Heavy alcohol consumption results in alcoholic liver disease(ALD)with inadequate therapeutic options.Here,we first report the potential beneficial effects of ginsenoside Rk2(Rk2),a rare dehydroprotopanaxadiol saponin ...Heavy alcohol consumption results in alcoholic liver disease(ALD)with inadequate therapeutic options.Here,we first report the potential beneficial effects of ginsenoside Rk2(Rk2),a rare dehydroprotopanaxadiol saponin isolated from streamed ginseng,against alcoholic liver injury in mice.Chronic-plus-single-binge ethanol feeding caused severe liver injury,as manifested by significantly elevated serum aminotransferase levels,hepatic histological changes,increased lipid accumulation,oxidative stress,and inflammation in the liver.These deleterious effects were alleviated by the treatment with Rk2(5 and 30 mg/kg).Acting as an nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)inhibitor,Rk2 ameliorates alcohol-induced liver inflammation by inhibiting NLRP3 inflammasome signaling in the liver.Meanwhile,the treatment with Rk2 alleviated the alcohol-induced intestinal barrier dysfunction via enhancing NLRP6 inflammasome in the intestine.Our findings indicate that Rk2 is a promising agent for the prevention and treatment of ALD and other NLPR3-driven diseases.展开更多
The effect of plant growth regulator 6-BA and GA, which were sprayed during the filling stage of rice on senescence in the later stage was studied.The results showed that 6-BA and GA can slow down the falling of the c...The effect of plant growth regulator 6-BA and GA, which were sprayed during the filling stage of rice on senescence in the later stage was studied.The results showed that 6-BA and GA can slow down the falling of the chlorophyll and protein in the flag leaves, restrain the decrease of the POD activity and the accumulation of MDA.To a certain extend, 6-BA and GA can retard the senescence of functional leaves, which benefit the filling of rice, and improve the yield and quality. Key words:展开更多
基金supported by grants from the Research Committee of the University of Macao(Grant No.:MYRG2022-00020-ICMS)the Science and Technology Development Fund,Macao SAR,China(File No.:0074/2021/AFJ and 0052/2022/A1).
文摘Heavy alcohol consumption results in alcoholic liver disease(ALD)with inadequate therapeutic options.Here,we first report the potential beneficial effects of ginsenoside Rk2(Rk2),a rare dehydroprotopanaxadiol saponin isolated from streamed ginseng,against alcoholic liver injury in mice.Chronic-plus-single-binge ethanol feeding caused severe liver injury,as manifested by significantly elevated serum aminotransferase levels,hepatic histological changes,increased lipid accumulation,oxidative stress,and inflammation in the liver.These deleterious effects were alleviated by the treatment with Rk2(5 and 30 mg/kg).Acting as an nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)inhibitor,Rk2 ameliorates alcohol-induced liver inflammation by inhibiting NLRP3 inflammasome signaling in the liver.Meanwhile,the treatment with Rk2 alleviated the alcohol-induced intestinal barrier dysfunction via enhancing NLRP6 inflammasome in the intestine.Our findings indicate that Rk2 is a promising agent for the prevention and treatment of ALD and other NLPR3-driven diseases.
文摘The effect of plant growth regulator 6-BA and GA, which were sprayed during the filling stage of rice on senescence in the later stage was studied.The results showed that 6-BA and GA can slow down the falling of the chlorophyll and protein in the flag leaves, restrain the decrease of the POD activity and the accumulation of MDA.To a certain extend, 6-BA and GA can retard the senescence of functional leaves, which benefit the filling of rice, and improve the yield and quality. Key words:
