To identify target energy balance-related behaviors（ERBs）,baseline data from 141overweight or obese schoolchildren（aged 8-14years old）was used to predict adiposity[body mass index（BMI）and fat percentage]one year...To identify target energy balance-related behaviors（ERBs）,baseline data from 141overweight or obese schoolchildren（aged 8-14years old）was used to predict adiposity[body mass index（BMI）and fat percentage]one year later.The ERBs included a modified Dietary Approach to Stop Hypertension diet score（DASH score）,leisure-time physical activity（PA,days/week）,and leisure screen time（minutes/day）.Several cardiometabolic variables were measured in the fasting state, including systolic blood pressure （SBP）, diastolic blood pressure （DBP）, blood glucose （GLU）, total cholesterol （TC）, triglycerides （TG）, low-density lipoprotein （LDL-C）, and high-density lipoprotein （HDL-C）.展开更多
Left-behind children comprise a special population inChinese rural areas. According to the 2007 China Census,the number ofleft-behind children aged≤14 years was estimated at 58 million which suggested that these chil...Left-behind children comprise a special population inChinese rural areas. According to the 2007 China Census,the number ofleft-behind children aged≤14 years was estimated at 58 million which suggested that these childrencon stituted a展开更多
The physical health has become a hot topic in today＇s society, in order to understand the physical health status quo of Hunan Han schoolchildren to collect 1985 -2010 six national student physical research data, sele...The physical health has become a hot topic in today＇s society, in order to understand the physical health status quo of Hunan Han schoolchildren to collect 1985 -2010 six national student physical research data, select Hunan Province Han schoolchildren in seven years （school age） and rural men and women a total of four set of data （1985 to 1995 due to the minimum age of 7 years old monitor, so the index is also unified in 2000 after seven years of age selected set of data）, performed with SPSSI8.0 Comparative Analysis of physique changing trends and urban and rural areas. The results show that： the physical development of children reach school age Hunan Province Han good, but the boys of height, weight and chest are still differences between urban and rural areas; respiratory function developmental level decreased to varying degrees, both urban and rural areas need strengthening exercise to improve respiratory function. Speed, endurance, power and strength endurance, strength, quality has a different rate of increase quality trends, and most has no specific differences between urban and rural areas; Felicity decline, but rural girls group performance has increased, shortening the urban and rural areas gap. Due to substantial improvements in the living conditions of rural, urban and rural differences have been gradually reduced, but from learning, family, social pressure, and the lack of good exercise habits, sports teachers and other reasons that students can not ensure adequate exercise time, which affects the Han physical level students in Hunan province, hoping to enter primary school-age children start, the implementation of the ＂National Student Physical Health Standard＂ and strive to ensure that physical education and physical exercise, strengthening and improving school sports to promote quality education, comprehensively enhance physical fitness of students in Hunan province.展开更多
BACKGROUND IFIH1 is a protein-coding gene.Disorders associated with IFIH1 include Aicardi-Goutières syndrome(AGS)type 7 and Singleton-Merten syndrome type 1.Related pathways include RIG-I/MDA5-mediated induction ...BACKGROUND IFIH1 is a protein-coding gene.Disorders associated with IFIH1 include Aicardi-Goutières syndrome(AGS)type 7 and Singleton-Merten syndrome type 1.Related pathways include RIG-I/MDA5-mediated induction of the interferon(IFN)-α/βpathway and the innate immune system.AGS type 7 is an autosomal dominant inflammatory disorder characterized by severe neurological impairment.In infancy,most patients present with psychomotor retardation,axial hypotonia,spasticity,and brain imaging changes Laboratory assessments showed increased IFN-αactivity with upregulation of IFN signaling and IFN-stimulated gene expression.Some patients develop normally in the early stage,and then have episodic neurological deficits.CASE SUMMARY The 5-year-old girl presented with postpartum height and weight growth retardation,language retardation,brain atrophy,convulsions,and growth hormone deficiency.DNA samples were obtained from peripheral blood from the child and her parents for whole-exome sequencing and test of genome-wide copy number variation.Heterozygous mutations in the IFIH1 gene were found.Physical examination at admission found that language development was delayed,the reaction to name calling was average,there was no communication with people,but there was eye contact,no social smile,and no autonomous language.However,the child had rich gesture language and body language,could understand instructions,had bad temper.When she wants to achieve something,she starts crying or shouting.Cardiopulmonary examination showed no obvious abnormality,and abdominal examination was normal.Bilateral muscle strength and muscle tone were symmetrical and slightly decreased.Physiological reflexes exist,but pathological reflexes were not elicited.CONCLUSION We reported the clinical characteristics of a Chinese child with a clinical diagnosis of AGS type 7,which expanded the mutational spectrum of the IFIH1 gene.展开更多
【目的】了解昆明市0-7岁儿童单纯性肥胖流行情况、变化趋势及影响因素。【方法】采用分层整群抽样方法,调查昆明市0-7岁儿童11 172人,按全国肥胖儿童调查标准进行肥胖儿的诊断、分度及对照组的设立。并对数据进行统计分析。【结果】昆...【目的】了解昆明市0-7岁儿童单纯性肥胖流行情况、变化趋势及影响因素。【方法】采用分层整群抽样方法,调查昆明市0-7岁儿童11 172人,按全国肥胖儿童调查标准进行肥胖儿的诊断、分度及对照组的设立。并对数据进行统计分析。【结果】昆明市0-7岁儿童单纯性肥胖检出率为1.56%,低于全国平均水平和主要城市检出率。肥胖检出率比1996年上升35.65%,是1986年的3.63倍。年龄、性别差异明显,男童高于女童。肥胖症相关影响因素有：食欲、进食速度、父母对子女肥胖态度、父母亲体质指数（body mass inaex,BMI）。【结论】昆明市0-7岁儿童单纯性肥胖检出率在全国处于较低水平,但近20年仍有明显增加。食欲好、进食快、父母BMI偏大、父母对子女肥胖不关注是肥胖发生的危险因素。防治肥胖症的主要方法是家庭干预和群体干预。展开更多
基金Research special fund of the Ministry of Health public service sectors funded projects(201202010)The 12th Five-year Key Project of Beijing Education Sciences Research Institute(AAA12011)
文摘To identify target energy balance-related behaviors（ERBs）,baseline data from 141overweight or obese schoolchildren（aged 8-14years old）was used to predict adiposity[body mass index（BMI）and fat percentage]one year later.The ERBs included a modified Dietary Approach to Stop Hypertension diet score（DASH score）,leisure-time physical activity（PA,days/week）,and leisure screen time（minutes/day）.Several cardiometabolic variables were measured in the fasting state, including systolic blood pressure （SBP）, diastolic blood pressure （DBP）, blood glucose （GLU）, total cholesterol （TC）, triglycerides （TG）, low-density lipoprotein （LDL-C）, and high-density lipoprotein （HDL-C）.
基金supported by grants from the National Natural Science Foundation of China [81172680]
文摘Left-behind children comprise a special population inChinese rural areas. According to the 2007 China Census,the number ofleft-behind children aged≤14 years was estimated at 58 million which suggested that these childrencon stituted a
文摘The physical health has become a hot topic in today＇s society, in order to understand the physical health status quo of Hunan Han schoolchildren to collect 1985 -2010 six national student physical research data, select Hunan Province Han schoolchildren in seven years （school age） and rural men and women a total of four set of data （1985 to 1995 due to the minimum age of 7 years old monitor, so the index is also unified in 2000 after seven years of age selected set of data）, performed with SPSSI8.0 Comparative Analysis of physique changing trends and urban and rural areas. The results show that： the physical development of children reach school age Hunan Province Han good, but the boys of height, weight and chest are still differences between urban and rural areas; respiratory function developmental level decreased to varying degrees, both urban and rural areas need strengthening exercise to improve respiratory function. Speed, endurance, power and strength endurance, strength, quality has a different rate of increase quality trends, and most has no specific differences between urban and rural areas; Felicity decline, but rural girls group performance has increased, shortening the urban and rural areas gap. Due to substantial improvements in the living conditions of rural, urban and rural differences have been gradually reduced, but from learning, family, social pressure, and the lack of good exercise habits, sports teachers and other reasons that students can not ensure adequate exercise time, which affects the Han physical level students in Hunan province, hoping to enter primary school-age children start, the implementation of the ＂National Student Physical Health Standard＂ and strive to ensure that physical education and physical exercise, strengthening and improving school sports to promote quality education, comprehensively enhance physical fitness of students in Hunan province.
文摘BACKGROUND IFIH1 is a protein-coding gene.Disorders associated with IFIH1 include Aicardi-Goutières syndrome(AGS)type 7 and Singleton-Merten syndrome type 1.Related pathways include RIG-I/MDA5-mediated induction of the interferon(IFN)-α/βpathway and the innate immune system.AGS type 7 is an autosomal dominant inflammatory disorder characterized by severe neurological impairment.In infancy,most patients present with psychomotor retardation,axial hypotonia,spasticity,and brain imaging changes Laboratory assessments showed increased IFN-αactivity with upregulation of IFN signaling and IFN-stimulated gene expression.Some patients develop normally in the early stage,and then have episodic neurological deficits.CASE SUMMARY The 5-year-old girl presented with postpartum height and weight growth retardation,language retardation,brain atrophy,convulsions,and growth hormone deficiency.DNA samples were obtained from peripheral blood from the child and her parents for whole-exome sequencing and test of genome-wide copy number variation.Heterozygous mutations in the IFIH1 gene were found.Physical examination at admission found that language development was delayed,the reaction to name calling was average,there was no communication with people,but there was eye contact,no social smile,and no autonomous language.However,the child had rich gesture language and body language,could understand instructions,had bad temper.When she wants to achieve something,she starts crying or shouting.Cardiopulmonary examination showed no obvious abnormality,and abdominal examination was normal.Bilateral muscle strength and muscle tone were symmetrical and slightly decreased.Physiological reflexes exist,but pathological reflexes were not elicited.CONCLUSION We reported the clinical characteristics of a Chinese child with a clinical diagnosis of AGS type 7,which expanded the mutational spectrum of the IFIH1 gene.
文摘【目的】了解昆明市0-7岁儿童单纯性肥胖流行情况、变化趋势及影响因素。【方法】采用分层整群抽样方法,调查昆明市0-7岁儿童11 172人,按全国肥胖儿童调查标准进行肥胖儿的诊断、分度及对照组的设立。并对数据进行统计分析。【结果】昆明市0-7岁儿童单纯性肥胖检出率为1.56%,低于全国平均水平和主要城市检出率。肥胖检出率比1996年上升35.65%,是1986年的3.63倍。年龄、性别差异明显,男童高于女童。肥胖症相关影响因素有：食欲、进食速度、父母对子女肥胖态度、父母亲体质指数（body mass inaex,BMI）。【结论】昆明市0-7岁儿童单纯性肥胖检出率在全国处于较低水平,但近20年仍有明显增加。食欲好、进食快、父母BMI偏大、父母对子女肥胖不关注是肥胖发生的危险因素。防治肥胖症的主要方法是家庭干预和群体干预。
