Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pa...Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., may influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes.展开更多
The coal mine roof rating(CMRR) was developed to bridge the gap between geological variation in underground coal mines and engineering design. The CMRR accounts for the compressive strength of the immediate roof, the ...The coal mine roof rating(CMRR) was developed to bridge the gap between geological variation in underground coal mines and engineering design. The CMRR accounts for the compressive strength of the immediate roof, the shear strength and intensity of any discontinuities present, and the moisture sensitivity of the immediate roof. The CMRR has been widely used and validated in Eastern US coal mines, but it has seen limited application in the Western US. This study focuses on roof behavior at a Western coal mine(Mine A). Mine A shows significant lateral geological variation, along with localized faulting and a laterally extensive sandstone channel network. The CMRR is not used to predict roof instability at the mine. It is, therefore, hypothesized that there are other factors that are correlated with roof instability in underground coal mines that could potentially also be considered in conjunction with the CMRR.This hypothesis was tested by collecting 30 CMRR measurements at Mine A. At each measurement location, a binary record of the roof condition(stable or unstable) was made, and other parameters such as depth of cover, presence of faulting, and sandstone channels were also recorded. ANOVA tests showed that the CMRR values and the roof conditions were not strongly correlated, indicating that the CMRR input criteria are not fully predictive of roof stability at this mine. The CMRR values showed statistically significant correlations(p less than 0.05) with faulting as well as with location at an intersection. For areas that had previously experienced roof fall but were currently stable, faulting was correlated with roof condition(p less than 0.05) only when the condition was classified as unstable.展开更多
这是一则读后让人大吃一惊的消息。美国东海岸一种名叫Pfiesterispiscicida的有毒微生物杀死了数以百万计的鱼。而且,有人也染上了一种可怕的神经综合症: …some sufferers would set out by car on an errand only to forget where the...这是一则读后让人大吃一惊的消息。美国东海岸一种名叫Pfiesterispiscicida的有毒微生物杀死了数以百万计的鱼。而且,有人也染上了一种可怕的神经综合症: …some sufferers would set out by car on an errand only to forget where theywere going and what they had planned to do once they got there. 因此,令人垂涎的所谓生猛海鲜也让人避退三舍: …the seafood industry saw sales plunge by more than $40 million as consumerspanicked over a supposed threat to local fisheries. 再看看我们这里的情形,也让人不寒而栗。据报道,我国渤海已成为一个死海,已无多少鱼虾可捕。 更让人难以置信的是,北极圈一带,由于核潜艇常出没,排放的有害物质污染了海面,侵入幼熊体内,造成它们有雄雌两套生殖器。 Pfiesteria piscicida是新词,我们向上海译文出版社词典编辑室询问此词,也得不到相应的汉译。读者中如有解此“密”者,请写信与我们联系。谢谢！展开更多
文摘Apoptosis is a form of genetically programmed cell death, which plays a key role in regulation of cellularity in a variety of tissue and cell types including the cardiovascular tissues. Under both physiological and pathophysiological conditions, various biophysiological and biochemical factors, including mechanical forces, reactive oxygen and nitrogen species, cytokines, growth factors, oxidized lipoproteins, etc., may influence apoptosis of vascular cells. The Fas/Fas ligand/caspase death-signaling pathway, Bcl-2 protein family/mitochondria, the tumor suppressive gene p53, and the proto-oncogene c-myc may be activated in atherosclerotic lesions, and mediates vascular apoptosis during the development of atherosclerosis. Abnormal expression and dysfunction of these apoptosis-regulating genes may attenuate or accelerate vascular cell apoptosis and affect the integrity and stability of atherosclerotic plaques. Clarification of the molecular mechanism that regulates apoptosis may help design a new strategy for treatment of atherosclerosis and its major complication, the acute vascular syndromes.
基金supported by a NIOSH Capacity Building grant (No. 200-2016-90154) to Drs. G. Walton and E. Holley and collaborators at the Colorado School of Mines
文摘The coal mine roof rating(CMRR) was developed to bridge the gap between geological variation in underground coal mines and engineering design. The CMRR accounts for the compressive strength of the immediate roof, the shear strength and intensity of any discontinuities present, and the moisture sensitivity of the immediate roof. The CMRR has been widely used and validated in Eastern US coal mines, but it has seen limited application in the Western US. This study focuses on roof behavior at a Western coal mine(Mine A). Mine A shows significant lateral geological variation, along with localized faulting and a laterally extensive sandstone channel network. The CMRR is not used to predict roof instability at the mine. It is, therefore, hypothesized that there are other factors that are correlated with roof instability in underground coal mines that could potentially also be considered in conjunction with the CMRR.This hypothesis was tested by collecting 30 CMRR measurements at Mine A. At each measurement location, a binary record of the roof condition(stable or unstable) was made, and other parameters such as depth of cover, presence of faulting, and sandstone channels were also recorded. ANOVA tests showed that the CMRR values and the roof conditions were not strongly correlated, indicating that the CMRR input criteria are not fully predictive of roof stability at this mine. The CMRR values showed statistically significant correlations(p less than 0.05) with faulting as well as with location at an intersection. For areas that had previously experienced roof fall but were currently stable, faulting was correlated with roof condition(p less than 0.05) only when the condition was classified as unstable.
文摘这是一则读后让人大吃一惊的消息。美国东海岸一种名叫Pfiesterispiscicida的有毒微生物杀死了数以百万计的鱼。而且,有人也染上了一种可怕的神经综合症: …some sufferers would set out by car on an errand only to forget where theywere going and what they had planned to do once they got there. 因此,令人垂涎的所谓生猛海鲜也让人避退三舍: …the seafood industry saw sales plunge by more than $40 million as consumerspanicked over a supposed threat to local fisheries. 再看看我们这里的情形,也让人不寒而栗。据报道,我国渤海已成为一个死海,已无多少鱼虾可捕。 更让人难以置信的是,北极圈一带,由于核潜艇常出没,排放的有害物质污染了海面,侵入幼熊体内,造成它们有雄雌两套生殖器。 Pfiesteria piscicida是新词,我们向上海译文出版社词典编辑室询问此词,也得不到相应的汉译。读者中如有解此“密”者,请写信与我们联系。谢谢！
