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Experimental,Numerical,and Analytical Studies on the Bending of Mechanically Lined Pipe 被引量:1
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作者 WEI Wen-bin YUAN Lin +1 位作者 ZHOU Jia-sheng LIU Zheng 《China Ocean Engineering》 SCIE EI CSCD 2024年第2期221-232,共12页
Mechanically lined pipe(MLP)is often used for offshore oil and gas transport because of its low cost and corrosion resistance.During installation and operation,the pipe may undergo severe bending deformation,which cau... Mechanically lined pipe(MLP)is often used for offshore oil and gas transport because of its low cost and corrosion resistance.During installation and operation,the pipe may undergo severe bending deformation,which causes the liner to separate from the outer pipe and buckles,affecting the stability of the whole line.In this paper,the buckling response of MLP subjected to bending is investigated to clarify its bending characteristics by employing both experiments,numerical simulation,as theoretical methods.Two types of MLPs were manufactured with GB 45 carbon steel(SLP)and Al 6061(ALP)used as the outer pipe material,respectively.The hydraulic expansion and bending experiments of small-scale MLPs are conducted.In addition to the ovalized shape of the cross-section for the SLP specimens,the copper liner was found to wrinkle on the compressive side.In contrast,the liner of ALP remains intact without developing any wrinkling and collapse mode.In addition,a dedicated numerical framework and theoretical models were also established.It was found both the manufacturing and bending responses of the MLP can be well reproduced,and the predicted maximum moment and critical curvatures are in good agreement with the experimental results. 展开更多
关键词 lined pipe bending nonlinear ring theory BUCKLING PLASTICITY
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Effect of characteristics and distribution of Mg_(17)Al_(12)precipitates on tensile and bending properties of high-Al-containing Mg alloys
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作者 Sumi Jo Gyo Myeong Lee +2 位作者 Jong Un Lee Young Min Kim Sung Hyuk Park 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第2期779-793,共15页
This study investigates the effect of characteristics and distribution of Mg_(17)Al_(12)precipitates on the uniaxial tensile and three-point bending properties of extruded Mg alloys containing high Al contents.The ext... This study investigates the effect of characteristics and distribution of Mg_(17)Al_(12)precipitates on the uniaxial tensile and three-point bending properties of extruded Mg alloys containing high Al contents.The extruded Mg–9Al–1Zn–0.3Mn(AZ91)alloy contains lamellar-structured Mg_(17)Al_(12)discontinuous precipitates along the grain boundaries,which are formed via static precipitation during natural air cooling.The extruded Mg–11Al–1Zn–0.3Mn(AZ111)alloy contains spherical Mg_(17)Al_(12)precipitates at the grain boundaries and inside the grains,which are formed via dynamic precipitation during extrusion.Due to inhomogeneous distribution of precipitates,the AZ111 alloy consists of two different precipitate regions:precipitate-rich region with numerous precipitates and finer grains and precipitate-scarce region with a few precipitates and coarser grains.The AZ111 alloy exhibits a higher tensile strength than the AZ91 alloy because its smaller grain size and more abundant precipitates result in stronger grain-boundary hardening and precipitation hardening effects,respectively.However,the tensile elongation of the AZ111 alloy is lower than that of the AZ91 alloy because the weak cohesion between the dynamic precipitates and the matrix facilitates the crack initiation and propagation.During bending,a macrocrack initiates on the outer surface of bending specimen in both alloys.The AZ111 alloy exhibits higher bending yield strength and lower failure bending strain than the AZ91 alloy.The bending specimens of the AZ91 alloy have similar bending formability,whereas those of the AZ111 alloy exhibit considerable differences in bending formability and crack propagation behavior,depending on the distribution and number density of precipitates in the specimen.In bending specimens of the AZ111 alloy,it is found that the failure bending strain(ε_(f,bending))is inversely proportional to the area fraction of precipitates in the outer zone of bending specimen(A_(ppt)),with a relationship ofε_(f,bending)=–0.1A_(ppt)+5.86. 展开更多
关键词 Mg–Al alloy EXTRUSION bending Precipitation Microstructure
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Bending Failure Mode and Prediction Method of the Compressive Strain Capacity of A Submarine Pipeline with Dent Defects
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作者 HOU Fu-heng JIA Lu-sheng +3 位作者 CHEN Yan-fei ZHANG Qi ZHONG Rong-feng WANG Chun-sha 《China Ocean Engineering》 SCIE EI CSCD 2024年第4期636-647,共12页
A dent is a common type of defects for submarine pipeline.For submarine pipelines,high hydrostatic pressure and internal pressure are the main loads.Once pipelines bend due to complex subsea conditions,the compression... A dent is a common type of defects for submarine pipeline.For submarine pipelines,high hydrostatic pressure and internal pressure are the main loads.Once pipelines bend due to complex subsea conditions,the compression strain capacity may be exceeded.Research into the local buckling failure and accurate prediction of the compressive strain capacity are important.A finite element model of a pipeline with a dent is established.Local buckling failure under a bending moment is investigated,and the compressive strain capacity is calculated.The effects of different parameters on pipeline local buckling are analyzed.The results show that the dent depth,external pressure and internal pressure lead to different local buckling failure modes of the pipeline.A higher internal pressure indicates a larger compressive strain capacity,and the opposite is true for external pressure.When the ratio of external pressure to collapse pressure of intact pipeline is greater than 0.1,the deeper the dent,the greater the compressive strain capacity of the pipeline.And as the ratio is less than 0.1,the opposite is true.On the basis of these results,a regression equation for predicting the compressive strain capacity of a dented submarine pipeline is proposed,which can be referred to during the integrity assessment of a submarine pipeline. 展开更多
关键词 submarine pipeline dent defect bending load local buckling compressive strain capacity
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Cryogenic springback of 2219-W aluminum alloy sheet through V-shaped bending
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作者 Xiao-bo FAN Qi-liang WANG +1 位作者 Fang-xing WU Xu-gang WANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第10期3185-3193,共9页
A V-shaped bending device was established to evaluate the effects of temperature and bending fillet radius on springback behavior of 2219-W aluminum alloy at cryogenic temperatures.The cryogenic springback mechanism w... A V-shaped bending device was established to evaluate the effects of temperature and bending fillet radius on springback behavior of 2219-W aluminum alloy at cryogenic temperatures.The cryogenic springback mechanism was elucidated through mechanical analyses and numerical simulations.The results indicated that the springback angle at cryogenic temperatures was greater than that at room temperature.The springback angle increased further as the temperature returned to ambient conditions,attributed to the combined effects of the “dual enhancement effect” and thermal expansion.Notably,a critical fillet radius made the springback angle zero for 90° V-shaped bending.The critical fillet radius at cryogenic temperatures was smaller than that at room temperature,owing to the influence of temperature variations on the bending moment ratio between the forward bending section at the fillet and the reverse bending section of the straight arm. 展开更多
关键词 2219-W aluminum alloy cryogenic forming V-shape bending SPRINGBACK critical fillet radius
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Analysis of deformation mechanisms in magnesium single crystals using a dedicated four-point bending tester
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作者 Yutaka Yoshida Rikuto Izawa Kenji Ohkubo 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2024年第5期1911-1917,共7页
In this study,we explored the deformation mechanisms of Mg single crystals using a combination of scanning electron microscopy and electron backscattered diffraction in conjunction with a dedicated four-point bending ... In this study,we explored the deformation mechanisms of Mg single crystals using a combination of scanning electron microscopy and electron backscattered diffraction in conjunction with a dedicated four-point bending tester.We prepared two single-crystal samples,oriented along the<1120>and<1010>directions,to assess the mechanisms of deformation when the initial basal slip was suppressed.In the<1120>sample,the primary{1012}twin(T1)was confirmed along the<1120>direction of the sample on the compression side with an increase in bending stress.In the<1010>sample,T1 and the secondary twin(T2)were confirmed to be along the<1120>direction,with an orientation of±60°with respect to the bending stress direction,and their direction matched with(0001)in T1 and T2.This result implies that crystallographically,the basal slip occurs readily.In addition,the<1010>sample showed the double twin in T1 on the compression side and the tertiary twin along the<1010>direction on the tension side.These results demonstrated that the maximum bending stress and displacement changed significantly under the bend loading because the deformation mechanisms were different for these single crystals.Therefore,the correlation between bending behavior and twin orientation was determined,which would be helpful for optimizing the bending properties of Mg-based materials. 展开更多
关键词 Four-point bending Magnesium single crystal TWINNING Basal slip Scanning electron microscopy Electron backscatter diffraction
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Bending strength degradation of a cantilever plate with surface energy due to partial debonding at the clamped boundary
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作者 Zhenliang HU Xueyang ZHANG Xianfang LI 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第9期1573-1594,共22页
This paper investigates the bending fracture problem of a micro/nanoscale cantilever thin plate with surface energy,where the clamped boundary is partially debonded along the thickness direction.Some fundamental mecha... This paper investigates the bending fracture problem of a micro/nanoscale cantilever thin plate with surface energy,where the clamped boundary is partially debonded along the thickness direction.Some fundamental mechanical equations for the bending problem of micro/nanoscale plates are given by the Kirchhoff theory of thin plates,incorporating the Gurtin-Murdoch surface elasticity theory.For two typical cases of constant bending moment and uniform shear force in the debonded segment,the associated problems are reduced to two mixed boundary value problems.By solving the resulting mixed boundary value problems using the Fourier integral transform,a new type of singular integral equation with two Cauchy kernels is obtained for each case,and the exact solutions in terms of the fundamental functions are determined using the PoincareBertrand formula.Asymptotic elastic fields near the debonded tips including the bending moment,effective shear force,and bulk stress components exhibit the oscillatory singularity.The dependence relations among the singular fields,the material constants,and the plate's thickness are analyzed for partially debonded cantilever micro-plates.If surface energy is neglected,these results reduce the bending fracture of a macroscale partially debonded cantilever plate,which has not been previously reported. 展开更多
关键词 micro/nanoscale cantilever plate partially debonded bending fracture singular integral equation oscillatory singularity
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A Light and Simplified Branch Bending Method for Young Pear Trees
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作者 Jintao XU Longfei LI +3 位作者 Minghui JI Huan LIU Lijuan GAO Baofeng HAO 《Plant Diseases and Pests》 2024年第2期19-21,共3页
Aiming at high cost and low efficiency of conventional branch bending method in the modern intensive planting and labor-saving cultivation mode of young pear trees,this paper provides a new branch bending method with ... Aiming at high cost and low efficiency of conventional branch bending method in the modern intensive planting and labor-saving cultivation mode of young pear trees,this paper provides a new branch bending method with wide source of raw materials,cheap price and simple operation,which is also suitable for the management of low-age branches in the process of high grafting and upgrading of traditional big trees. 展开更多
关键词 Pear tree Light and simplified Branch bending METHOD
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The Effects of the Longitudinal Axis of Loading upon Bending, Shear and Torsion of a Thin-Walled Cantilever Channel Beam
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作者 David W. A. Rees Abdelraouf M. Sami Alsheikh 《World Journal of Mechanics》 2024年第5期73-96,共24页
Three aluminium channel sections of US standard extruded dimension are mounted as cantilevers with x-axis symmetry. The flexural bending and shear that arise with applied axial torsion are each considered theoreticall... Three aluminium channel sections of US standard extruded dimension are mounted as cantilevers with x-axis symmetry. The flexural bending and shear that arise with applied axial torsion are each considered theoretically and numerically in terms of two longitudinal axes of loading not coincident with the shear centre. In particular, the warping displacements, stiffness and stress distributions are calculated for torsion applied to longitudinal axes passing through the section’s centroid and its web centre. The stress conversions derived from each action are superimposed to reveal a net sectional stress distribution. Therein, the influence of the axis position upon the net axial and shear stress distributions is established compared to previous results for each beam when loading is referred to a flexural axis through the shear centre. Within the net stress analysis is, it is shown how the constraint to free warping presented by the end fixing modifies the axial stress. The latter can be identified with the action of a ‘bimoment’ upon each thin-walled section. 展开更多
关键词 Thin-Aluminium Channels Cantilever Beam bending Shear Torsion WARPING BIMOMENT Flexural Axis Centre of Twist CENTROID Shear Centre Torsional Stiffness Constrained Stress
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“90后”员工离职倾向影响因素研究 被引量:2
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作者 刘富成 韩梦佳 《长春大学学报》 2024年第1期18-27,共10页
在竞争激烈的商业环境中,90后员工离职成为大多数企业面临的挑战。通过问卷调查,从员工需求与激励、工作与生活平衡、工作前景与预期这3个维度运用SPSS探究90后员工离职倾向的影响因素。研究发现:本科学历的90后员工对工作的前景与预期... 在竞争激烈的商业环境中,90后员工离职成为大多数企业面临的挑战。通过问卷调查,从员工需求与激励、工作与生活平衡、工作前景与预期这3个维度运用SPSS探究90后员工离职倾向的影响因素。研究发现:本科学历的90后员工对工作的前景与预期更高;需求与激励因素对90后员工离职倾向影响最大。因此,企业应该采取措施如建立并完善激励机制、为90后布置个性化任务和采取弹性工作制等减少员工离职现象发生。 展开更多
关键词 90后员工 离职倾向 影响因素
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基于MSISE-90研究高海拔宇宙线观测站处的大气深度廓线模型
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作者 祝凤荣 柳靖 +2 位作者 夏君集 张丰 刘虎 《物理学报》 SCIE EI CAS CSCD 北大核心 2024年第16期229-237,共9页
高海拔宇宙线观测站(LHAASO)位于四川省稻城县海子山,它的广角切伦科夫望远镜阵(WFCTA)主要是通过观测广延大气簇射过程中产生的切伦科夫光信号对宇宙线进行研究.WFCTA的标定、模拟和重建都和大气深度有关,目前使用的大气深度模型是美... 高海拔宇宙线观测站(LHAASO)位于四川省稻城县海子山,它的广角切伦科夫望远镜阵(WFCTA)主要是通过观测广延大气簇射过程中产生的切伦科夫光信号对宇宙线进行研究.WFCTA的标定、模拟和重建都和大气深度有关,目前使用的大气深度模型是美国标准大气深度廓线模型.本研究中将美国标准大气深度廓线模型与卫星TIMED搭载的红外辐射计SABER记录到的LHAASO处14-50 km处的大气深度廓线进行比较,同时也与LHAASO处地面气象站记录的大气深度进行比较,美国标准大气模型的大气深度均偏小.MSISE-90大气模型描述了地球大气中从地面到热层的中性温度和密度,进一步研究发现MSISE-90大气模型与TIMED/SABER和LHAASO处地面标准气象站记录的大气深度的一致性较好.根据MSISE-90大气模型计算得到LHAASO处的大气深度均值廓线在1月最低,其次是2月、3月、4月、11月和12月,这也是WFCTA运行的最佳观测月份.4月份的大气边界层最高,其大气深度存在约2%的日变化.利用美国标准大气模型的函数形式,拟合每月的4.4-100 km处的大气深度廓线,得到了LHAASO处的每月的大气深度廓线模型,并比较了30°天顶角入射的100 TeV的宇宙线质子在MSISE-90大气模型和美国标准大气模型中产生的切伦科夫光的横分布的差异,二者最大差异约可以达到20%. 展开更多
关键词 MSISE-90大气模型 大气深度廓线 高海拔宇宙线观测站 切伦科夫光
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90°转角微流道内导流板应用特性数值研究
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作者 张敏 徐长杰 《华北科技学院学报》 2024年第5期51-56,共6页
改善转角微流道内流体的二次流特性对提高微流体传输的可靠性具有重要意义。针对90°转角矩形截面微流道,本文提出在微流道转角处增加导流板来实现该区域二次流的主动调节和控制。本文设计了圆弧型和弧—直组合型两种导流板结构,建... 改善转角微流道内流体的二次流特性对提高微流体传输的可靠性具有重要意义。针对90°转角矩形截面微流道,本文提出在微流道转角处增加导流板来实现该区域二次流的主动调节和控制。本文设计了圆弧型和弧—直组合型两种导流板结构,建立了五种不同结构微流道模型,开展了流场对称性和Dean涡分析,流体相对横向动能ksec和流道局部阻力系数ζ90°计算。结果表明,导流板结构能有效改善微流道转角区的流场对称性,加速Dean涡的消失,降低二次流强度,同时也会引起流体流动局部阻力系数有所增加。 展开更多
关键词 导流板 90°转角 微流道 二次流 Dean涡
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结肠癌中Hsp90α的表达及临床意义
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作者 张阳 吴晓婷 +3 位作者 王芳 戴星辰 张玉环 高玉婧 《临床与实验病理学杂志》 CAS 北大核心 2024年第8期845-852,共8页
目的探讨热休克蛋白90α(heat shock protein 90α,Hsp90α)在结肠癌中的表达及潜在的临床价值。方法采用生物信息学和免疫组化法分析结肠癌中Hsp90α的表达水平,及其与临床病理学特征、预后和免疫细胞浸润水平的关系;采用CCK-8细胞增... 目的探讨热休克蛋白90α(heat shock protein 90α,Hsp90α)在结肠癌中的表达及潜在的临床价值。方法采用生物信息学和免疫组化法分析结肠癌中Hsp90α的表达水平,及其与临床病理学特征、预后和免疫细胞浸润水平的关系;采用CCK-8细胞增殖实验和平板克隆实验检测敲除Hsp90AA1前后结肠癌细胞的增殖能力。结果生物信息学分析结果显示,Hsp90AA1在结肠癌组织中异常高表达,其表达水平越高,患者预后越差;Hsp90AA1表达与CD4^(+)T细胞(Th2)、CD8^(+)T细胞、髓样抑制细胞、Tregs细胞、中性粒细胞、巨噬细胞、M1巨噬细胞、M2巨噬细胞的浸润水平呈正相关;免疫组化结果显示结肠癌组织中Hsp90α表达明显高于癌旁正常组织,Hsp90α表达与患者性别、肿瘤大小、位置、分化程度、TNM分期、淋巴结转移、脉管癌栓、神经侵犯、远处转移等无关(P>0.05),与结肠癌患者年龄具有相关性(P<0.05)。Hsp90α高表达是影响结肠癌患者预后的独立危险因素。细胞实验结果显示,敲除Hsp90AA1可抑制结肠癌细胞的生长及增殖能力。结论Hsp90α在结肠癌中高表达,可能是结肠癌预后不良的潜在分子学标志物。 展开更多
关键词 结肠肿瘤 HSP90Α 免疫浸润 免疫组织化学
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80W-90车辆齿轮油低温表观黏度的相关性研究
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作者 林国就 揭斌华 +1 位作者 邹小芸 梁启源 《润滑油》 CAS 2024年第2期52-56,共5页
文章在不添加黏度指数改进剂的前提下,考察了基础油对80W-90车辆齿轮油低温表观黏度的影响,并开展了基础油理化指标与80W-90车辆齿轮油低温表观黏度的相关性研究,掌握了80W-90车辆齿轮油低温表观黏度的变化规律,确定了80W-90车辆齿轮油... 文章在不添加黏度指数改进剂的前提下,考察了基础油对80W-90车辆齿轮油低温表观黏度的影响,并开展了基础油理化指标与80W-90车辆齿轮油低温表观黏度的相关性研究,掌握了80W-90车辆齿轮油低温表观黏度的变化规律,确定了80W-90车辆齿轮油生产过程控制指标,以降低低温表观黏度的质量风险,指导精益生产。结果表明:固定主剂和降凝剂的加入量,混合基础油的黏度指数、密度与成品油低温表观黏度的相关性较高,可较好地反映80W-90车辆齿轮油的低温表观黏度大小。 展开更多
关键词 80W-90车辆齿轮油 低温表观黏度 黏度指数 密度 相关性
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ERG理论视角下高职院校“90后”教师职业压力的成因与对策研究
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作者 汪海伟 《职业技术》 2024年第7期45-50,共6页
“90后”青年教师是高校教师队伍的新生力量,是学校可持续发展的主力军,他们的身心健康直接影响着高等职业教育事业的发展。文章根据奥尔德弗的ERG理论,从人的三种核心需求出发,研究高职院校“90后”教师职业压力的形成原因、主要特征... “90后”青年教师是高校教师队伍的新生力量,是学校可持续发展的主力军,他们的身心健康直接影响着高等职业教育事业的发展。文章根据奥尔德弗的ERG理论,从人的三种核心需求出发,研究高职院校“90后”教师职业压力的形成原因、主要特征和表现形式,并从新的理论视角就“90后”教师职业压力的应对策略进行研究,旨在缓解“90后”教师职业压力,助力青年教师健康成长。 展开更多
关键词 ERG理论 高职院校“90后”教师 职业压力 成因与对策
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热休克蛋白90对hERG-A561V通道蛋白转运及通道功能影响的研究
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作者 王英 叶佳纯 +2 位作者 黄晓燕 陈邦盛 廉姜芳 《心电与循环》 2024年第2期107-112,共6页
目的探讨热休克蛋白90(Hsp90)对人类ether-a-go-go相关基因(hERG)-A561V通道蛋白转运及通道功能影响的研究。方法构建野生型(WT)、突变型(A561V)、杂合型(WT/A561V)细胞模型,采用蛋白质印迹法检测各组细胞hERG及Hsp90蛋白表达差异。转... 目的探讨热休克蛋白90(Hsp90)对人类ether-a-go-go相关基因(hERG)-A561V通道蛋白转运及通道功能影响的研究。方法构建野生型(WT)、突变型(A561V)、杂合型(WT/A561V)细胞模型,采用蛋白质印迹法检测各组细胞hERG及Hsp90蛋白表达差异。转染减表达空载(Itf NC)、Hsp90减表达(Hsp90-)、过表达空载(Ovp NC)或Hsp90过表达(Hsp90+)质粒至各细胞模型(即Itf NC组、Hsp90-组、Ovp NC组、Hsp90+组),另设不加载体的对照(Ctl)组,采用蛋白质印迹法检测各组细胞调控Hsp90前后hERG及Hsp90蛋白表达差异。采用免疫荧光法检测Hsp90调控前后杂合型细胞模型hERG及Hsp90蛋白定位表达情况。采用全细胞膜片钳技术检测调控Hsp90前后杂合型细胞模型hERG通道激活电流及尾电流密度。结果突变型、杂合型细胞模型Hsp90及hERG(135 kDa)蛋白表达水平均较野生型明显升高(均P<0.05)。野生型细胞模型Hsp90+组hERG(135 kDa)、hERG(155 kDa)蛋白表达水平较Ctl组、Ovp NC组均明显升高(均P<0.05),突变型细胞模型Hsp90+组hERG(135 kDa)蛋白表达水平较Ctl组、Ovp NC组均明显升高(均P<0.05),杂合型细胞模型Hsp90+组hERG(155 kDa)蛋白表达水平较Ctl组、Ovp NC组均明显升高(均P<0.05)。融合Hsp90和hERG蛋白后,Ctl组hERG表达于细胞膜、细胞质,Hsp90-组细胞膜上hERG蛋白表达减少,Hsp90+组细胞膜上hERG蛋白表达增多。与Ctl组比较,Hsp90+组Ikr曲线左移14.709,斜率因子k值未见明显变化。杂合型细胞模型Ctl组、Hsp90-组、Hsp90+组激活电流及尾电流密度均在50 mV处达到最高;杂合型细胞模型Hsp90+组在20、30 mV处的激活电流密度均明显高于Ctl组、Hsp90-组(均P<0.05),在30、40 mV处的尾电流密度均明显高于Ctl组、Hsp90-组(均P<0.05)。结论Hsp90在hERG-A561V通道蛋白折叠转运中起作用,而上调Hsp90可促进WT/A561V hERG的折叠转运,进而影响通道功能。 展开更多
关键词 热休克蛋白90 遗传性长QT综合征 人类ether-a-go-go相关基因 A561V突变 蛋白转运
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热休克蛋白90α在肺癌患者中诊断价值的荟萃分析 被引量:1
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作者 陈晨 戎彪学 +4 位作者 李俏苒 宋陈晨 张超贻 梁天赐 赵悦 《临床医学进展》 2024年第1期552-564,共13页
目的:肺癌是临床上最为常见的恶性肿瘤,晚期患者预后差,5年生存率低,因此早期诊断成为提高患者预后的关键。本研究旨在评价热休克蛋白90α在肺癌诊断中的应用价值。方法:计算机检索中国知网、万方、维普、PubMed、Embase等数据库,搜索... 目的:肺癌是临床上最为常见的恶性肿瘤,晚期患者预后差,5年生存率低,因此早期诊断成为提高患者预后的关键。本研究旨在评价热休克蛋白90α在肺癌诊断中的应用价值。方法:计算机检索中国知网、万方、维普、PubMed、Embase等数据库,搜索有关热休克蛋白90α与肺癌相关的研究,检索时间均从建库至2023年8月,并根据纳入与排除标准进行文献筛选。采用Meta-Disc1.4、RevMan5.4和Stata16.0软件进行了偏倚风险、适用性评价、Meta分析、回归分析、亚组分析、发表偏倚、敏感性分析和临床应用价值等统计学分析。结果:最终纳入文献18篇,综合各项数据后,采用随机效应模型进行分析。热休克蛋白90α诊断肺癌的合并敏感度为0.76 (95% CI: 0.680.83),合并特异性为0.81 (95% CI: 0.730.87),合并阳性似然比为3.98 (95% CI: 2.805.57),合并阴性似然比为0.29 (95% CI: 0.220.39),合并诊断比值比为13 (95% CI: 822),综合受试者工作特征(SROC)曲线下面积为0.85。费根(Fagan)列线图显示,设定验前概率为50%,诊断肺癌的符合率为80%。结论:血液标本中热休克蛋白90α的表达水平有助于肺癌的临床诊断,可作为辅助诊断肺癌的分子生物学标志物。 展开更多
关键词 肺癌 非小细胞肺癌 热休克蛋白90Α 肿瘤标记物 META分析
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90锶敷贴疗法对瘢痕增生患者症状改善、应激指标及安全性的影响
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作者 林晓华 陈海波 翁咏梅 《吉林医学》 CAS 2024年第7期1732-1735,共4页
目的:研究90锶敷贴疗法对瘢痕增生患者症状改善、应激指标及安全性的影响。方法:选取北京大学深圳医院2019年2月~2021年2月收治的82例瘢痕增生患者,以电脑编号随机法分为试验组及参考组,每组各41例。所有患者均予以基础护理干预,而试验... 目的:研究90锶敷贴疗法对瘢痕增生患者症状改善、应激指标及安全性的影响。方法:选取北京大学深圳医院2019年2月~2021年2月收治的82例瘢痕增生患者,以电脑编号随机法分为试验组及参考组,每组各41例。所有患者均予以基础护理干预,而试验组则予以90锶敷贴疗法干预。对比两组症状改善,应激指标、不良反应发生情况以及患者满意度。结果:试验组治疗总有效率高于参考组,差异有统计学意义(P<0.05)。干预后,试验组汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)评分均低于参考组,差异有统计学意义(P<0.05)。两组疼痛、出血、皮肤破溃以及心律失常发生率比较,差异无统计学意义(P>0.05)。试验组患者总满意度为82.68%,高于参考组的75.61%,差异有统计学意义(P<0.05)。结论:90锶敷贴疗法对瘢痕增生患者症状改善效果显著,且能降低应激反应程度,安全性较佳。 展开更多
关键词 瘢痕增生 90锶敷贴疗法 症状改善 应激指标 不良反应
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基于动态边界的90°弯管壁面渐进磨损特性 被引量:1
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作者 陈雨 李仁年 +1 位作者 韩伟 周巍巍 《排灌机械工程学报》 CSCD 北大核心 2024年第4期380-387,共8页
固定边界磨损预测方法只能得到磨损初始边界状态下的磨损特性,无法获得壁面破坏后的流场动力学响应.由此,基于计算流体力学提出动态边界的水力机械过流壁面渐进磨损数值预测方法,通过研究90°弯管在不同磨损时刻的磨损表面形貌,流... 固定边界磨损预测方法只能得到磨损初始边界状态下的磨损特性,无法获得壁面破坏后的流场动力学响应.由此,基于计算流体力学提出动态边界的水力机械过流壁面渐进磨损数值预测方法,通过研究90°弯管在不同磨损时刻的磨损表面形貌,流场特性、磨损特性和颗粒冲击特性,揭示由于过流壁面磨损形貌演变引起的多相流特性和磨损演变机理.研究结果表明:在来流速度6.3 m/s、颗粒体积分数为0.35%的90°弯管中,磨损主要集中在末端(50°~90°)内壁附近,且在20000 h以后,外侧内壁的平均磨损率与内侧之比增大到2倍附近;颗粒冲击速度呈现先增加后减小的规律,最大变化量为0.81 m/s,而颗粒冲击角度呈现近乎线性增加,平均最大增幅为1.13°;此外,磨损坑内颗粒冲击速度减小,磨损坑边缘冲击速度增加,说明随着磨损时间的增加磨损范围会进一步扩大,研究结果为弯管的磨损防护提供了一定的参考. 展开更多
关键词 90°弯管 动态边界 磨损 数值预测 磨损机理 流动特性
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“90后”高职院校辅导员培养策略研究——基于SWOT模型的分析
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作者 孙丹 《兰州职业技术学院学报》 2024年第3期68-72,共5页
辅导员是高职院校师资的重要组成部分。借助SWOT模型,分析了“90后”高职院校辅导员队伍的优势、劣势、机遇和挑战,并从理念、能力、保障等方面提出了培养“90后”高职院校辅导员的策略。
关键词 90后”辅导员 高职院校 SWOT模型
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Electro-chemo-mechanical analysis of the effect of bending deformation on the interface of flexible solid-state battery 被引量:2
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作者 Yutao SHI Chengjun XU +2 位作者 Bingbing CHEN Jianqiu ZHOU Rui CAI 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2023年第2期189-206,共18页
Flexible solid-state battery has several unique characteristics including high flexibility,easy portability,and high safety,which may have broad application prospects in new technology products such as rollup displays... Flexible solid-state battery has several unique characteristics including high flexibility,easy portability,and high safety,which may have broad application prospects in new technology products such as rollup displays,power implantable medical devices,and wearable equipments.The interfacial mechanical and electrochemical problems caused by bending deformation,resulting in the battery damage and failure,are particularly interesting.Herein,a fully coupled electro-chemo-mechanical model is developed based on the actual solid-state battery structure.Concentration-dependent material parameters,stress-dependent diffusion,and potential shift are considered.According to four bending forms(k=8/mm,0/mm,-8/mm,and free),the results show that the negative curvature bending is beneficial to reducing the plastic strain during charging/discharging,while the positive curvature is detrimental.However,with respect to the electrochemical performance,the negative curvature bending creates a negative potential shift,which causes the battery to reach the cut-off voltage earlier and results in capacity loss.These results enlighten us that suitable electrode materials and charging strategy can be tailored to reduce plastic deformation and improve battery capacity for different forms of battery bending. 展开更多
关键词 solid-state battery electro-chemo-mechanical coupling model bending deformation PHASE-TRANSFORMATION plastic deformation
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