In this review,recent studies regarding riboflavin-ultraviolet A(UVA)collagen cross-linking for the treatment of acanthamoeba keratitis(AK)were reviewed.English written studies about acanthamoeba,keratitis,riboflavin ...In this review,recent studies regarding riboflavin-ultraviolet A(UVA)collagen cross-linking for the treatment of acanthamoeba keratitis(AK)were reviewed.English written studies about acanthamoeba,keratitis,riboflavin and collagen cross-linking were retrieved from PubMed search engine(www.ncbi.nlm.nih.gov/pubmed).Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK,experimental studies(in vivo and in vitro)failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking.In conclusion,the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable.It is necessary to conduct a prospective case-control study for clear guidance for clinicians.展开更多
基金The study is supported in part by a grant of Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2016R1D1A1B03931724).
文摘In this review,recent studies regarding riboflavin-ultraviolet A(UVA)collagen cross-linking for the treatment of acanthamoeba keratitis(AK)were reviewed.English written studies about acanthamoeba,keratitis,riboflavin and collagen cross-linking were retrieved from PubMed search engine(www.ncbi.nlm.nih.gov/pubmed).Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK,experimental studies(in vivo and in vitro)failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking.In conclusion,the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable.It is necessary to conduct a prospective case-control study for clear guidance for clinicians.
