本文探讨99mTc-MIBI显像联合彩色多普勒超声诊断与临床触诊法在乳腺癌新辅助化疗(neoadjuvant chemotherapy, NAC)疗效评估的应用价值。研究对象为70例未接受手术的乳腺癌患者(76个病灶),分别在NAC化疗前和进行2~3疗程化疗后进行临床触...本文探讨99mTc-MIBI显像联合彩色多普勒超声诊断与临床触诊法在乳腺癌新辅助化疗(neoadjuvant chemotherapy, NAC)疗效评估的应用价值。研究对象为70例未接受手术的乳腺癌患者(76个病灶),分别在NAC化疗前和进行2~3疗程化疗后进行临床触诊、彩色多普勒超声以及99mTc-MIBI显像检查。以99mTc-MIBI显像的核素肿瘤反应(STR) > 30%为有效标准,临床疗效参照WHO标准评价。以NAC后手术切除病理反应为标准,以I级定为无效,II、III级定为有效。99mTc-MIBI显像法检查NAC化疗前后乳腺癌患者的放射性计数比值(T/N),NAC化疗有效者45例,其T/N值前后分别为3.326 ± 1.119和1.996 ± 0.792,差异有统计学意义(t = 19.986, p t = 8.181, p p p = 0.342 > 0.05)。99mTc-MIBI显像法、彩色多普勒超声诊断法和临床触诊法评价NAC疗效的敏感度、特异度和准确度分别为87.500%、89.286%、88.158%,80.851%、82.759%、81.579%,72.727%、75.001%、73.750%。以病理检查为标准,99mTc-MIBI显像评价NAC疗效的灵敏度、特异性和准确性高于彩色多普勒超声诊断法和临床触诊法,后续对乳腺癌患者可进行99mTc-MIBI显像与彩色多普勒超声共同检查,提高NAC疗效评估的准确性。展开更多
BACKGROUND Ureteropelvic junction obstruction(UPJO)is a common congenital urinary tract disorder in children.It can be diagnosed as early as in utero due to the presence of hydronephrosis or later in life due to sympt...BACKGROUND Ureteropelvic junction obstruction(UPJO)is a common congenital urinary tract disorder in children.It can be diagnosed as early as in utero due to the presence of hydronephrosis or later in life due to symptomatic occurrence.AIM To evaluate the discrepancy between dynamic contrast-enhanced magnetic resonance urography(dMRU)and scintigraphy 99m-technetium mercaptoacetyltriglycine(MAG-3)for the functional evaluation of UPJO.METHODS Between 2016 and 2020,126 patients with UPJO underwent surgery at Robert DebréHospital.Of these,83 received a prenatal diagnosis,and 43 were diagnosed during childhood.Four of the 126 patients underwent surgery based on the clinical situation and postnatal ultrasound findings without undergoing functional imaging evaluation.Split renal function was evaluated preoperatively using scintigraphy MAG-3(n=28),dMRU(n=53),or both(n=40).In this study,we included patients who underwent surgery for UPJO and scintigraphy MAG-3+dMRU but excluded those who underwent only scintigraphy MAG-3 or dMRU.The patients were divided into groups A(<10%discrepancy)and B(>10%discrepancy).We examined the discrepancy in split renal function between the two modalities and investigated the possible risk factors.RESULTS The split renal function between the two kidneys was compared in 40 patients(28 boys and 12 girls)using scintigraphy MAG-3 and dMRU.Differential renal function,as determined using both modalities,showed a difference of<10%in 31 children and>10%in 9 children.Calculation of the relative renal function using dMRU revealed an excellent correlation coefficient with renal scintigraphy MAG-3 for both kidneys.CONCLUSION Our findings demonstrated that dMRU is equivalent to scintigraphy MAG-3 for evaluating split renal function in patients with UPJO.展开更多
文摘本文探讨99mTc-MIBI显像联合彩色多普勒超声诊断与临床触诊法在乳腺癌新辅助化疗(neoadjuvant chemotherapy, NAC)疗效评估的应用价值。研究对象为70例未接受手术的乳腺癌患者(76个病灶),分别在NAC化疗前和进行2~3疗程化疗后进行临床触诊、彩色多普勒超声以及99mTc-MIBI显像检查。以99mTc-MIBI显像的核素肿瘤反应(STR) > 30%为有效标准,临床疗效参照WHO标准评价。以NAC后手术切除病理反应为标准,以I级定为无效,II、III级定为有效。99mTc-MIBI显像法检查NAC化疗前后乳腺癌患者的放射性计数比值(T/N),NAC化疗有效者45例,其T/N值前后分别为3.326 ± 1.119和1.996 ± 0.792,差异有统计学意义(t = 19.986, p t = 8.181, p p p = 0.342 > 0.05)。99mTc-MIBI显像法、彩色多普勒超声诊断法和临床触诊法评价NAC疗效的敏感度、特异度和准确度分别为87.500%、89.286%、88.158%,80.851%、82.759%、81.579%,72.727%、75.001%、73.750%。以病理检查为标准,99mTc-MIBI显像评价NAC疗效的灵敏度、特异性和准确性高于彩色多普勒超声诊断法和临床触诊法,后续对乳腺癌患者可进行99mTc-MIBI显像与彩色多普勒超声共同检查,提高NAC疗效评估的准确性。
文摘BACKGROUND Ureteropelvic junction obstruction(UPJO)is a common congenital urinary tract disorder in children.It can be diagnosed as early as in utero due to the presence of hydronephrosis or later in life due to symptomatic occurrence.AIM To evaluate the discrepancy between dynamic contrast-enhanced magnetic resonance urography(dMRU)and scintigraphy 99m-technetium mercaptoacetyltriglycine(MAG-3)for the functional evaluation of UPJO.METHODS Between 2016 and 2020,126 patients with UPJO underwent surgery at Robert DebréHospital.Of these,83 received a prenatal diagnosis,and 43 were diagnosed during childhood.Four of the 126 patients underwent surgery based on the clinical situation and postnatal ultrasound findings without undergoing functional imaging evaluation.Split renal function was evaluated preoperatively using scintigraphy MAG-3(n=28),dMRU(n=53),or both(n=40).In this study,we included patients who underwent surgery for UPJO and scintigraphy MAG-3+dMRU but excluded those who underwent only scintigraphy MAG-3 or dMRU.The patients were divided into groups A(<10%discrepancy)and B(>10%discrepancy).We examined the discrepancy in split renal function between the two modalities and investigated the possible risk factors.RESULTS The split renal function between the two kidneys was compared in 40 patients(28 boys and 12 girls)using scintigraphy MAG-3 and dMRU.Differential renal function,as determined using both modalities,showed a difference of<10%in 31 children and>10%in 9 children.Calculation of the relative renal function using dMRU revealed an excellent correlation coefficient with renal scintigraphy MAG-3 for both kidneys.CONCLUSION Our findings demonstrated that dMRU is equivalent to scintigraphy MAG-3 for evaluating split renal function in patients with UPJO.
