The structures and stabilities of all the 21 possible isomers for C77B^- based on C78 （C2v） were studied by the INDO series of methods. The most two stable geometries are C77B^-（10） and C77B^-（7）, where B（10） ...The structures and stabilities of all the 21 possible isomers for C77B^- based on C78 （C2v） were studied by the INDO series of methods. The most two stable geometries are C77B^-（10） and C77B^-（7）, where B（10） and B（7） are located at the apexes among two hexagons and a pentagon near the shortest axis of C78 （C2v）, and the former is more stable than the latter by 0.1902 eV. Based on the optimized geometries, the electronic spectra of the C77B^- isomers were investigated with the INDO/CIS method and the electronic transitions were assigned. The reason for the red-shift of the first absorption peaks for C77B^- compared with that of C78 （C2v） was discussed.展开更多
A linkage and association of the CD45 (protein tyrosine phosphatase, receptor type C) C77G polymorphism and multiple sclerosis (MS) has been found in some s tudies but not in others. We analysed the C77G polymorphism ...A linkage and association of the CD45 (protein tyrosine phosphatase, receptor type C) C77G polymorphism and multiple sclerosis (MS) has been found in some s tudies but not in others. We analysed the C77G polymorphism in MS patients from the genetically homogeneous population of Sardinia. Using the ransmission disequ ilibrium test, the mutation has been sought in 241 patients and 217 healthy sibs (HS) from singleton MS families and it was found in 5 (2.07%) affected and 3 ( 1.38%) HS from 7 heterozygous parents (1.45%). Transmission of the G77 allele was 71.4%(TDT = 1.3, P = 0.26) in patients and 50%(TDT = 0, P = 1) in HS. Str atifying families according to carriage of MS predisposing (DR+) or not predi sposing(DR ) HLA DR DQ genotype in patients, percentage of G77 transmission t o DR+patients was 33 (TDT = 0.33, P = 0.56, Pc = 1.12), while it was 100 (TDT = 4, P = 0.045, Pc = 0.09) in the DR patients. We concluded that, despite the pr esence of CD45 G77 polymorphism in a few patients who did not carry the HLA DR DQ MS predisposing molecules, CD45 did not contribute to development of the d isease in Sardinian MS.展开更多
文摘The structures and stabilities of all the 21 possible isomers for C77B^- based on C78 （C2v） were studied by the INDO series of methods. The most two stable geometries are C77B^-（10） and C77B^-（7）, where B（10） and B（7） are located at the apexes among two hexagons and a pentagon near the shortest axis of C78 （C2v）, and the former is more stable than the latter by 0.1902 eV. Based on the optimized geometries, the electronic spectra of the C77B^- isomers were investigated with the INDO/CIS method and the electronic transitions were assigned. The reason for the red-shift of the first absorption peaks for C77B^- compared with that of C78 （C2v） was discussed.
文摘A linkage and association of the CD45 (protein tyrosine phosphatase, receptor type C) C77G polymorphism and multiple sclerosis (MS) has been found in some s tudies but not in others. We analysed the C77G polymorphism in MS patients from the genetically homogeneous population of Sardinia. Using the ransmission disequ ilibrium test, the mutation has been sought in 241 patients and 217 healthy sibs (HS) from singleton MS families and it was found in 5 (2.07%) affected and 3 ( 1.38%) HS from 7 heterozygous parents (1.45%). Transmission of the G77 allele was 71.4%(TDT = 1.3, P = 0.26) in patients and 50%(TDT = 0, P = 1) in HS. Str atifying families according to carriage of MS predisposing (DR+) or not predi sposing(DR ) HLA DR DQ genotype in patients, percentage of G77 transmission t o DR+patients was 33 (TDT = 0.33, P = 0.56, Pc = 1.12), while it was 100 (TDT = 4, P = 0.045, Pc = 0.09) in the DR patients. We concluded that, despite the pr esence of CD45 G77 polymorphism in a few patients who did not carry the HLA DR DQ MS predisposing molecules, CD45 did not contribute to development of the d isease in Sardinian MS.
