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694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗黄褐斑的临床疗效
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作者 李林丽 刘平 +2 位作者 苏慧 王雨婷 袁仪珮 《保健医学研究与实践》 2024年第5期85-89,共5页
目的探讨694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗黄褐斑的临床疗效,以期为临床治疗黄褐斑提供参考。方法选取2019年7月-2023年3月西电集团医院收治的106例黄褐斑患者为研究对象,根据治疗方案不同分为对照组(52例)和观察组(5... 目的探讨694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗黄褐斑的临床疗效,以期为临床治疗黄褐斑提供参考。方法选取2019年7月-2023年3月西电集团医院收治的106例黄褐斑患者为研究对象,根据治疗方案不同分为对照组(52例)和观察组(54例)。对照组患者采用694 nm调Q红宝石点阵激光治疗,观察组患者采用694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗。比较2组患者的临床疗效,治疗前后黄褐斑面积和严重程度指数(MASI)评分、皮肤状态、复发率及不良反应发生情况。结果观察组患者的治疗总有效率为83.33%(45/54),高于对照组的63.46%(33/52),差异有统计学意义(χ^(2)=5.382,P=0.020)。2组患者治疗前MASI评分比较,差异无统计学意义(P>0.05);2组患者治疗后MASI评分均低于治疗前,且观察组低于对照组,差异均有统计学意义(P<0.05)。2组患者治疗前皮肤毛孔、纹理、皱纹、色素斑4项皮肤状态评分比较,差异均无统计学意义(P>0.05);2组患者治疗后皮肤毛孔、皱纹、纹理、色素斑4项皮肤状态评分均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。观察组患者黄褐斑复发率为5.56%(3/54),低于对照组的19.23%(10/52),差异有统计学意义(χ^(2)=4.604,P=0.032)。对照组和观察组患者不良反应发生率分别为9.62%(5/52)和7.41%(4/54),差异无统计学意义(χ^(2)=0.004,P=0.953)。结论黄褐斑患者采用694 nm调Q红宝石点阵激光联合氨甲环酸注射液外敷治疗效果较好,可有效改善患者皮肤色素沉着症状,且不良反应发生风险及复发风险均较低。 展开更多
关键词 694 nm调Q红宝石点阵激光 氨甲环酸注射液 黄褐斑 临床疗效 皮肤状态 复发风险
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694 nm调Q红宝石点阵激光联合氨甲环酸治疗黄褐斑的临床效果观察
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作者 樊雪 索静飞 +1 位作者 岳路 张大雷 《临床医学工程》 2024年第4期401-402,共2页
目的探讨694 nm调Q红宝石点阵激光联合氨甲环酸治疗黄褐斑的临床效果。方法62例黄褐斑患者随机分为两组。对照组采用氨甲环酸胶囊治疗,研究组在对照组基础上采用694 nm调Q红宝石点阵激光治疗。比较两组的疗效、黄褐斑症状、不良反应及... 目的探讨694 nm调Q红宝石点阵激光联合氨甲环酸治疗黄褐斑的临床效果。方法62例黄褐斑患者随机分为两组。对照组采用氨甲环酸胶囊治疗,研究组在对照组基础上采用694 nm调Q红宝石点阵激光治疗。比较两组的疗效、黄褐斑症状、不良反应及复发率。结果研究组的治疗总有效率为96.77%,显著高于对照组的80.65%(P<0.05)。治疗后,研究组的MASI评分显著低于对照组(P<0.05)。治疗期间,两组均无明显不良反应发生。研究组的复发率为3.23%,显著低于对照组的22.58%(P<0.05)。结论694 nm调Q红宝石点阵激光联合氨甲环酸治疗黄褐斑的效果显著,可明显降低患者的MASI评分和复发率。 展开更多
关键词 694 nm调Q红宝石点阵激光 氨甲环酸 黄褐斑 临床疗效 MASI评分
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Effects of laser irradiation on Trichophyton rubrum growth and ultrastructure 被引量:10
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作者 XU Zhi-li XU Jing +5 位作者 ZHUO Feng-lin WANG Li XU Wei XU Ying ZHANG Xiao-yan ZHAO Jun-ying 《Chinese Medical Journal》 SCIE CAS CSCD 2012年第20期3697-3700,共4页
Background Trichophyton rubrum (T. rubrum) is the most common causative agent of dermatophytosis worldwide. In this study, we examined the effect of laser irradiation on the growth and morphology of T. rubrum. Metho... Background Trichophyton rubrum (T. rubrum) is the most common causative agent of dermatophytosis worldwide. In this study, we examined the effect of laser irradiation on the growth and morphology of T. rubrum. Methods Colonies of T. rubrum were isolated (one colony per plate), and randomly assigned to 5 treatment groups: Q-switched 694 nm ruby laser treatment, long-pulsed Nd:YAG 1064 nm laser treatment, intense pulsed light (IPL) treatment, 308 nm excimer laser treatment and the blank control group without treatment. Standardized photographs were obtained from grown-up fungal plates prior to treatment. Colonies were then exposed to various wavelengths and fluences of laser light. To compare the growth of colonies, they were re-photographed under identical conditions three and six days post-treatment. To investigate the morphology of T. rubrum, scanning electron microscope (SEM) and transmission electron microscope (TEM) images were obtained from specimens exposed to 24 hours of laser treatment. Results Growth of T. rubrum colonies was significantly inhibited following irradiation by 694 nm Q-switched and 1064 nm long-pulsed Nd:YAG lasers. Other treatments exerted little or no effect. Q-switched laser irradiation exerted a stronger growth inhibitory effect than long-pulsed Nd:YAG laser irradiation. Following treatment by the Q-switched ruby laser system, T. rubrum hyphae became shrunken and deflated, and SEM images revealed rough, fractured hyphal surfaces, punctured with small destructive holes. TEM images showed that the hyphae were degenerating, as evidenced by the irregular shape of hyphae, rough and loose cell wall, and obscure cytoplasmic texture. Initially high electron density structure was visible in the cell; later, low-density structure appeared as a result of cytoplasmic dissolution. In contrast, the blank control group showed no obvious changes in morphology. 展开更多
关键词 The q-switched 694 nm ruby laser treatment significantly inhibits the growth and changes the morphologyof T. rubrum.
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