冲压件生产中,开卷落料的矫直参数直接影响了板料面品质量和材料性能,进而影响成形性。为了确定可靠的矫直参数范围、保证开卷后板料的面品质量和材料性能,进而有效指导开卷落料生产,以机盖外板为例进行研究。所用材料为6000系Al Si Mg...冲压件生产中,开卷落料的矫直参数直接影响了板料面品质量和材料性能,进而影响成形性。为了确定可靠的矫直参数范围、保证开卷后板料的面品质量和材料性能,进而有效指导开卷落料生产,以机盖外板为例进行研究。所用材料为6000系Al Si Mg合金,材料厚度为1 mm,材料性能偏上限需求,通过调整矫直参数(矫直机入口高度)得到不同性能的材料,并利用CAE分析、实际生产验证、后工序合边验证等方法,最终确定了机盖的矫直参数≥-0.6 mm (矫直机入口高度≥-0.6 mm)。其他在产零件可依据此方法确定矫直参数范围,减少停机时间,降低材料不合格风险,提高生产效率,降低生产成本。展开更多
Aim To prepare and characterize solid dispersions of silymarin with the intention of improving their dissolution properties. Methods The solid dispersions were prepared by the fusion method with polyethylene glycol ...Aim To prepare and characterize solid dispersions of silymarin with the intention of improving their dissolution properties. Methods The solid dispersions were prepared by the fusion method with polyethylene glycol 6000(PEG 6000) as the carrier. Evaluation of the properties of the dispersions was performed using dissolution studies, X ray powder diffraction and Fourier transform infrared (FT IR) spectroscopy. Results The rate of dissolution of silymarin was considerably improved as compared with pure silymarin when formulated in solid dispersions with PEG 6000. The data of the X ray diffraction showed some changes in the parameters of lattice spacing [ d ], peak position and relative intensities. FT IR together with those from X ray diffraction showed the absence of well defined drug polymer interactions. Conclusion The dissolution improvement of poorly soluble silymarin could be illuminated by the changes of the lattice parameters of PEG 6000 and the drug.展开更多
文摘冲压件生产中,开卷落料的矫直参数直接影响了板料面品质量和材料性能,进而影响成形性。为了确定可靠的矫直参数范围、保证开卷后板料的面品质量和材料性能,进而有效指导开卷落料生产,以机盖外板为例进行研究。所用材料为6000系Al Si Mg合金,材料厚度为1 mm,材料性能偏上限需求,通过调整矫直参数(矫直机入口高度)得到不同性能的材料,并利用CAE分析、实际生产验证、后工序合边验证等方法,最终确定了机盖的矫直参数≥-0.6 mm (矫直机入口高度≥-0.6 mm)。其他在产零件可依据此方法确定矫直参数范围,减少停机时间,降低材料不合格风险,提高生产效率,降低生产成本。
文摘Aim To prepare and characterize solid dispersions of silymarin with the intention of improving their dissolution properties. Methods The solid dispersions were prepared by the fusion method with polyethylene glycol 6000(PEG 6000) as the carrier. Evaluation of the properties of the dispersions was performed using dissolution studies, X ray powder diffraction and Fourier transform infrared (FT IR) spectroscopy. Results The rate of dissolution of silymarin was considerably improved as compared with pure silymarin when formulated in solid dispersions with PEG 6000. The data of the X ray diffraction showed some changes in the parameters of lattice spacing [ d ], peak position and relative intensities. FT IR together with those from X ray diffraction showed the absence of well defined drug polymer interactions. Conclusion The dissolution improvement of poorly soluble silymarin could be illuminated by the changes of the lattice parameters of PEG 6000 and the drug.
