Objective: This paper aims to understand the psychological experience and needs of pregnant women who need induction of labor due to fetal abnormalities at less than 20 weeks of gestation through in-depth interviews. ...Objective: This paper aims to understand the psychological experience and needs of pregnant women who need induction of labor due to fetal abnormalities at less than 20 weeks of gestation through in-depth interviews. Methods: Using the phenomenological research method in qualitative research, 12 pregnant women with fetal abnormalities less than 20 weeks of gestation in the obstetrics department of a hospital from January to April 2023 were selected as the research objects for semi-structured in-depth interviews. After information was collected to saturation, Colaizzi content analysis method was used to sort out, analyze and refine the data. Results: Through the interview results, three themes were refined from the transcript. Those are: 1) the support and assistance needed during the induction of labor;2) inner feelings after labor induction;3) The vision of future life. Conclusion: Abnormal fetal development at <20 weeks of gestation can cause anxiety, depression, guilt, loneliness and other negative emotions for pregnant women, and they need to get corresponding psychological support, especially during the period from fetal abnormality to induction of labor, pregnant women have to experience many physical and mental suffering, and need to get the care of family, relatives, friends, medical staff and society. Medical staff can help them seek multi-directional support, provide professional knowledge, and help them with self-management.展开更多
目的探讨妊娠糖尿病(gestational diabetes mellitus,GDM)患者尿液RNA氧化标志物8G-氧化鸟苷(8-oxo-7,8-dihydroguanosine,8-oxo-Gsn)的水平及与妊娠结局的关系。方法选取2018年2月~2021年2月汉川市中医医院收治的106例GDM患者为观察组...目的探讨妊娠糖尿病(gestational diabetes mellitus,GDM)患者尿液RNA氧化标志物8G-氧化鸟苷(8-oxo-7,8-dihydroguanosine,8-oxo-Gsn)的水平及与妊娠结局的关系。方法选取2018年2月~2021年2月汉川市中医医院收治的106例GDM患者为观察组,根据妊娠结局情况分为妊娠结局良好组和妊娠结局不良组。另选取同期进行体检的90例健康孕妇为对照组。收集所有孕妇的临床资料并进行比较。采用同位素稀释高效液相-串联质谱法(isotope dilution high performance liquid phase-tandem mass spectrometry,ID-LC-MS/MS)分析尿液中8-oxo-Gsn水平。采用ROC曲线评估8-oxo-Gsn对GDM患者不良妊娠结局的评估价值。多因素回归分析影响GDM患者不良妊娠结局的危险因素。结果与对照组相比,观察组尿液8-oxo-Gsn水平(3.89±0.63μmol/mol vs 2.26±0.47μmol/mol)及不良妊娠结局的发生率(29.25%vs 11.11%)明显升高,差异有统计学意义(t=20.225,χ^(2)=9.676,均P<0.05)。与妊娠结局良好组相比,妊娠结局不良组患者尿液8-oxo-Gsn水平(4.67±0.77μmol/mol vs 3.56±0.57μmol/mol)升高,差异有统计学意义(t=8.197,P<0.05)。ROC曲线分析结果显示,8-oxo-Gsn预测GDM患者不良妊娠结局的曲线下面积为0.847,截断值为4.049μmol/mol,敏感度和特异度分别为77.40%,81.30%。HOMA-IR[OR(95%CI):4.726(2.027~11.021)],8-oxo-Gsn[OR(95%CI):5.591(2.239~13.964)]是GDM患者发生不良妊娠结局的独立危险因素(均P<0.05)。结论GDM患者尿液8-oxo-Gsn水平升高,与患者不良妊娠结局有关,且对不良妊娠结局具有较优的预测价值。展开更多
Objective To compare the efficacy and safety of medical abortion of different regimens for termination of pregnancy at 8-16 weeks of gestation. Methods Healthy pregnant women requesting medical abortion at 8-16 weeks...Objective To compare the efficacy and safety of medical abortion of different regimens for termination of pregnancy at 8-16 weeks of gestation. Methods Healthy pregnant women requesting medical abortion at 8-16 weeks＇ gestation within 12 hospitals in Shanghai were randomly allocated to four treatment groups. Three intervention groups were given mifepristone 200 mg as a single dose then 24 h later misoprostol 600 #g at 3 h intervals vaginally, orally or vaginally followed by orally, respectively. Control group was given mifepristone 100 mg for 2 d, followed at 48 h by initiation of misoprostol 600 μg vaginally every 12 h. The primary outcome measures were the successful abortion rate, the induction-to-abortion interval, vaginal bleeding and side effects. Results Efficacy outcomes were analyzed for 1 112 women （92.67%）, excluding 88 protocol violations. Termination successful rates were similar among the four groups from 97.1% to 97.8%. The average dose of misoprostol and the incidence of side effects in control group were lower than those in three intervention groups. Stratified analysis showed that the interval of induction-to-abortion at gestation of 1116 weeks was decreased in control group. Conclusion The four regimens have the similar termination successful rates in spite of different administration intervals or routes. Control group was recommended for the advantages of reduced dose of misoprostol and fewer side effects.展开更多
目的比较分析阿司匹林在不同孕周对子痫前期高风险孕妇干预后的疗效,为提高妊娠安全性提供参考。方法择取2019年9月—2022年9月在南通大学附属江阴医院接受治疗的80例子痫前期高风险孕妇作为研究对象,随机将其分成A组(n=28)、B组(n=28)...目的比较分析阿司匹林在不同孕周对子痫前期高风险孕妇干预后的疗效,为提高妊娠安全性提供参考。方法择取2019年9月—2022年9月在南通大学附属江阴医院接受治疗的80例子痫前期高风险孕妇作为研究对象,随机将其分成A组(n=28)、B组(n=28)、空白对照组(n=24,未服用阿司匹林)。A组患者自妊娠12周服用100 mg阿司匹林,B组患者自妊娠16周服用100 mg阿司匹林,两组妊娠28周时停药,控制血压为130~155/80~105 mm Hg,若并发脏器功能障碍,则控制为130~139/80~89 mm Hg,比较三组子痫前期发生情况与妊娠结局、分娩方式、新生儿相关结局、尿液错误折叠蛋白阳性率。结果A组与B组子痫前期、不良妊娠结局发生率比较,差异无统计学意义(P>0.05);A组、B组子痫前期、不良妊娠结局发生率较对照组低,差异有统计学意义(P<0.05)。A组与B组剖宫产率、顺产率比较,差异无统计学意义(P>0.05);A组、B组剖宫产率低于对照组,顺产率高于对照组,差异有统计学意义(P<0.05)。A组与B组新生儿Apgar评分、新生儿不良结局发生率比较,差异无统计学意义(P>0.05);A组、B组新生儿Apgar评分高于对照组,新生儿不良结局发生率低于对照组,差异有统计学意义(P<0.05)。A组孕28周、32周的尿液错误折叠蛋白阳性率均显著低于对照组,且A组阳性率低于B组,差异有统计学意义(P<0.05)。结论阿司匹林在预防子痫前期中具有显著效果,高风险孕妇在妊娠12周及16周时服用阿司匹林均可有效降低子痫前期发生率,同时还可提高顺产率,降低母婴不良结局发生率。展开更多
文摘Objective: This paper aims to understand the psychological experience and needs of pregnant women who need induction of labor due to fetal abnormalities at less than 20 weeks of gestation through in-depth interviews. Methods: Using the phenomenological research method in qualitative research, 12 pregnant women with fetal abnormalities less than 20 weeks of gestation in the obstetrics department of a hospital from January to April 2023 were selected as the research objects for semi-structured in-depth interviews. After information was collected to saturation, Colaizzi content analysis method was used to sort out, analyze and refine the data. Results: Through the interview results, three themes were refined from the transcript. Those are: 1) the support and assistance needed during the induction of labor;2) inner feelings after labor induction;3) The vision of future life. Conclusion: Abnormal fetal development at <20 weeks of gestation can cause anxiety, depression, guilt, loneliness and other negative emotions for pregnant women, and they need to get corresponding psychological support, especially during the period from fetal abnormality to induction of labor, pregnant women have to experience many physical and mental suffering, and need to get the care of family, relatives, friends, medical staff and society. Medical staff can help them seek multi-directional support, provide professional knowledge, and help them with self-management.
文摘目的探讨妊娠糖尿病(gestational diabetes mellitus,GDM)患者尿液RNA氧化标志物8G-氧化鸟苷(8-oxo-7,8-dihydroguanosine,8-oxo-Gsn)的水平及与妊娠结局的关系。方法选取2018年2月~2021年2月汉川市中医医院收治的106例GDM患者为观察组,根据妊娠结局情况分为妊娠结局良好组和妊娠结局不良组。另选取同期进行体检的90例健康孕妇为对照组。收集所有孕妇的临床资料并进行比较。采用同位素稀释高效液相-串联质谱法(isotope dilution high performance liquid phase-tandem mass spectrometry,ID-LC-MS/MS)分析尿液中8-oxo-Gsn水平。采用ROC曲线评估8-oxo-Gsn对GDM患者不良妊娠结局的评估价值。多因素回归分析影响GDM患者不良妊娠结局的危险因素。结果与对照组相比,观察组尿液8-oxo-Gsn水平(3.89±0.63μmol/mol vs 2.26±0.47μmol/mol)及不良妊娠结局的发生率(29.25%vs 11.11%)明显升高,差异有统计学意义(t=20.225,χ^(2)=9.676,均P<0.05)。与妊娠结局良好组相比,妊娠结局不良组患者尿液8-oxo-Gsn水平(4.67±0.77μmol/mol vs 3.56±0.57μmol/mol)升高,差异有统计学意义(t=8.197,P<0.05)。ROC曲线分析结果显示,8-oxo-Gsn预测GDM患者不良妊娠结局的曲线下面积为0.847,截断值为4.049μmol/mol,敏感度和特异度分别为77.40%,81.30%。HOMA-IR[OR(95%CI):4.726(2.027~11.021)],8-oxo-Gsn[OR(95%CI):5.591(2.239~13.964)]是GDM患者发生不良妊娠结局的独立危险因素(均P<0.05)。结论GDM患者尿液8-oxo-Gsn水平升高,与患者不良妊娠结局有关,且对不良妊娠结局具有较优的预测价值。
基金supported by the Science and Technology Commission of Shanghai Municipality (No. 09DZ 1905700)the EBM-CONNECT Collaboration (Proposal No.: 101377 Grant Agreement No.: 247613)
文摘Objective To compare the efficacy and safety of medical abortion of different regimens for termination of pregnancy at 8-16 weeks of gestation. Methods Healthy pregnant women requesting medical abortion at 8-16 weeks＇ gestation within 12 hospitals in Shanghai were randomly allocated to four treatment groups. Three intervention groups were given mifepristone 200 mg as a single dose then 24 h later misoprostol 600 #g at 3 h intervals vaginally, orally or vaginally followed by orally, respectively. Control group was given mifepristone 100 mg for 2 d, followed at 48 h by initiation of misoprostol 600 μg vaginally every 12 h. The primary outcome measures were the successful abortion rate, the induction-to-abortion interval, vaginal bleeding and side effects. Results Efficacy outcomes were analyzed for 1 112 women （92.67%）, excluding 88 protocol violations. Termination successful rates were similar among the four groups from 97.1% to 97.8%. The average dose of misoprostol and the incidence of side effects in control group were lower than those in three intervention groups. Stratified analysis showed that the interval of induction-to-abortion at gestation of 1116 weeks was decreased in control group. Conclusion The four regimens have the similar termination successful rates in spite of different administration intervals or routes. Control group was recommended for the advantages of reduced dose of misoprostol and fewer side effects.
文摘目的比较分析阿司匹林在不同孕周对子痫前期高风险孕妇干预后的疗效,为提高妊娠安全性提供参考。方法择取2019年9月—2022年9月在南通大学附属江阴医院接受治疗的80例子痫前期高风险孕妇作为研究对象,随机将其分成A组(n=28)、B组(n=28)、空白对照组(n=24,未服用阿司匹林)。A组患者自妊娠12周服用100 mg阿司匹林,B组患者自妊娠16周服用100 mg阿司匹林,两组妊娠28周时停药,控制血压为130~155/80~105 mm Hg,若并发脏器功能障碍,则控制为130~139/80~89 mm Hg,比较三组子痫前期发生情况与妊娠结局、分娩方式、新生儿相关结局、尿液错误折叠蛋白阳性率。结果A组与B组子痫前期、不良妊娠结局发生率比较,差异无统计学意义(P>0.05);A组、B组子痫前期、不良妊娠结局发生率较对照组低,差异有统计学意义(P<0.05)。A组与B组剖宫产率、顺产率比较,差异无统计学意义(P>0.05);A组、B组剖宫产率低于对照组,顺产率高于对照组,差异有统计学意义(P<0.05)。A组与B组新生儿Apgar评分、新生儿不良结局发生率比较,差异无统计学意义(P>0.05);A组、B组新生儿Apgar评分高于对照组,新生儿不良结局发生率低于对照组,差异有统计学意义(P<0.05)。A组孕28周、32周的尿液错误折叠蛋白阳性率均显著低于对照组,且A组阳性率低于B组,差异有统计学意义(P<0.05)。结论阿司匹林在预防子痫前期中具有显著效果,高风险孕妇在妊娠12周及16周时服用阿司匹林均可有效降低子痫前期发生率,同时还可提高顺产率,降低母婴不良结局发生率。
