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基于合成数据集的多目标识别与6-DoF位姿估计
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作者 胡广华 欧美彤 李振东 《华南理工大学学报(自然科学版)》 EI CAS CSCD 北大核心 2024年第4期42-50,共9页
多目标识别及六自由度(6-DoF)位姿估计是实现物料无序堆放状态下机器人自动分拣的关键。近年来,基于深度神经网络的方法在目标识别及位姿估计领域受到广泛关注,但此类方法依赖大量训练样本,而样本的采集及标注费时费力,限制了其实用性... 多目标识别及六自由度(6-DoF)位姿估计是实现物料无序堆放状态下机器人自动分拣的关键。近年来,基于深度神经网络的方法在目标识别及位姿估计领域受到广泛关注,但此类方法依赖大量训练样本,而样本的采集及标注费时费力,限制了其实用性。其次,当成像条件差、目标相互遮挡时,现有位姿估计方法无法保证结果的可靠性,进而导致抓取失败。为此,文中提出了一种基于合成数据样本的目标识别、分割及位姿估计方法。首先,以目标对象的3维(3D)几何模型为基础,利用3D图形编程工具生成虚拟场景的多视角RGB-D合成图像,并对生成的RGB图像及深度图像分别进行风格迁移和噪声增强,从而提高合成数据的真实感,以适应真实场景的检测需要;接着,利用合成数据集训练YOLOv7-mask实例分割模型,运用真实数据进行测试,结果验证了该方法的有效性;然后,以分割结果为基础,基于ES6D目标位姿估计模型,提出了一种在线姿态评估方法,以自动滤除严重失真的估计结果;最后,采用基于主动视觉的位姿估计校正策略,引导机械臂运动到新的视角重新检测,以解决因遮挡而导致位姿估计偏差的问题。在自行搭建的6自由度工业机器人视觉分拣系统上进行了实验,结果表明,文中提出的方法能较好地适应复杂环境下工件的识别与6-DoF姿态估计要求。 展开更多
关键词 目标识别 位置测量 6-dof位姿估计 机器人自动分拣 RGB-D图像
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一种6-DOF小行星着陆轨迹序列凸优化方法
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作者 初彦峰 穆荣军 +1 位作者 梁浩 崔乃刚 《宇航学报》 EI CAS CSCD 北大核心 2024年第3期341-351,共11页
针对6自由度的小行星动力着陆多约束轨迹优化问题,提出了一种基于序列凸优化的小行星着陆轨迹优化算法。首先采用多面体引力场模型计算小行星的引力场,其可用于描述任意形状的小行星引力场,且比质点群法和球谐函数展开法等方法计算精度... 针对6自由度的小行星动力着陆多约束轨迹优化问题,提出了一种基于序列凸优化的小行星着陆轨迹优化算法。首先采用多面体引力场模型计算小行星的引力场,其可用于描述任意形状的小行星引力场,且比质点群法和球谐函数展开法等方法计算精度更高。为了在凸约束下解决小行星着陆过程燃料消耗最优问题,通过对探测器动力学模型及其约束进行线性化和离散化,将原来的非凸连续时间优化问题转化为凸化的子问题,即二阶锥规划问题(SOCP);然后引入了虚拟控制项和信赖域,以增强算法的鲁棒性。通过在形状不规则小行星上的着陆模拟,验证了所提出算法的有效性,仿真结果满足各项约束条件,可实现高精度着陆和燃料消耗最优的目标。 展开更多
关键词 小行星着陆 多面体引力场模型 6自由度 序列凸优化
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Assessing the Performance of CMIP6 Models in Simulating Droughts across Global Drylands 被引量:1
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作者 Xiaojing YU Lixia ZHANG +1 位作者 Tianjun ZHOU Jianghua ZHENG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第2期193-208,共16页
Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the curr... Both the attribution of historical change and future projections of droughts rely heavily on climate modeling. However,reasonable drought simulations have remained a challenge, and the related performances of the current state-of-the-art Coupled Model Intercomparison Project phase 6(CMIP6) models remain unknown. Here, both the strengths and weaknesses of CMIP6 models in simulating droughts and corresponding hydrothermal conditions in drylands are assessed.While the general patterns of simulated meteorological elements in drylands resemble the observations, the annual precipitation is overestimated by ~33%(with a model spread of 2.3%–77.2%), along with an underestimation of potential evapotranspiration(PET) by ~32%(17.5%–47.2%). The water deficit condition, measured by the difference between precipitation and PET, is 50%(29.1%–71.7%) weaker than observations. The CMIP6 models show weaknesses in capturing the climate mean drought characteristics in drylands, particularly with the occurrence and duration largely underestimated in the hyperarid Afro-Asian areas. Nonetheless, the drought-associated meteorological anomalies, including reduced precipitation, warmer temperatures, higher evaporative demand, and increased water deficit conditions, are reasonably reproduced. The simulated magnitude of precipitation(water deficit) associated with dryland droughts is overestimated by 28%(24%) compared to observations. The observed increasing trends in drought fractional area,occurrence, and corresponding meteorological anomalies during 1980–2014 are reasonably reproduced. Still, the increase in drought characteristics, associated precipitation and water deficit are obviously underestimated after the late 1990s,especially for mild and moderate droughts, indicative of a weaker response of dryland drought changes to global warming in CMIP6 models. Our results suggest that it is imperative to employ bias correction approaches in drought-related studies over drylands by using CMIP6 outputs. 展开更多
关键词 DROUGHTS hydrothermal conditions DRYLANDS CMIP6 model evaluation
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6-DOFs机器臂在位置模式下追随运动意图的研究
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作者 刘环宇 陈明祥 +1 位作者 高孟扬 王钰 《科学技术创新》 2024年第1期59-62,共4页
为了使脑卒中患者在主动康复中能够得到准确、实时、稳定的识别效果,本研究提出了基于6-DOFs协作机器人作为一种康复运动设备。患者的运动意图通过其手与机器臂末端的六维力传感器作用的程度与方向来捕捉,控制系统则通过解析出的运动意... 为了使脑卒中患者在主动康复中能够得到准确、实时、稳定的识别效果,本研究提出了基于6-DOFs协作机器人作为一种康复运动设备。患者的运动意图通过其手与机器臂末端的六维力传感器作用的程度与方向来捕捉,控制系统则通过解析出的运动意图实现机器臂末端运动方向与速度的设置和驱动。运动意图主要由运动方向和运动程度两个指标表达,前者由力传感器各分力的合力方向确定,后者由合力的大小确定,同时还要检测合力与TCP所在轨迹点处切线方向的夹角,最终确定出机器臂末端沿轨迹运动的速度。 展开更多
关键词 6-dofs 运动意图 运动控制算法
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Spatiotemporal Evaluation and Future Projection of Diurnal Temperature Range over the Tibetan Plateau in CMIP6 Models
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作者 Suguo ZHANG Qin HU +2 位作者 Xianhong MENG Yaqiong LÜ Xianyu YANG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第11期2245-2258,共14页
The diurnal temperature range(DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR varia... The diurnal temperature range(DTR) serves as a vital indicator reflecting both natural climate variability and anthropogenic climate change. This study investigates the historical and projected multitemporal DTR variations over the Tibetan Plateau. It assesses 23 climate models from phase 6 of the Coupled Model Intercomparison Project(CMIP6) using CN05.1 observational data as validation, evaluating their ability to simulate DTR over the Tibetan Plateau. Then, the evolution of DTR over the Tibetan Plateau under different shared socioeconomic pathway(SSP) scenarios for the near,middle, and long term of future projection are analyzed using 11 selected robustly performing models. Key findings reveal:(1) Among the models examined, BCC-CSM2-MR, EC-Earth3, EC-Earth3-CC, EC-Earth3-Veg, EC-Earth3-Veg-LR,FGOALS-g3, FIO-ESM-2-0, GFDL-ESM4, MPI-ESM1-2-HR, MPI-ESM1-2-LR, and INM-CM5-0 exhibit superior integrated simulation capability for capturing the spatiotemporal variability of DTR over the Tibetan Plateau.(2) Projection indicates a slightly increasing trend in DTR on the Tibetan Plateau in the SSP1-2.6 scenario, and decreasing trends in the SSP2-4.5, SSP3-7.0, and SPP5-8.5 scenarios. In certain areas, such as the southeastern edge of the Tibetan Plateau, western hinterland of the Tibetan Plateau, southern Kunlun, and the Qaidam basins, the changes in DTR are relatively large.(3) Notably, the warming rate of maximum temperature under SSP2-4.5, SSP3-7.0, and SPP5-8.5 is slower compared to that of minimum temperature, and it emerges as the primary contributor to the projected decrease in DTR over the Tibetan Plateau in the future. 展开更多
关键词 Tibetan Plateau CMIP6 models diurnal temperature range model assessment historical period future projection
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Establishment of a humanized ST6GAL1 mouse model for influenza research
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作者 Lyu Chao Han Feng +10 位作者 Gao Qian Lv Limin Lu Ziwei Lu Shuangshuang Li Xiaoyan Hu Yuechao Yang Mengjie Zhao Yingze Liu Jun Lu Xuancheng Duo Shuguang 《Animal Models and Experimental Medicine》 CAS CSCD 2024年第3期337-346,共10页
Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encodi... Background:This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1.Methods:Humanized fragments,consisting of the endothelial cell-specific K18 promoter,human ST6GAL1-encoding gene,and luciferase gene,were microinjected into the fertilized eggs of mice.The manipulated embryos were transferred into the oviducts of pseudopregnant female mice.The offspring were identified using PCR.Mice exhibiting elevated expression of the hST6GAL1 gene were selectively bred for propagation,and in vivo analysis was performed for screening.Expression of the humanized gene was tested by performing immunohistochemical(IHC)analysis.Hematologic and biochemical analyses using the whole blood and serum of humanized hST6GAL1 mice were performed.Results:Successful integration of the human ST6GAL1 gene into the mouse genome led to the overexpression of human SiaT ST6GAL1.Seven mice were identified as carrying copies of the humanized gene,and the in vivo analysis indicated that hST6GAL1gene expression in positive mice mirrored influenza virus infection characteristics.The IHC results revealed that hST6GAL1 was expressed in the lungs of humanized mice.Moreover,the hematologic and biochemical parameters of the positive mice were within the normal range.Conclusion:A humanized influenza mouse model expressing the hST6GAL1 gene was successfully established and characterized. 展开更多
关键词 hST6GAL1 humanized mice influenza animal model
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The bio-active components of the Mongolian medicine Horcha-6 and therapeutic mechanism in the rat migraine model
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作者 Ao Qier Naren Mandula +7 位作者 Qiburi Qiburi Manda Manda Tegexi Baiyin Xilinqiqige Bao Huricha Baigued Chang-Shan Wang Temuqile Temuqile De-Zhi Yang 《Traditional Medicine Research》 2024年第2期8-17,共10页
Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass spectrometry.Also,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treati... Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass spectrometry.Also,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treating migraines through the use of network pharmacology and a rat migraine model.Methods:After identifying the active components of Horcha-6,the corresponding genes of the active components’target were obtained from the Universal Protein database,and a“compound-target-disease”network was constructed using Cytoscape 3.9.0 software.For the in vivo experiments,nitroglycerin was injected intraperitoneally into rats to create a migraine model.Pre-treatment with Horcha-6 was administered orally for 14 days,and rats were subjected to migraine-related behavior tests.RNA sequencing was performed to identify the gene expression regulated by Horcha-6 in the trigeminal nerve.Results:A total of 903 chemical components of Horcha-6 have been collected in the liquid chromatography with tandem mass spectrometry.We discovered 55 of the Horcha-6 bio-active components that were evaluated based on their Percent Human Oral Absorption(≥30%)and DL values(≥0.185)on the traditional Chinese medicine systems pharmacology database.The“compound-target-disease”network contained 163 intersection targets with the migraine state.Gene Ontology analysis indicated that these components significantly regulated the immune response,vascular function,oxidative stress,etc.When Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed,we observed that most of the target genes were significantly enriched in the inflammation and neuro-related signaling pathway,toll-like receptor signaling pathway,neuroactive ligand-receptor interaction,etc.These predictions were further demonstrated via in vivo animal model experiments.The RNA sequencing results showed that 41 genes were down-regulated(P<0.05)and 86 genes were up-regulated(P<0.05)in the Horcha-6 treated group compared with the untreated group.Those genes were mainly involved in neuromodulation,vascular function,and hormone metabolism.Conclusion:The 55 bio-active components in Horcha-6 regulate inflammation,hormone metabolism,and neurotransmitters and have potential as a therapy to treat migraines. 展开更多
关键词 Horcha-6 bio-active components rat migraine model inflammation hormone metabolism NEUROTRANSMITTER
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A Probabilistic Trust Model and Control Algorithm to Protect 6G Networks against Malicious Data Injection Attacks in Edge Computing Environments
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作者 Borja Bordel Sánchez Ramón Alcarria Tomás Robles 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第10期631-654,共24页
Future 6G communications are envisioned to enable a large catalogue of pioneering applications.These will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control l... Future 6G communications are envisioned to enable a large catalogue of pioneering applications.These will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control loops critical for managing Industry 5.0 deployments,digital agriculture systems,and essential infrastructures.The provision of extensive machine-type communications through 6G will render many of these innovative systems autonomous and unsupervised.While full automation will enhance industrial efficiency significantly,it concurrently introduces new cyber risks and vulnerabilities.In particular,unattended systems are highly susceptible to trust issues:malicious nodes and false information can be easily introduced into control loops.Additionally,Denialof-Service attacks can be executed by inundating the network with valueless noise.Current anomaly detection schemes require the entire transformation of the control software to integrate new steps and can only mitigate anomalies that conform to predefined mathematical models.Solutions based on an exhaustive data collection to detect anomalies are precise but extremely slow.Standard models,with their limited understanding of mobile networks,can achieve precision rates no higher than 75%.Therefore,more general and transversal protection mechanisms are needed to detect malicious behaviors transparently.This paper introduces a probabilistic trust model and control algorithm designed to address this gap.The model determines the probability of any node to be trustworthy.Communication channels are pruned for those nodes whose probability is below a given threshold.The trust control algorithmcomprises three primary phases,which feed themodel with three different probabilities,which are weighted and combined.Initially,anomalous nodes are identified using Gaussian mixture models and clustering technologies.Next,traffic patterns are studied using digital Bessel functions and the functional scalar product.Finally,the information coherence and content are analyzed.The noise content and abnormal information sequences are detected using a Volterra filter and a bank of Finite Impulse Response filters.An experimental validation based on simulation tools and environments was carried out.Results show the proposed solution can successfully detect up to 92%of malicious data injection attacks. 展开更多
关键词 6G networks noise injection attacks Gaussian mixture model Bessel function traffic filter Volterra filter
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Hydrologic Response to Future Climate Change in the Dulong-Irra-waddy River Basin Based on Coupled Model Intercomparison Project 6
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作者 XU Ziyue MA Kai +1 位作者 YUAN Xu HE Daming 《Chinese Geographical Science》 SCIE CSCD 2024年第2期294-310,共17页
Within the context of the Belt and Road Initiative(BRI)and the China-Myanmar Economic Corridor(CMEC),the Dulong-Ir-rawaddy(Ayeyarwady)River,an international river among China,India and Myanmar,plays a significant role... Within the context of the Belt and Road Initiative(BRI)and the China-Myanmar Economic Corridor(CMEC),the Dulong-Ir-rawaddy(Ayeyarwady)River,an international river among China,India and Myanmar,plays a significant role as both a valuable hydro-power resource and an essential ecological passageway.However,the water resources and security exhibit a high degree of vulnerabil-ity to climate change impacts.This research evaluates climate impacts on the hydrology of the Dulong-Irrawaddy River Basin(DIRB)by using a physical-based hydrologic model.We crafted future climate scenarios using the three latest global climate models(GCMs)from Coupled Model Intercomparison Project 6(CMIP6)under two shared socioeconomic pathways(SSP2-4.5 and SSP5-8.5)for the near(2025-2049),mid(2050-2074),and far future(2075-2099).The regional model using MIKE SHE based on historical hydrologic processes was developed to further project future streamflow,demonstrating reliable performance in streamflow simulations with a val-idation Nash-Sutcliffe Efficiency(NSE)of 0.72.Results showed that climate change projections showed increases in the annual precip-itation and potential evapotranspiration(PET),with precipitation increasing by 11.3%and 26.1%,and PET increasing by 3.2%and 4.9%,respectively,by the end of the century under SSP2-4.5 and SSP5-8.5.These changes are projected to result in increased annual streamflow at all stations,notably at the basin’s outlet(Pyay station)compared to the baseline period(with an increase of 16.1%and 37.0%at the end of the 21st century under SSP2-4.5 and SSP5-8.5,respectively).Seasonal analysis for Pyay station forecasts an in-crease in dry-season streamflow by 31.3%-48.9%and 22.5%-76.3%under SSP2-4.5 and SSP5-8.5,respectively,and an increase in wet-season streamflow by 5.8%-12.6%and 2.8%-33.3%,respectively.Moreover,the magnitude and frequency of flood events are pre-dicted to escalate,potentially impacting hydropower production and food security significantly.This research outlines the hydrological response to future climate change during the 21st century and offers a scientific basis for the water resource management strategies by decision-makers. 展开更多
关键词 climate change hydrologic response Coupled model Intercomparison Project 6(CMIP6) MIKE SHE(Système Hydrologique Europeén) Dulong-Irrawaddy River Basin
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Variability of the Pacific subtropical cells under global warming in CMIP6 models
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作者 Xue HAN Junqiao FENG +1 位作者 Yunlong LU Dunxin HU 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第1期24-40,共17页
The Pacific subtropical cells(STCs)are shallow meridional overturning circulations connecting the tropics and subtropics,and are assumed to be an important driver of the tropical Pacific decadal variability.The variab... The Pacific subtropical cells(STCs)are shallow meridional overturning circulations connecting the tropics and subtropics,and are assumed to be an important driver of the tropical Pacific decadal variability.The variability of STCs under global warming is investigated using multimodal outputs from the latest phase of the Coupled Model Inter-comparison Project(CMIP6)and ocean reanalysis products.Firstly,the volume transport diagnostic analysis is employed to evaluate how coupled models and ocean reanalysis products reproduce interior STC transport.The variation of heat transport by the interior STC under the high-emissions warming scenarios is also analyzed.The results show that the multimodal-mean linear trends of the interior STC transport along 9°S and 9°N are-0.02 Sv/a and 0.04 Sv/a under global warming,respectively,which is mainly due to the combined effect of the strengthened upper oceanic stratification and the weakening of wind field.There is a compensation relationship between the interior STC and the western boundary transport in the future climate,and the compensation relationship of 9°S is more significant than that of 9°N.In addition,compared with ocean reanalysis products,the coupled models tend to underestimate the variability of the interior STC transport convergence,and thus may lose some sea surface temperature(SST)driving force,which may be the reason for the low STC-SST correlation simulated by the model.The future scenario simulation shows that the heat transport of interior STC is weakened under global warming,with a general agreement across models. 展开更多
关键词 interior subtropical cell(STC) global warming Coupled model Inter-comparison Project(CMIP6) western boundary transport
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CMIP 6 models simulation of the connection between North/South Pacific Meridional Mode and ENSO
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作者 Yunlong LU Junqiao FENG Dunxin HU 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2024年第2期439-453,共15页
The subtropical North and South Pacific Meridional Modes(NPMM and SPMM)are well known precursors of El Niño-Southern Oscillation(ENSO).However,relationship between them is not constant.In the early 1980,the relat... The subtropical North and South Pacific Meridional Modes(NPMM and SPMM)are well known precursors of El Niño-Southern Oscillation(ENSO).However,relationship between them is not constant.In the early 1980,the relationship experienced an interdecadal transition.Changes in this connection can be attributed mainly to the phase change of the Pacific decadal oscillation(PDO).During the positive phase of PDO,a shallower thermocline in the central Pacific is responsible for the stronger trade wind charging(TWC)mechanism,which leads to a stronger equatorial subsurface temperature evolution.This dynamic process strengthens the connection between NPMM and ENSO.Associated with the negative phase of PDO,a shallower thermocline over southeastern Pacific allows an enhanced wind-evaporation-SST(WES)feedback,strengthening the connection between SPMM and ENSO.Using 35 Coupled Model Intercomparison Project Phase 6(CMIP6)models,we examined the NPMM/SPMM performance and its connection with ENSO in the historical runs.The great majority of CMIP6 models can reproduce the pattern of NPMM and SPMM well,but they reveal discrepant ENSO and NPMM/SPMM relationship.The intermodal uncertainty for the connection of NPMM-ENSO is due to different TWC mechanism.A stronger TWC mechanism will enhance NPMM forcing.For SPMM,few models can simulate a good relationship with ENSO.The intermodel spread in the relationship of SPMM and ENSO owing to SST bias in the southeastern Pacific,as WES feedback is stronger when the southeastern Pacific is warmer. 展开更多
关键词 North and South Pacific Meridional Modes(NPMM and SPMM) El Niño-Southern Oscillation(ENSO) Pacific decadal oscillation(PDO) Coupled model Intercomparison Project Phase 6(CMIP6)
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白细胞介素-6对胰腺癌小鼠癌组织的细胞增殖及上皮间质转化的影响
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作者 崔彦杰 宋金萍 +1 位作者 郝立君 黄国虹 《检验医学与临床》 CAS 2024年第16期2328-2333,共6页
目的 探讨白细胞介素-6(IL-6)在胰腺癌裸鼠模型癌组织增殖与上皮间质化中的作用,并分析其分子机制。方法 将18只成功构建胰腺癌细胞荷瘤的BALB/c裸鼠模型随机分为模型对照组、IL-6过表达组和免疫球蛋白G(IgG)抗体组,每组6只。模型对照... 目的 探讨白细胞介素-6(IL-6)在胰腺癌裸鼠模型癌组织增殖与上皮间质化中的作用,并分析其分子机制。方法 将18只成功构建胰腺癌细胞荷瘤的BALB/c裸鼠模型随机分为模型对照组、IL-6过表达组和免疫球蛋白G(IgG)抗体组,每组6只。模型对照组于肿瘤部位注射生理盐水进行干预,IL-6过表达组于肿瘤部位注射IL-6过表达质粒进行干预,IgG抗体组予肿瘤部位注射IgG抗体进行干预。3组均于末次给药24 h后处死小鼠,并收集胰腺肿瘤组织。对各组肿瘤组织进行离体称重并计算抑瘤率。通过苏木精-伊红(HE)染色观察胰腺组织的病理学改变。采用酶联免疫吸附试验(ELISA)检测各组裸鼠肿瘤组织中IL-6、p-STAT3、NF-κB p65和VEGF蛋白的表达水平。采用蛋白质印迹法(Western blot)检测各组肿瘤组织中E-cadherin、Vimentin、MMP-9蛋白的表达水平。采用实时荧光定量聚合酶链反应(qRT-PCR)检测各组IL-6、p-STAT3、SOCS3基因的表达水平。结果 3组裸鼠胰腺肿瘤组织的平均瘤重及抑瘤率比较,差异均无统计学意义(P>0.05)。HE染色结果显示,模型对照组肿瘤组织细胞体积增大,癌细胞排列呈巢状;IL-6过表达组可见肿瘤组织轻度纤维化,少量炎症浸润;IgG抗体组可见核分裂象,大量肿瘤细胞坏死,局灶组织纤维化。IL-6过表达组E-cadherin蛋白、SOCS3基因表达水平低于模型对照组和IgG抗体组,而Vimentin、MMP-9、IL-6、p-STAT3、NF-κB p65、VEGF蛋白的表达水平及IL-6、NF-κB p65基因的表达水平高于模型对照组和IgG抗体组,差异均有统计学意义(P<0.05);IgG抗体组Vimentin、MMP-9、IL-6、p-STAT3、NF-κB p65、VEGF蛋白的表达水平及IL-6、NF-κB p65基因的表达水平低于模型对照组,而E-cadherin和SOCS3基因水平高于模型对照组,差异均有统计学意义(P<0.05)。结论 IL-6可以通过p-STAT3和(或)NF-κB p65信号通路调节胰腺癌裸鼠模型肿瘤组织中的相关细胞因子,影响肿瘤组织的增殖及上皮间质化。 展开更多
关键词 白细胞介素-6 胰腺癌 裸鼠模型 增殖 上皮间质化 信号通路
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外圆磨削18CrNiMo7-6力模型及表面完整性研究
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作者 王栋 陈磊 张志鹏 《中国机械工程》 EI CAS CSCD 北大核心 2024年第3期381-393,共13页
为了准确和有效地控制磨削参数对磨削力及表面完整性的影响,通过解析法,以磨粒与材料间的塑性变形、压痕理论以及剪切应变效应为理论依据,建立了三阶段的磨削力理论模型。选定棕刚玉砂轮进行磨削试验,探究了磨削参数对磨削力的影响以及... 为了准确和有效地控制磨削参数对磨削力及表面完整性的影响,通过解析法,以磨粒与材料间的塑性变形、压痕理论以及剪切应变效应为理论依据,建立了三阶段的磨削力理论模型。选定棕刚玉砂轮进行磨削试验,探究了磨削参数对磨削力的影响以及磨削参数和磨削力对表面完整性的影响,通过外圆横向磨削正交试验获得了外圆磨削最优工艺参数。结果表明,外圆磨削力模型法向磨削力和切向磨削力的预测平均误差分别为5.56%和7.08%;砂轮径向进给速度f_(r)对磨削力的影响最大,磨削宽度b次之,工件转速n_(w)和砂轮粒度的影响较小;f_(r)和b对残余应力的影响较大,砂轮粒度对表面粗糙度的影响最大;随着磨削力的增大,表面粗糙度值一直增大,残余应力先减小后增大,沿深度方向残余应力最大值先增大后减小,在试验所取参数条件下,影响残余应力的深度分布范围基本在20~40μm;最优工艺参数组合如下:f_(r)=0.15 mm/min,n_(w)=120 r/min,b=10 mm,砂轮粒度80。 展开更多
关键词 外圆磨削 横向磨削 磨削力模型 18CrNiMo7-6 表面完整性
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鄂尔多斯盆地蟠龙地区长6储层四性关系研究
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作者 李杰 宁波 +2 位作者 马钰凯 程妮 肖鄂 《能源与环保》 2024年第3期115-121,129,共8页
针对蟠龙地区长6储层四性关系的研究与认识不足,利用蟠龙地区的测井数据、录完井数据、岩心分析和化验资料等资料进行整理与分析,对研究区储层岩性、物性、电性与含油性特征及其相互间的关系进行了研究。研究结果表明,①蟠龙地区长6油... 针对蟠龙地区长6储层四性关系的研究与认识不足,利用蟠龙地区的测井数据、录完井数据、岩心分析和化验资料等资料进行整理与分析,对研究区储层岩性、物性、电性与含油性特征及其相互间的关系进行了研究。研究结果表明,①蟠龙地区长6油层组以长石砂岩为主;②储层平均孔隙度为8%,平均渗透率为0.79×10-3μm 2,属于低孔特低渗至低孔超低渗储层;③录井中岩心以油迹含油级别为主;④结合岩心测试资料建立了储层参数测井解释模型,并最终确定有效储层物性下限为:渗透率0.15×10^(-3)μm^(2),孔隙度5.5%,电阻率20Ω·m,声波时差215μs/m。研究了储层四性基本特征及其关系,并得出了蟠龙地区储层物性和含油性的电性解释图版,为后续蟠龙地区油层解释以及探明储量参数的确定提供了依据。 展开更多
关键词 鄂尔多斯盆地 蟠龙地区 6储层 四性关系 测井解释模型
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6-DOF机械臂运动学分析和验证 被引量:2
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作者 罗贵成 胡添嗣 《现代机械》 2023年第2期68-73,共6页
为了实现6-DOF机械臂末端的运动控制,利用改进D-H方法推导了机械臂的正运动学齐次变换矩阵,基于齐次变换矩阵,推导出了机械臂的四组运动学逆解,针对运动控制过程中逆解的选取问题,提出了一种基于机械臂初始角的逆解选取方法,并根据解的... 为了实现6-DOF机械臂末端的运动控制,利用改进D-H方法推导了机械臂的正运动学齐次变换矩阵,基于齐次变换矩阵,推导出了机械臂的四组运动学逆解,针对运动控制过程中逆解的选取问题,提出了一种基于机械臂初始角的逆解选取方法,并根据解的特性推导出了初始角的可选范围;通过matlab机器人工具箱仿真验证了机器人正逆解以及逆解选取方法的正确性,利用twincat3-机械臂控制系统进行实验,进一步验证了逆解选取方法的正确有效。 展开更多
关键词 6-dof机械臂 D-H方法 运动学逆解 逆解的选取
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CAS FGOALS-f3-L Model Datasets for CMIP6 DCPP Experiment
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作者 Shuai HU Bo WU +8 位作者 Yiming WANG Tianjun ZHOU Yongqiang YU Bian HE Pengfei LIN Qing BAO Hailong LIU Kangjun CHEN Shuwen ZHAO 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第10期1911-1922,共12页
The outputs of the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System(FGOALSf3-L)model for the decadal climate prediction project(DCPP)of the Coupled Model Intercomparison Project Phase 6(CMI... The outputs of the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System(FGOALSf3-L)model for the decadal climate prediction project(DCPP)of the Coupled Model Intercomparison Project Phase 6(CMIP6)are described in this paper.The FGOALS-f3-L was initialized through the upgraded,weakly coupled data assimilation scheme,referred to as EnOI-IAU,which assimilates observational anomalies of sea surface temperature(SST)and upper-level(0–1000-m)ocean temperature and salinity profiles into the coupled model.Then,nine ensemble members of 10-year hindcast/forecast experiments were conducted for each initial year over the period of 1960–2021,based on initial conditions produced by three initialization experiments.The hindcast and forecast experiments follow the experiment designs of the Component-A and Component-B of the DCPP,respectively.The decadal prediction output datasets contain a total of 44 monthly mean atmospheric and oceanic variables.The preliminary evaluation indicates that the hindcast experiments show significant predictive skill for the interannual variations of SST in the north Pacific and multi-year variations of SST in the subtropical Pacific and the southern Indian Ocean. 展开更多
关键词 CMIP6 DCPP FGOALS-f3-L decadal prediction model initialization
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Projected Regional 1.50℃and 2.00℃Warming Threshold-crossing Time Worldwide Using the CMIP6 Models
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作者 MENG Yali DUAN Keqin +5 位作者 SHANG Wei SHI Peihong LI Shuangshuang CHENG Ying CHEN Rong ZHANG Zhaopeng 《Chinese Geographical Science》 SCIE CSCD 2023年第6期1095-1108,共14页
The Paris Agreement aims to limit global warming to well below 2.00℃and pursue efforts to limit the temperature increase to 1.50℃.However,the response of climate change to unbalanced global warming is affected by sp... The Paris Agreement aims to limit global warming to well below 2.00℃and pursue efforts to limit the temperature increase to 1.50℃.However,the response of climate change to unbalanced global warming is affected by spatial and temporal sensitivities.To better understand the regional warming response to global warming at 1.50℃and 2.00℃,we detected the 1.50℃and 2.00℃warming threshold-crossing time(WTT)above pre-industrial levels globally using the Coupled Model Intercomparison Project phase 6(CMIP6)models.Our findings indicate that the 1.50℃or 2.00℃WTT differs substantially worldwide.The warming rate of land would be approximately 1.35–1.46 times that of the ocean between 60°N–60°S in 2015–2100.Consequently,the land would experience a 1.50℃(2.00℃)warming at least 10–20 yr earlier than the time when the global mean near-surface air temperature reaches 1.50℃(2.00℃)WTT.Meanwhile,the Southern Ocean between 0°and 60°S considerably slows down the global 1.50℃and 2.00℃WTT.In 2040–2060,over 98.70%(77.50%),99.70%(89.30%),99.80%(93.40%),and 100.00%(98.00%)of the land will have warmed by over 1.50℃(2.00℃)under SSP(Shared Socioeconomic Pathway)1–2.6,SSP2-4.5,SSP3-7.0,and SSP5-8.5,respectively.We conclude that regional 1.50℃(2.00℃)WTT should be fully considered,especially in vulnerable high-latitude and high-altitude regions. 展开更多
关键词 CMIP6(Coupled model Intercomparison Project phase 6) global warming 1.50℃warming time 2.00℃warming time regional differences
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Spatial Inhomogeneity of Atmospheric CO_(2) Concentration and Its Uncertainty in CMIP6 Earth System Models
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作者 Chengjun XIE Tongwen WU +7 位作者 Jie ZHANG Kalli FURTADO Yumeng ZHOU Yanwu ZHANG Fanghua WU Weihua JIE He ZHAO Mengzhe ZHENG 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2023年第11期2108-2126,共19页
This paper provides a systematic evaluation of the ability of 12 Earth System Models(ESMs)participating in the Coupled Model Intercomparison Project Phase 6(CMIP6)to simulate the spatial inhomogeneity of the atmospher... This paper provides a systematic evaluation of the ability of 12 Earth System Models(ESMs)participating in the Coupled Model Intercomparison Project Phase 6(CMIP6)to simulate the spatial inhomogeneity of the atmospheric carbon dioxide(CO_(2))concentration.The multi-model ensemble mean(MME)can reasonably simulate the increasing trend of CO_(2) concentration from 1850 to 2014,compared with the observation data from the Scripps CO_(2) Program and CMIP6 prescribed data,and improves upon the CMIP5 MME CO_(2) concentration(which is overestimated after 1950).The growth rate of CO_(2) concentration in the northern hemisphere(NH)is higher than that in the southern hemisphere(SH),with the highest growth rate in the mid-latitudes of the NH.The MME can also reasonably simulate the seasonal amplitude of CO_(2) concentration,which is larger in the NH than in the SH and grows in amplitude after the 1950s(especially in the NH).Although the results of the MME are reasonable,there is a large spread among ESMs,and the difference between the ESMs increases with time.The MME results show that regions with relatively large CO_(2) concentrations(such as northern Russia,eastern China,Southeast Asia,the eastern United States,northern South America,and southern Africa)have greater seasonal variability and also exhibit a larger inter-model spread.Compared with CMIP5,the CMIP6 MME simulates an average spatial distribution of CO_(2) concentration that is much closer to the site observations,but the CMIP6-inter-model spread is larger.The inter-model differences of the annual means and seasonal cycles of atmospheric CO_(2) concentration are both attributed to the differences in natural sources and sinks of CO_(2) between the simulations. 展开更多
关键词 CMIP6 Earth System models the simulation of atmospheric CO_(2)concentration spatial inhomogeneity UNCERTAINTY
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基于GF-6/WFV卫星遥感的大田冬小麦叶片氮素含量估测
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作者 姚永胜 任妮 +4 位作者 李卫国 李伟 马廷淮 张宏 董建宾 《麦类作物学报》 CAS CSCD 北大核心 2024年第7期911-918,共8页
为对大田冬小麦叶片氮素含量(LNC)进行快速、准确及无损监测,通过在江苏省泰州泰兴市、盐城大丰区和南通如皋市布设冬小麦遥感监测大田试验,在获取试验样点冬小麦冠层红光波段反射率(REDref)、近红外波段反射率(NIRref)和计算的十个光... 为对大田冬小麦叶片氮素含量(LNC)进行快速、准确及无损监测,通过在江苏省泰州泰兴市、盐城大丰区和南通如皋市布设冬小麦遥感监测大田试验,在获取试验样点冬小麦冠层红光波段反射率(REDref)、近红外波段反射率(NIRref)和计算的十个光谱指数(RVI、NDVI、DVI、SAVI、OSAVI、MSR、RDVI、EVI2、NLI和SVI)基础上,将12个遥感光谱指标与冬小麦LNC进行相关分析,选出与LNC相关性较好的作为模型输入变量,构建基于BP神经网络的冬小麦LNC估测模型,并利用GF-6/WFV卫星遥感影像对县域冬小麦LNC的空间分布开展监测。结果表明,12个遥感光谱指标与冬小麦LNC之间存在不同程度的相关性,其中NDVI、RVI、MSR、OSAVI和NLI与冬小麦LNC的相关性较好(相关系数不低于0.65)。将优选的5个遥感光谱指标作为模型输入变量,构建基于BP神经网络的冬小麦LNC估测模型(LNC-BPEM),模型的估测精度r^(2)=0.866,RMSE=0.246%,ARE=12.9%。将冬小麦LNC-BPEM估测模型和GF-6/WFV影像结合对县域冬小麦LNC的空间信息监测,获得了如皋县域冬小麦LNC的空间分布特征,该区域冬小麦LNC范围在0.9%~2.0%(长势正常)的种植面积为29 693.3 hm^(2),占冬小麦总种植面积的74%。这说明利用GF-6/WFV卫星的多个遥感光谱指标与神经网络结合建模可有效估测县域大田冬小麦叶片氮素含量。 展开更多
关键词 冬小麦 GF-6/WFV卫星遥感 神经网络 叶片氮素含量 估测模型
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安塞油田黑山梁区长6油层组单砂体构型分析及平面展布特征
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作者 马江波 冯纪慧 +3 位作者 李刚 韩彦斌 张寰萌 郭岭 《地质科学》 CAS CSCD 北大核心 2024年第4期1018-1033,共16页
安塞油田黑山梁区块位于延安市安塞区,三叠系延长组长6油层组是其主力产油层。目前该区已进入注水开发阶段,但砂体展布、非均质性、砂体叠置规律等认识不清,导致开发过程中存在注水受效程度不均衡,整体水驱效果差等问题。为此,本次研究... 安塞油田黑山梁区块位于延安市安塞区,三叠系延长组长6油层组是其主力产油层。目前该区已进入注水开发阶段,但砂体展布、非均质性、砂体叠置规律等认识不清,导致开发过程中存在注水受效程度不均衡,整体水驱效果差等问题。为此,本次研究依托丰富的测井、录井资料,以及岩心、镜下薄片资料和分析测试数据,开展地层精细刻画、沉积微相、砂体平面分布及单砂体叠置规律的综合研究。结果表明:黑山梁地区长6时期主要发育三角洲前缘亚相,岩性以细粒长石砂岩为主,分选性中等-好,磨圆度中等,水下分流河道和分流间湾微相较为多见,河口坝微相发育较少;水下分流河道为优势相,砂岩分布广、厚度大,沿河道方向延伸,早期形成的河口坝由于波浪作用和分流河道侵蚀作用被破坏,河口坝无法保存完整,仅有部分痕迹。砂体类型包括水下分流河道砂和河口坝砂两种,单砂体垂向叠置可分为孤立型、叠加型和切叠型3种;侧向拼接样式可分为孤立式、对接式和侧切式3种。研究区内砂体沿北东-南西方向呈长条状展布,由于河道频繁摆动和分叉,砂体切叠现象明显,顺物源方向砂体连通性较好,垂直物源方向砂体被分流间湾泥隔开,砂体连通性较差,并结合生产动态数据,认为砂体连通程度越高,水驱动用效果越好。基于该研究成果建立了研究区曲流河三角洲沉积模式,为后期油藏完善注采井网、分层注水开发方案调整提供地质依据。 展开更多
关键词 曲流河三角洲 砂体构型 沉积模式 6油层组 黑山梁区 安塞油田
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