Composition of HT-7 LHCD and its Protection Systems

In this paper, the composition of HT-7 LHCD system along with its protection systems is introduced. It is very important for us to run the LHCD system safely and efficiently.

A Study on Main Breaker for Quench Protection of HT-7U Toroidal Superconducting Tokamak

This paper proposes a quench protection project of HT-7U toroidal superconducting tokamak through a forced commutation analysis of DC circuit breaker (DCCB) paralleling fuse. Based on the requirement of quench protection, main parameters are selected. Experimental results demonstrate the validity of this proposed project.

Boost the Modernization of Human Rights Protection Systems and Endeavor to Fulfill the Chinese Dream——An Address at the Opening Ceremony of the 7th Beijing Forum on Human Rights, Sept. 17, 2014

This session of the Forum has the theme, “The Chinese Dream： New Progress in the Cause of Human Rights in China.” This theme concentrates on such important subtopics as “The Chinese Dream and Human Rights” ,

Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens

We developed an H5/H7 trivalent inactivated vaccine by using Re-11, Re-12, and H7-Re2 vaccine seed viruses, which were generated by reverse genetics and derived their HA genes from A/duck/Guizhou/S4184/2017(H5N6) (DK/GZ/S4184/17) (a clade 2.3.4.4d virus), A/chicken/Liaoning/SD007/2017(H5N1) (CK/LN/SD007/17) (a clade 2.3.2.1d virus), and A/chicken/ Guangxi/SD098/2017(H7N9) (CK/GX/SD098/17), respectively. The protective efficacy of this novel vaccine and that of the recently used H5/H7 bivalent inactivated vaccine against different H5 and H7N9 viruses was evaluated in chickens. We found that the H5/H7 bivalent vaccine provided solid protection against the H7N9 virus CK/GX/SD098/17, but only 50–60% protection against different H5 viruses. In contrast, the novel H5/H7 trivalent vaccine provided complete protection against the H5 and H7 viruses tested. Our study underscores the importance of timely updating of vaccines for avian influenza control.

Protective efficacy of an H5/H7 trivalent inactivated vaccine(H5-Re13,H5-Re14, and H7-Re4 strains) in chickens, ducks, and geese against newly detected H5N1, H5N6, H5N8, and H7N9 viruses

Some H5 viruses isolated in poultry or wild birds between 2020 and 2021 were found to be antigenically different from the vaccine strains(H5-Re11 and H5-Re12) used in China. In this study, we generated three new recombinant vaccine seed viruses by using reverse genetics and used them for vaccine production. The vaccine strain H5-Re13 contains the hemagglutinin(HA) and neuraminidase(NA) genes of an H5 N6 virus that bears the clade 2.3.4.4 h HA gene, H5-Re14 contains the HA and NA genes of an H5 N8 virus that bears the clade 2.3.4.4 b HA gene, and H7-Re4 contains the HA and NA genes of H7 N9 virus detected in 2021. We evaluated the protective efficacy of the novel H5/H7 trivalent inactivated vaccine in chickens, ducks, and geese. The inactivated vaccine was immunogenic and induced substantial antibody responses in the birds tested. Three weeks after vaccination, chickens were challenged with five different viruses detected in 2020 and 2021: three viruses(an H5 N1 virus, an H5 N6 virus, and an H5 N8 virus) bearing the clade 2.3.4.4 b HA gene, an H5 N6 virus bearing the clade 2.3.4.4 h HA gene, and an H7 N9 virus. All of the control birds shed high titers of virus and died within 4 days post-challenge, whereas the vaccinated chickens were completely protected from these viruses. Similar protective efficacy against H5 viruses bearing the clade 2.3.4.4 h or 2.3.4.4 b HA gene was observed in ducks and geese. Our study indicates that the newly updated H5/H7 vaccine can provide solid protection against the H5 and H7 N9 viruses that are currently circulating in nature.

The Study of Natural Solution Protective Activity on H7N9 Virus

Background: One of potentially dangerous problems for a human organism is the new strain of a virus of bird flu-A/H7N9. As it is regular mutation of bird flu virus, it obvious, that of antibacterial preparations is not efficient. Efficiency decreases when the number of agents with multiple stability to antimicrobic remedy vastly increases, the part of associate infections enlarges, and aggression of opportunistic pathogenic flora rises. This reduces the role of the preparations in prevention of epidemics. Therefore, the optimization of only etiotropic therapies does not fully solve the problem. In this connection natural preparations seem extremely promising which strengthen the functional condition of immune system and, thereby, activate protective forces of macroorganism. Objectives: One of such preparations is BAE Synergy Liquid, a natural mineral water which was underwent subtle energetic changes at the natural energetic deposit. Design: An estimation of protective efficiency of naturally modified mineral BAE SL water was performed on white outbred mice-males in models of H7N9 virus. The animals were monitored during 16 days after infection, and survived and fallen mice were counted daily. Results: The results revealed significant effect of the investigated preparation as possible prophylactic care and medical remedy to the mentioned virus. This means that one can be considered as potential effective remedy for human. Conclusions: As significant effect of the immune system resistance was revealed, the experimental model with studied naturally modified mineral water is potentially generalizable.

Antibodies elicited by Newcastle disease virus-vectored H7N9 avian influenza vaccine are functional in activating the complement system

H7N9 subtype avian influenza virus poses a great challenge for poultry industry.Newcastle disease virus(NDV)-vectored H7N9 avian influenza vaccines(NDV_(vec)H7N9)are effective in disease control because they are protective and allow mass administration.Of note,these vaccines elicit undetectable H7N9-specific hemagglutination-inhibition(HI)but high IgG antibodies in chickens.However,the molecular basis and protective mechanism underlying this particular antibody immunity remain unclear.Herein,immunization with an NDV_(vec)H7N9 induced low anti-H7N9 HI and virus neutralization titers but high levels of hemagglutinin(HA)-binding IgG antibodies in chickens.Three residues(S150,G151 and S152)in HA of H7N9 virus were identified as the dominant epitopes recognized by the NDV_(vec)H7N9 immune serum.Passively transferred NDV_(vec)H7N9 immune serum conferred complete protection against H7N9 virus infection in chickens.The NDV_(vec)H7N9 immune serum can mediate a potent lysis of HA-expressing and H7N9 virus-infected cells and significantly suppress H7N9 virus infectivity.These activities of the serum were significantly impaired after heat-inactivation or treatment with complement inhibitor,suggesting the engagement of the complement system.Moreover,mutations in the 150-SGS-152 sites in HA resulted in significant reductions in cell lysis and virus neutralization mediated by the NDV_(vec)H7N9 immune serum,indicating the requirement of antibody-antigen binding for complement activity.Therefore,antibodies induced by the NDV_(vec)H7N9 can activate antibody-dependent complement-mediated lysis of H7N9 virus-infected cells and complement-mediated neutralization of H7N9 virus.Our findings unveiled a novel role of the complement in protection conferred by the NDV_(vec)H7N9,highlighting a potential benefit of engaging the complement system in H7N9 vaccine design.

Line Differential Protection Scheme Modelling for Underground 420 kV Cable Systems

Based on the analysis of a specific relay model and an HVAC （high voltage alternating current） cable system, a detailed approach to EMTDC/PSCAD modelling of protective relays is presented. Such approach allows to create complex and accurate relay models derived from the original algorithms. Relay models can be applied with various systems, allowing to obtain the most optimal configuration of the protective relaying. The present paper describes modelling methodology on the basis of Siemens SIPROTEC 4 7SD522/610. Relay model was verified experimentally with its real equivalent by both EMTP-simulated and real world generated current signals connected to the relay.

基于NDIR技术的微量环保绝缘气体C_(4)F_(7)N检测

C_(4)F_(7)N混合气体由于其优异的绝缘性能和更低的温室效应被认为是一种优异的替代SF_(6)的环保绝缘气体,C_(4)F_(7)N/CO_(2)混合气体绝缘设备已被逐渐推广和使用。由于混合气体的绝缘性能与C_(4)F_(7)N的体积分数有关,通过对混合气体中微量C_(4)F_(7)N的检测,可以对C_(4)F_(7)N/CO_(2)混合气体电气设备的绝缘状态进行有效评估。文中通过红外光谱平台,确定了C_(4)F_(7)N的红外光谱信息通过对C_(4)F_(7)N体积分数为100~2 000μL/L的C_(4)F_(7)N/CO_(2)混合气体检测,确定了微量C_(4)F_(7)N的最佳检测波段。搭建了基于NDIR技术的微量C_(4)F_(7)N检测平台,测量通道滤光片为7.9μm,实现了对12.6~52.5μL/L的微量C_(4)F_(7)N定量检测,C_(4)F_(7)N气体体积分数与反演信号值的线性拟合系数R^(2)为0.989,最大绝对误差为0.107。研究成果为C_(4)F_(7)N/CO_(2)混合气体绝缘设备的绝缘状态评估提供了一种可行方案。

蒙药德都红花-7味丸对DMN致慢性肝损伤的保肝降酶作用的实验研究

目的:动态观察蒙药德都红花-7味丸对不同病变阶段慢性肝损伤的降酶保肝作用,为临床合理用药提供依据。方法:将小鼠随机分为空白组、模型组、乙肝宁组、德都红花-7味丸高、低剂量组。除空白组外,其余小鼠腹腔注射DMN致慢性肝损伤,造模同时德都红花-7味丸高、低剂量组、乙肝宁组分别灌胃每日0.87、0.5和0.5g/kg。于第5、7次注射DMN后观察小鼠体重,检测ALT、AST、TP、ALB含量和观察肝组织病理学的变化。结果:第5、7次注射DMN后与空白组比较模型组体重明显减轻,肝功能明显异常,有显著性差异(P<0.05);与模型组比较德都红花-7味丸低剂量组体重明显增加,ALT、AST明显下降,ALB明显上升,有显著性差异(P<0.05)。第5、7次注射DMN后慢性肝炎炎症活动度分级(G)和慢性肝炎程度(G/S)比较模型组处于迁延加重趋势,主要表现为中、重度病变状态;德都红花-7味丸处于轻、中度病变状态。结论:德都红花-7味丸对不同阶段、不同程度的慢性肝损伤有不同程度的降酶保肝作用,尤其对轻、中程度的慢性肝损伤有较好的疗效,建议临床上应随着病情变化给予合理的辨证用药。

日本血吸虫SjC21.7核酸疫苗诱导小鼠保护性免疫作用的研究

目的 研究日本血吸虫中国大陆株 2 1.7k Da膜蛋白分子 (Sj C2 1.7)核酸疫苗对 BAL B/ c小鼠的免疫保护性作用。 方法 采用 PCR方法扩增出特异性 Sj C2 1.7基因的开放阅读框序列 ,在其起始密码子处引入 Kozark序列。将目的基因片段亚克隆到真核表达质粒 pc DNA3.1中 ,构建重组真核表达质粒 Sj C2 1.7- pc DNA3.1。 4 8只 BAL B/ c小鼠分为对照组、实验组和加强组。对照组小鼠的股四头肌注射接种 pc DNA3.1,实验组同法注射重组质粒 Sj C2 1.7- pc D-NA3.1,加强组除注射重组质粒 Sj C2 1.7- pc DNA3.1外 ,同时注射重组质粒 P35 - pc DNA3.1及 P4 0 - pc DNA。每隔 2 wk免疫 1次 ,共免疫 3次。第 3次免疫后第 30天 ,每只鼠感染 4 5± 1条尾蚴 ,4 5 d后剖杀计数各组小鼠成虫数及肝卵数。通过 EL ISA和免疫组化分析观察小鼠免疫学特征的变化。 结果 免疫组化分析显示 ,实验组小鼠股四头肌局部组织有特异性抗原蛋白表达。EL ISA分析表明 ,免疫后实验组和加强组有部分小鼠出现特异性 Ig G抗体。与对照组比较 ,实验组减虫率及减卵率分别为 2 9.9%及 13.8% ,加强组分别为 31.9%及 2 8.0 %。加强组减卵率显著高于实验组(P<0 .0 5 )。 结论 Sj C2 1.7核酸疫苗能诱导 BAL B/

纳米α-Fe_2O_3/H_2O_2异相Fenton催化降解酸性橙7

以水热法制备纳米α-Fe_2O_3,并应用于异相Fenton体系中催化降解酸性橙7。用扫描电子显微镜(SEM)、X射线衍射仪(XRD)表征样品的结构;在异相Fenton催化体系中,通过优化初始p H、初始底物浓度、双氧水添加量、α-Fe_2O_3添加量、温度,探究合适的催化降解条件,通过多次循环催化对催化剂稳定性进行研究,并通过催化过程中产生的自由基,分析其催化机理。结果表明,α-Fe_2O_3为长约70 nm,宽约20 nm的均匀单一纳米棒。在异相Fenton催化体系中,最佳催化条件为初始p H=3.0,初始底物质量浓度200 mg/L,反应温度为30℃,双氧水的添加量为w(H_2O_2)=1.5%,催化剂α-Fe_2O_3添加量为500 mg/L,在反应120 min时脱色率为98.74%,COD去除率为73%;稳定性良好,铁离子溶出量低于0.8 mg/L,循环实验5次脱色率始终在90%以上;此外,对自由基的研究表明,·OH在本体系降解过程中占主要作用。

7-氨基-6-硝基苯并二氧化呋咱的合成、晶体结构及热分析

以间二氯苯胺为起始原料,用氯乙酰基保护氨基的方法,经乙酰化、硝化、叠氮化及脱氮、水解4步合成了7-氨基-6-硝基苯并二氧化呋咱(ANBDF),其中叠氮化及脱氮反应不经分离一锅完成,脱氮反应在80℃完成,其余反应均在0℃至室温下完成。4步反应的得率分别为97.7%,70.0%,82.5%和80.0%。以IR1、HNMR、MS及元素分析对目标化合物的结构进行了表征。制备并测定了ANBDF的晶体结构,其晶体结构属正交晶系,空间群P2121/n;晶胞参数:a=1.3626(3)nm,b=0.6961(13)nm,c=0.95745(3);Dc=1.931 g.cm-3。晶体结构分析表明,ANBDF是一平面分子,分子内存在氢键,分子结构紧密,密度大。DSC分析结果证明,ANBDF在199.3℃达到最大放热峰,是热稳定性能极佳、极具前途的高能量高密度化合物。

基于选择性羟基保护合成3-烷基-5,7-二羟基-6-氯-4-色满酮

以2,4,6-三羟基苯甲酸为起始原料,经氯代、脱羧、酰化得1-(3-氯-2,4,6-三羟基苯基)烷基酮,该中间体采用MOMCl进行选择性羟基保护,随后经环合、脱保护得到两个标题化合物,总收率分别为30.9%和32.2%。产物结构经1HNMR、ESI-MS进行确证。此合成方法具有原料廉价易得、操作简单、收率较高等特点,适合在多酚羟基存在的条件下利用选择性酚羟基保护策略区域选择性地合成目标产物。

施肥量和种植密度对大豆牡丰7号保护性酶活性的影响

为了明确种植密度及施肥量对大豆保护性酶活性的影响,以牡丰7号为研究对象,采取裂区设计,施肥量为主区,种植密度为副区,研究了不同施肥量和种植密度下大豆不同时期超氧化物歧化酶(SOD)、过氧化物酶(POD)和过氧化氢酶(CAT)的变化规律。结果表明:施肥量和种植密度对大豆牡丰7号不同时期叶片保护性酶活性有着较大的影响。从始花期到鼓粒期,3种保护性酶存在着先升后降的变化规律。随施肥量的增加,保护性酶活性的变化幅度增大,在一定范围内提高施肥量有利于增强牡丰7号抗逆性。随着种植密度增加SOD活性下降;CAT活性随种植密度的变化在不同时期表现出了不同的规律。POD活性与种植密度关系不大。

基于S7-200的新型磨浆机控制系统设计

根据磨浆机工作特点,设计了基于S7-200的新型磨浆机控制系统。该系统以PLC为核心,与功率变送器和变频器综合应用,且将专家控制思想应用于磨浆机进退刀量控制,结合自学习算法自动修改不合适的输入输出量化值,具有调节速度快、过渡时间短、超调量小等优点,更准确地控制磨浆机的磨刀进退位移量。该系统具有高稳定性与快速动态响应特性,既实现了打浆过程的平稳、精确控制,又大大提高了控制系统的可靠性和安全性,达到了高质、低耗、自动控制的目的。

新疆百重7井区油田开发对地下水环境的影响分析

新疆百重７井区为新疆百口泉地下水源的汇集径流区，是克拉玛依市生活生产用水水源之一。在此处进行油田开发，使得保护该区地下水环境成为开发工程的重中之重。由新疆百重７井区油田开发对地下水环境的影响分析可知，正常状况下油田开发对地下水的影响很小，一旦发生事故，则对地下水的影响很大，必须采取适当措施，保护该区丰富的地下水资源。

头孢他啶中间体7β位三苯甲基侧链酸的合成

目的研究头孢他啶 7β位三苯甲基侧链酸 (Z) 2 [(1 叔丁氧基羰基 1 甲乙氧 )亚氨基 ] 2 (2 三苯甲氨基噻唑 4 基 )乙酸的合成路线。方法以 (Z) 2 酮肟 2 (2 氨基噻唑 4 基 )乙酸乙酯为原料 ,经过氨基保护、醚化、选择性水解等反应 ,合成头孢他啶 7β位三苯甲基侧链酸 (Z) 2 [(1 叔丁氧基羰基 1 甲乙氧 )亚氨基 ] 2 (2 三苯甲氨基噻唑 4 基 )乙酸。结果和结论合成了头孢他啶7β位三苯甲基侧链酸 (Z) 2 [(1 叔丁氧基羰基 1 甲乙氧 )亚氨基 ] 2 (2 三苯甲氨基噻唑 4 基 )乙酸 ,核磁共振氢谱确证了目标化合物及各个中间体的结构。

骨形态发生蛋白7在肾脏发育及保护中的作用

骨形态发生蛋白7(BMP-7)是转化生长因子β超家族成员,参与器官发生,细胞增殖、分化及凋亡等,尤其对维持肾脏正常结构和功能有重要意义。本文就BMP-7分子结构及信号转导机制,其在肾脏发育和肾脏保护中的作用及可能机制等方面进行综述。

Windows 7操作系统关键内存防攻击研究

GS Stack Protection、SafeSEH、Heap Protection、DEP、ASLR技术是Windows7操作系统内存保护机制的关键技术,这五种技术对缓解缓冲区溢出攻击起到显著作用。文章以对Windows7的内存保护机制的原理分析为基础,测试了Windows7环境下绕过这些保护机制的可能性;最后对Windows7内存保护机制抵御缓冲区溢出攻击的整体效果进行了分析,指出Windows7仍然不能完全抵御缓冲区溢出攻击,并讨论了更全面提高系统安全性的改进方案。