This study aimed to examine the diagnosis performance of^（99m）Tc-methoxyisobutylisonitrisonitrile （^（99m）Tc-MIBI） and multimodality imaging [ultrasound, single-photon emission computed tomography/computed tomogr...This study aimed to examine the diagnosis performance of^（99m）Tc-methoxyisobutylisonitrisonitrile （^（99m）Tc-MIBI） and multimodality imaging [ultrasound, single-photon emission computed tomography/computed tomography（SPECT/CT）] for hyperparathyroidism（HPT）. From Nov. 2009 to Dec. 2015, clinical data of a total of 43 HPT patients（16 males and 27 females; 26–70 years old, average age： 51.60±10.66 years old） were retrospectively analyzed. Among them, 19 patients with primary hyperparathyroidism（PHPT） underwent ^（99m）Tc-MIBI planar imaging, 24 [15 with PHPT and 9 with secondary hyperparathyroidism（SHPT）] underwent SPECT/CT hybrid imaging, and 41（33 with PHPT and 8 with SHPT） had neck ultrasound imaging. Final diagnosis was determined by pathological examination after surgery. The positive rate was compared between different imaging modalities, and the correlation analysis was conducted between imaging results and lesion size or serum parathyroid hormone（PTH） level. The results showed that the total positive rates of^（99m）Tc-MIBI imaging, ultrasound, and the two combined imaging in the 43 HPT cases were 90.70%（39/43）, 58.54%（24/41）, and 100%（41/41）, respectively. According to lesion numbers, the positive rates were 79.10%（53/67）, 53.23%（33/62）, and 88.71%（55/62）, respectively. SPECT/CT hybrid images were positive in all the 24 patients who underwent this examination. The mean maximum diameters of the lesions in ^（99m）Tc-MIBI positive and negative patients were 1.96±0.95 cm and 1.36±0.67 cm respectively, with statistically significant difference noted（P=0.03）. The T/NT of ^（99m）Tc-MIBI imaging at the early phase was correlated positively with serum PTH level（r=0.40, P=0.01）. The T/NT of ^（99m）Tc-MIBI imaging at both the early phase and the delay phase was correlated positively with lesion size（r=0.51, and r=0.45, respectively; P〈0.01 for both）. It was concluded that ^（99m）Tc-MIBI imaging presents significant value for location diagnosis of HPT, especially when combined with SPECT/CT hybrid imaging or ultrasound. The ^（99m）Tc-MIBI uptake correlates positively with serum PTH level and lesion size.展开更多
Lymphoscintigraphy readily provides confirmation of chylothorax but not detailed localization of the leakage site. A 77-year-old woman developed traumatic chylothorax and underwent lymphoscintigraphy with radiolabeled...Lymphoscintigraphy readily provides confirmation of chylothorax but not detailed localization of the leakage site. A 77-year-old woman developed traumatic chylothorax and underwent lymphoscintigraphy with radiolabeled albumin to identify the site of lymph leakage. Dynamic imaging demonstrated appearance of focal activity presumably in the upper mediastinum, followed by spread to the left hemithorax. Subsequently, SPECT/CT showed that the leakage site was located in the left side of the upper mediastinum, and this location was confirmed during video-assisted thoracoscopic surgery. Dynamic imaging demonstrated the site of first appearance of abnormal activity, and SPECT/CT enabled detailed localization of the abnormal activity with anatomic correlation. The combination of dynamic imaging with SPECT/CT appears to be recommendable for lymphoscintigraphic assessment of chylothorax.展开更多
文摘This study aimed to examine the diagnosis performance of^（99m）Tc-methoxyisobutylisonitrisonitrile （^（99m）Tc-MIBI） and multimodality imaging [ultrasound, single-photon emission computed tomography/computed tomography（SPECT/CT）] for hyperparathyroidism（HPT）. From Nov. 2009 to Dec. 2015, clinical data of a total of 43 HPT patients（16 males and 27 females; 26–70 years old, average age： 51.60±10.66 years old） were retrospectively analyzed. Among them, 19 patients with primary hyperparathyroidism（PHPT） underwent ^（99m）Tc-MIBI planar imaging, 24 [15 with PHPT and 9 with secondary hyperparathyroidism（SHPT）] underwent SPECT/CT hybrid imaging, and 41（33 with PHPT and 8 with SHPT） had neck ultrasound imaging. Final diagnosis was determined by pathological examination after surgery. The positive rate was compared between different imaging modalities, and the correlation analysis was conducted between imaging results and lesion size or serum parathyroid hormone（PTH） level. The results showed that the total positive rates of^（99m）Tc-MIBI imaging, ultrasound, and the two combined imaging in the 43 HPT cases were 90.70%（39/43）, 58.54%（24/41）, and 100%（41/41）, respectively. According to lesion numbers, the positive rates were 79.10%（53/67）, 53.23%（33/62）, and 88.71%（55/62）, respectively. SPECT/CT hybrid images were positive in all the 24 patients who underwent this examination. The mean maximum diameters of the lesions in ^（99m）Tc-MIBI positive and negative patients were 1.96±0.95 cm and 1.36±0.67 cm respectively, with statistically significant difference noted（P=0.03）. The T/NT of ^（99m）Tc-MIBI imaging at the early phase was correlated positively with serum PTH level（r=0.40, P=0.01）. The T/NT of ^（99m）Tc-MIBI imaging at both the early phase and the delay phase was correlated positively with lesion size（r=0.51, and r=0.45, respectively; P〈0.01 for both）. It was concluded that ^（99m）Tc-MIBI imaging presents significant value for location diagnosis of HPT, especially when combined with SPECT/CT hybrid imaging or ultrasound. The ^（99m）Tc-MIBI uptake correlates positively with serum PTH level and lesion size.
文摘Lymphoscintigraphy readily provides confirmation of chylothorax but not detailed localization of the leakage site. A 77-year-old woman developed traumatic chylothorax and underwent lymphoscintigraphy with radiolabeled albumin to identify the site of lymph leakage. Dynamic imaging demonstrated appearance of focal activity presumably in the upper mediastinum, followed by spread to the left hemithorax. Subsequently, SPECT/CT showed that the leakage site was located in the left side of the upper mediastinum, and this location was confirmed during video-assisted thoracoscopic surgery. Dynamic imaging demonstrated the site of first appearance of abnormal activity, and SPECT/CT enabled detailed localization of the abnormal activity with anatomic correlation. The combination of dynamic imaging with SPECT/CT appears to be recommendable for lymphoscintigraphic assessment of chylothorax.
