A new three-dimensional coordination polymer {[Co(BPTC)0.5(bix)]′(H2O)}n (1, H4BPTC = 1,1′-biphenyl-2,2′,6,6′-tetracarboxylic acid, bix = 1,3-bis(imidazol-l-ylmethyl)-benzene) has been synthesized by the...A new three-dimensional coordination polymer {[Co(BPTC)0.5(bix)]′(H2O)}n (1, H4BPTC = 1,1′-biphenyl-2,2′,6,6′-tetracarboxylic acid, bix = 1,3-bis(imidazol-l-ylmethyl)-benzene) has been synthesized by the hydrothermal method and characterized by IR, elemental analysis, and single-crystal X-ray analysis. The crystal is of orthorhombic, space group Pbcn with a = 13.2975(10), b = 13.8424(12), c = 22.6367(17) A, CoC22H19N4Os, Mr = 478.34, V = 4166.7(6) A3, Dc = 1.525 g/cm^3, F(000) = 1968,μ = 0.867 mm^-1, S = 1.023 and Z = 8. The final R = 0.0683 and wR = 0.1529 for 3655 observed reflections with I 〉 20(I). In the title complex, the 2D Co-BPTC layer is formed through self-assembly of Co(II) ions and bridging BPTC4-ligands in a molar ratio of 2:1. The metal-organic lattice layers are further united together through the second bridging ligand bix to form a 3D metal-organic framework. The thermal stability of the title complex was studied by thermal gravimetric (TG) and differential thermal analysis (DTA).展开更多
The title compound {[Mn(H2BPTC)(tpy)(H2O)]·(H2O)3}, (1, H4BPTC = 1,1'- biphenyl-2,2',6,6'-tetracarboxylic acid, tby = 2,2':6,2'-terpyridine) has been synthesized by the hydrothermal reaction, and ...The title compound {[Mn(H2BPTC)(tpy)(H2O)]·(H2O)3}, (1, H4BPTC = 1,1'- biphenyl-2,2',6,6'-tetracarboxylic acid, tby = 2,2':6,2'-terpyridine) has been synthesized by the hydrothermal reaction, and its structure was determined by X-ray diffraction and characterized by elemental analysis, IR spectrum and thermogravimetric analysis. The crystal is of monoclinic, space group P21/c with a = 10.971(2), b = 20.776(4), c = 14.332(3) A, β = 109.25(3)°, MnC31H27N3O12, Mr = 688.50, V= 3084.1(10) A^3, Dc = 1.483 g/cm^3, F(000) = 1420, p = 0.498 mm^-1, S = 1.066 and Z = 4. The final refinement gave R = 0.0447 and wR = 0.1103 for 5107 observed reflections with I 〉 2σ(I). The title complex has a {[Mn(H2BPTC)(tpy)(H2O)]}, chain structure, and the hydrogen bonding interactions make it more stable. Each chain is further connected to the adjacent ones through π…π, C-H…π and rich hydrogen bonds to form a metal-organic coordination polymer.展开更多
基金supported by the International Technology Cooperation Project of Science and Technology Department of Henan Province (No. 124300510050)
文摘A new three-dimensional coordination polymer {[Co(BPTC)0.5(bix)]′(H2O)}n (1, H4BPTC = 1,1′-biphenyl-2,2′,6,6′-tetracarboxylic acid, bix = 1,3-bis(imidazol-l-ylmethyl)-benzene) has been synthesized by the hydrothermal method and characterized by IR, elemental analysis, and single-crystal X-ray analysis. The crystal is of orthorhombic, space group Pbcn with a = 13.2975(10), b = 13.8424(12), c = 22.6367(17) A, CoC22H19N4Os, Mr = 478.34, V = 4166.7(6) A3, Dc = 1.525 g/cm^3, F(000) = 1968,μ = 0.867 mm^-1, S = 1.023 and Z = 8. The final R = 0.0683 and wR = 0.1529 for 3655 observed reflections with I 〉 20(I). In the title complex, the 2D Co-BPTC layer is formed through self-assembly of Co(II) ions and bridging BPTC4-ligands in a molar ratio of 2:1. The metal-organic lattice layers are further united together through the second bridging ligand bix to form a 3D metal-organic framework. The thermal stability of the title complex was studied by thermal gravimetric (TG) and differential thermal analysis (DTA).
基金supported by the Natural Science Foundation of Henan Province (No. 2010A140009) the International Technology Cooperation Project of Science and Technology Department of Henan Province (No. 104300510044)
文摘The title compound {[Mn(H2BPTC)(tpy)(H2O)]·(H2O)3}, (1, H4BPTC = 1,1'- biphenyl-2,2',6,6'-tetracarboxylic acid, tby = 2,2':6,2'-terpyridine) has been synthesized by the hydrothermal reaction, and its structure was determined by X-ray diffraction and characterized by elemental analysis, IR spectrum and thermogravimetric analysis. The crystal is of monoclinic, space group P21/c with a = 10.971(2), b = 20.776(4), c = 14.332(3) A, β = 109.25(3)°, MnC31H27N3O12, Mr = 688.50, V= 3084.1(10) A^3, Dc = 1.483 g/cm^3, F(000) = 1420, p = 0.498 mm^-1, S = 1.066 and Z = 4. The final refinement gave R = 0.0447 and wR = 0.1103 for 5107 observed reflections with I 〉 2σ(I). The title complex has a {[Mn(H2BPTC)(tpy)(H2O)]}, chain structure, and the hydrogen bonding interactions make it more stable. Each chain is further connected to the adjacent ones through π…π, C-H…π and rich hydrogen bonds to form a metal-organic coordination polymer.
文摘目的检测子痫前期孕妇血清中人端粒酶反转录酶(human telomerase reverse transcriptase,hTERT)、沉默信息调节因子6(silent information regulator 6,Sirt6)表达,并探究hTERT,Sirt6水平表达与疾病严重程度及妊娠结局评估中的价值。方法选取2018年1月~2022年12月在陕西省人民医院进行诊治的300例子痫前期孕妇作为子痫前期组,孕妇均符合《妊娠期高血压疾病诊治指南(2015)》中子痫前期诊断标准,选取同时期孕检的300例健康孕妇为对照组,根据病情严重程度将子痫前期组分为轻症子痫前期组(n=180)和重症子痫前期组(n=120),根据是否发生不良妊娠结局将子痫前期组分为正常妊娠组(n=165)和不良妊娠组(n=135)。酶联免疫吸附实验(enzyme-linked immunosorbnent assay,ELISA)法检测血清中hTERT和Sirt6水平,Spearman相关性分析血清中hTERT和Sirt6水平与子痫前期孕妇病情严重程度的相关性,利用受试者工作特征(receiver operating characteristic,ROC)曲线评估血清hTERT和Sirt6水平在子痫前期诊断及妊娠结局预测中的价值。结果与对照组比较,子痫前期组血清hTERT(22.15±5.82 ng/ml vs 30.12±9.56 ng/ml),Sirt6(5.26±1.62 ng/ml vs 7.06±2.29 ng/ml)水平降低,差异具有统计学意义(t=12.334,11.114,均P<0.001)。与轻症子痫前期组比较,重症子痫前期组孕妇血清hTERT(18.28±4.11 ng/ml vs 24.73±6.96 ng/ml),Sirt6(4.03±1.17 ng/ml vs 6.08±1.92 ng/ml)水平降低,差异具有统计学意义(t=9.142,10.469,均P<0.001)。与正常妊娠组比较,不良妊娠组子痫前期孕妇血清中hTERT(17.75±4.61 ng/ml vs 25.75±6.81 ng/ml),Sirt6(4.06±0.96 ng/ml vs 6.24±2.16 ng/ml)水平降低,差异具有统计学意义(t=11.639,10.878,均P<0.001)。Spearman相关性分析显示,血清hTERT,Sirt6水平与子痫前期孕妇疾病严重程度均呈负相关(r=-0.562,-0.604,均P<0.001)。ROC曲线分析结果显示,血清hTERT,Sirt6诊断子痫前期的曲线下面积(95%置信区间)[AUC(95%CI)]分别为0.711(0.673~0.747),0.727(0.689~0.762),两者联合诊断子痫前期的AUC(95%CI)为0.788(0.753~0.820),高于两者单独诊断(Z=2.719,2.154,P=0.007,0.031);血清hTERT,Sirt6预测子痫前期不良妊娠结局的AUC(95%CI)分别为0.786(0.735~0.831),0.783(0.732~0.829),两者联合预测子痫前期不良妊娠结局的AUC(95%CI)为0.849(0.804~0.888),高于两者单独预测(Z=1.855,1.861,P=0.032,0.031)。结论hTERT和Sirt6在子痫前期孕妇血清中水平较低,与子痫前期孕妇疾病严重程度均呈负相关,并对妊娠结局具有一定的评估价值。