Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and Wayanad.Methods:Sites were selected based on soil-transmitted helminths pr...Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and Wayanad.Methods:Sites were selected based on soil-transmitted helminths prevalence,different sociocultural-geographical characteristics and operational feasibility.9-12 Years old children from 14 schools were included.The study was conducted in two rounds:baseline&follow up survey.All eligible children found positive for A.lumbricoides at baseline were administered supervised single tablet albendazole 400 mg under the National Deworming Day Initiative.During post-treatment follow-up survey,eligible children who provided second stool sample were included in the final analysis.Stool samples were examined using WHO recommended Kato-Katz technique.Efficacy was estimated based on cure rate(CR)and Fecal Egg Count Reduction Rate(FECRR)among children found positive in baseline and follow-up surveys.Results:328 Out of 625(52.5%)were found positive for A.lumbricoides in the baseline survey and 85 out of 178 samples(47.8%)during post-treatment follow-up survey.Overall,the estimated CR was 52.2%.FECRR(95%CI)for albendazole was 72.6%(79.2%-66.0%).The FECRR was highest in East Godaveri[89.7%(96.8%-82.6%)],followed by Sundergarh[86.4%(95.3%-77.5%)]and Wayanad[69%(81.7%-56.4%)].Conclusions:Our study confirmed overall reduction in FEC although with varying albendazole efficacy for A.lumbricoides infection at three different locations in India.However,these finding may be assessed in context of ongoing MDA under Filaria control program and further studies by in vivo as well as in vitro methods are required to reach to a conclusion on possible resistance if any.展开更多
Ascaris lumbricoides (A. lumbricoides), the soil-transmitted helminth is the most prevalent parasitic infection of the gastrointestinal tract in developing countries. Heavy worm loads mainly due to untreated worm infe...Ascaris lumbricoides (A. lumbricoides), the soil-transmitted helminth is the most prevalent parasitic infection of the gastrointestinal tract in developing countries. Heavy worm loads mainly due to untreated worm infestations are often associated with increased risk of severe sequelae. We report the first complicated case of A. lumbricoides causing small bowel obstruction in a 9-year-old boy that necessitated surgical intervention on a tropical island in the Indian Ocean, where cases of Ascariasis are rarely encountered.展开更多
为探讨人蛔虫提取物对肿瘤的作用及其免疫学机制,将45只C57BL/6小鼠随机分为A、B、C、D和E等5组,每组9只,其中B、D组分别为A、C组的实验对照组,E组为阴性对照组,不做任何处理。A组每鼠隔天腹腔注射0.1 ml蛔虫提取物(BEAL),10 d后每鼠右...为探讨人蛔虫提取物对肿瘤的作用及其免疫学机制,将45只C57BL/6小鼠随机分为A、B、C、D和E等5组,每组9只,其中B、D组分别为A、C组的实验对照组,E组为阴性对照组,不做任何处理。A组每鼠隔天腹腔注射0.1 ml蛔虫提取物(BEAL),10 d后每鼠右前肢腋下皮下接种0.1 ml Lewis肺癌细胞(LLC),进行肿瘤造模;B组小鼠注射等量生理盐水,10 d后进行肿瘤造模。C组每鼠注射0.1 ml LLC细胞悬液进行肿瘤造模,2 d后腹腔注射0.1 ml BEAL,隔天1次,共注射5次;D组小鼠肿瘤造模2 d后,注射等量生理盐水,隔天1次。记录各组小鼠成瘤时间,称瘤重,计算抑瘤率。结果显示,A、B、C和D组小鼠的成瘤时间分别为(7.0±1.1)、(6.0±0.7)、(9.0±1.2)和(7.0±0.9)d。BEAL提前干预的A组小鼠肿瘤重量为(722.2±413.5)mg,显著重于其对照组B组[(338.9±282.2)mg](P<0.05)。小鼠荷瘤后BEAL干预的C组抑瘤率最强,为33.3%,其肿瘤重量[(237.8±101.8)mg]明显轻于对照组D组[(356.7±176.9)mg](P<0.05)。提示BEAL可影响肿瘤的形成,在一定条件下具有明显的抑瘤作用。展开更多
文摘Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and Wayanad.Methods:Sites were selected based on soil-transmitted helminths prevalence,different sociocultural-geographical characteristics and operational feasibility.9-12 Years old children from 14 schools were included.The study was conducted in two rounds:baseline&follow up survey.All eligible children found positive for A.lumbricoides at baseline were administered supervised single tablet albendazole 400 mg under the National Deworming Day Initiative.During post-treatment follow-up survey,eligible children who provided second stool sample were included in the final analysis.Stool samples were examined using WHO recommended Kato-Katz technique.Efficacy was estimated based on cure rate(CR)and Fecal Egg Count Reduction Rate(FECRR)among children found positive in baseline and follow-up surveys.Results:328 Out of 625(52.5%)were found positive for A.lumbricoides in the baseline survey and 85 out of 178 samples(47.8%)during post-treatment follow-up survey.Overall,the estimated CR was 52.2%.FECRR(95%CI)for albendazole was 72.6%(79.2%-66.0%).The FECRR was highest in East Godaveri[89.7%(96.8%-82.6%)],followed by Sundergarh[86.4%(95.3%-77.5%)]and Wayanad[69%(81.7%-56.4%)].Conclusions:Our study confirmed overall reduction in FEC although with varying albendazole efficacy for A.lumbricoides infection at three different locations in India.However,these finding may be assessed in context of ongoing MDA under Filaria control program and further studies by in vivo as well as in vitro methods are required to reach to a conclusion on possible resistance if any.
文摘Ascaris lumbricoides (A. lumbricoides), the soil-transmitted helminth is the most prevalent parasitic infection of the gastrointestinal tract in developing countries. Heavy worm loads mainly due to untreated worm infestations are often associated with increased risk of severe sequelae. We report the first complicated case of A. lumbricoides causing small bowel obstruction in a 9-year-old boy that necessitated surgical intervention on a tropical island in the Indian Ocean, where cases of Ascariasis are rarely encountered.
文摘为探讨人蛔虫提取物对肿瘤的作用及其免疫学机制,将45只C57BL/6小鼠随机分为A、B、C、D和E等5组,每组9只,其中B、D组分别为A、C组的实验对照组,E组为阴性对照组,不做任何处理。A组每鼠隔天腹腔注射0.1 ml蛔虫提取物(BEAL),10 d后每鼠右前肢腋下皮下接种0.1 ml Lewis肺癌细胞(LLC),进行肿瘤造模;B组小鼠注射等量生理盐水,10 d后进行肿瘤造模。C组每鼠注射0.1 ml LLC细胞悬液进行肿瘤造模,2 d后腹腔注射0.1 ml BEAL,隔天1次,共注射5次;D组小鼠肿瘤造模2 d后,注射等量生理盐水,隔天1次。记录各组小鼠成瘤时间,称瘤重,计算抑瘤率。结果显示,A、B、C和D组小鼠的成瘤时间分别为(7.0±1.1)、(6.0±0.7)、(9.0±1.2)和(7.0±0.9)d。BEAL提前干预的A组小鼠肿瘤重量为(722.2±413.5)mg,显著重于其对照组B组[(338.9±282.2)mg](P<0.05)。小鼠荷瘤后BEAL干预的C组抑瘤率最强,为33.3%,其肿瘤重量[(237.8±101.8)mg]明显轻于对照组D组[(356.7±176.9)mg](P<0.05)。提示BEAL可影响肿瘤的形成,在一定条件下具有明显的抑瘤作用。
