Dihydroxy-7,4′-dimethoxy-dihydroflavonol and (±)-3,5,7-trihydroxy-4′-methoxy-dihydroflavonol were found in many medicinal plants, here we describe a concise synthesis route by selective protection, aldol-cond...Dihydroxy-7,4′-dimethoxy-dihydroflavonol and (±)-3,5,7-trihydroxy-4′-methoxy-dihydroflavonol were found in many medicinal plants, here we describe a concise synthesis route by selective protection, aldol-condensation, 30% H2O2 epoxidation, cyclization and deprotection from 2,4,6-trihydroxyacetophone and anisaldehyde.展开更多
目的:建立RP-HPLC法,测定细叶鸢尾中一种具有抗老年痴呆症活性的二氢黄酮:5,2',3'-三羟基-6,7-亚甲二氧基二氢黄酮。方法采用Agilent 1260HC-C18(4.6 mm ×250 mm,5μm)色谱柱,流动相为甲醇—1%冰醋酸梯度洗脱,流速...目的:建立RP-HPLC法,测定细叶鸢尾中一种具有抗老年痴呆症活性的二氢黄酮:5,2',3'-三羟基-6,7-亚甲二氧基二氢黄酮。方法采用Agilent 1260HC-C18(4.6 mm ×250 mm,5μm)色谱柱,流动相为甲醇—1%冰醋酸梯度洗脱,流速为1 mL ·min^-1,检测波长为295 nm,柱温为25℃。结果该二氢黄酮在37.6~188 mg·L^-1浓度范围内线性关系良好,相关系数为0.9994;回收率为101.26%(RSD=1.17%)。测得该活性化合物在细叶鸢尾中的含量非常高,6批药材中的含量为57.70~59.35 mg·g^-1。结论该检测方法准确,适用于细叶鸢尾中5,2',3'-三羟基-6,7-亚甲二氧基二氢黄酮的测定。展开更多
文摘Dihydroxy-7,4′-dimethoxy-dihydroflavonol and (±)-3,5,7-trihydroxy-4′-methoxy-dihydroflavonol were found in many medicinal plants, here we describe a concise synthesis route by selective protection, aldol-condensation, 30% H2O2 epoxidation, cyclization and deprotection from 2,4,6-trihydroxyacetophone and anisaldehyde.
文摘目的:建立RP-HPLC法,测定细叶鸢尾中一种具有抗老年痴呆症活性的二氢黄酮:5,2',3'-三羟基-6,7-亚甲二氧基二氢黄酮。方法采用Agilent 1260HC-C18(4.6 mm ×250 mm,5μm)色谱柱,流动相为甲醇—1%冰醋酸梯度洗脱,流速为1 mL ·min^-1,检测波长为295 nm,柱温为25℃。结果该二氢黄酮在37.6~188 mg·L^-1浓度范围内线性关系良好,相关系数为0.9994;回收率为101.26%(RSD=1.17%)。测得该活性化合物在细叶鸢尾中的含量非常高,6批药材中的含量为57.70~59.35 mg·g^-1。结论该检测方法准确,适用于细叶鸢尾中5,2',3'-三羟基-6,7-亚甲二氧基二氢黄酮的测定。