In recent years,field trials of non-pillar longwall mining using complete backfill have been implemented successively in the Chinese coal mining industry.The objective of this paper is to get a scientific understandin...In recent years,field trials of non-pillar longwall mining using complete backfill have been implemented successively in the Chinese coal mining industry.The objective of this paper is to get a scientific understanding of surface subsidence control effect using such techniques.It begins with a brief overview on complete backfill methods primarily used in China,followed by an analysis of collected subsidence factors under mining with complete backfill.It is concluded that non-pillar longwall panel layout cannot protect surface structures against damages at a relatively large mining height,even though complete backfill is conducted.In such cases,separated longwall panel layout should be applied,i.e.,panel width should be subcritical and stable coal pillars should be left between the adjacent panels.The proposed method takes the principles of subcritical extraction and partial extraction;in conjunction with gob backfilling,surface subsidence can be effectively mitigated,thus protecting surface buildings against mining-induced damage.A general design principle and method of separated panel layout have also been proposed.展开更多
僵尸网络(Botnet)是一种从传统恶意代码形态进化而来的新型攻击方式,为攻击者提供了隐匿、灵活且高效的一对多命令与控制信道(Command and Control channel,C&C)机制,可以控制大量僵尸主机实现信息窃取、分布式拒绝服务攻击和垃圾...僵尸网络(Botnet)是一种从传统恶意代码形态进化而来的新型攻击方式,为攻击者提供了隐匿、灵活且高效的一对多命令与控制信道(Command and Control channel,C&C)机制,可以控制大量僵尸主机实现信息窃取、分布式拒绝服务攻击和垃圾邮件发送等攻击目的。该文提出一种与僵尸网络结构和C&C协议无关,不需要分析数据包的特征负载的僵尸网络检测方法。该方法首先使用预过滤规则对捕获的流量进行过滤,去掉与僵尸网络无关的流量;其次对过滤后的流量属性进行统计;接着使用基于X-means聚类的两步聚类算法对C&C信道的流量属性进行分析与聚类,从而达到对僵尸网络检测的目的。实验证明,该方法高效准确地把僵尸网络流量与其他正常网络流量区分,达到从实际网络中检测僵尸网络的要求,并且具有较低的误判率。展开更多
Threshold decision is an important function of nuclear instrument control system based on physical parameters threshold decision. Because the conventional decision methods lack correlation with time and conditions, by...Threshold decision is an important function of nuclear instrument control system based on physical parameters threshold decision. Because the conventional decision methods lack correlation with time and conditions, by analyzing the existing methods, some optimized methods are adopted. Considering safety, those methods are improved in data processing algorithms, floating threshold with multiple values, association with specific working condition, etc. These measures im- prove the nuclear instrument control system in fault tolerance and fault diagnosis, especially, the shutdown number of nucle- ar power plant decreases.展开更多
BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the pre...BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population.展开更多
Recently, it has become clear that mild abnormal glucose tolerance increases the incidence of perinatal maternalinfant complications, and so the definition and diagnostic criteria of gestational diabetes mellitus(GDM)...Recently, it has become clear that mild abnormal glucose tolerance increases the incidence of perinatal maternalinfant complications, and so the definition and diagnostic criteria of gestational diabetes mellitus(GDM) have been changed. Therefore, in patients with GDM and pregnant women with diabetes mellitus, even stricter glycemic control than before is required to reduce the incidence of perinatal maternal-infant complications. Strict glycemic control cannot be attained without an indicator of glycemic control; this review proposes a reliable indicator. The gold standard indicator of glycemic control in patients with diabetes mellitus is hemoglobin A1c(Hb A1c); however, we have demonstrated that Hb A1 c does not reflect glycemic control accurately during pregnancy because of iron deficiency. It has also become clear that glycated albumin, another indicator of glycemic control, is not influenced by iron deficiency and therefore might be a better indicator of glycemic control in patients with GDM and pregnant women with diabetes mellitus. However, largepopulation epidemiological studies are necessary in order to confirm our proposal. Here, we outline the most recent findings about the indicators of glycemic control during pregnancy including fructosamine and 1,5-anhydroglucitol.展开更多
Feature recognition aims at extracting manufacturing features with geometrical information from solid model and is considered to be an efficient way of changing the interactive NC machining programming mode.Existing r...Feature recognition aims at extracting manufacturing features with geometrical information from solid model and is considered to be an efficient way of changing the interactive NC machining programming mode.Existing recognition methods have some disadvantages in practical applications.They can essentially handle prismatic components with regular shapes and are difficult to recognize the intersecting features and curved surfaces.Besides,the robustness of them is not strong enough.A new feature recognition approach is proposed based on the analysis of aircraft integral panels' geometry and machining characteristics.In this approach,the aircraft integral panel is divided into a number of local machining domains.The machining domains are extracted and recognized first by finding the principal face of machining domain and extracting the sides around the principal face.Then the machining domains are divided into various features in terms of the face type.The main sections of the proposed method are presented including the definition,classification and structure of machining domain,the relationship between machining domain and principal face loop,the rules of machining domains recognition,and the algorithm of machining feature recognition.In addition,a robotic feature recognition module is developed for aircraft integral panels and tested with several panels.Test results show that the strategy presented is robust and valid.Features extracted can be post processed and linked to various downstream applications.The approach is able to solve the difficulties in recognizing the aircraft integral panel's features and automatic obtaining the machining zone in NC programming,and can be used to further develop the automatic programming of NC machining.展开更多
Two sets of super-synchronization speed control assemblies for two 80 MVA motor-generator units have been developed successfully in order to satisfy the demand of the toroidal field system in the HL-2A tokamak. Based ...Two sets of super-synchronization speed control assemblies for two 80 MVA motor-generator units have been developed successfully in order to satisfy the demand of the toroidal field system in the HL-2A tokamak. Based on the three-phase logical no-circumfluence a.c./a.c. cycloconverter, the speeds of two 2500 kW double fed drive motors have been regulated by means of the vector control technology. The maximum operating speed of each motor- generator unit has been raised from 1488 rpm (revolutions per minute) to 1650 rpm and the released energy of each unit during a pulsed discharge can reach 500 MJ. As a result, the toroidal field system has the capacity to provide 2.8 tesla (T) in HL-2A experiments.展开更多
The benchmark for assessing quality of long-term glycemic control and adjustment of therapy is currently glycated hemoglobin(Hb A1c). Despite its importance as an indicator for the development of diabeticcomplications...The benchmark for assessing quality of long-term glycemic control and adjustment of therapy is currently glycated hemoglobin(Hb A1c). Despite its importance as an indicator for the development of diabeticcomplications, recent studies have revealed that this metric has some limitations; it conveys a rather complex message, which has to be taken into consideration for diabetes screening and treatment. On the basis of recent clinical trials, the relationship between Hb A1 c and cardiovascular outcomes in long-standing diabetes has been called into question. It becomes obvious that other surrogate and biomarkers are needed to better predict cardiovascular diabetes complications and assess efficiency of therapy. Glycated albumin, fructosamin, and 1,5-anhydroglucitol have received growing interest as alternative markers of glycemic control. In addition to measures of hyperglycemia, advanced glucose monitoring methods became available. An indispensible adjunct to Hb A1 c in routine diabetes care is selfmonitoring of blood glucose. This monitoring method is now widely used, as it provides immediate feedback to patients on short-term changes, involving fasting, preprandial, and postprandial glucose levels. Beyond the traditional metrics, glycemic variability has been identified as a predictor of hypoglycemia, and it might also be implicated in the pathogenesis of vascular diabetes complications. Assessment of glycemic variability is thus important, but exact quantification requires frequently sampled glucose measurements. In order to optimize diabetes treatment, there is a need for both key metrics of glycemic control on a day-to-day basis and for more advanced, user-friendly monitoring methods. In addition to traditional discontinuous glucose testing, continuous glucose sensing has become a useful tool to reveal insufficient glycemic management. This new technology is particularly effective in patients with complicated diabetes and provides the opportunity to characterize glucose dynamics. Several continuous glucose monitoring(CGM) systems, which have shown usefulness in clinical practice, are presently on the market. They can broadly be divided into systems providing retrospective or real-time information on glucose patterns. The widespread clinical application of CGM is still hampered by the lack of generallyaccepted measures for assessment of glucose profiles and standardized reporting of glucose data. In this article, we will discuss advantages and limitations of various metrics for glycemic control as well as possibilities for evaluation of glucose data with the special focus on glycemic variability and application of CGM to improve individual diabetes management.展开更多
Neonatal diabetes mellitus(NDM) is a type of diabetes mellitus caused by genetic abnormality which devel ops in insulin dependent state within 6 mo after birth HbA1c is widely used in clinical practice for diabetes me...Neonatal diabetes mellitus(NDM) is a type of diabetes mellitus caused by genetic abnormality which devel ops in insulin dependent state within 6 mo after birth HbA1c is widely used in clinical practice for diabetes mellitus as the gold standard glycemic control indica tor; however, fetal hemoglobin(HbF) is the main he moglobin in neonates and so HbA1c cannot be used as a glycemic control indicator in NDM. Glycated albumin(GA), another glycemic control indicator, is not affected by HbF. We reported that GA can be used as a glycemic control indicator in NDM. However, it was later found that because of increased metabolism of albumin, GA shows an apparently lower level in relation to plasma glucose in NDM; measures to solve this problem were needed. In this review, we outlined the most recen findings concerning glycemic control indicators in neo nates or NDM.展开更多
AIM To characterize the survival of cirrhotic patients with Barcelona Clinic Liver Cancer(BCLC) stage C hepatocellular carcinoma(HCC) and to ascertain the factors predicting the achievement of disease control(DC).METH...AIM To characterize the survival of cirrhotic patients with Barcelona Clinic Liver Cancer(BCLC) stage C hepatocellular carcinoma(HCC) and to ascertain the factors predicting the achievement of disease control(DC).METHODS The cirrhotic patients with BCLC stage C HCC evaluated by the Hepatocatt multidisciplinary group were subjected to the investigation. Demographic, clinical and tumor features, along with the best tumor response and overall survival were recorded. RESULTS One hundred and ten BCLC stage C patients were included in the analysis; the median overall survival was 13.4 mo(95%CI: 10.6-17.0). Only alphafetoprotein(AFP) serum level > 200 ng/m L and DC could independently predict survival but in a time dependent manner, the former was significantly associated with increased risk of mortality within the first 6 mo of follow-up(HR = 5.073, 95%CI: 2.159-11.916, P = 0.0002), whereas the latter showed a protective effect against death after one year(HR = 0.110, 95%CI: 0.038-0.314, P < 0.0001). Only patients showing microvascular invasion and/or extrahepatic spread recorded lower chances of achieving DC(OR = 0.263, 95%CI: 0.111-0.622, P = 0.002).CONCLUSION The BCLC stage C HCC includes a wide heterogeneous group of cirrhotic patients suitable for potentially curative treatments. The reverse and time dependent effect of AFP serum level and DC on patients' survival confers them as useful predictive tools for treatment management and clinical decisions.展开更多
In recent years,the exponential proliferation of smart devices with their intelligent applications poses severe challenges on conventional cellular networks.Such challenges can be potentially overcome by integrating c...In recent years,the exponential proliferation of smart devices with their intelligent applications poses severe challenges on conventional cellular networks.Such challenges can be potentially overcome by integrating communication,computing,caching,and control(i4C)technologies.In this survey,we first give a snapshot of different aspects of the i4C,comprising background,motivation,leading technological enablers,potential applications,and use cases.Next,we describe different models of communication,computing,caching,and control(4C)to lay the foundation of the integration approach.We review current stateof-the-art research efforts related to the i4C,focusing on recent trends of both conventional and artificial intelligence(AI)-based integration approaches.We also highlight the need for intelligence in resources integration.Then,we discuss the integration of sensing and communication(ISAC)and classify the integration approaches into various classes.Finally,we propose open challenges and present future research directions for beyond 5G networks,such as 6G.展开更多
In our previous work, the reactive dividing wall column(RDWC) was proposed and proved to be effective for selective hydrogenation and separation of C3 stream. In the present paper, the dynamics and control of the prop...In our previous work, the reactive dividing wall column(RDWC) was proposed and proved to be effective for selective hydrogenation and separation of C3 stream. In the present paper, the dynamics and control of the proposed RDWC are investigated. Four control structures including composition and temperature controls are proposed. The feed forward controllers are employed in the four control strategies to shorten the dynamic response time, reduce the maximum deviations and offer an immediate adjustment. The control structures are compared by applying them into the RDWC system with 20% disturbances in both the feed flow rate and the feed compositions, and the results are discussed.展开更多
As mines go deeper and get larger,mine designs become more fragile largely due to the response of the rock mass to mining.Ground control and rock support become important levers in the mine construction schedule,produ...As mines go deeper and get larger,mine designs become more fragile largely due to the response of the rock mass to mining.Ground control and rock support become important levers in the mine construction schedule,production performance,and excavation health.For example,in cave mines,the production footprint together with associated mine infrastructure are significant investments in a modern caving operation.This investment must be protected and maintained to reduce the risk of ground-related production disruptions.It is necessary to preserve the health of these excavations and their maintenance through an effective rock support design.Rock support thus becomes a strategic element in asset management.This article focuses on support design for brittle ground when displacements induced by stress-fracturing consume much of the support’s capacity.It deals with the functionality of the support in deforming ground.Several interlinked concepts are important when assessing excavation health.Designs must not only account for load equilibrium but also for deformation compatibility and capacity consumption.Most importantly,the support’s displacement capacity is being consumed when the rock mass is deformed after support installation.Hence,it is necessary to design for the support capacity remaining at the time when the support is needed.If support capacity can be consumed,it can also be restored by means of preventive support maintenance(PSM).This concept for cost-effective ground control is introduced and illustrated on operational evidence.Furthermore,how design can impact construction costs and schedule are discussed.Support is installed to provide a safe environment and preserve an operationally functional excavation.It also must assure senior management that investments in high quality support and its maintenance will substantially reduce delays and with it,costs.It is demonstrated that the use of‘gabion-like’support systems can achieve these goals.A technical summary of the‘gabion panel’support system design is presented.展开更多
In previous years, several high-power micro-satellites below ~100 kg have been developed for high-functional spacecraft. This paper proposes a functional and high-power thermal control system with no power supply and ...In previous years, several high-power micro-satellites below ~100 kg have been developed for high-functional spacecraft. This paper proposes a functional and high-power thermal control system with no power supply and a simple configuration for micro-satellite: 100 W, 3 U. The proposed system consists of a heat storage panel (HSP) with pitch type CFRP (Carbon Fiber Reinforced Polymer), a micro loop heat pipe (m-LHP) and a flexible re-deployable radiator (FRDR) as an active thermal control system. The aim of this research is to try not only to verify the thermal control devices, but also to perform a water phase change experiment as a payload using an electric power generation of 100 W in space environment. In this paper, the basic design of the satellite, the analysis of the feasibility by the thermal mathematical model, and the fabrication of thermal test model including water phase chamber are reported. The main results of thermal analysis as feasibility verification showed that the paddles could absorb the thermal energy up to 97 W at the solar input of 180 W, and the operating temperature of bus equipment became within the allowable temperature range (0°C - 40°C). At thermal vacuum test, the difference between the analysis and the experiment for the temperature history of water due to the discordance for the value of thermal conductance was discussed.展开更多
文摘In recent years,field trials of non-pillar longwall mining using complete backfill have been implemented successively in the Chinese coal mining industry.The objective of this paper is to get a scientific understanding of surface subsidence control effect using such techniques.It begins with a brief overview on complete backfill methods primarily used in China,followed by an analysis of collected subsidence factors under mining with complete backfill.It is concluded that non-pillar longwall panel layout cannot protect surface structures against damages at a relatively large mining height,even though complete backfill is conducted.In such cases,separated longwall panel layout should be applied,i.e.,panel width should be subcritical and stable coal pillars should be left between the adjacent panels.The proposed method takes the principles of subcritical extraction and partial extraction;in conjunction with gob backfilling,surface subsidence can be effectively mitigated,thus protecting surface buildings against mining-induced damage.A general design principle and method of separated panel layout have also been proposed.
文摘僵尸网络(Botnet)是一种从传统恶意代码形态进化而来的新型攻击方式,为攻击者提供了隐匿、灵活且高效的一对多命令与控制信道(Command and Control channel,C&C)机制,可以控制大量僵尸主机实现信息窃取、分布式拒绝服务攻击和垃圾邮件发送等攻击目的。该文提出一种与僵尸网络结构和C&C协议无关,不需要分析数据包的特征负载的僵尸网络检测方法。该方法首先使用预过滤规则对捕获的流量进行过滤,去掉与僵尸网络无关的流量;其次对过滤后的流量属性进行统计;接着使用基于X-means聚类的两步聚类算法对C&C信道的流量属性进行分析与聚类,从而达到对僵尸网络检测的目的。实验证明,该方法高效准确地把僵尸网络流量与其他正常网络流量区分,达到从实际网络中检测僵尸网络的要求,并且具有较低的误判率。
基金Research Project of Hunan Province Education Department(No.14C0972)
文摘Threshold decision is an important function of nuclear instrument control system based on physical parameters threshold decision. Because the conventional decision methods lack correlation with time and conditions, by analyzing the existing methods, some optimized methods are adopted. Considering safety, those methods are improved in data processing algorithms, floating threshold with multiple values, association with specific working condition, etc. These measures im- prove the nuclear instrument control system in fault tolerance and fault diagnosis, especially, the shutdown number of nucle- ar power plant decreases.
基金Supported by National Natural Science Foundation of China,No.81302593,No.81271848 and No.81101589the Grant of Beijing Nova Program of China,No.Z121107002512071+1 种基金the National Key Basic Research Program of China,No.2009CB522507the National Grand Program on Key Infectious Disease,No.2009ZX10005-017 and No.2012ZX10002007
文摘AIM: To investigate the risk factors for liver-related mortality in chronic hepatitis C (CHC) patients.
基金supported by grants from Zhejiang Health Bureau (2008B073)Zhejiang Education Bureau (Y200909640)
文摘BACKGROUND: Hemodialysis (HD) patients are at high risk of infection by hepatitis B virus (HBV) or hepatitis C virus (HCV). The present study was designed to determine the impact of quality control measures on the prevention of transmission of blood-borne viruses. METHODS: A total of 6182 adult maintenance HD patients from all HD units in Zhejiang Province were recruited on January 1, 2007. The baseline demographic and clinical characteristics were recorded and all patients were followed up until death or survival at 4 years later. The Quality Control Standards of Hemodialysis were gradually implemented in HD units. The HBV or HCV seroconversion rates of the recruited patients were calculated and compared every year during the observation period. RESULTS: The prevalence of HBV was 8.3% at the beginning of the study, and 6.6% for HCV. With the implementation of the HD quality control measures, the HBV seroconversion rate tended to decrease year by year (χ 2 =6.620, P=0.085), and the HCV seroconversion rate decreased significantly (χ 2 =10.41, P=0.015). Compared with the data in 2007, the HBV seroconversion rate (χ 2 =4.204, P=0.040, relative risk ratio 0.393, 95% CI 0.156-0.991) and the HCV seroconversion rate (χ 2 =7.373, P=0.007, relative risk ratio 0.386, 95% CI 0.189-0.787) decreased significantly in 2010. CONCLUSION: Quality control measures for HD decreased the seroconversion rates of HBV or HCV in HD patients, showing that updated quality control measures reduce the risk for transmission of blood-borne viruses in the HD population.
文摘Recently, it has become clear that mild abnormal glucose tolerance increases the incidence of perinatal maternalinfant complications, and so the definition and diagnostic criteria of gestational diabetes mellitus(GDM) have been changed. Therefore, in patients with GDM and pregnant women with diabetes mellitus, even stricter glycemic control than before is required to reduce the incidence of perinatal maternal-infant complications. Strict glycemic control cannot be attained without an indicator of glycemic control; this review proposes a reliable indicator. The gold standard indicator of glycemic control in patients with diabetes mellitus is hemoglobin A1c(Hb A1c); however, we have demonstrated that Hb A1 c does not reflect glycemic control accurately during pregnancy because of iron deficiency. It has also become clear that glycated albumin, another indicator of glycemic control, is not influenced by iron deficiency and therefore might be a better indicator of glycemic control in patients with GDM and pregnant women with diabetes mellitus. However, largepopulation epidemiological studies are necessary in order to confirm our proposal. Here, we outline the most recent findings about the indicators of glycemic control during pregnancy including fructosamine and 1,5-anhydroglucitol.
文摘Feature recognition aims at extracting manufacturing features with geometrical information from solid model and is considered to be an efficient way of changing the interactive NC machining programming mode.Existing recognition methods have some disadvantages in practical applications.They can essentially handle prismatic components with regular shapes and are difficult to recognize the intersecting features and curved surfaces.Besides,the robustness of them is not strong enough.A new feature recognition approach is proposed based on the analysis of aircraft integral panels' geometry and machining characteristics.In this approach,the aircraft integral panel is divided into a number of local machining domains.The machining domains are extracted and recognized first by finding the principal face of machining domain and extracting the sides around the principal face.Then the machining domains are divided into various features in terms of the face type.The main sections of the proposed method are presented including the definition,classification and structure of machining domain,the relationship between machining domain and principal face loop,the rules of machining domains recognition,and the algorithm of machining feature recognition.In addition,a robotic feature recognition module is developed for aircraft integral panels and tested with several panels.Test results show that the strategy presented is robust and valid.Features extracted can be post processed and linked to various downstream applications.The approach is able to solve the difficulties in recognizing the aircraft integral panel's features and automatic obtaining the machining zone in NC programming,and can be used to further develop the automatic programming of NC machining.
基金the Tenth-Five-Year Nuclear Energy Development of the Commission of Science and TechnologyNational Defense Industry of the China National Nuclear Corporation
文摘Two sets of super-synchronization speed control assemblies for two 80 MVA motor-generator units have been developed successfully in order to satisfy the demand of the toroidal field system in the HL-2A tokamak. Based on the three-phase logical no-circumfluence a.c./a.c. cycloconverter, the speeds of two 2500 kW double fed drive motors have been regulated by means of the vector control technology. The maximum operating speed of each motor- generator unit has been raised from 1488 rpm (revolutions per minute) to 1650 rpm and the released energy of each unit during a pulsed discharge can reach 500 MJ. As a result, the toroidal field system has the capacity to provide 2.8 tesla (T) in HL-2A experiments.
文摘The benchmark for assessing quality of long-term glycemic control and adjustment of therapy is currently glycated hemoglobin(Hb A1c). Despite its importance as an indicator for the development of diabeticcomplications, recent studies have revealed that this metric has some limitations; it conveys a rather complex message, which has to be taken into consideration for diabetes screening and treatment. On the basis of recent clinical trials, the relationship between Hb A1 c and cardiovascular outcomes in long-standing diabetes has been called into question. It becomes obvious that other surrogate and biomarkers are needed to better predict cardiovascular diabetes complications and assess efficiency of therapy. Glycated albumin, fructosamin, and 1,5-anhydroglucitol have received growing interest as alternative markers of glycemic control. In addition to measures of hyperglycemia, advanced glucose monitoring methods became available. An indispensible adjunct to Hb A1 c in routine diabetes care is selfmonitoring of blood glucose. This monitoring method is now widely used, as it provides immediate feedback to patients on short-term changes, involving fasting, preprandial, and postprandial glucose levels. Beyond the traditional metrics, glycemic variability has been identified as a predictor of hypoglycemia, and it might also be implicated in the pathogenesis of vascular diabetes complications. Assessment of glycemic variability is thus important, but exact quantification requires frequently sampled glucose measurements. In order to optimize diabetes treatment, there is a need for both key metrics of glycemic control on a day-to-day basis and for more advanced, user-friendly monitoring methods. In addition to traditional discontinuous glucose testing, continuous glucose sensing has become a useful tool to reveal insufficient glycemic management. This new technology is particularly effective in patients with complicated diabetes and provides the opportunity to characterize glucose dynamics. Several continuous glucose monitoring(CGM) systems, which have shown usefulness in clinical practice, are presently on the market. They can broadly be divided into systems providing retrospective or real-time information on glucose patterns. The widespread clinical application of CGM is still hampered by the lack of generallyaccepted measures for assessment of glucose profiles and standardized reporting of glucose data. In this article, we will discuss advantages and limitations of various metrics for glycemic control as well as possibilities for evaluation of glucose data with the special focus on glycemic variability and application of CGM to improve individual diabetes management.
文摘Neonatal diabetes mellitus(NDM) is a type of diabetes mellitus caused by genetic abnormality which devel ops in insulin dependent state within 6 mo after birth HbA1c is widely used in clinical practice for diabetes mellitus as the gold standard glycemic control indica tor; however, fetal hemoglobin(HbF) is the main he moglobin in neonates and so HbA1c cannot be used as a glycemic control indicator in NDM. Glycated albumin(GA), another glycemic control indicator, is not affected by HbF. We reported that GA can be used as a glycemic control indicator in NDM. However, it was later found that because of increased metabolism of albumin, GA shows an apparently lower level in relation to plasma glucose in NDM; measures to solve this problem were needed. In this review, we outlined the most recen findings concerning glycemic control indicators in neo nates or NDM.
文摘AIM To characterize the survival of cirrhotic patients with Barcelona Clinic Liver Cancer(BCLC) stage C hepatocellular carcinoma(HCC) and to ascertain the factors predicting the achievement of disease control(DC).METHODS The cirrhotic patients with BCLC stage C HCC evaluated by the Hepatocatt multidisciplinary group were subjected to the investigation. Demographic, clinical and tumor features, along with the best tumor response and overall survival were recorded. RESULTS One hundred and ten BCLC stage C patients were included in the analysis; the median overall survival was 13.4 mo(95%CI: 10.6-17.0). Only alphafetoprotein(AFP) serum level > 200 ng/m L and DC could independently predict survival but in a time dependent manner, the former was significantly associated with increased risk of mortality within the first 6 mo of follow-up(HR = 5.073, 95%CI: 2.159-11.916, P = 0.0002), whereas the latter showed a protective effect against death after one year(HR = 0.110, 95%CI: 0.038-0.314, P < 0.0001). Only patients showing microvascular invasion and/or extrahepatic spread recorded lower chances of achieving DC(OR = 0.263, 95%CI: 0.111-0.622, P = 0.002).CONCLUSION The BCLC stage C HCC includes a wide heterogeneous group of cirrhotic patients suitable for potentially curative treatments. The reverse and time dependent effect of AFP serum level and DC on patients' survival confers them as useful predictive tools for treatment management and clinical decisions.
基金supported in part by National Key R&D Program of China(2019YFE0196400)Key Research and Development Program of Shaanxi(2022KWZ09)+4 种基金National Natural Science Foundation of China(61771358,61901317,62071352)Fundamental Research Funds for the Central Universities(JB190104)Joint Education Project between China and Central-Eastern European Countries(202005)the 111 Project(B08038)。
文摘In recent years,the exponential proliferation of smart devices with their intelligent applications poses severe challenges on conventional cellular networks.Such challenges can be potentially overcome by integrating communication,computing,caching,and control(i4C)technologies.In this survey,we first give a snapshot of different aspects of the i4C,comprising background,motivation,leading technological enablers,potential applications,and use cases.Next,we describe different models of communication,computing,caching,and control(4C)to lay the foundation of the integration approach.We review current stateof-the-art research efforts related to the i4C,focusing on recent trends of both conventional and artificial intelligence(AI)-based integration approaches.We also highlight the need for intelligence in resources integration.Then,we discuss the integration of sensing and communication(ISAC)and classify the integration approaches into various classes.Finally,we propose open challenges and present future research directions for beyond 5G networks,such as 6G.
基金Supported by the National Basic Research Program of China(2012CB720500)the National Supporting Research Program of China(2013BAA03B01)+1 种基金the National Natural Science Foundation of China(21176178)China Scholarship Council(CSC[2015]3022)
文摘In our previous work, the reactive dividing wall column(RDWC) was proposed and proved to be effective for selective hydrogenation and separation of C3 stream. In the present paper, the dynamics and control of the proposed RDWC are investigated. Four control structures including composition and temperature controls are proposed. The feed forward controllers are employed in the four control strategies to shorten the dynamic response time, reduce the maximum deviations and offer an immediate adjustment. The control structures are compared by applying them into the RDWC system with 20% disturbances in both the feed flow rate and the feed compositions, and the results are discussed.
基金facilitated by financial support from NSERC(Canada’s Natural Sciences and Engineering Research Council)ORF(Ontario Research Fund)。
文摘As mines go deeper and get larger,mine designs become more fragile largely due to the response of the rock mass to mining.Ground control and rock support become important levers in the mine construction schedule,production performance,and excavation health.For example,in cave mines,the production footprint together with associated mine infrastructure are significant investments in a modern caving operation.This investment must be protected and maintained to reduce the risk of ground-related production disruptions.It is necessary to preserve the health of these excavations and their maintenance through an effective rock support design.Rock support thus becomes a strategic element in asset management.This article focuses on support design for brittle ground when displacements induced by stress-fracturing consume much of the support’s capacity.It deals with the functionality of the support in deforming ground.Several interlinked concepts are important when assessing excavation health.Designs must not only account for load equilibrium but also for deformation compatibility and capacity consumption.Most importantly,the support’s displacement capacity is being consumed when the rock mass is deformed after support installation.Hence,it is necessary to design for the support capacity remaining at the time when the support is needed.If support capacity can be consumed,it can also be restored by means of preventive support maintenance(PSM).This concept for cost-effective ground control is introduced and illustrated on operational evidence.Furthermore,how design can impact construction costs and schedule are discussed.Support is installed to provide a safe environment and preserve an operationally functional excavation.It also must assure senior management that investments in high quality support and its maintenance will substantially reduce delays and with it,costs.It is demonstrated that the use of‘gabion-like’support systems can achieve these goals.A technical summary of the‘gabion panel’support system design is presented.
文摘In previous years, several high-power micro-satellites below ~100 kg have been developed for high-functional spacecraft. This paper proposes a functional and high-power thermal control system with no power supply and a simple configuration for micro-satellite: 100 W, 3 U. The proposed system consists of a heat storage panel (HSP) with pitch type CFRP (Carbon Fiber Reinforced Polymer), a micro loop heat pipe (m-LHP) and a flexible re-deployable radiator (FRDR) as an active thermal control system. The aim of this research is to try not only to verify the thermal control devices, but also to perform a water phase change experiment as a payload using an electric power generation of 100 W in space environment. In this paper, the basic design of the satellite, the analysis of the feasibility by the thermal mathematical model, and the fabrication of thermal test model including water phase chamber are reported. The main results of thermal analysis as feasibility verification showed that the paddles could absorb the thermal energy up to 97 W at the solar input of 180 W, and the operating temperature of bus equipment became within the allowable temperature range (0°C - 40°C). At thermal vacuum test, the difference between the analysis and the experiment for the temperature history of water due to the discordance for the value of thermal conductance was discussed.