In advanced technologies, single event upset reversal(SEUR) due to charge sharing can make the upset state of SRAM cells recover to their initial state, which can reduce the soft error for SRAMs in radiation environme...In advanced technologies, single event upset reversal(SEUR) due to charge sharing can make the upset state of SRAM cells recover to their initial state, which can reduce the soft error for SRAMs in radiation environments. By using the full 3D TCAD simulations, this paper presents a new kind of SEUR triggered by the charge collection of the Off-PMOS and the delayed charge collection of the On-NMOS in commercial 40-nm 6 T SRAM cells. The simulation results show that the proposed SEUR can not occur at normal incidence,but can present easily at angular incidence. It is also found that the width of SET induced by this SEUR remains the same after linear energy transfer(LET) increases to a certain value. In addition, through analyzing the effect of the spacing, the adjacent transistors, the drain area, and some other dependent parameters on this new kind of SEUR, some methods are proposed to strengthen the recovery ability of SRAM cells.展开更多
目的探讨乙型肝炎病毒(HBV)感染者T细胞和白细胞介素-6(IL-6)表达的水平及其临床意义。方法选择2014年1月至2017年6月成都医学院第一附属医院收治的HBV感染者286例(急性乙肝患者48例,慢性乙肝患者192例,乙型肝炎肝硬化患者46例),同时选...目的探讨乙型肝炎病毒(HBV)感染者T细胞和白细胞介素-6(IL-6)表达的水平及其临床意义。方法选择2014年1月至2017年6月成都医学院第一附属医院收治的HBV感染者286例(急性乙肝患者48例,慢性乙肝患者192例,乙型肝炎肝硬化患者46例),同时选取同期体检健康者60例作为对照组,实时荧光定量 PCR法测定HBV感染者血液中HBV-DNA载量,应用流式细胞仪检测各组T细胞分布,应用酶联免疫吸附法测定各组血清IL-6水平,评价HBV感染者、载量不同HBV感染者的IL-6、T细胞水平及其和HBV-DNA载量的关系。结果急性组、慢性组、乙肝肝硬化组的CD3^+、CD4^+、CD4^+/CD8^+低于对照组( P <0.05),CD8^+高于对照组;随疾病进展,CD3^+、CD4^+和CD4^+/CD8^+逐渐降低,CD8^+、HBV-DNA载量、IL-6水平逐渐升高,各组CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、HBV-DNA载量、IL-6比较,差异有统计学意义( P <0.05)。低、中、高载量组CD3^+、CD4^+、CD4^+/CD8^+低于阴性组( P <0.05),CD8^+明显高于阴性组,随HBV-DNA载量增加,CD3^+、CD4^+和CD4^+/CD8^+逐渐降低,CD8^+、IL-6逐渐升高,各组CD3^+、CD4^+、CD8^+和CD4^+/CD8^+比较差异有统计学意义( P <0.05)。经Pearson相关分析,HBV感染者CD3^+、CD4^+、CD4^+/CD8^+、HBV-DNA载量与IL-6正相关,CD8^+与IL-6负相关( P <0.05)。结论 HBV感染者CD3^+、CD4^+和CD4^+/CD8^+明显降低,CD8^+、IL-6明显升高,T细胞及IL-6水平与疾病类型、HBV-DNA载量有密切关系。展开更多
基金Supported by National Natural Science Foundation of China(Nos.61176030 and 61373032)Specialized Research Fund for the Doctor Program of Higher Education of China(No.20124307110016)
文摘In advanced technologies, single event upset reversal(SEUR) due to charge sharing can make the upset state of SRAM cells recover to their initial state, which can reduce the soft error for SRAMs in radiation environments. By using the full 3D TCAD simulations, this paper presents a new kind of SEUR triggered by the charge collection of the Off-PMOS and the delayed charge collection of the On-NMOS in commercial 40-nm 6 T SRAM cells. The simulation results show that the proposed SEUR can not occur at normal incidence,but can present easily at angular incidence. It is also found that the width of SET induced by this SEUR remains the same after linear energy transfer(LET) increases to a certain value. In addition, through analyzing the effect of the spacing, the adjacent transistors, the drain area, and some other dependent parameters on this new kind of SEUR, some methods are proposed to strengthen the recovery ability of SRAM cells.
文摘目的探讨乙型肝炎病毒(HBV)感染者T细胞和白细胞介素-6(IL-6)表达的水平及其临床意义。方法选择2014年1月至2017年6月成都医学院第一附属医院收治的HBV感染者286例(急性乙肝患者48例,慢性乙肝患者192例,乙型肝炎肝硬化患者46例),同时选取同期体检健康者60例作为对照组,实时荧光定量 PCR法测定HBV感染者血液中HBV-DNA载量,应用流式细胞仪检测各组T细胞分布,应用酶联免疫吸附法测定各组血清IL-6水平,评价HBV感染者、载量不同HBV感染者的IL-6、T细胞水平及其和HBV-DNA载量的关系。结果急性组、慢性组、乙肝肝硬化组的CD3^+、CD4^+、CD4^+/CD8^+低于对照组( P <0.05),CD8^+高于对照组;随疾病进展,CD3^+、CD4^+和CD4^+/CD8^+逐渐降低,CD8^+、HBV-DNA载量、IL-6水平逐渐升高,各组CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、HBV-DNA载量、IL-6比较,差异有统计学意义( P <0.05)。低、中、高载量组CD3^+、CD4^+、CD4^+/CD8^+低于阴性组( P <0.05),CD8^+明显高于阴性组,随HBV-DNA载量增加,CD3^+、CD4^+和CD4^+/CD8^+逐渐降低,CD8^+、IL-6逐渐升高,各组CD3^+、CD4^+、CD8^+和CD4^+/CD8^+比较差异有统计学意义( P <0.05)。经Pearson相关分析,HBV感染者CD3^+、CD4^+、CD4^+/CD8^+、HBV-DNA载量与IL-6正相关,CD8^+与IL-6负相关( P <0.05)。结论 HBV感染者CD3^+、CD4^+和CD4^+/CD8^+明显降低,CD8^+、IL-6明显升高,T细胞及IL-6水平与疾病类型、HBV-DNA载量有密切关系。
