Aging induces decrease of locomotor capacity and its decrease is associated with an increased risk of falls. Several lines of evidence indicate that both change in muscle power and aerobic fitness are causative. Mobil...Aging induces decrease of locomotor capacity and its decrease is associated with an increased risk of falls. Several lines of evidence indicate that both change in muscle power and aerobic fitness are causative. Mobility tests are usually based on a maximal exercise stress test;however, this test is often difficult and sometimes frightening to older persons. Therefore, the objective of this study was to examine age and gender differences in 3-min walk distance test (3WDT), and time of chair-rising test (CRT) of functional mobility. 153 men and 159 women aged from 20 to 78 years were recruited as subjects of the present study. The body composition measured the height, body mass (BM), body mass index (BMI), lean tissue mass (LTM), and waist circumference (WC). The Functional mobility tests measured the peak oxygen uptake (VO2peak), 3WDT, leg extension strength (LES), and times of CRT. Both in men and women, height and BMI, WC decreased and increased, respectively, with age. Height, BM, LTM, WC in men are higher than in women. We found no correlation between ages and 3WDT in women and a significant, negative correlation in men. All parameters of fitness performance were negatively correlated with age. Both in men and women, all parameters of fitness performance were positively correlated with sex. Both in men and women, VO2peak, 3WDT, and LES decreased with age. All parameters of fitness performance in men are higher than in women. Both in men and women were observed for the correlation between 3WDT and VO2peak, LES and CRT respectively. Although as the correlation coefficient between 3WTD and VO2peak, LES and CRT were low (r = 0.28 - 0.38), an error may occur, this study shows that 3WDT and CRT test can be a feasible method of providing the information for muscle power and aerobic fitness, possibly avoiding the need for a maximal stress test.展开更多
目的:研究、观察并分析规范、有效练习传统保健项目五禽戏对慢性心力衰竭(简称慢性心衰)患者6 min步行试验距离(6-minute Walk Test Distance,6 MWT)以及主要临床症状的影响,并综合评价其安全性。方法:研究对象选择2019年7月-2020年7月...目的:研究、观察并分析规范、有效练习传统保健项目五禽戏对慢性心力衰竭(简称慢性心衰)患者6 min步行试验距离(6-minute Walk Test Distance,6 MWT)以及主要临床症状的影响,并综合评价其安全性。方法:研究对象选择2019年7月-2020年7月济宁市中医院心血管病科收治的60例符合慢性心衰中、西医诊断标准的患者,中医辨证分型为阳虚水泛证者,采用随机双盲数字表法分为对照组(30例)和五禽戏组(30例)。对照组应用常规西医治疗方案。五禽戏组在常规西医治疗方案的基础上,规范、有效练习传统保健体育项目五禽戏4周。观察并对比两组患者治疗前后6 MWT、主要临床症状的改善情况;治疗前后进行常规检查、记录不良反应以评价习练五禽戏对患者的安全性的影响。结果:经4周规范、有效治疗,五禽戏组的6 MWT水平、主要临床症状改善较对照组更显著,差异具有统计学意义(P<0.05)。两组患者治疗前后各项安全指标未发现明显变化。结论:规范有效进行五禽戏锻炼对慢性心衰患者的6 MWT、主要临床症状具有明显的改善作用,对患者心脏功能的恢复有显著功效,进而提高患者的生活质量,其安全性综合评价较强且优势显著,是特别适合慢性心衰患者进行心脏康复的运动处方之一,值得大范围的推广。展开更多
This study compared the efficacy and safety of tiotropium bromide inhalation powder （spiriva） and doxofylline oral tablet （doxofylline） in the treatment of chronic obstructive pulmonary disease （COPD）. A multi-c...This study compared the efficacy and safety of tiotropium bromide inhalation powder （spiriva） and doxofylline oral tablet （doxofylline） in the treatment of chronic obstructive pulmonary disease （COPD）. A multi-center, randomized, double-blind, double-dummy, parallel-controlled study involved 127 eligible stable moderate to severe COPD patients treated with inhaled tiotropium dry powder （18 μg/day） or oral doxofylline tablets （0.2 g/time, 2 times a day） for 12 and 24 weeks. Before and after treatment for 12 weeks and 24 weeks, respectively, pulmonary function, 6-min walking distance and dyspnea index were recorded. The results showed that in both tiotropium group and doxofylline groups, after 12-week treatment, FEV1, FEV1/FVC% and 6-min walk distance were sig-nificantly higher than those before the medication, while dyspnea index decreased as compared with that before treatment. After 24-week treatment, a slight improvement in the measures was observed as compared with that of 12-weeks treatment, but the difference was not statistically significant. With both 12-week and 24-week treatment, the effect of tiotropium was slightly better than that of doxofylline tablets, with the difference being statistically insignificant. The major adverse events in the tiotropium group and doxofylline group were observed in 9 cases （9.9%） and 12 cases （12.9%）, respectively, and no statistically significant difference was found between them. We are led to conclude that both tiotropium at 18 μg a day and doxofylline tablets at 0.2 g/day （two times a day） are effective and safe for the treatment of COPD.展开更多
目的评价芪苈强心胶囊(QLQX)治疗心力衰竭(HF)的临床疗效。方法利用计算机检索PubMed、Web of Science、中国知网、万方、维普等5个数据库中常规治疗基础上加用QLQX治疗HF的临床随机对照试验文献,检索时间为数据库建库至2021年7月。采用...目的评价芪苈强心胶囊(QLQX)治疗心力衰竭(HF)的临床疗效。方法利用计算机检索PubMed、Web of Science、中国知网、万方、维普等5个数据库中常规治疗基础上加用QLQX治疗HF的临床随机对照试验文献,检索时间为数据库建库至2021年7月。采用Revman 5.3软件对文献中的左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、氨基末端脑钠肽前体(NT-proBNP)、脑钠肽(BNP)、6 min步行试验距离(6MWT)等指标进行Meta分析,系统评价QLQX治疗HF的临床疗效。结果共纳入26项研究,5161例患者。Meta分析显示,QLQX明显升高HF患者的LVEF[WMD=5.63,95%CI(4.33,6.93),P<0.01]和6MWT距离[WMD=58.86,95%CI(39.57,78.14),P<0.01],降低LVEDD[WMD=-3.08,95%CI(-4.07,-2.10),P<0.01]、NT-proBNP[WMD=-572.28,95%CI(-1022.45,-122.11),P=0.01]、BNP水平[WMD=-774.96,95%CI(-1102.41,-44.50),P<0.01]。结论常规治疗基础上加用QLQX能够进一步提高HF患者的临床疗效。展开更多
文摘Aging induces decrease of locomotor capacity and its decrease is associated with an increased risk of falls. Several lines of evidence indicate that both change in muscle power and aerobic fitness are causative. Mobility tests are usually based on a maximal exercise stress test;however, this test is often difficult and sometimes frightening to older persons. Therefore, the objective of this study was to examine age and gender differences in 3-min walk distance test (3WDT), and time of chair-rising test (CRT) of functional mobility. 153 men and 159 women aged from 20 to 78 years were recruited as subjects of the present study. The body composition measured the height, body mass (BM), body mass index (BMI), lean tissue mass (LTM), and waist circumference (WC). The Functional mobility tests measured the peak oxygen uptake (VO2peak), 3WDT, leg extension strength (LES), and times of CRT. Both in men and women, height and BMI, WC decreased and increased, respectively, with age. Height, BM, LTM, WC in men are higher than in women. We found no correlation between ages and 3WDT in women and a significant, negative correlation in men. All parameters of fitness performance were negatively correlated with age. Both in men and women, all parameters of fitness performance were positively correlated with sex. Both in men and women, VO2peak, 3WDT, and LES decreased with age. All parameters of fitness performance in men are higher than in women. Both in men and women were observed for the correlation between 3WDT and VO2peak, LES and CRT respectively. Although as the correlation coefficient between 3WTD and VO2peak, LES and CRT were low (r = 0.28 - 0.38), an error may occur, this study shows that 3WDT and CRT test can be a feasible method of providing the information for muscle power and aerobic fitness, possibly avoiding the need for a maximal stress test.
文摘目的:研究、观察并分析规范、有效练习传统保健项目五禽戏对慢性心力衰竭(简称慢性心衰)患者6 min步行试验距离(6-minute Walk Test Distance,6 MWT)以及主要临床症状的影响,并综合评价其安全性。方法:研究对象选择2019年7月-2020年7月济宁市中医院心血管病科收治的60例符合慢性心衰中、西医诊断标准的患者,中医辨证分型为阳虚水泛证者,采用随机双盲数字表法分为对照组(30例)和五禽戏组(30例)。对照组应用常规西医治疗方案。五禽戏组在常规西医治疗方案的基础上,规范、有效练习传统保健体育项目五禽戏4周。观察并对比两组患者治疗前后6 MWT、主要临床症状的改善情况;治疗前后进行常规检查、记录不良反应以评价习练五禽戏对患者的安全性的影响。结果:经4周规范、有效治疗,五禽戏组的6 MWT水平、主要临床症状改善较对照组更显著,差异具有统计学意义(P<0.05)。两组患者治疗前后各项安全指标未发现明显变化。结论:规范有效进行五禽戏锻炼对慢性心衰患者的6 MWT、主要临床症状具有明显的改善作用,对患者心脏功能的恢复有显著功效,进而提高患者的生活质量,其安全性综合评价较强且优势显著,是特别适合慢性心衰患者进行心脏康复的运动处方之一,值得大范围的推广。
基金supported by grants from the Clinical Chronic Respiratory Diseases Research Foundation of Chinese Medical Association (No. 07010030011)Key Research Program of the Ministry of Health of China (No. 2007353)the Special Funds for Scientific Research on Public Causes of Ministry of Health of China (No. 201002008)
文摘This study compared the efficacy and safety of tiotropium bromide inhalation powder （spiriva） and doxofylline oral tablet （doxofylline） in the treatment of chronic obstructive pulmonary disease （COPD）. A multi-center, randomized, double-blind, double-dummy, parallel-controlled study involved 127 eligible stable moderate to severe COPD patients treated with inhaled tiotropium dry powder （18 μg/day） or oral doxofylline tablets （0.2 g/time, 2 times a day） for 12 and 24 weeks. Before and after treatment for 12 weeks and 24 weeks, respectively, pulmonary function, 6-min walking distance and dyspnea index were recorded. The results showed that in both tiotropium group and doxofylline groups, after 12-week treatment, FEV1, FEV1/FVC% and 6-min walk distance were sig-nificantly higher than those before the medication, while dyspnea index decreased as compared with that before treatment. After 24-week treatment, a slight improvement in the measures was observed as compared with that of 12-weeks treatment, but the difference was not statistically significant. With both 12-week and 24-week treatment, the effect of tiotropium was slightly better than that of doxofylline tablets, with the difference being statistically insignificant. The major adverse events in the tiotropium group and doxofylline group were observed in 9 cases （9.9%） and 12 cases （12.9%）, respectively, and no statistically significant difference was found between them. We are led to conclude that both tiotropium at 18 μg a day and doxofylline tablets at 0.2 g/day （two times a day） are effective and safe for the treatment of COPD.
文摘目的评价芪苈强心胶囊(QLQX)治疗心力衰竭(HF)的临床疗效。方法利用计算机检索PubMed、Web of Science、中国知网、万方、维普等5个数据库中常规治疗基础上加用QLQX治疗HF的临床随机对照试验文献,检索时间为数据库建库至2021年7月。采用Revman 5.3软件对文献中的左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、氨基末端脑钠肽前体(NT-proBNP)、脑钠肽(BNP)、6 min步行试验距离(6MWT)等指标进行Meta分析,系统评价QLQX治疗HF的临床疗效。结果共纳入26项研究,5161例患者。Meta分析显示,QLQX明显升高HF患者的LVEF[WMD=5.63,95%CI(4.33,6.93),P<0.01]和6MWT距离[WMD=58.86,95%CI(39.57,78.14),P<0.01],降低LVEDD[WMD=-3.08,95%CI(-4.07,-2.10),P<0.01]、NT-proBNP[WMD=-572.28,95%CI(-1022.45,-122.11),P=0.01]、BNP水平[WMD=-774.96,95%CI(-1102.41,-44.50),P<0.01]。结论常规治疗基础上加用QLQX能够进一步提高HF患者的临床疗效。
