Axillary hyperhydrosis in children and teenagers may be severe enough to affect social development. Current treatments range from aluminum chloride compounds to surgical removal of sweat glands and sympathectomy. Intr...Axillary hyperhydrosis in children and teenagers may be severe enough to affect social development. Current treatments range from aluminum chloride compounds to surgical removal of sweat glands and sympathectomy. Intradermal injection of botulinum A toxin has recently been found to be a safe and effective alternative in the adult population. Use in children has so far not been documented. We hereby report a case illustrating the use of botulinum A toxin in a 14- year-old girl with disabling axillary hyperhydrosis.展开更多
Hyperhidrosis is an idiopathic condition of exaggerated sweat production by the eccrine glands that affects approximately 1% of the population. There are many viable therapeutic options and the use of botulinum toxin ...Hyperhidrosis is an idiopathic condition of exaggerated sweat production by the eccrine glands that affects approximately 1% of the population. There are many viable therapeutic options and the use of botulinum toxin has become an important treatment option and received FDA approval for this disorder in July 2004. The other forms of aberrant sweating; bromhidrosis (malodorous) and chromhidrosis (pigmented) are much rarer and more recalcitrant to treatment. This is the first case report of dark-colored facial sweat in a young woman that was adequately controlled with botulinum toxin. Chromhidrosis is an unusual clinical entity with an ill defined glandular etiology. The successful response to botulinum toxin supports the eccrine gland as a source of the sweat production and, furthermore, that the administration of this toxin should be considered as a form of therapy.展开更多
Purpose: To report 7 patients with paradoxical use of the frontalis muscle des pite postsurgical correction of ptosis with good postoperative eyelid position. Successful treatment with botulinumA toxin facilitated mot...Purpose: To report 7 patients with paradoxical use of the frontalis muscle des pite postsurgical correction of ptosis with good postoperative eyelid position. Successful treatment with botulinumA toxin facilitated motor relearning and cess ation of muscle contraction. Design: Interventional case series. Participants: S even patients, in 2 eye-plastic clinics, who underwent successful surgical corr ection of upper eyelid ptosis. Methods: Review of clinical history, clinical pho tographs, treatment, and follow-up. Main Outcome Measures: Frontalis muscle con traction and upper eyelid position. Results: Patients underwent successful surgi cal correction of ptosis but continued using the frontalis muscle despite good e yelid position postoperatively. Frontalis contraction ceased spontaneously in 2 patients, but required botulinum A toxin injection in 5. The effects of a single treatment of botulinum A toxin lasted from 3 months to 2 years, longer than the expected effect of the toxin. Conclusion: Patients with long-standing eyelid p tosis may paradoxically continue utilizing the frontalis after successful surgic al correction and despite good postoperative eyelid position. Cessation of front alis contraction can be achieved with a single injection of botulinum A toxin. W e hypothesize that chemodenervation, achieved with the toxin, may influence the central nervous system to relearn the set point for muscle contraction and may b e associated with permanent motor relearning. Spontaneous resolution of muscle c ontraction can occur in the first months after surgery.展开更多
文摘Axillary hyperhydrosis in children and teenagers may be severe enough to affect social development. Current treatments range from aluminum chloride compounds to surgical removal of sweat glands and sympathectomy. Intradermal injection of botulinum A toxin has recently been found to be a safe and effective alternative in the adult population. Use in children has so far not been documented. We hereby report a case illustrating the use of botulinum A toxin in a 14- year-old girl with disabling axillary hyperhydrosis.
文摘Hyperhidrosis is an idiopathic condition of exaggerated sweat production by the eccrine glands that affects approximately 1% of the population. There are many viable therapeutic options and the use of botulinum toxin has become an important treatment option and received FDA approval for this disorder in July 2004. The other forms of aberrant sweating; bromhidrosis (malodorous) and chromhidrosis (pigmented) are much rarer and more recalcitrant to treatment. This is the first case report of dark-colored facial sweat in a young woman that was adequately controlled with botulinum toxin. Chromhidrosis is an unusual clinical entity with an ill defined glandular etiology. The successful response to botulinum toxin supports the eccrine gland as a source of the sweat production and, furthermore, that the administration of this toxin should be considered as a form of therapy.
文摘Purpose: To report 7 patients with paradoxical use of the frontalis muscle des pite postsurgical correction of ptosis with good postoperative eyelid position. Successful treatment with botulinumA toxin facilitated motor relearning and cess ation of muscle contraction. Design: Interventional case series. Participants: S even patients, in 2 eye-plastic clinics, who underwent successful surgical corr ection of upper eyelid ptosis. Methods: Review of clinical history, clinical pho tographs, treatment, and follow-up. Main Outcome Measures: Frontalis muscle con traction and upper eyelid position. Results: Patients underwent successful surgi cal correction of ptosis but continued using the frontalis muscle despite good e yelid position postoperatively. Frontalis contraction ceased spontaneously in 2 patients, but required botulinum A toxin injection in 5. The effects of a single treatment of botulinum A toxin lasted from 3 months to 2 years, longer than the expected effect of the toxin. Conclusion: Patients with long-standing eyelid p tosis may paradoxically continue utilizing the frontalis after successful surgic al correction and despite good postoperative eyelid position. Cessation of front alis contraction can be achieved with a single injection of botulinum A toxin. W e hypothesize that chemodenervation, achieved with the toxin, may influence the central nervous system to relearn the set point for muscle contraction and may b e associated with permanent motor relearning. Spontaneous resolution of muscle c ontraction can occur in the first months after surgery.
