Background Early evaluation of prognosis in cardiogenic shock(CS)is crucial for tailored treatment selection.Both lactate clearance and lactate levels are considered useful prognostic biomarkers in patients with CS.Ho...Background Early evaluation of prognosis in cardiogenic shock(CS)is crucial for tailored treatment selection.Both lactate clearance and lactate levels are considered useful prognostic biomarkers in patients with CS.However,there is yet no literature comparing the 6-hour lactate clearance rate(Δ6Lac)with lactate levels measured at admission(L1)and after 6 h(L2)to predict 30-day mortality in CS.Methods In this observational cohort study,95 patients with CS were treated at Department of Intensive Care Unit,Yiwu Central Hospital between January 2020 and December 2022.Of these,88 patients met the eligibility criteria.The lactate levels were measured after admission(L1)as the baseline lactate value,and were measured after 6 h(L2)following admission.The primary endpoint of the study was survival rate at 30 days.A receiver operating characteristic curve was used for data analysis.Univariate and multivariate Cox regression analyses were performed based onΔ6Lac.Kaplan–Meier(KM)survival curves were generated to compare the 30-day survival rates among L1,L2,andΔ6Lac.Results TheΔ6Lac model showed the highest area under the curve value(0.839),followed by the L2(0.805)and L1(0.668)models.TheΔ6Lac model showed a sensitivity of 84.2%and specificity of 75.4%.The L1 and L2 models had sensitivities of 57.9%each and specificities of 89.9%and 98.6%,respectively.The cut-off values forΔ6Lac,L1,and L2 were 18.2%,6.7 mmol/L,and 6.1 mmol/L,respectively.Univariate Cox regression analysis revealed a significant association betweenΔ6Lac and 30-day mortality.After adjusting for five models in multivariate Cox regression,Δ6Lac remained a significant risk factor for 30-day mortality in patients with CS.In our fifth multivariate Cox regression model,Δ6Lac remained a risk factor associated with 30-day mortality(hazard ratio[HR]=5.14,95%confidence interval[CI]:1.48 to 17.89,P=0.010)as well as L2(HR=8.42,95%CI:1.26 to 56.22,P=0.028).The KM survival curve analysis revealed that L1>6.7 mmol/L(HR=8.08,95%CI:3.23 to 20.20,P<0.001),L2>6.1 mmol/L(HR=25.97,95%CI:9.76 to 69.15,P<0.001),andΔ6Lac≤18.2%(HR=8.92,95%CI:2.95 to 26.95,P<0.001)were associated with a higher risk of 30-day mortality.ConclusionsΔ6Lac is a better predictor for 30-day mortality in CS than lactate levels at admission.It has a predictive value equivalent to that of lactate level at 6 h after admission,making it an important surrogate indicator for evaluating the suitability as well as poor prognosis after CS treatment.We found that a cut-off value of 18.2%forΔ6Lac provided the most accurate assessment of early prognosis in CS.展开更多
目的 探讨心率判定脓毒症心肌病(SIC)病情及短期预后的临床价值。方法 选取2020-01-10-2022-01-10乳山市人民医院重症医学科(ICU)收治的128例SIC患者为研究对象,根据入院28 d预后将患者分为生存组和死亡组。比较2组患者入ICU时的基线资...目的 探讨心率判定脓毒症心肌病(SIC)病情及短期预后的临床价值。方法 选取2020-01-10-2022-01-10乳山市人民医院重症医学科(ICU)收治的128例SIC患者为研究对象,根据入院28 d预后将患者分为生存组和死亡组。比较2组患者入ICU时的基线资料、序贯器官衰竭评分(SOFA)、急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)、抗脓毒症集束化治疗6 h后乳酸清除率(6 h LCR)、入院时心率(HR1)和抗脓毒症集束化治疗6 h后心率(HR2)的差异;分析HR1和HR2与SOFA、APACHEⅡ、6 h LCR的相关性,并绘制受试者工作特征曲线(ROC),评估心率对SIC患者短期预后的应用价值。结果 128例患者中,生存组54例,占比42.2%;死亡组74例,占比57.8%。死亡组患者HR1、HR2、SOFA评分、APACHEⅡ均高于生存组,6 h LCR低于生存组,差异有统计学意义,均P<0.05。相关性分析结果显示,HR1、HR2与SOFA、APACHEⅡ呈正相关,与6 h LCR呈负相关,但HR2与SOFA、APACHEⅡ、6 h LCR的相关性更好。HR1、HR2的曲线下面积(AUC)分别为0.604、0.766,灵敏度分别为64.86%、82.43%,特异度分别为55.56%、57.41%,HR2较HR1灵敏度及特异度更高。结论 心率可作为SIC病情评估和短期预后的有效指标。展开更多
基金supported by the Major(Key)Science and Technology Research Project of Jinhua(Grant No.2021-3-019).
文摘Background Early evaluation of prognosis in cardiogenic shock(CS)is crucial for tailored treatment selection.Both lactate clearance and lactate levels are considered useful prognostic biomarkers in patients with CS.However,there is yet no literature comparing the 6-hour lactate clearance rate(Δ6Lac)with lactate levels measured at admission(L1)and after 6 h(L2)to predict 30-day mortality in CS.Methods In this observational cohort study,95 patients with CS were treated at Department of Intensive Care Unit,Yiwu Central Hospital between January 2020 and December 2022.Of these,88 patients met the eligibility criteria.The lactate levels were measured after admission(L1)as the baseline lactate value,and were measured after 6 h(L2)following admission.The primary endpoint of the study was survival rate at 30 days.A receiver operating characteristic curve was used for data analysis.Univariate and multivariate Cox regression analyses were performed based onΔ6Lac.Kaplan–Meier(KM)survival curves were generated to compare the 30-day survival rates among L1,L2,andΔ6Lac.Results TheΔ6Lac model showed the highest area under the curve value(0.839),followed by the L2(0.805)and L1(0.668)models.TheΔ6Lac model showed a sensitivity of 84.2%and specificity of 75.4%.The L1 and L2 models had sensitivities of 57.9%each and specificities of 89.9%and 98.6%,respectively.The cut-off values forΔ6Lac,L1,and L2 were 18.2%,6.7 mmol/L,and 6.1 mmol/L,respectively.Univariate Cox regression analysis revealed a significant association betweenΔ6Lac and 30-day mortality.After adjusting for five models in multivariate Cox regression,Δ6Lac remained a significant risk factor for 30-day mortality in patients with CS.In our fifth multivariate Cox regression model,Δ6Lac remained a risk factor associated with 30-day mortality(hazard ratio[HR]=5.14,95%confidence interval[CI]:1.48 to 17.89,P=0.010)as well as L2(HR=8.42,95%CI:1.26 to 56.22,P=0.028).The KM survival curve analysis revealed that L1>6.7 mmol/L(HR=8.08,95%CI:3.23 to 20.20,P<0.001),L2>6.1 mmol/L(HR=25.97,95%CI:9.76 to 69.15,P<0.001),andΔ6Lac≤18.2%(HR=8.92,95%CI:2.95 to 26.95,P<0.001)were associated with a higher risk of 30-day mortality.ConclusionsΔ6Lac is a better predictor for 30-day mortality in CS than lactate levels at admission.It has a predictive value equivalent to that of lactate level at 6 h after admission,making it an important surrogate indicator for evaluating the suitability as well as poor prognosis after CS treatment.We found that a cut-off value of 18.2%forΔ6Lac provided the most accurate assessment of early prognosis in CS.
文摘目的 探讨心率判定脓毒症心肌病(SIC)病情及短期预后的临床价值。方法 选取2020-01-10-2022-01-10乳山市人民医院重症医学科(ICU)收治的128例SIC患者为研究对象,根据入院28 d预后将患者分为生存组和死亡组。比较2组患者入ICU时的基线资料、序贯器官衰竭评分(SOFA)、急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ)、抗脓毒症集束化治疗6 h后乳酸清除率(6 h LCR)、入院时心率(HR1)和抗脓毒症集束化治疗6 h后心率(HR2)的差异;分析HR1和HR2与SOFA、APACHEⅡ、6 h LCR的相关性,并绘制受试者工作特征曲线(ROC),评估心率对SIC患者短期预后的应用价值。结果 128例患者中,生存组54例,占比42.2%;死亡组74例,占比57.8%。死亡组患者HR1、HR2、SOFA评分、APACHEⅡ均高于生存组,6 h LCR低于生存组,差异有统计学意义,均P<0.05。相关性分析结果显示,HR1、HR2与SOFA、APACHEⅡ呈正相关,与6 h LCR呈负相关,但HR2与SOFA、APACHEⅡ、6 h LCR的相关性更好。HR1、HR2的曲线下面积(AUC)分别为0.604、0.766,灵敏度分别为64.86%、82.43%,特异度分别为55.56%、57.41%,HR2较HR1灵敏度及特异度更高。结论 心率可作为SIC病情评估和短期预后的有效指标。
