Background Acute coronary syndrome （ACS） is a leading cause of mortality and morbidity worldwide, which comprises unstable angina （UA） and acute myocardial infarction （AMI）, and the investigation of bio- logical...Background Acute coronary syndrome （ACS） is a leading cause of mortality and morbidity worldwide, which comprises unstable angina （UA） and acute myocardial infarction （AMI）, and the investigation of bio- logical markers to assess those most at risk of recurrent cardiovascular events is necessary. Methods Sixty-six healthy control people and 67 cases of UA patients were enrolled in Guangdong general hospital. Enzyme linked immunosorbent assay （ELISA） was used to detect the level of plasma ACTG2. The receiver operating characteristic curve （ROC） was used to analyze the prediction value of ACTG2 for UA. According to the aver- age level of plasma ACTG2 in UA patients, UA patients were divided into the low ACTG2 group （ 〈 average level） and the high ACTG2 group （≥ average level）, and the differences in clinical characteristics between the two groups were investigated. Results The ELISA result showed that the level of plasma ACTG2 was 67.823 ± 58.479 pg/mL in healthy people, while the plasma ACTG2 was 94.514 ± 65.453 pg/mL in UA pa- tients, with a significant difference （P 〈 0.05）. ROC analysis result showed that the Area under curve（AUC） for the prediction of UA was 0.653 （95% CI 0.559-0.747）, with a high statistical significance, indicating that circulating ACTG2 may possess high prediction value for UA. In addition, among the 67 UA patients, 39 were allocated to the low ACTG2 group and 28 to the high ACTG2 group. Comparison of the baseline charac- teristics between the two groups showed that patients in the high ACTG2 group were older than those in the low ACTG2 group. In addition, levels of Lipoprotein （a）（Lpa）, Total bilirubin（TBIL） and Pro-Brain Natri- uretic Peptide （ProBNP） in the high ACTG2 group were also higher than those in the low ACTG2 group. Conclusions Circulating ACTG2 could significantly increase in UA patients, which may be used as a biomarker for the prediction of UA.展开更多
基金supported by the National Natural Science Foundation of China(No.81270222/81470439)the Natural Science Foundation of the Guangdong Province(No.S2011020005911/S2015010009453)
文摘Background Acute coronary syndrome （ACS） is a leading cause of mortality and morbidity worldwide, which comprises unstable angina （UA） and acute myocardial infarction （AMI）, and the investigation of bio- logical markers to assess those most at risk of recurrent cardiovascular events is necessary. Methods Sixty-six healthy control people and 67 cases of UA patients were enrolled in Guangdong general hospital. Enzyme linked immunosorbent assay （ELISA） was used to detect the level of plasma ACTG2. The receiver operating characteristic curve （ROC） was used to analyze the prediction value of ACTG2 for UA. According to the aver- age level of plasma ACTG2 in UA patients, UA patients were divided into the low ACTG2 group （ 〈 average level） and the high ACTG2 group （≥ average level）, and the differences in clinical characteristics between the two groups were investigated. Results The ELISA result showed that the level of plasma ACTG2 was 67.823 ± 58.479 pg/mL in healthy people, while the plasma ACTG2 was 94.514 ± 65.453 pg/mL in UA pa- tients, with a significant difference （P 〈 0.05）. ROC analysis result showed that the Area under curve（AUC） for the prediction of UA was 0.653 （95% CI 0.559-0.747）, with a high statistical significance, indicating that circulating ACTG2 may possess high prediction value for UA. In addition, among the 67 UA patients, 39 were allocated to the low ACTG2 group and 28 to the high ACTG2 group. Comparison of the baseline charac- teristics between the two groups showed that patients in the high ACTG2 group were older than those in the low ACTG2 group. In addition, levels of Lipoprotein （a）（Lpa）, Total bilirubin（TBIL） and Pro-Brain Natri- uretic Peptide （ProBNP） in the high ACTG2 group were also higher than those in the low ACTG2 group. Conclusions Circulating ACTG2 could significantly increase in UA patients, which may be used as a biomarker for the prediction of UA.
