BACKGROUND The efficacy of mesenchymal stem cells(MSCs)in treating liver fibrosis has been demonstrated in several clinical studies.However,their low survival and liver implantation rates remain problematic.In recent ...BACKGROUND The efficacy of mesenchymal stem cells(MSCs)in treating liver fibrosis has been demonstrated in several clinical studies.However,their low survival and liver implantation rates remain problematic.In recent years,a large number of studies in animal models of liver fibrosis have shown that MSCs combined with drugs can improve the efficacy of MSCs in the treatment of liver fibrosis alone and inhibit its progression to end-stage liver disease.This has inspired new ways of thinking about treating liver fibrosis.AIM To investigate the effectiveness and mechanisms of MSCs combined with drugs in treating liver fibrosis.METHODS Data sources included four electronic databases and were constructed until January 2024.The subjects,interventions,comparators,outcomes,and study design principle were used to screen the literature,and the quality of the literature was evaluated to assess the risk of bias.Relevant randomised controlled trials were selected,and the final 13 studies were included in the final study.RESULTS A total of 13 studies were included after screening.Pooled analysis showed that MSCs combined with drug therapy significantly improved liver function,promoted the repair of damaged liver tissues,reduced the level of liver fibrosis-related indexes,and effectively ameliorated hepatic fibrosis by modulating the hepatic inflammatory microenvironment,promoting the homing of MSCs,and regulating the relevant signaling pathways,and the treatment efficacy was superior to MSCs alone.However,the combined treatment statistics showed no amelioration in serum albumin levels(standardized mean difference=0.77,95%confidence interval:-0.13 to 1.68,P=0.09).CONCLUSION In conclusion,MSCs combined with drugs for treating liver fibrosis effectively make up for the shortcomings of MSCs in their therapeutic effects.However,due to the different drugs,the treatment mechanism and effect also differ.Therefore,more randomized controlled trials are needed to compare the therapeutic efficacy of different drugs in combination with MSCs,aiming to select the“best companion”of MSCs in treating hepatic fibrosis.展开更多
This article presents the history and challenges of patient graduation,positioning it as a means of supporting patient engagement and user involvement in the healthcare system.A set of laws related to patient rights a...This article presents the history and challenges of patient graduation,positioning it as a means of supporting patient engagement and user involvement in the healthcare system.A set of laws related to patient rights and healthcare quality allows for the integration of patients into the healthcare system,but they face the unpreparedness of institutions in this new field of practices.Patient graduation requires transformations in the modes of reception and financing of universities,as well as in the pedagogical methods that need to be tailored to the reception and training of individuals in vulnerable situations.The article provides a detailed description of the example,history,and effects of the creation of the first open diploma in oncology for patient partners in France and concludes by emphasizing the need for concrete mechanisms for social recognition of user engagement in the healthcare system.展开更多
BACKGROUND Postpartum depression(PPD)not only affects the psychological and physiological aspects of maternal health but can also affect neonatal growth and development.Partners who are in close contact with parturien...BACKGROUND Postpartum depression(PPD)not only affects the psychological and physiological aspects of maternal health but can also affect neonatal growth and development.Partners who are in close contact with parturient women play a key role in communication and emotional support.This study explores the PPD support relationship with partners and its influencing factors,which is believed to establish psychological well-being and improve maternal partner support.AIM To explore the correlation between PPD and partner support during breastfeeding and its influencing factors.METHODS Convenience sampling was used to select lactating women(200 women)who underwent postpartum examinations at the Huzhou Maternity and Child Health Care Hospital from July 2022 to December 2022.A cross-sectional survey was conducted on the basic information(general information questionnaire),depression level[edinburgh postnatal depression scale(EPDS)],and partner support score[dyadic coping inventory(DCI)]of the selected subjects.Pearson’s correlation analysis was used to analyze the correlation between PPD and DCI in lactating women.Factors affecting PPD levels during lactation were analyzed using multiple linear regression.RESULTS The total average score of EPDS in 200 lactating women was(9.52±1.53),and the total average score of DCI was(115.78±14.90).Dividing the EPDS,the dimension scores were:emotional loss(1.91±0.52),anxiety(3.84±1.05),and depression(3.76±0.96).Each dimension of the DCI was subdivided into:Pressure communication(26.79±6.71),mutual support(39.76±9.63),negative support(24.97±6.68),agent support(6.87±1.92),and joint support(17.39±4.19).Pearson’s correlation analysis demonstrated that the total mean score and individual dimension scores of EPDS during breastfeeding were inversely correlated with the total score of partner support,stress communication,mutual support,and cosupport(P<0.05).The total mean score of the EPDS and its dimensions were positively correlated with negative support(P<0.05).Multiple linear regression analysis showed that the main factors affecting PPD during breastfeeding were marital harmony,newborn health,stress communication,mutual support,negative support,cosupport,and the total score of partner support(P<0.05).CONCLUSION PPD during breastfeeding was associated with marital harmony,newborn health,stress communication,mutual support,negative support,joint support,and the total DCI score.展开更多
China has remained Africa’s largest trading partner for 15 consecutive years,with bilateral trade reaching a record$282.1 billion in 2023,Ministry of Commerce official Jiang Wei said at a press conference on 31 Janua...China has remained Africa’s largest trading partner for 15 consecutive years,with bilateral trade reaching a record$282.1 billion in 2023,Ministry of Commerce official Jiang Wei said at a press conference on 31 January.Economic and trade cooperation is the ballast and propeller of China-Africa relations,he said.展开更多
In the face of fierce market competition,enterprises must ensure the competitiveness of their products or services through technological innovation.However,the complexity of technology often surpasses the capabilities...In the face of fierce market competition,enterprises must ensure the competitiveness of their products or services through technological innovation.However,the complexity of technology often surpasses the capabilities of individual enterprises,leading them to deepen cooperation with other organizations.The entities within the enterprise innovation ecosystem depend on each other,collaborate closely,and rely on core enterprises to integrate resources,thereby creating system value and enhancing competitiveness.The purpose of this paper is to explore the process of selecting appropriate ecosystem partners.It begins by providing an overview of relevant concepts,characteristics,selection factors,and methods.Subsequently,it analyzes the roles,resources,and synergy evolution of the entities within the ecosystem.An evaluation system encompassing operation,core,synergy,and development capability is then established.This system comprises 16 indicators,including organization scale and reputation,and is accompanied by a hierarchical evaluation model.Finally,the validity of the evaluation system is confirmed through empirical analysis,utilizing the Analytic Hierarchy Process(AHP)and the fuzzy comprehensive evaluation method.展开更多
基金Supported by the National Natural Science Foundation of China,No.32060232Jiangxi Provincial Natural Science Foundation,No.20212BAB206075.
文摘BACKGROUND The efficacy of mesenchymal stem cells(MSCs)in treating liver fibrosis has been demonstrated in several clinical studies.However,their low survival and liver implantation rates remain problematic.In recent years,a large number of studies in animal models of liver fibrosis have shown that MSCs combined with drugs can improve the efficacy of MSCs in the treatment of liver fibrosis alone and inhibit its progression to end-stage liver disease.This has inspired new ways of thinking about treating liver fibrosis.AIM To investigate the effectiveness and mechanisms of MSCs combined with drugs in treating liver fibrosis.METHODS Data sources included four electronic databases and were constructed until January 2024.The subjects,interventions,comparators,outcomes,and study design principle were used to screen the literature,and the quality of the literature was evaluated to assess the risk of bias.Relevant randomised controlled trials were selected,and the final 13 studies were included in the final study.RESULTS A total of 13 studies were included after screening.Pooled analysis showed that MSCs combined with drug therapy significantly improved liver function,promoted the repair of damaged liver tissues,reduced the level of liver fibrosis-related indexes,and effectively ameliorated hepatic fibrosis by modulating the hepatic inflammatory microenvironment,promoting the homing of MSCs,and regulating the relevant signaling pathways,and the treatment efficacy was superior to MSCs alone.However,the combined treatment statistics showed no amelioration in serum albumin levels(standardized mean difference=0.77,95%confidence interval:-0.13 to 1.68,P=0.09).CONCLUSION In conclusion,MSCs combined with drugs for treating liver fibrosis effectively make up for the shortcomings of MSCs in their therapeutic effects.However,due to the different drugs,the treatment mechanism and effect also differ.Therefore,more randomized controlled trials are needed to compare the therapeutic efficacy of different drugs in combination with MSCs,aiming to select the“best companion”of MSCs in treating hepatic fibrosis.
文摘This article presents the history and challenges of patient graduation,positioning it as a means of supporting patient engagement and user involvement in the healthcare system.A set of laws related to patient rights and healthcare quality allows for the integration of patients into the healthcare system,but they face the unpreparedness of institutions in this new field of practices.Patient graduation requires transformations in the modes of reception and financing of universities,as well as in the pedagogical methods that need to be tailored to the reception and training of individuals in vulnerable situations.The article provides a detailed description of the example,history,and effects of the creation of the first open diploma in oncology for patient partners in France and concludes by emphasizing the need for concrete mechanisms for social recognition of user engagement in the healthcare system.
基金Supported by Medical Health Science and Technology Project of Huzhou City,No.2022GY41.
文摘BACKGROUND Postpartum depression(PPD)not only affects the psychological and physiological aspects of maternal health but can also affect neonatal growth and development.Partners who are in close contact with parturient women play a key role in communication and emotional support.This study explores the PPD support relationship with partners and its influencing factors,which is believed to establish psychological well-being and improve maternal partner support.AIM To explore the correlation between PPD and partner support during breastfeeding and its influencing factors.METHODS Convenience sampling was used to select lactating women(200 women)who underwent postpartum examinations at the Huzhou Maternity and Child Health Care Hospital from July 2022 to December 2022.A cross-sectional survey was conducted on the basic information(general information questionnaire),depression level[edinburgh postnatal depression scale(EPDS)],and partner support score[dyadic coping inventory(DCI)]of the selected subjects.Pearson’s correlation analysis was used to analyze the correlation between PPD and DCI in lactating women.Factors affecting PPD levels during lactation were analyzed using multiple linear regression.RESULTS The total average score of EPDS in 200 lactating women was(9.52±1.53),and the total average score of DCI was(115.78±14.90).Dividing the EPDS,the dimension scores were:emotional loss(1.91±0.52),anxiety(3.84±1.05),and depression(3.76±0.96).Each dimension of the DCI was subdivided into:Pressure communication(26.79±6.71),mutual support(39.76±9.63),negative support(24.97±6.68),agent support(6.87±1.92),and joint support(17.39±4.19).Pearson’s correlation analysis demonstrated that the total mean score and individual dimension scores of EPDS during breastfeeding were inversely correlated with the total score of partner support,stress communication,mutual support,and cosupport(P<0.05).The total mean score of the EPDS and its dimensions were positively correlated with negative support(P<0.05).Multiple linear regression analysis showed that the main factors affecting PPD during breastfeeding were marital harmony,newborn health,stress communication,mutual support,negative support,cosupport,and the total score of partner support(P<0.05).CONCLUSION PPD during breastfeeding was associated with marital harmony,newborn health,stress communication,mutual support,negative support,joint support,and the total DCI score.
文摘China has remained Africa’s largest trading partner for 15 consecutive years,with bilateral trade reaching a record$282.1 billion in 2023,Ministry of Commerce official Jiang Wei said at a press conference on 31 January.Economic and trade cooperation is the ballast and propeller of China-Africa relations,he said.
基金The 2022 Sichuan Tourism Development Research Center General Project“A Study on the Perceived Evaluation and Differences of Tourism Supply between Tourists and Local Residents along the Sichuan Tibet Railway”(Project number:LY22-25)。
文摘In the face of fierce market competition,enterprises must ensure the competitiveness of their products or services through technological innovation.However,the complexity of technology often surpasses the capabilities of individual enterprises,leading them to deepen cooperation with other organizations.The entities within the enterprise innovation ecosystem depend on each other,collaborate closely,and rely on core enterprises to integrate resources,thereby creating system value and enhancing competitiveness.The purpose of this paper is to explore the process of selecting appropriate ecosystem partners.It begins by providing an overview of relevant concepts,characteristics,selection factors,and methods.Subsequently,it analyzes the roles,resources,and synergy evolution of the entities within the ecosystem.An evaluation system encompassing operation,core,synergy,and development capability is then established.This system comprises 16 indicators,including organization scale and reputation,and is accompanied by a hierarchical evaluation model.Finally,the validity of the evaluation system is confirmed through empirical analysis,utilizing the Analytic Hierarchy Process(AHP)and the fuzzy comprehensive evaluation method.