Introduction: Mediastinal parathyroid adenoma localization is a rare entity. We report a case of excision by manubriotomy of intrathymic parathyroid adenoma detected by Computed Tomography scan of the chest and neck a...Introduction: Mediastinal parathyroid adenoma localization is a rare entity. We report a case of excision by manubriotomy of intrathymic parathyroid adenoma detected by Computed Tomography scan of the chest and neck and confirmed by Technetium-99 m-sestamibi scan (99 mTc-MIBI). Case Presentation: A 68 years old woman with history of hypercalcaemia, PTH elevation and operation for pathological fracture of the left femur 7 days before was presented to our service. The patient underwent manubriotomy and the adenoma was found within the right lobe of the thymus gland. Conclusion: The Technetium-99 m-sestamibi scan evaluation can be useful in the preoperative localization of ectopic parathyroid adenomas. The surgical approach by manubriotomy is privileged when the ectopic adenoma is in the upper part of anterior mediastinum.展开更多
Misdiagnosis of benign renal neoplasms can lead to unnecessary surgical resections,which increases the risk of other morbid and mortality.Therefore,it is crucial to find a diagnostic modality for differentiation betwe...Misdiagnosis of benign renal neoplasms can lead to unnecessary surgical resections,which increases the risk of other morbid and mortality.Therefore,it is crucial to find a diagnostic modality for differentiation between benign and malignant renal masses.In the current study,we summarized published pieces of evidence concerning the use of technetium-99m(^(99m)Tc)-sestamibi single-photon emission computed tomography/computed tomography(SPECT/CT)as a promising diagnostic nuclear imaging modality for the differentiation of renal neoplasms.The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement for Systematic Reviews and Meta-Analyses.We conducted a systematic electronic database search for suitable studies from inception till February 20,2020 in 9 databases.The risk of bias was assessed for the included studies using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.We identified 9373 records after exclusion of 8978 duplicates using EndNote software.Title and abstract screening resulted in 761 records for further full-text screening.Finally,four studies were included with total sample size of 80 patients.The overall risk of bias was low to moderate.The results of all the included studies supported using^(99m)Tc-sestamibi SPECT/CT for the differentiation between benign and malignant renal neoplasms.The use of^(99m)Tc-sestamibi SPECT/CT could be a rapid,less invasive,promising diagnostic modality for histological diagnosis and staging of renal neoplasm,as well as monitoring post-therapy tumor's response.However,more studies with large sample sizes are essential to confirm the reliability and accuracy of this modality for usage.展开更多
文摘Introduction: Mediastinal parathyroid adenoma localization is a rare entity. We report a case of excision by manubriotomy of intrathymic parathyroid adenoma detected by Computed Tomography scan of the chest and neck and confirmed by Technetium-99 m-sestamibi scan (99 mTc-MIBI). Case Presentation: A 68 years old woman with history of hypercalcaemia, PTH elevation and operation for pathological fracture of the left femur 7 days before was presented to our service. The patient underwent manubriotomy and the adenoma was found within the right lobe of the thymus gland. Conclusion: The Technetium-99 m-sestamibi scan evaluation can be useful in the preoperative localization of ectopic parathyroid adenomas. The surgical approach by manubriotomy is privileged when the ectopic adenoma is in the upper part of anterior mediastinum.
文摘Misdiagnosis of benign renal neoplasms can lead to unnecessary surgical resections,which increases the risk of other morbid and mortality.Therefore,it is crucial to find a diagnostic modality for differentiation between benign and malignant renal masses.In the current study,we summarized published pieces of evidence concerning the use of technetium-99m(^(99m)Tc)-sestamibi single-photon emission computed tomography/computed tomography(SPECT/CT)as a promising diagnostic nuclear imaging modality for the differentiation of renal neoplasms.The study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement for Systematic Reviews and Meta-Analyses.We conducted a systematic electronic database search for suitable studies from inception till February 20,2020 in 9 databases.The risk of bias was assessed for the included studies using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.We identified 9373 records after exclusion of 8978 duplicates using EndNote software.Title and abstract screening resulted in 761 records for further full-text screening.Finally,four studies were included with total sample size of 80 patients.The overall risk of bias was low to moderate.The results of all the included studies supported using^(99m)Tc-sestamibi SPECT/CT for the differentiation between benign and malignant renal neoplasms.The use of^(99m)Tc-sestamibi SPECT/CT could be a rapid,less invasive,promising diagnostic modality for histological diagnosis and staging of renal neoplasm,as well as monitoring post-therapy tumor's response.However,more studies with large sample sizes are essential to confirm the reliability and accuracy of this modality for usage.
