The synthesis of the title compound ([C28H22ClN2]·ClO4) has been synthesized and its structure was determined by X-ray diffraction. The compound belongs to the monoclinic system, space group P21/n with a = 15.113...The synthesis of the title compound ([C28H22ClN2]·ClO4) has been synthesized and its structure was determined by X-ray diffraction. The compound belongs to the monoclinic system, space group P21/n with a = 15.113(5), b = 8.616(3), c = 19.556(7) ?, β = 92.562(7)°, Z = 4, V = 2544(2) ?3, Mr = 521.38, Dc = 1.361 g/cm3, F(000) = 1080, μ = 0.293 mm-1, the final R = 0.0580 and wR = 0.0788 (I > 2σ(I)). The structure was solved by direct methods and refined by full-matrix least-squares techniques. X-ray analysis revealed that there exist four ring planes of 10H-indolium, pyridinium, p-chlorophenyl and indolyl in the molecule, of which the pyridinium ring forms a conjugated system with the p-chlorophenyl plane. According to the molecular structure of the title compound, it is presumed that the synthetic reaction may undergo the processes of C-addition, cyclization and aromatization.展开更多
Sp) Octyl 8 chloroadenosine 3′5′cyclophosphate (OCC), a newly synthesized 8 Cl c AMP derivative, strongly induced inhibition and differentiation in human leukemia HL 60 cells. In flow cytometry, OCC brought a...Sp) Octyl 8 chloroadenosine 3′5′cyclophosphate (OCC), a newly synthesized 8 Cl c AMP derivative, strongly induced inhibition and differentiation in human leukemia HL 60 cells. In flow cytometry, OCC brought about a block at the G1 phase of HL 60 cell cycle. OCC inhibited strongly the synthesis of DNA without affecting the synthesis of RNA and protein in HL 60 cells and also activated the c AMP dependent protein kinase in the cytosol of HL 60 cells. 8 Chloroadenosine is the active metabolite of OCC and inhibited significantly the growth of tumour in vitro and in vivo tests. 8 Chloroadenosine can induce differentiation of gastric mucoid adenocarcinoma cell line MGc80 3 and induce apoptosis in the MOLT 4 cells. The mechanism of the antitumour effects of 8 chloroadenosine was discussed.展开更多
文摘The synthesis of the title compound ([C28H22ClN2]·ClO4) has been synthesized and its structure was determined by X-ray diffraction. The compound belongs to the monoclinic system, space group P21/n with a = 15.113(5), b = 8.616(3), c = 19.556(7) ?, β = 92.562(7)°, Z = 4, V = 2544(2) ?3, Mr = 521.38, Dc = 1.361 g/cm3, F(000) = 1080, μ = 0.293 mm-1, the final R = 0.0580 and wR = 0.0788 (I > 2σ(I)). The structure was solved by direct methods and refined by full-matrix least-squares techniques. X-ray analysis revealed that there exist four ring planes of 10H-indolium, pyridinium, p-chlorophenyl and indolyl in the molecule, of which the pyridinium ring forms a conjugated system with the p-chlorophenyl plane. According to the molecular structure of the title compound, it is presumed that the synthetic reaction may undergo the processes of C-addition, cyclization and aromatization.
文摘Sp) Octyl 8 chloroadenosine 3′5′cyclophosphate (OCC), a newly synthesized 8 Cl c AMP derivative, strongly induced inhibition and differentiation in human leukemia HL 60 cells. In flow cytometry, OCC brought about a block at the G1 phase of HL 60 cell cycle. OCC inhibited strongly the synthesis of DNA without affecting the synthesis of RNA and protein in HL 60 cells and also activated the c AMP dependent protein kinase in the cytosol of HL 60 cells. 8 Chloroadenosine is the active metabolite of OCC and inhibited significantly the growth of tumour in vitro and in vivo tests. 8 Chloroadenosine can induce differentiation of gastric mucoid adenocarcinoma cell line MGc80 3 and induce apoptosis in the MOLT 4 cells. The mechanism of the antitumour effects of 8 chloroadenosine was discussed.
