Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other fields.This study describes ametho...Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other fields.This study describes amethod developed to fabricate modular three-dimensional(3D)paper-based microfluidic chips based on projection-based 3D printing(PBP)technology.A series of two-dimensional(2D)paper-based microfluidic modules was designed and fabricated.After evaluating the effect of exposure time on the accuracy of the flow channel,the resolution of this channel was experimentally analyzed.Furthermore,several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods,with good channel connectivity.Scaffold-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible.Furthermore,by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips,multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paperbased microfluidic chips,confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications.展开更多
This study aims to develop a low-cost refractometer for measuring the sucrose content of fruit juice,which is an important factor affecting human health.While laboratory-grade refractometers are expensive and unsuitab...This study aims to develop a low-cost refractometer for measuring the sucrose content of fruit juice,which is an important factor affecting human health.While laboratory-grade refractometers are expensive and unsuitable for personal use,existing low-cost commercial options lack stability and accuracy.To address this gap,we propose a refractometer that replaces the expensive CCD sensor and light source with a conventional LED and a reasonably priced CMOS sensor.By analyzing the output waveform pattern of the CMOS sensor,we achieve high precision with a personal-use-appropriate accuracy of 0.1%.We tested the proposed refractometer by conducting 100 repeated measurements on various fruit juice samples,and the results demonstrate its reliability and consistency.Running on a 48 MHz ARM processor,the algorithm can acquire data within 0.2 seconds.Our low-cost refractometer is suitable for personal health management and small-scale production,providing an affordable and reliable method for measuring sucrose concentration in fruit juice.It improves upon the existing low-cost options by offering better stability and accuracy.This accessible tool has potential applications in optimizing the sucrose content of fruit juice for better health and quality control.展开更多
Analyzing the influence on Q factor, which was caused by the parasitic effect in a CMOS RF on chip integrated inductor, a concise method to increase the Q factor has been obtained when optimizing the layout parameter....Analyzing the influence on Q factor, which was caused by the parasitic effect in a CMOS RF on chip integrated inductor, a concise method to increase the Q factor has been obtained when optimizing the layout parameter. Using this method, the Q factor of 7.9 can be achieved in a 5nH inductor (operating frequency is 2GHz) while the errors in inductance are less than 0.5% compared with the aimed values. It is proved by experiments that this method can guarantee the sufficient accuracy but require less computation time. Therefore, it is of great use for the design of the inductor in CMOS RF IC’s.展开更多
The proposed DAC consists of a unit current-cell matrix for 8MSBs and a binary-weighted array for 4LSBs,trading-off between the precision,speed,and size of the chip.In order to ensure the linearity of the DAC,a double...The proposed DAC consists of a unit current-cell matrix for 8MSBs and a binary-weighted array for 4LSBs,trading-off between the precision,speed,and size of the chip.In order to ensure the linearity of the DAC,a double Centro symmetric current matrix is designed by the Q2 random walk strategy.To achieve better dynamic performance,a latch is added in front of the current switch to change the input signal,such as its optimal cross-point and voltage level.For a 12bit resolution,the converter reaches an update rate of 300MHz.展开更多
基金sponsored by the National Natural Science Foundation of China(No.52235007,YH)the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004,YH)+3 种基金the NationalNatural Science Foundation of China(No.52305300,MJX)the Fellowship of China Postdoctoral Science Foundation(No.2022M722826,MJX)the National Natural Science Foundation of China(No.82203602,JW)the Zhejiang Provincial Natural Science Foundation of China(No.LQ22H160020,JW)。
文摘Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other fields.This study describes amethod developed to fabricate modular three-dimensional(3D)paper-based microfluidic chips based on projection-based 3D printing(PBP)technology.A series of two-dimensional(2D)paper-based microfluidic modules was designed and fabricated.After evaluating the effect of exposure time on the accuracy of the flow channel,the resolution of this channel was experimentally analyzed.Furthermore,several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods,with good channel connectivity.Scaffold-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible.Furthermore,by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips,multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paperbased microfluidic chips,confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications.
文摘This study aims to develop a low-cost refractometer for measuring the sucrose content of fruit juice,which is an important factor affecting human health.While laboratory-grade refractometers are expensive and unsuitable for personal use,existing low-cost commercial options lack stability and accuracy.To address this gap,we propose a refractometer that replaces the expensive CCD sensor and light source with a conventional LED and a reasonably priced CMOS sensor.By analyzing the output waveform pattern of the CMOS sensor,we achieve high precision with a personal-use-appropriate accuracy of 0.1%.We tested the proposed refractometer by conducting 100 repeated measurements on various fruit juice samples,and the results demonstrate its reliability and consistency.Running on a 48 MHz ARM processor,the algorithm can acquire data within 0.2 seconds.Our low-cost refractometer is suitable for personal health management and small-scale production,providing an affordable and reliable method for measuring sucrose concentration in fruit juice.It improves upon the existing low-cost options by offering better stability and accuracy.This accessible tool has potential applications in optimizing the sucrose content of fruit juice for better health and quality control.
文摘Analyzing the influence on Q factor, which was caused by the parasitic effect in a CMOS RF on chip integrated inductor, a concise method to increase the Q factor has been obtained when optimizing the layout parameter. Using this method, the Q factor of 7.9 can be achieved in a 5nH inductor (operating frequency is 2GHz) while the errors in inductance are less than 0.5% compared with the aimed values. It is proved by experiments that this method can guarantee the sufficient accuracy but require less computation time. Therefore, it is of great use for the design of the inductor in CMOS RF IC’s.
文摘The proposed DAC consists of a unit current-cell matrix for 8MSBs and a binary-weighted array for 4LSBs,trading-off between the precision,speed,and size of the chip.In order to ensure the linearity of the DAC,a double Centro symmetric current matrix is designed by the Q2 random walk strategy.To achieve better dynamic performance,a latch is added in front of the current switch to change the input signal,such as its optimal cross-point and voltage level.For a 12bit resolution,the converter reaches an update rate of 300MHz.
