Introduction:Nail psoriasis is a type of psoriasis involving nail lesions characterized by pitting,onycholysis,longitudinal ridges,and subungual hyperkeratosis.We herein describe a 9-year-old girl with nail psoriasis ...Introduction:Nail psoriasis is a type of psoriasis involving nail lesions characterized by pitting,onycholysis,longitudinal ridges,and subungual hyperkeratosis.We herein describe a 9-year-old girl with nail psoriasis who presented with nail crumbling and was treated with topical cream containing 45μg/g mouse monoclonal antibody to human interleukin-8.Case presentation:A 9-year-old Chinese girl presented with a 6-month history of a rough,thickened fingernail and toenails.Nail plate crumbling,onycholysis,and fissured periungual folds were observed under dermoscopy and ultraviolet dermoscopy.The nails were soaked in warm water,then topical wrapped with Abcream cream overnight.After about 4 months of treatment,the nails significantly improved by both dermoscopy and ultraviolet-dermoscopy evaluattion.Discussion:Due to the different wavelengths of light emitted by polarized light dermatoscope and ultraviolet-dermatoscope,the characteristics of observation will be different.Abcream acts by antagonizing human interleukin-8,inhibiting leukocyte chemotaxis and neovascularization,and regulating the abnormal proliferation and differentiation of keratinocytes.Conclusion:Ultraviolet-dermoscopy is pivotal in evaluating the severity and potency of nail psoriasis.And Abcream can be regarded as a new drug for the treatment of nail psoriasis in children.展开更多
基金This research was supported by the Project for Disciplines of Excellence(No.ZYJC18033)the HX-Academician Project(No.HXYS19003)of West China Hospital,Sichuan University China.
文摘Introduction:Nail psoriasis is a type of psoriasis involving nail lesions characterized by pitting,onycholysis,longitudinal ridges,and subungual hyperkeratosis.We herein describe a 9-year-old girl with nail psoriasis who presented with nail crumbling and was treated with topical cream containing 45μg/g mouse monoclonal antibody to human interleukin-8.Case presentation:A 9-year-old Chinese girl presented with a 6-month history of a rough,thickened fingernail and toenails.Nail plate crumbling,onycholysis,and fissured periungual folds were observed under dermoscopy and ultraviolet dermoscopy.The nails were soaked in warm water,then topical wrapped with Abcream cream overnight.After about 4 months of treatment,the nails significantly improved by both dermoscopy and ultraviolet-dermoscopy evaluattion.Discussion:Due to the different wavelengths of light emitted by polarized light dermatoscope and ultraviolet-dermatoscope,the characteristics of observation will be different.Abcream acts by antagonizing human interleukin-8,inhibiting leukocyte chemotaxis and neovascularization,and regulating the abnormal proliferation and differentiation of keratinocytes.Conclusion:Ultraviolet-dermoscopy is pivotal in evaluating the severity and potency of nail psoriasis.And Abcream can be regarded as a new drug for the treatment of nail psoriasis in children.
文摘目的:观察补肺化痰膏对慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)稳定期肺脾气虚证患者生活质量、肺功能及对血清中白细胞介素-6(interleukin-6,IL-6)和IL-8水平的影响。方法:78例COPD稳定期患者随机分为对照组39例和观察组39例。对照组给予常规治疗,观察组在对照组治疗基础上给予补肺化痰膏。两组疗程均为12周。比较两组患者肺功能、生活质量及临床疗效。比较两组患者血清中IL-6和IL-8水平。结果:治疗后,观察组第1秒钟用力肺活量占预计值百分比(forced expiratory volume in first second,FEV1)%和FEV1/用力肺活量(forced vital capacity,FVC)分别为(53.57±5.67)%、(55.88±5.71),对照组FEV1%、FEV1/FVC分别为(50.04±5.26)%、(52.96±5.56),两组比较,差异均有统计学意义(P<0.05)。观察组圣乔治呼吸问卷(St Georges respiratory questionnaire,SGRQ)量表呼吸症状、活动能力、疾病影响、SGRQ总分别为(12.15±1.63)分、(9.06±1.15)分、(13.05±1.66)分、(34.26±4.12)分,对照组以上指标分别为(14.31±1.95)分、(11.52±1.71)分、(15.96±5.56)分、(41.79±4.93)分,两组比较,差异均有统计学意义(P<0.05)。观察组有效率为92.31%,明显高于对照组的71.79%(P<0.05)。观察组治疗后血清中IL-6和IL-8水平分别为(1.06±0.14)ng·L^(-1)、(2.12±0.27)ng·L^(-1),对照组治疗后以上指标分别为(2.45±0.27)ng·L^(-1)、(4.30±0.48)ng·L^(-1),两组比较,差异均有统计学意义(P<0.05)。结论:补肺化痰膏治疗稳定期COPD肺脾气虚证患者临床疗效显著,可显著改善COPD稳定期肺脾气虚证患者的生活质量和肺功能,下调血清中IL-6和IL-8水平可能是其作用机制之一。
