Argentum 5-Hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate:Synthesis,Crystal Structure and Antitumor Activity

In order to improve the water solubility and bioavailability of 5-hydroxy-7-methoxyflavone,argentum 5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate[Ag4(H2O)6](C(16)H(11)O4SO3)4·H2O(1,C(16)H(11)O4SO3=5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate)was synthesized by sulfonation reaction.The structure of 1 was characterized by FT-IR,elemental analysis and X-ray single-crystal diffraction.Complex 1 belongs to the triclinic system,space group P1,a=8.077(4),b=12.365(4),c=17.735(7)A,V=1685.0(12)A3,Z=1,μ=1.372 mm^–1,Dc=1.936 g/cm^3,F(000)=984,the final R=0.0819 and wR=0.2332 with I>2σ(I).3D structure of 1 exhibits alternating organic and inorganic regions.O–H×××O hydrogen bonds and Ag–O coordination interactions exist among crystal water,coordinated water and sulfo group,which constructed an organic zone.Flavone skeletons form organic region of 1.Sulfo group is the bridge linking these two regions.The in vitro antitumor activity of 1 against human lymphoma cells U937 and human breast cancer cells MCF-7 were evaluated with CCK-8 assay.The result shows that 1 showed inhibitory activity against tumour cell U937 and MCF-7,and indicated that flavone sulfonate derivatives may be potential leads for further biological screenings and may generate drug-like molecules.

飞龙掌血根的化学成分研究

目的研究飞龙掌血Toddalia asiatica(L.)Lam.根的化学成分。方法运用硅胶柱层析、Sephadex LH-20凝胶色谱、制备高效液相色谱等方法分离飞龙掌血根乙醇提物的化学成分,利用理化性质及NMR,HR-ESI-MS等波谱数据鉴定化合物结构。结果从该植物根中分离得到13个化合物,分别鉴定为6-methoxy-7-demethylcoumurrayin(1)、茴芹内酯(2)、异茴芹内酯(3)、珊瑚菜内酯(4)、走马芹内酯(5)、布拉易林(6)、九里香内酯(7)、别欧前胡素(8)、飞龙掌血香豆醌(9)、茵芋碱(10)、大叶桉亭(11)、白藓碱(12)以及4α-ethoxy-10α-hydroxyguai-6-ene(13),抑菌活性测试结果表明化合物11对白假丝酵母菌有一定的抑制作用。结论化合物1为新化合物,化合物13为首次从芸香科中分离得到。化合物11对白假丝酵母菌有一定的抑制作用,MIC值为32μg·mL^(-1)。

青蕨植物化学成分的研究(英文)

从青蕨根部的乙酸乙酯提取物中分离得到4个化合物.通过化学及波谱分析鉴定其结构为:saucerneolD1,dehydrogoniothalamin2,1-acetoxyl-2-piperonyl-6-[6-methoxyl-piperonyl]-3,7-dioxabicyclo-[3,3,0]-octane3and5,5′-dihydroxy-3-methoxy-6,8,3″,3″-tetramethylpyran-3′,4′flavone-7-O-[β-D-apiofuranosyl-1→6]-β-D-glucopyranoside4.其中化合物4为新化合物,化合物1为首次从该属植物中分离得到.

Two New Flavonoid Glycosides from Chrysanthemum morifolium

Two new flavonoid glycosides were isolated from the flowering heads of Chrysanthemum morifolium. Their structures were determined to be luteolin 4＇-methoxy-7- O-（6＂-O-acetyl）-β-D-glucopyranoside （1） and acacetin 7-O-（3＂-O-acetyl）-β-D-glucopyranoside （2） by means of 1H and 13C NMR spectroscopic analysis, including 2D NMR technique.

Two new isoflavonoids from the rhizomes of Belamcanda chinensis

Two new isoflavonoids, 6-methoxy-5,7,8,4′-tetrahydryoxyisoflavone (1) and 4′-methoxy -5,6-dihydroxyisoflavone-7-O-β-d-glucopyranoside (2), were isolated from the rhizomes of Belamcanda chinensis (L.) DC. Their structures were elucidated by extensive spectroscopic evidence including 1D NMR, 2D NMR, MS and IR spectra.

湖北麦冬地下部分化学成分

目的：研究百合科山麦冬属植物湖北麦冬Liriope spicata var.prolifera地下部分的化学成分,进一步丰富该植物的化学信息并为其开发和利用提供理论指导。方法：采用60%乙醇对湖北麦冬地下部分进行提取,综合利用大孔吸附树脂,正、反向硅胶,小孔树脂（MCI）及葡聚糖凝胶等柱色谱法对提取物进行分离和纯化,并根据化合物的理化性质及谱学数据鉴定其结构。结果：从湖北麦冬地下部分共分离并鉴定了12个化合物,其中包括4个黄酮类成分（化合物1~4）,4个酚类及苯甲酸类衍生物（化合物5~8）,2个酰胺类生物碱（化合物9,10）及2个其他类成分（化合物11,12）。分别鉴定为2＇,4,4＇-三羟基查耳酮（1）,木犀草素（2）,槲皮苷（3）,3,5-dihydroxy-7-methoxy-6-methyl-3-（4-hydroxybenzyl）chroman-4-one（4）,2,6-二甲氧基-4-硝基苯酚（5）,烯丙基焦儿茶酚（6）,3,4-dihydroxyallylbenzene 4-O-[α-L-rhamnopyranosyl（1→6）]-β-D-glucopyranoside（7）,丁香酸（8）,E-阿魏酰酪胺（9）,反式对羟基桂皮酸（10）,（1S,4S,5R,6R,7S,10S）-1,4,6-trihydroxyeudesmane-6-O-β-Dglucopyranoside（11）和5-羟甲基糠醛（12）。结论：其中化合物1~3,5~8及化合物10~12均为首次从山麦冬属植物中分离得到,化合物4和9为首次从该植物中分离得到。