent photocatalytic performance has been obtained for the oxidation of 1,2,3,4-tetrahydroquinoline to produce quinoline and cause antibiotic degradation.The reaction mechanism of the oxidation of 1,2,3,4-tetrahydroquinoline to quinoline over the OVBMO materials is elucidated in terms of heterogeneous Catal.via a radical pathway.展开更多
A series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]quinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized fr...A series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]quinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry（MS） and 1H NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.展开更多
Quinoline is widely used in the production of drugs as a highly effective insecticide,and its derivatives can also be used to produce dyes.It has a teratogenic carcinogen to wildlife and humans once entering into the ...Quinoline is widely used in the production of drugs as a highly effective insecticide,and its derivatives can also be used to produce dyes.It has a teratogenic carcinogen to wildlife and humans once entering into the aquatic environment.In this study,the degradation mechanism of quinoline in drinking water by a strong ionization dielectric barrier discharge(DBD)lowtemperature plasma with large volume was explored.High concentration of hydroxyl radical(·OH)(0.74 mmol l^(-1))and ozone(O3)(58.2 mg l^(-1))produced by strongly ionized discharge DBD system were quantitatively analyzed based on the results of electron spin resonance and O3 measurements.The influencing reaction conditions of input voltages,initial pH value,·OH inhibitors,initial concentration and inorganic ions on the removal efficiency of quinoline were systematically studied.The obtained results showed that the removal efficiency and TOC removal of quinoline achieved 94.8%and 32.2%,degradation kinetic constant was 0.050 min^(-1) at 3.8 k V and in a neutral pH(7.2).The proposed pathways of quinoline were suggested based on identified intermediates as hydroxy pyridine,fumaric acid,oxalic acid,and other small molecular acids by high-performance liquid chromatography/tandem mass spectrometry analysis.Moreover,the toxicity analysis on the intermediates demonstrated that its acute toxicity,bioaccumulation factor and mutagenicity were reduced.The overall findings provided theoretical and experimental basis for the application of a high capacity strong ionization DBD water treatment system in the removal of quinoline from drinking water.展开更多
The title compound,2,6-bis（2-pyridinylmethyl）-3,5-bis（2-hydroxyl-5-chlorophe nyl）-pyrazine（C26H12Cl2N4O2C2H8O2,Mr=551.41）,has been synthesized and characterized by LC-ESIMS,NMR,UV and IR spectroscopy as well as ...The title compound,2,6-bis（2-pyridinylmethyl）-3,5-bis（2-hydroxyl-5-chlorophe nyl）-pyrazine（C26H12Cl2N4O2C2H8O2,Mr=551.41）,has been synthesized and characterized by LC-ESIMS,NMR,UV and IR spectroscopy as well as by X-ray single-crystal diffraction.The compound behaves as a substituted pyrazine.The hydrogen atoms on C（2） and C（3） are substituted by 2-pyridinyl,whereas those on C（1） and C（4） are substituted by 2-hydroxyl-5-chlorophenyl.It crystallizes in the monoclinic system,space group P21/c with a=8.9433（12）,b=32.003（4）,c=10.5209（18）,β=111.199（2）°,V=2807.5（7）3,Z=4,Dc=1.305 mg/m3,F（000）=1144 and μ=0.094 mm-1.A total of 13235 reflections were collected in the range of 2.17～25.01o by using a phi and omega scan mode,of which 4923 were unique（Rint=0.0692） and 2872 observed reflections with Ⅰ 〉2σ（Ⅰ） were used in the structure solution and refinement.展开更多
Preost-Woodward hydroxylation of 2 gave the 22S,23S-glycol(3), contrary to expectation.It is suggested that the formation of the two possible iodonium ions(4a and 4b)are reversible,thus allowing the discriminatory ace...Preost-Woodward hydroxylation of 2 gave the 22S,23S-glycol(3), contrary to expectation.It is suggested that the formation of the two possible iodonium ions(4a and 4b)are reversible,thus allowing the discriminatory acetoxy group to follow the less hindered route,reacting with 4a virtually exclusively.展开更多
目的建立脑内灌流6-羟基多巴胺(6-OHDA)所致大鼠纹状体细胞外液羟自由基升高的模型,为老年退行性病变和其它氧化应激所致脑细胞损伤的研究和药物筛选提供可利用的方法。方法微透析脑内灌流6-OHDA造模,采用水杨酸捕获羟自由基,高效液相-...目的建立脑内灌流6-羟基多巴胺(6-OHDA)所致大鼠纹状体细胞外液羟自由基升高的模型,为老年退行性病变和其它氧化应激所致脑细胞损伤的研究和药物筛选提供可利用的方法。方法微透析脑内灌流6-OHDA造模,采用水杨酸捕获羟自由基,高效液相-电化学检测技术,对活体脑内羟自由基所形成的2,3二羟基苯甲酸(2,3-DHBA)和2,5二羟基苯甲酸(2,5-DHBA)进行测定。结果6-OHDA脑内灌流后,模型组大鼠纹状体细胞外液2,3-DHBA和2,5-DH-BA在75 m in分别为对照组的6.6和3.4倍;2,3-DHBA在观察的全程中,一直高于对照组(P<0.01);2,5DHBA大部分时间点也高于对照组(P<0.05或P<0.01);维生素EC组的2,3-DHBA有4个时点低于模型组(P<0.05或P<0.01),2,5-DHBA各时点均低于模型组,但差异无显著性。结论6-OHDA脑内灌流可以造成大鼠纹状体细胞外液羟自由基升高的急性模型。展开更多
文摘Novel Bi_(2)MoO_(6) nanocrystals with tunable oxygen vacancies have been developed via a facile low-cost approach with the assistance of a glyoxal reductant under solvothermal conditions.With the introduction of oxygen vacancies,the optical absorption of Bi_(2)MoO_(6) is extended and its bandgap narrowed.Oxygen vacancies not only lead to the appearance of a defect band level in the forbidden band but can also result in a minor up-shift of the valence band maximum,promoting the mobility of photogenerated holes.Moreover,oxygen vacancies can act as electron acceptors,temporarily capturing electrons excited by light and reducing the recombination of electrons and holes.At the same time,oxygen vacancies help to capture oxygen,which reacts with the captured photogenerated electrons to generate more superoxide radicals(·O_(2)-)to participate in the reaction,thereby significantly promoting the redox performance of the photocatalyst.From Bi_(2)MoO_(6) containing these oxygen vacancies(OVBMO),excellent photocatalytic performance has been obtained for the oxidation of 1,2,3,4-tetrahydroquinoline to produce quinoline and cause antibiotic degradation.The reaction mechanism of the oxidation of 1,2,3,4-tetrahydroquinoline to quinoline over the OVBMO materials is elucidated in terms of heterogeneous Catal.via a radical pathway.
基金Supported by the National Science and Technology Major Projects of China(No.2009ZX09301-012)
文摘A series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo[4,3-c]quinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry（MS） and 1H NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities against the tested fungi at different levels.
基金National Natural Science Foundation of China(No.32071521)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX18_2272)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment for their support of this work。
文摘Quinoline is widely used in the production of drugs as a highly effective insecticide,and its derivatives can also be used to produce dyes.It has a teratogenic carcinogen to wildlife and humans once entering into the aquatic environment.In this study,the degradation mechanism of quinoline in drinking water by a strong ionization dielectric barrier discharge(DBD)lowtemperature plasma with large volume was explored.High concentration of hydroxyl radical(·OH)(0.74 mmol l^(-1))and ozone(O3)(58.2 mg l^(-1))produced by strongly ionized discharge DBD system were quantitatively analyzed based on the results of electron spin resonance and O3 measurements.The influencing reaction conditions of input voltages,initial pH value,·OH inhibitors,initial concentration and inorganic ions on the removal efficiency of quinoline were systematically studied.The obtained results showed that the removal efficiency and TOC removal of quinoline achieved 94.8%and 32.2%,degradation kinetic constant was 0.050 min^(-1) at 3.8 k V and in a neutral pH(7.2).The proposed pathways of quinoline were suggested based on identified intermediates as hydroxy pyridine,fumaric acid,oxalic acid,and other small molecular acids by high-performance liquid chromatography/tandem mass spectrometry analysis.Moreover,the toxicity analysis on the intermediates demonstrated that its acute toxicity,bioaccumulation factor and mutagenicity were reduced.The overall findings provided theoretical and experimental basis for the application of a high capacity strong ionization DBD water treatment system in the removal of quinoline from drinking water.
基金supported by the research grant of Phytochemistry Key Laboratory of Shaanxi Province (No. 02js40)
文摘The title compound,2,6-bis（2-pyridinylmethyl）-3,5-bis（2-hydroxyl-5-chlorophe nyl）-pyrazine（C26H12Cl2N4O2C2H8O2,Mr=551.41）,has been synthesized and characterized by LC-ESIMS,NMR,UV and IR spectroscopy as well as by X-ray single-crystal diffraction.The compound behaves as a substituted pyrazine.The hydrogen atoms on C（2） and C（3） are substituted by 2-pyridinyl,whereas those on C（1） and C（4） are substituted by 2-hydroxyl-5-chlorophenyl.It crystallizes in the monoclinic system,space group P21/c with a=8.9433（12）,b=32.003（4）,c=10.5209（18）,β=111.199（2）°,V=2807.5（7）3,Z=4,Dc=1.305 mg/m3,F（000）=1144 and μ=0.094 mm-1.A total of 13235 reflections were collected in the range of 2.17～25.01o by using a phi and omega scan mode,of which 4923 were unique（Rint=0.0692） and 2872 observed reflections with Ⅰ 〉2σ（Ⅰ） were used in the structure solution and refinement.
文摘Preost-Woodward hydroxylation of 2 gave the 22S,23S-glycol(3), contrary to expectation.It is suggested that the formation of the two possible iodonium ions(4a and 4b)are reversible,thus allowing the discriminatory acetoxy group to follow the less hindered route,reacting with 4a virtually exclusively.
文摘目的建立脑内灌流6-羟基多巴胺(6-OHDA)所致大鼠纹状体细胞外液羟自由基升高的模型,为老年退行性病变和其它氧化应激所致脑细胞损伤的研究和药物筛选提供可利用的方法。方法微透析脑内灌流6-OHDA造模,采用水杨酸捕获羟自由基,高效液相-电化学检测技术,对活体脑内羟自由基所形成的2,3二羟基苯甲酸(2,3-DHBA)和2,5二羟基苯甲酸(2,5-DHBA)进行测定。结果6-OHDA脑内灌流后,模型组大鼠纹状体细胞外液2,3-DHBA和2,5-DH-BA在75 m in分别为对照组的6.6和3.4倍;2,3-DHBA在观察的全程中,一直高于对照组(P<0.01);2,5DHBA大部分时间点也高于对照组(P<0.05或P<0.01);维生素EC组的2,3-DHBA有4个时点低于模型组(P<0.05或P<0.01),2,5-DHBA各时点均低于模型组,但差异无显著性。结论6-OHDA脑内灌流可以造成大鼠纹状体细胞外液羟自由基升高的急性模型。
