A new jatrophane diterpenoid ester (2S, 3S, 4R, 5R, 7S, 8R, 13R, 15R) - 3, 5, 7, 8, 15- pentaacetoxy-9, 14-dioxojatropha-6(17), 11E-diene was isolated from the whole plant of Euphorbia turczaninowii Kar. & Kit.. ...A new jatrophane diterpenoid ester (2S, 3S, 4R, 5R, 7S, 8R, 13R, 15R) - 3, 5, 7, 8, 15- pentaacetoxy-9, 14-dioxojatropha-6(17), 11E-diene was isolated from the whole plant of Euphorbia turczaninowii Kar. & Kit.. Its structure was characterized by spectral analysis and confurmed by X-ray crystallographic analysis.展开更多
The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsun...The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsunobu reaction. At the same time we developed a short synthetic route for 6R-(+)-goniothalamin 3 and (6R, 7R, 8R)-(+)-goniothalamin oxide 4. And according to this route the configuration of 5-acetoxygoniothalamin 1 was confirmed as (5S, 6S).展开更多
文摘A new jatrophane diterpenoid ester (2S, 3S, 4R, 5R, 7S, 8R, 13R, 15R) - 3, 5, 7, 8, 15- pentaacetoxy-9, 14-dioxojatropha-6(17), 11E-diene was isolated from the whole plant of Euphorbia turczaninowii Kar. & Kit.. Its structure was characterized by spectral analysis and confurmed by X-ray crystallographic analysis.
基金We are grateful to the National Natural Science Foundation of China(No.2017223)for financial support
文摘The first enantioselective total synthesis of 5-acetoxygoniothalamin 1 and 5-acetoxyisogoniothalamin oxide 2 was achieved through the Sharpless kinetic resolution of racemic secondary 2- furylmethanol 5 and the Mitsunobu reaction. At the same time we developed a short synthetic route for 6R-(+)-goniothalamin 3 and (6R, 7R, 8R)-(+)-goniothalamin oxide 4. And according to this route the configuration of 5-acetoxygoniothalamin 1 was confirmed as (5S, 6S).