Methyluracil and 5-nitro-6-methyluracil react with variable molar quantities of benzoyl chloride in acetonitrile-pyridine at room temperature to give 1-N, 3-N-dibenzoyl-6- methyluracil 3b and 1-N-benzoyl-5-nitro-6-met...Methyluracil and 5-nitro-6-methyluracil react with variable molar quantities of benzoyl chloride in acetonitrile-pyridine at room temperature to give 1-N, 3-N-dibenzoyl-6- methyluracil 3b and 1-N-benzoyl-5-nitro-6-methyluracil 4b. The reactive rates of debenzoylation of 3b and 4b were investigated.展开更多
Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the respective hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain...Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the respective hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives. Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin respectively. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA.展开更多
Complex [Zn（L）（SO4）]0.5H20 （L = 2-（2-chloro-6-fluorophenyl）-lH-imidazo[4,5- J][1,10]phenanthroline） has been synthesized under hydrothermal conditions. The compound was characterized by elemental analysis, IR,...Complex [Zn（L）（SO4）]0.5H20 （L = 2-（2-chloro-6-fluorophenyl）-lH-imidazo[4,5- J][1,10]phenanthroline） has been synthesized under hydrothermal conditions. The compound was characterized by elemental analysis, IR, TG and single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P21/n with a = 9.9916（7）, b = 12.3834（9）, c = 29.259（2） A, fl = 97.7720（10）°, V = 3587.0（4） A^3, Z = 2, C76H41CI4F4NI60952Zn2, Mr = 1734.91, Dc = 1.606 g/cm^3, F（000） = 1754, p（MoKa） = 0.959 mm-1, R = 0.0492 and wR = 0.1385. The asymmetric unit of 1 contains one Zn（lI） atom, two L ligands, one sulfate anion and half a water molecule. Each Zn（lI） atom is five-coordinated by four nitrogen atoms from two different L ligands and one sulfate oxygen atom in a tetragonal pyramidal coordination environment. The N-H＇＂O hydrogen bonds link the discrete structure of 1 into a 2D supramolecular architecture. The photoluminescent property of 1 has also been studied in the solid state at room temperature.展开更多
基金We thank the National Natural Science Foundation of China(NO．20172007)for financial support
文摘Methyluracil and 5-nitro-6-methyluracil react with variable molar quantities of benzoyl chloride in acetonitrile-pyridine at room temperature to give 1-N, 3-N-dibenzoyl-6- methyluracil 3b and 1-N-benzoyl-5-nitro-6-methyluracil 4b. The reactive rates of debenzoylation of 3b and 4b were investigated.
文摘Hydrazinolysis of 6-chloro-1-methyluracil followed by condensation of the product with different aromatic aldehyde gives the respective hydrazones which undergoes oxidative cyclization using thionyl chloride to obtain pyrazolo[3,4-d]pyrimidines in good yields. On the other hand, nitrosation of 6-aminouracils followed by the reaction with different arylidineanilines gives new xanthine derivatives. Finally, indenopyrrolopyrimidine and indenopteridine are obtained in good yields via the reaction of 6-aminouracils and 5,6-diaminouracil with ninhydrin respectively. The newly synthesized compounds show binding, chelation and fragmentation of the nucleic acid DNA.
基金Supported by Jilin Province Science and Technology Development Projects (No.No.201105085)the Science and Technology Research Projects of the Education Committee of Jilin Province (No.2013206)
文摘Complex [Zn（L）（SO4）]0.5H20 （L = 2-（2-chloro-6-fluorophenyl）-lH-imidazo[4,5- J][1,10]phenanthroline） has been synthesized under hydrothermal conditions. The compound was characterized by elemental analysis, IR, TG and single-crystal X-ray diffraction. It crystallizes in monoclinic, space group P21/n with a = 9.9916（7）, b = 12.3834（9）, c = 29.259（2） A, fl = 97.7720（10）°, V = 3587.0（4） A^3, Z = 2, C76H41CI4F4NI60952Zn2, Mr = 1734.91, Dc = 1.606 g/cm^3, F（000） = 1754, p（MoKa） = 0.959 mm-1, R = 0.0492 and wR = 0.1385. The asymmetric unit of 1 contains one Zn（lI） atom, two L ligands, one sulfate anion and half a water molecule. Each Zn（lI） atom is five-coordinated by four nitrogen atoms from two different L ligands and one sulfate oxygen atom in a tetragonal pyramidal coordination environment. The N-H＇＂O hydrogen bonds link the discrete structure of 1 into a 2D supramolecular architecture. The photoluminescent property of 1 has also been studied in the solid state at room temperature.
