A genuine technological issue–the thermal convection of liquid in a rotating cavity–is investigated experimentally.The experiments are conducted within a horizontal annulus with isothermal boundaries. The inner boun...A genuine technological issue–the thermal convection of liquid in a rotating cavity–is investigated experimentally.The experiments are conducted within a horizontal annulus with isothermal boundaries. The inner boundaryof the annulus has a higher temperature, thus exerting a stabilising influence on the system. It is shown that whenthe layer rotation velocity diminishes, two-dimensional azimuthally periodic convective rolls, rotating togetherwith the cavity, emerge in a threshold manner. The development of convection is accompanied by a significantintensification of heat transfer through the layer. It is shown that the averaged thermal convection excitation inthe form of a system of two-dimensional rolls occurs against the background of oscillations of a non-isothermalfluid in the cavity reference frame caused by the gravity field. The excitation threshold and the structure ofconvective rolls are consistent with the results of the earlier theoretical studies by the authors performed usingthe equations of “vibrational” convection obtained by the averaging method. Furthermore, the experiments haverevealed a new type of averaged flow in the form of a spatially periodic system of toroidal vortices. It is shown thata steady streaming, excited by the inertial oscillations of the fluid, is responsible for the generation of the toroidalvortices. These flows develop in a non-threshold manner and are most clearly manifested in a case of resonantexcitation of one of the inertial modes.展开更多
A comprehensive mathematical model of annulus-electromagnetic direct chill (A-EMDC) casting of A357 aluminum alloy was established with corresponding experimental verification. The model was based on a combination o...A comprehensive mathematical model of annulus-electromagnetic direct chill (A-EMDC) casting of A357 aluminum alloy was established with corresponding experimental verification. The model was based on a combination of the commercial finite element package ANSYS and the commercial finite volume package FLUENT. The effects of structural parameters on fluid flow, temperature field and solidification during A-EMDC process were investigated numerically. The results show that structural parameters such as annulus gap width, annulus gap position, and centre pipe length influence the flow and temperature fields. The smaller the annulus gap width is, the more uniform the temperature is, and the smaller the temperature gradient is. With increasing the centre pipe length, the circular flow would decrease due to the dislocation of centre pipe. Specially, when the annulus gap is located at periphery of the billet, the temperature gradient of the longitudinal direction in the solidification region falls evidently.展开更多
In order to investigate the apoptotic pathway of rabbit annulus fibrosus(AF) cells induced by mechanical overload,an experimental air-pressure model was established in this study to pressurize the rabbit AF cells in v...In order to investigate the apoptotic pathway of rabbit annulus fibrosus(AF) cells induced by mechanical overload,an experimental air-pressure model was established in this study to pressurize the rabbit AF cells in vitro.Cells were randomly divided into five groups in which the cells were exposed to a continuous pressure of 1.1 MPa for different lengths of time(0,5,12,24 and 36 h).The cell proliferation and apoptosis were detected by cell counting kit-8(CCK-8) assay and flow cytometry;the alterations in mitochondrial membrane potential were measured by fluorescence microscopy and fluorescence spectrophotometer;the activities of caspase-8 and 9 were determined by spectrophotometry.The results showed that after the cells were subjected to the pressure for 24 or 36 h,the cell proliferation was inhibited;the ratio of cell apoptosis was increased;the mitochondrial membrane potential was decreased;the activity of caspase-9 was enhanced;no activity changes were observed in caspase-8.The results suggested that treatment with a pressure of 1.1 MPa for more than 24 h can lead to the proliferation inhibition and the apoptosis of rabbit AF cells in vitro,and the mitochondrial-dependent pathway is implicated in the pressure-induced AF cell apoptosis.展开更多
The existence of radial solutions of Δu + λg(|x|)f(u) = 0 in annuli with Dirichlet(Dirichlet/Neumann) boundary conditions is investigated.It is proved that the problems have at least two positive radial sol...The existence of radial solutions of Δu + λg(|x|)f(u) = 0 in annuli with Dirichlet(Dirichlet/Neumann) boundary conditions is investigated.It is proved that the problems have at least two positive radial solutions on any annulus if f is superlinear at 0 and sublinear at ∞.展开更多
Miniaturization of electronic equipment has forced researchers to devise more effective methods for dissipating the generated heat in these devices.In this study,two methods,including porous media inserting and adding...Miniaturization of electronic equipment has forced researchers to devise more effective methods for dissipating the generated heat in these devices.In this study,two methods,including porous media inserting and adding nanoparticles to the base fluid,are used to improve heat transfer in an annulus heated on both walls.To study porous media insert,porous ribs are used on the outer and inner walls independently.The results show that when porous ribs are placed on the outer wall,although the heat transfer enhances,the pressure drop increment is so considerable that performance number (the ratio of heat transfer enhancement pressure increment,PN) is less than unity for all porous rib heights and porous media permeabilities that are studied.On the other hand,the PN of cases where porous ribs were placed on the inner wall depends on the Darcy number (Da).For example,for ribs with Da=0.1 and Da=0.0001,the maximum performance number,PN=4,occurs at the porous ribs height to hydraulic diameter ratios H/Dh=1 and H/Dh=0.25.Under these conditions,heat transfer is enhanced by two orders of magnitude.It is found that adding 5% nanoparticles to the base fluid in the two aforementioned cases improves the Nusselt number and PN by 10%–40%.展开更多
Heat transfer and entropy generation of developing laminar forced convection flow of water-Al_2O_3 nanofluid in a concentric annulus with constant heat flux on the walls is investigated numerically. In order to determ...Heat transfer and entropy generation of developing laminar forced convection flow of water-Al_2O_3 nanofluid in a concentric annulus with constant heat flux on the walls is investigated numerically. In order to determine entropy generation of fully developed flow, two approaches are employed and it is shown that only one of these methods can provide appropriate results for flow inside annuli. The effects of concentration of nanoparticles, Reynolds number and thermal boundaries on heat transfer enhancement and entropy generation of developing laminar flow inside annuli with different radius ratios and same cross sectional areas are studied. The results show that radius ratio is a very important decision parameter of an annular heat exchanger such that in each Re, there is an optimum radius ratio to maximize Nu and minimize entropy generation. Moreover, the effect of nanoparticles concentration on heat transfer enhancement and minimizing entropy generation is stronger at higher Reynolds.展开更多
Stress corrosion cracking (SCC) behavior of P 110 tubing steel in simulated C02 injection well annulus environments was investigated through three-point bent tests, potentiodynamic polarization and EIS measurements....Stress corrosion cracking (SCC) behavior of P 110 tubing steel in simulated C02 injection well annulus environments was investigated through three-point bent tests, potentiodynamic polarization and EIS measurements. The results demonstrate that SCC of P110 tubing steel could occur in acidulous simulated environment, and the sensitivity of SCC increases with the decrease ofpH, as well as increase of sulfide concentration and total environmental pressure. Both anodic dissolution and hydrogen embrittlement make contributions to the SCC. Adequate concentration of corrosion inhibitor can inhibit the occurrence of SCC on account of the inhibition of localized anodic dissolution and cathodic hydrogen evolution.展开更多
The present work relates to a numerical investigation of double diffusive mixed convection around a horizontal annulus with a finned inner cylinder.The solutal and thermal buoyancy forces are sustained by maintaining ...The present work relates to a numerical investigation of double diffusive mixed convection around a horizontal annulus with a finned inner cylinder.The solutal and thermal buoyancy forces are sustained by maintaining the inner and outer cylinders at uniform temperatures and concentrations.Buoyancy effects are also considered,with the Boussinesq approximation.The forced convection effect is induced by the outer cylinder rotating with an angular velocity(ω)in an anti-clockwise direction.The studies are made for various combinations of dimensionless numbers;buoyancy ratio number(N),Lewis number(Le),Richardson number(Ri)and Grashof number(Gr).The isotherms,isoconcentrations and streamlines as well as both average and local Nusselt and Sherwood numbers were studied.A finite volume scheme is adopted to solve the transport equations for continuity,momentum,energy and mass transfer.The results indicate that the use of fins on the inner cylinder with outer cylinder rotation,significantly improves the heat and mass transfer in the annulus.展开更多
Annulus fibrosus (AF) tissue engineering has recently received increasing attention as a treatment for intervertebral disc 0VD) degeneration; however, such engineering remains challenging because of the remarkable ...Annulus fibrosus (AF) tissue engineering has recently received increasing attention as a treatment for intervertebral disc 0VD) degeneration; however, such engineering remains challenging because of the remarkable complexity of AF tissue. In order to engineer a functional AF replacement, the fabrication of cell-scaffold constructs that mimic the cellular, biochemical and structural features of native AF tissue is critical. In this study, we fabricated aligned fibroua polyurethane scaffolds using an electrospinning technique and used them for culturing AF-derived-stem/progenitor cells (AFSCs). Random fibrous scaffolds, also prepared via electrospinningy were used as a control. We compared the morphology, proliferation, gene expression and matrix production of AFSCs on aligned scaffolds and random scaffolds. There was no apparent difference in the attachment or proliferation of cells cultured on aligned scaffolds and random scaffolds. However, compared to cells on random scaffolds, the AFSCs on aligned scaffolds were more elongated and better aligned, and they exhibited higher gene expression and matrix production of coUagen-I and aggrecan. The gene expression and protein production of coUagen-II did not appear to differ between the two groups. Together, these findings indicate that aligned fibrous scaffolds may provide a favourable microenvironment for the differentiation of AFSCs into cells similar to outer AF cells, which predominantly produce collagen-I matrix.展开更多
Improving the closure effect of surgical suture for repair of annulus fibrosus defects remains an unsolved problem.A new type of porcine fibrin glue was reported for the repair of annulus fibrous defects in sheep mode...Improving the closure effect of surgical suture for repair of annulus fibrosus defects remains an unsolved problem.A new type of porcine fibrin glue was reported for the repair of annulus fibrous defects in sheep models in this study.Continuous axial loading test showed that this glue could effectively improve the closure effect of surgical suture for annulus fibrous defect.Magnetic resonance imaging (MRI) of the lumbar spine confirmed that,compared with nonfibrin glue treated intervertebral discs,it contributed to preservation of the nucleus pulposus and maintained the physiological hydration of the intervertebral discs.Moreover,histomorphology evaluation showed that the porcine fibrin glue could partially reverse degeneration of the injured intervertebral discs.Taken together,porcine fibrin glue can effectively enhance the closure effect of surgical suture on annulus fibrosus,improve the repair effect and slow down the degeneration of the intervertebral disc,and provide a potential therapeutic strategy for degenerative intervertebral disc disease.展开更多
The convective heat transfer of hybrid nanoliquids within a concentric annulus has wide engineering applications such as chemical industries, solar collectors, gas turbines, heat exchangers, nuclear reactors, and elec...The convective heat transfer of hybrid nanoliquids within a concentric annulus has wide engineering applications such as chemical industries, solar collectors, gas turbines, heat exchangers, nuclear reactors, and electronic component cooling due to their high heat transport rate. Hence, in this study, the characteristics of the heat transport mechanism in an annulus filled with the Ag-MgO/H_2O hybrid nanoliquid under the influence of quadratic thermal radiation and quadratic convection are analyzed. The nonuniform heat source/sink and induced magnetic field mechanisms are used to govern the basic equations concerning the transport of the composite nanoliquid. The dependency of the Nusselt number on the effective parameters(thermal radiation, nonlinear convection,and temperature-dependent heat source/sink parameter) is examined through sensitivity analyses based on the response surface methodology(RSM) and the face-centered central composite design(CCD). The heat transport of the composite nanoliquid for the spacerelated heat source/sink is observed to be higher than that for the temperature-related heat source/sink. The mechanisms of quadratic convection and quadratic thermal radiation are favorable for the momentum of the nanoliquid. The heat transport rate is more sensitive towards quadratic thermal radiation.展开更多
Large-deflection flexure pivot is widely used in high precision rotation application, but there are less flexure configurations and simple and convenient design methods, This paper presents a novel large-deflection cu...Large-deflection flexure pivot is widely used in high precision rotation application, but there are less flexure configurations and simple and convenient design methods, This paper presents a novel large-deflection curved-compliant annulus-shaped flexure pivot composed of six curved beam flexure elements. It can offer more than lO^angular stroke theoretically. Firstly, main-motion pseudo-rigid-body method is introduced to establish the flexure pivot model. Although pseudo-rigid-body method can be used to analyze the large-deformation flexure pivot performance, the method is definitely a laborious and difficult task for designing this novel flexure pivot. In order to simply the designing process, dimension-design graphs based on the parametric models and finite element analysis is presented. Using the dimension-design method as a tool, the designers can determine the optimal geometry rapidly, based on the stiffness and rotation demands of an annulus-shaped flexure pivot. Finally, dimension-design graph examples are given whose primary design aims to achieve a rotation stroke of annulus-shaped flexure pivot. The finite element analysis results show that the relative designing error between anticipative rotation stroke and graph design result is less than 4%. The dimensionless method used in designing annulus-shaped flexure pivot can reduce design process in both time and complexity. The novel annulus-shaped flexure pivot and dimension-design method are helpful supplement to configuration and design method of large-deflection flexure pivot.展开更多
We report an acoustic focusing lens composed of two-layer annuluses made of metal cylinders in air. We find that the cylindrical waves can be focused into a perfect point without diffraction in the centre of the annul...We report an acoustic focusing lens composed of two-layer annuluses made of metal cylinders in air. We find that the cylindrical waves can be focused into a perfect point without diffraction in the centre of the annuluses, which arises from the Mie-resonance modes in the annuluses. The focusing frequencies are related to the size of the inner annulus, and the focusing effect can be applied to the annuluses with different shapes and incident positions. Interesting applications of the focusing lens in the acoustic beam splitter and directional transmitter with energy enhancement are further discussed.展开更多
A thermoelastic problem of a circular annulus made of functionally graded materials with an arbitrary gradient is investigated. Different from previous works, our analysis neither requires a special form of the gradie...A thermoelastic problem of a circular annulus made of functionally graded materials with an arbitrary gradient is investigated. Different from previous works, our analysis neither requires a special form of the gradient of material properties nor demands partitioning the entire structure into a multilayered homogeneous structure. Instead, we propose a new method for solving the thermoelastic problem of a functionally graded circular annulus by transforming it to a Fredholm integral equation. The distribution of thermal stresses and radial displacement can be obtained by solving the resulting equation. Illustrative examples are given to show the effects of varying gradients on the thermal stresses and radial displacement for given temperature changes at the inner and outer surfaces. The results indicate that the thermal stresses can be relaxed for specified gradients, which is beneficial to design an inhomogeneous annulus to maintain structural integrity.展开更多
In this study, integral operational methods are used to investigate the thermally induced transverse vibration of a thin elliptic annulus plate with elastic supports at both radial boundaries.The axisymmetric temperat...In this study, integral operational methods are used to investigate the thermally induced transverse vibration of a thin elliptic annulus plate with elastic supports at both radial boundaries.The axisymmetric temperature distribution is determined by the heat conduction differential equation and its corresponding boundary conditions by employing a unified integral transform technique by use of Mathieu functions and modified Mathieu functions. The solution of thermally induced vibration of the plate with both ends encased with elastic supports is obtained by employing an integral transform for double Laplace differential equation. The thermal moment is derived on the basis of temperature distribution, and its stresses are obtained based on resultant bending moments per unit width. The numerical calculations of the distributions of the transient temperature and its associated stress distributions are shown in the figures.展开更多
Let Mi be a compact orientable 3-manifold, and Ai a non-separating incompressible annulus on a component of δMi, say Fi, i = 1, 2. Let h : A1 → A2 be a homeomorphism, and M→M1 ∪h M2, the annulus sum of Mi and M2 ...Let Mi be a compact orientable 3-manifold, and Ai a non-separating incompressible annulus on a component of δMi, say Fi, i = 1, 2. Let h : A1 → A2 be a homeomorphism, and M→M1 ∪h M2, the annulus sum of Mi and M2 along A1 and A2. Suppose that Mi has a Heegaard splitting Vi ∪Si Wi with distance d(Si) ≥ 2g(Mi) + 2g(F3-i) + 1, i = 1, 2. Then g(M) = g(M1) + g(M2), and the minimal Heegaard splitting of M is unique, which is the natural Heegaard splitting of M induced from Vi∪S1 Wi and V2 ∪S2 W2.展开更多
The interaction of transient fully developed natural convection flow with thermal radiation inside a vertical annulus is analyzed both analytically and numerically. The Rosseland approximation is used to describe the ...The interaction of transient fully developed natural convection flow with thermal radiation inside a vertical annulus is analyzed both analytically and numerically. The Rosseland approximation is used to describe the radiative heat flux in the energy equation. The mathematical model capturing the present physical situation is highly non-linear due to the presence of radiation effect. The solution of transient model is obtained by implicit finite difference method. To check accuracy of the numerical solution, steady state solution for energy and momentum equations are derived analytically using perturbation series method. Skin-friction and Nusselt number at the outer surface of inner cylinder as well as inner surface of the outer cylinder are obtained. Selected sets of graphical results illustrating the effects of various controlling parameters involved in the problem on flow formation are discussed.展开更多
Mitral Annular Calcification (MAC) is a degenerative process involving the fibrous ring of the mitral valve. Caseous Calcification of Mitral Annulus (CCMA) is a rare variant of MAC. This condition is benign and usuall...Mitral Annular Calcification (MAC) is a degenerative process involving the fibrous ring of the mitral valve. Caseous Calcification of Mitral Annulus (CCMA) is a rare variant of MAC. This condition is benign and usually needs no treatment. This is a case report of a 67-year-old woman with non-specific symptoms in whom a cardiac tumor was suspected by transthoracic Echocardiography. The use of multi-modality imaging strategy with transesophageal Echocardiography and cardiac MR scanning revealed however the diagnosis of CCMA and spared the patient an unnecessary operation.展开更多
基金supported by the Ministry of Education of the Russian Federation(Project KPZU-2023-0002).
文摘A genuine technological issue–the thermal convection of liquid in a rotating cavity–is investigated experimentally.The experiments are conducted within a horizontal annulus with isothermal boundaries. The inner boundaryof the annulus has a higher temperature, thus exerting a stabilising influence on the system. It is shown that whenthe layer rotation velocity diminishes, two-dimensional azimuthally periodic convective rolls, rotating togetherwith the cavity, emerge in a threshold manner. The development of convection is accompanied by a significantintensification of heat transfer through the layer. It is shown that the averaged thermal convection excitation inthe form of a system of two-dimensional rolls occurs against the background of oscillations of a non-isothermalfluid in the cavity reference frame caused by the gravity field. The excitation threshold and the structure ofconvective rolls are consistent with the results of the earlier theoretical studies by the authors performed usingthe equations of “vibrational” convection obtained by the averaging method. Furthermore, the experiments haverevealed a new type of averaged flow in the form of a spatially periodic system of toroidal vortices. It is shown thata steady streaming, excited by the inertial oscillations of the fluid, is responsible for the generation of the toroidalvortices. These flows develop in a non-threshold manner and are most clearly manifested in a case of resonantexcitation of one of the inertial modes.
基金Project (2009AA03Z534) supported by the Hi-tech Research and Development Program of China Project (2006CB605203) supported by National Basic Research Program of China
文摘A comprehensive mathematical model of annulus-electromagnetic direct chill (A-EMDC) casting of A357 aluminum alloy was established with corresponding experimental verification. The model was based on a combination of the commercial finite element package ANSYS and the commercial finite volume package FLUENT. The effects of structural parameters on fluid flow, temperature field and solidification during A-EMDC process were investigated numerically. The results show that structural parameters such as annulus gap width, annulus gap position, and centre pipe length influence the flow and temperature fields. The smaller the annulus gap width is, the more uniform the temperature is, and the smaller the temperature gradient is. With increasing the centre pipe length, the circular flow would decrease due to the dislocation of centre pipe. Specially, when the annulus gap is located at periphery of the billet, the temperature gradient of the longitudinal direction in the solidification region falls evidently.
基金supported by a grant from National Natural Sciences Foundation of China (No.30700841)
文摘In order to investigate the apoptotic pathway of rabbit annulus fibrosus(AF) cells induced by mechanical overload,an experimental air-pressure model was established in this study to pressurize the rabbit AF cells in vitro.Cells were randomly divided into five groups in which the cells were exposed to a continuous pressure of 1.1 MPa for different lengths of time(0,5,12,24 and 36 h).The cell proliferation and apoptosis were detected by cell counting kit-8(CCK-8) assay and flow cytometry;the alterations in mitochondrial membrane potential were measured by fluorescence microscopy and fluorescence spectrophotometer;the activities of caspase-8 and 9 were determined by spectrophotometry.The results showed that after the cells were subjected to the pressure for 24 or 36 h,the cell proliferation was inhibited;the ratio of cell apoptosis was increased;the mitochondrial membrane potential was decreased;the activity of caspase-9 was enhanced;no activity changes were observed in caspase-8.The results suggested that treatment with a pressure of 1.1 MPa for more than 24 h can lead to the proliferation inhibition and the apoptosis of rabbit AF cells in vitro,and the mitochondrial-dependent pathway is implicated in the pressure-induced AF cell apoptosis.
基金Supported by the National Natural Science Foundation of China (10726004)the Natural Science Foundation for the Youth of Shandong Province (Q2007A02)
文摘The existence of radial solutions of Δu + λg(|x|)f(u) = 0 in annuli with Dirichlet(Dirichlet/Neumann) boundary conditions is investigated.It is proved that the problems have at least two positive radial solutions on any annulus if f is superlinear at 0 and sublinear at ∞.
文摘Miniaturization of electronic equipment has forced researchers to devise more effective methods for dissipating the generated heat in these devices.In this study,two methods,including porous media inserting and adding nanoparticles to the base fluid,are used to improve heat transfer in an annulus heated on both walls.To study porous media insert,porous ribs are used on the outer and inner walls independently.The results show that when porous ribs are placed on the outer wall,although the heat transfer enhances,the pressure drop increment is so considerable that performance number (the ratio of heat transfer enhancement pressure increment,PN) is less than unity for all porous rib heights and porous media permeabilities that are studied.On the other hand,the PN of cases where porous ribs were placed on the inner wall depends on the Darcy number (Da).For example,for ribs with Da=0.1 and Da=0.0001,the maximum performance number,PN=4,occurs at the porous ribs height to hydraulic diameter ratios H/Dh=1 and H/Dh=0.25.Under these conditions,heat transfer is enhanced by two orders of magnitude.It is found that adding 5% nanoparticles to the base fluid in the two aforementioned cases improves the Nusselt number and PN by 10%–40%.
文摘Heat transfer and entropy generation of developing laminar forced convection flow of water-Al_2O_3 nanofluid in a concentric annulus with constant heat flux on the walls is investigated numerically. In order to determine entropy generation of fully developed flow, two approaches are employed and it is shown that only one of these methods can provide appropriate results for flow inside annuli. The effects of concentration of nanoparticles, Reynolds number and thermal boundaries on heat transfer enhancement and entropy generation of developing laminar flow inside annuli with different radius ratios and same cross sectional areas are studied. The results show that radius ratio is a very important decision parameter of an annular heat exchanger such that in each Re, there is an optimum radius ratio to maximize Nu and minimize entropy generation. Moreover, the effect of nanoparticles concentration on heat transfer enhancement and minimizing entropy generation is stronger at higher Reynolds.
基金Project(2012AA040105)supported by the High-tech Research and Development Program of ChinaProject(2014CB643300)supported by National Basic Research Program of ChinaProject(51741034)supported by National Natural Science Foundation of China
文摘Stress corrosion cracking (SCC) behavior of P 110 tubing steel in simulated C02 injection well annulus environments was investigated through three-point bent tests, potentiodynamic polarization and EIS measurements. The results demonstrate that SCC of P110 tubing steel could occur in acidulous simulated environment, and the sensitivity of SCC increases with the decrease ofpH, as well as increase of sulfide concentration and total environmental pressure. Both anodic dissolution and hydrogen embrittlement make contributions to the SCC. Adequate concentration of corrosion inhibitor can inhibit the occurrence of SCC on account of the inhibition of localized anodic dissolution and cathodic hydrogen evolution.
文摘The present work relates to a numerical investigation of double diffusive mixed convection around a horizontal annulus with a finned inner cylinder.The solutal and thermal buoyancy forces are sustained by maintaining the inner and outer cylinders at uniform temperatures and concentrations.Buoyancy effects are also considered,with the Boussinesq approximation.The forced convection effect is induced by the outer cylinder rotating with an angular velocity(ω)in an anti-clockwise direction.The studies are made for various combinations of dimensionless numbers;buoyancy ratio number(N),Lewis number(Le),Richardson number(Ri)and Grashof number(Gr).The isotherms,isoconcentrations and streamlines as well as both average and local Nusselt and Sherwood numbers were studied.A finite volume scheme is adopted to solve the transport equations for continuity,momentum,energy and mass transfer.The results indicate that the use of fins on the inner cylinder with outer cylinder rotation,significantly improves the heat and mass transfer in the annulus.
基金supported by the National Natural Science Foundation of China (81171479, 51303120, 81471790)the China Postdoctoral Science Foundation (2012M521121)+2 种基金the Natural Science Foundation of Jiangsu Province (BK20130335)the Jiangsu Provincial Special Program of Medical Science (BL2012004)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘Annulus fibrosus (AF) tissue engineering has recently received increasing attention as a treatment for intervertebral disc 0VD) degeneration; however, such engineering remains challenging because of the remarkable complexity of AF tissue. In order to engineer a functional AF replacement, the fabrication of cell-scaffold constructs that mimic the cellular, biochemical and structural features of native AF tissue is critical. In this study, we fabricated aligned fibroua polyurethane scaffolds using an electrospinning technique and used them for culturing AF-derived-stem/progenitor cells (AFSCs). Random fibrous scaffolds, also prepared via electrospinningy were used as a control. We compared the morphology, proliferation, gene expression and matrix production of AFSCs on aligned scaffolds and random scaffolds. There was no apparent difference in the attachment or proliferation of cells cultured on aligned scaffolds and random scaffolds. However, compared to cells on random scaffolds, the AFSCs on aligned scaffolds were more elongated and better aligned, and they exhibited higher gene expression and matrix production of coUagen-I and aggrecan. The gene expression and protein production of coUagen-II did not appear to differ between the two groups. Together, these findings indicate that aligned fibrous scaffolds may provide a favourable microenvironment for the differentiation of AFSCs into cells similar to outer AF cells, which predominantly produce collagen-I matrix.
基金This study was supported by the National Natural Science Foundation of China (No.81260287).
文摘Improving the closure effect of surgical suture for repair of annulus fibrosus defects remains an unsolved problem.A new type of porcine fibrin glue was reported for the repair of annulus fibrous defects in sheep models in this study.Continuous axial loading test showed that this glue could effectively improve the closure effect of surgical suture for annulus fibrous defect.Magnetic resonance imaging (MRI) of the lumbar spine confirmed that,compared with nonfibrin glue treated intervertebral discs,it contributed to preservation of the nucleus pulposus and maintained the physiological hydration of the intervertebral discs.Moreover,histomorphology evaluation showed that the porcine fibrin glue could partially reverse degeneration of the injured intervertebral discs.Taken together,porcine fibrin glue can effectively enhance the closure effect of surgical suture on annulus fibrosus,improve the repair effect and slow down the degeneration of the intervertebral disc,and provide a potential therapeutic strategy for degenerative intervertebral disc disease.
文摘The convective heat transfer of hybrid nanoliquids within a concentric annulus has wide engineering applications such as chemical industries, solar collectors, gas turbines, heat exchangers, nuclear reactors, and electronic component cooling due to their high heat transport rate. Hence, in this study, the characteristics of the heat transport mechanism in an annulus filled with the Ag-MgO/H_2O hybrid nanoliquid under the influence of quadratic thermal radiation and quadratic convection are analyzed. The nonuniform heat source/sink and induced magnetic field mechanisms are used to govern the basic equations concerning the transport of the composite nanoliquid. The dependency of the Nusselt number on the effective parameters(thermal radiation, nonlinear convection,and temperature-dependent heat source/sink parameter) is examined through sensitivity analyses based on the response surface methodology(RSM) and the face-centered central composite design(CCD). The heat transport of the composite nanoliquid for the spacerelated heat source/sink is observed to be higher than that for the temperature-related heat source/sink. The mechanisms of quadratic convection and quadratic thermal radiation are favorable for the momentum of the nanoliquid. The heat transport rate is more sensitive towards quadratic thermal radiation.
基金supported by National Natural Science Foundation of China(Grant No. 50675007)Program for New Century Excellent Talents in University of China (Grant No. NCET-06-0165)
文摘Large-deflection flexure pivot is widely used in high precision rotation application, but there are less flexure configurations and simple and convenient design methods, This paper presents a novel large-deflection curved-compliant annulus-shaped flexure pivot composed of six curved beam flexure elements. It can offer more than lO^angular stroke theoretically. Firstly, main-motion pseudo-rigid-body method is introduced to establish the flexure pivot model. Although pseudo-rigid-body method can be used to analyze the large-deformation flexure pivot performance, the method is definitely a laborious and difficult task for designing this novel flexure pivot. In order to simply the designing process, dimension-design graphs based on the parametric models and finite element analysis is presented. Using the dimension-design method as a tool, the designers can determine the optimal geometry rapidly, based on the stiffness and rotation demands of an annulus-shaped flexure pivot. Finally, dimension-design graph examples are given whose primary design aims to achieve a rotation stroke of annulus-shaped flexure pivot. The finite element analysis results show that the relative designing error between anticipative rotation stroke and graph design result is less than 4%. The dimensionless method used in designing annulus-shaped flexure pivot can reduce design process in both time and complexity. The novel annulus-shaped flexure pivot and dimension-design method are helpful supplement to configuration and design method of large-deflection flexure pivot.
基金supported by the Major Program of the National Natural Science Foundation of China(Grant No.51239005)the National Natural Science Foundation of China(Grant No.11404147)+3 种基金the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20140519)the China Postdoctoral Science Foundation(Grant No.2015M571672)the Research Fund for Advanced Talents of Jiangsu University,China(Grant No.11JDG118)the Training Project of Young Backbone Teachers of Jiangsu University,China
文摘We report an acoustic focusing lens composed of two-layer annuluses made of metal cylinders in air. We find that the cylindrical waves can be focused into a perfect point without diffraction in the centre of the annuluses, which arises from the Mie-resonance modes in the annuluses. The focusing frequencies are related to the size of the inner annulus, and the focusing effect can be applied to the annuluses with different shapes and incident positions. Interesting applications of the focusing lens in the acoustic beam splitter and directional transmitter with energy enhancement are further discussed.
基金supported by the National Natural Science Foundation of China (No. 10672189)
文摘A thermoelastic problem of a circular annulus made of functionally graded materials with an arbitrary gradient is investigated. Different from previous works, our analysis neither requires a special form of the gradient of material properties nor demands partitioning the entire structure into a multilayered homogeneous structure. Instead, we propose a new method for solving the thermoelastic problem of a functionally graded circular annulus by transforming it to a Fredholm integral equation. The distribution of thermal stresses and radial displacement can be obtained by solving the resulting equation. Illustrative examples are given to show the effects of varying gradients on the thermal stresses and radial displacement for given temperature changes at the inner and outer surfaces. The results indicate that the thermal stresses can be relaxed for specified gradients, which is beneficial to design an inhomogeneous annulus to maintain structural integrity.
文摘In this study, integral operational methods are used to investigate the thermally induced transverse vibration of a thin elliptic annulus plate with elastic supports at both radial boundaries.The axisymmetric temperature distribution is determined by the heat conduction differential equation and its corresponding boundary conditions by employing a unified integral transform technique by use of Mathieu functions and modified Mathieu functions. The solution of thermally induced vibration of the plate with both ends encased with elastic supports is obtained by employing an integral transform for double Laplace differential equation. The thermal moment is derived on the basis of temperature distribution, and its stresses are obtained based on resultant bending moments per unit width. The numerical calculations of the distributions of the transient temperature and its associated stress distributions are shown in the figures.
文摘Let Mi be a compact orientable 3-manifold, and Ai a non-separating incompressible annulus on a component of δMi, say Fi, i = 1, 2. Let h : A1 → A2 be a homeomorphism, and M→M1 ∪h M2, the annulus sum of Mi and M2 along A1 and A2. Suppose that Mi has a Heegaard splitting Vi ∪Si Wi with distance d(Si) ≥ 2g(Mi) + 2g(F3-i) + 1, i = 1, 2. Then g(M) = g(M1) + g(M2), and the minimal Heegaard splitting of M is unique, which is the natural Heegaard splitting of M induced from Vi∪S1 Wi and V2 ∪S2 W2.
文摘The interaction of transient fully developed natural convection flow with thermal radiation inside a vertical annulus is analyzed both analytically and numerically. The Rosseland approximation is used to describe the radiative heat flux in the energy equation. The mathematical model capturing the present physical situation is highly non-linear due to the presence of radiation effect. The solution of transient model is obtained by implicit finite difference method. To check accuracy of the numerical solution, steady state solution for energy and momentum equations are derived analytically using perturbation series method. Skin-friction and Nusselt number at the outer surface of inner cylinder as well as inner surface of the outer cylinder are obtained. Selected sets of graphical results illustrating the effects of various controlling parameters involved in the problem on flow formation are discussed.
文摘Mitral Annular Calcification (MAC) is a degenerative process involving the fibrous ring of the mitral valve. Caseous Calcification of Mitral Annulus (CCMA) is a rare variant of MAC. This condition is benign and usually needs no treatment. This is a case report of a 67-year-old woman with non-specific symptoms in whom a cardiac tumor was suspected by transthoracic Echocardiography. The use of multi-modality imaging strategy with transesophageal Echocardiography and cardiac MR scanning revealed however the diagnosis of CCMA and spared the patient an unnecessary operation.
文摘The annulus and disk complex is defined and researched. Especially, we prove that this complex is contractible and quasi-convex in the curve complex.