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Treatment of lacrimal gland adenoid cystic carcinoma:a systematic review and Meta-analysis 被引量:2
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作者 Hai-Han Yan Rui Liu +4 位作者 Nan Wang Liang-Yuan Xu Qi-Han Guo Jing Li Jian-Min Ma 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第1期164-172,共9页
AIM:To evaluate lacrimal gland adenoid cystic carcinoma(LGACC)of prognosis in patients who underwent different treatment regimens.METHODS:We searched PubMed,EMBASE,and the Cochrane Library for studies done on the trea... AIM:To evaluate lacrimal gland adenoid cystic carcinoma(LGACC)of prognosis in patients who underwent different treatment regimens.METHODS:We searched PubMed,EMBASE,and the Cochrane Library for studies done on the treatment of LGACC,between January 1987 and April 2022.A Metaanalysis was conducted to pool the 5-year overall survival rate(OR),and the 5-year recurrence rate(RR)and 5-year metastasis rate(MR)were assessed.RESULTS:The 30 studies involved 585 patients were included in the Meta-analysis.The pooled 5-year OR with surgery alone was 50%,the 5-year RR was 63%,and the 5-year MR was 34%.The pooled 5-year OR with surgery and adjuvant radiotherapy combined was 67%(95%CI 61%,73%),the 5-year RR was 41%,and the 5-year MR was 35%.The pooled 5-year OR with surgery and adjuvant chemoradiotherapy combined was 72%(95%CI 59%,84%),the 5-year RR was 48%,and the 5-year MR was 36%.The pooled 5-year OR with surgery,intra-arterial cytoreductive chemotherapy,and adjuvant chemoradiotherapy combined was 78%(95%CI 68%,89%),the 5-year RR was 15%,and the 5-year MR was 27%.CONCLUSION:Comprehensive treatment is more effective than surgery alone.Surgery combined with intraarterial chemotherapy and adjuvant chemoradiotherapy seems to add value to the therapeutic effect of comprehensive treatment of LGACC but further high-quality research is required to validate this. 展开更多
关键词 adenoid cystic carcinoma lacrimal gland META-ANALYSIS
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阿帕替尼治疗腺样囊性癌肺转移1例
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作者 井溢鑫 丁一鸣 +1 位作者 马廷耀 陈晓红 《中国耳鼻咽喉头颈外科》 CSCD 2024年第2期131-132,共2页
腺样囊性癌(adenoid cystic carcinoma,ACC)是一种较少见的来源于腺体的恶性肿瘤,约占头颈部恶性肿瘤的1%[1]。其病程进展缓慢但极易侵袭,有较高的复发率和远处转移率,最常见的转移部位是肺[2]。对于ACC肺转移患者,目前并无特效药物。MY... 腺样囊性癌(adenoid cystic carcinoma,ACC)是一种较少见的来源于腺体的恶性肿瘤,约占头颈部恶性肿瘤的1%[1]。其病程进展缓慢但极易侵袭,有较高的复发率和远处转移率,最常见的转移部位是肺[2]。对于ACC肺转移患者,目前并无特效药物。MYB基因表达失调是ACC患者最常见的突变。 展开更多
关键词 腺样囊性(Carcinoma Adenoid Cystic) 阿帕替尼(Apatinib) 化疗(Chemotherapy) 基因靶向(Gene Targeting)
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Expression of Innate Immunity Genes in Epithelial Cells of Hypertrophic Adenoids with and without Pediatric Chronic Rhinosinusitis: A Preliminary Report 被引量:4
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作者 Xiao-Peng Qu Zhen-Xiao Huang +10 位作者 Yan Sun Ting Ye Shun-Jiu Cui Qian Huang Li-Jing Ma Qing-Wen Yang Hong Wang Er-Zhong Fan Ying Li Liang Zhang Bing Zhou 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第21期2913-2918,共6页
Background: Adenoid hypertrophy (AH) is associated with pediatric chronic rhinosinusitis (pCRS), but its role in the inflammatory process of pCRS is unclear. It is thought that innate immunity gene expression is ... Background: Adenoid hypertrophy (AH) is associated with pediatric chronic rhinosinusitis (pCRS), but its role in the inflammatory process of pCRS is unclear. It is thought that innate immunity gene expression is disrupted in the epithelium of patients with chronic rhinosinusitis (CRS), including antimicrobial peptides and pattern recognition receptors (PRRs). The aim of this preliminary study was to detect the expression of innate immunity genes in epithelial cells of hypertrophic adenoids with and without pCRS to better understand their role in pCRS. Methods: Nine pCRS patients and nine simple AH patients undergoing adenoidectomy were recruited for the study. Adenoidal epithelium was isolated, and real-time quantitative polymerase chain reaction (RT-qPCR) was employed to measure relative expression levels of the following messenger RNAs in hypertrophic adenoid epithelial cells of pediatric patients with and without CRS: Human β-defensin (HBD) 2 and 3, surfactant protein (SP)-A and D, toll-like receptors 1-10, nucleotide-binding oligomerization domain (NOD)-like receptors NOD 1, NOD 2, and NACHT, LRR and PYD domains-containing protein 3, retinoic acid-induced gene 1, melanoma differentiation-associated gene 5, and nuclear factor-riB (NF-KB). RT-qPCR data from two groups were analyzed by independent sample t-tests and Mann-Whitney U-tests. Results: The relative expression of SP-D in adenoidal epithelium ofpCRS group was significantly lower than that in AH group (pCRS 0.73 ± 0.10 vs. AH 1.21 ±0.15; P = 0.0173, t = 2.654). The relative expression levels of all tested PRRs and NF-κB, as well as HBD-2, HBD-3, and SP-A, showed no statistically significant differences in isolated adenoidal epithelium between pCRS group and AH group. Conclusions: Down-regulated SP-D levels in adenoidal epithelium may contribute to the development of pCRS. PRRs, however, are unlikely to play a significant role in the inflammatory process ofpCRS. 展开更多
关键词 adenoids Epithelial Cell Innate Immunity: Pattern Recognition Receptors Pediatric Chronic Rhinosinusitis
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Anatomy and physiology of the palatine tonsils, adenoids, and lingual tonsils 被引量:7
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作者 Alexandra Arambula Jason RBrown Laura Neff 《World Journal of Otorhinolaryngology-Head and Neck Surgery》 2021年第3期155-160,共6页
Objective::This review aims to discuss the basic anatomy and physiology of the palatine and pharyngeal tonsils,with reference to how this foundational understanding may affect patient management and surgical procedure... Objective::This review aims to discuss the basic anatomy and physiology of the palatine and pharyngeal tonsils,with reference to how this foundational understanding may affect patient management and surgical procedures in these regions of the upper airway.Methods::A literature search was performed using PubMed and Google Scholar using the MeSH terms tonsils,adenoids,anatomy,physiology,and adenotonsillectomy.Primary sources were excluded if they were abstracts only,non-English language,or non-human studies.Thirty-five sources were included in this review.Results and conclusions::The pharyngeal and palatine tonsils are compact yet physiologically complex mucosa-associated lymphoid tissues that make up a portion of Waldeyer’s ring.As part of the mucosal immune system,these structures function in exogenous antigen sampling and stimulation of immune responses.Aberrant immune activation and/or regulation can lead to a myriad of pathologies,with adenotonsillar hypertrophy,chronic tonsillitis/adenoiditis,and recurrent otitis media among the most commonly encountered conditions by otolaryngologists.While the pathophysiology of these conditions is still incompletely understood,current evidence and future investigations may reveal patterns amenable to targeted medical management.When medical management fails,tonsillectomy and/or adenoidectomy may be indicated for patient care.Though routine procedures,the execution of tonsil and/or adenoid removal requires a thorough understanding of the anatomy of these lymphoepithelial organs so as to minimize the risk for rare serious complications that can occur. 展开更多
关键词 Anatomy of tonsils adenoids Waldeyer’s ring
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Prognostic factors for lacrimal gland adenoid cystic carcinoma:a retrospective study in Chinese patients
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作者 Lu-Di Yang Shi-Chong Jia +3 位作者 Jie Yang Xin Song Ye-Fei Wang Xian-Qun Fan 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第8期1423-1430,共8页
AIM:To explore the prognostic factors for lacrimal gland adenoid cystic carcinoma(LGACC)in Chinese patients.METHODS:Clinical and histopathological data were reviewed in patients with pathologically confirmed LGACC.Loc... AIM:To explore the prognostic factors for lacrimal gland adenoid cystic carcinoma(LGACC)in Chinese patients.METHODS:Clinical and histopathological data were reviewed in patients with pathologically confirmed LGACC.Local recurrence,metastasis,and disease-specific death were the main outcome measures.Univariate and multivariate analyses were performed by the Kaplan-Meier method and a Cox proportional hazard model.RESULTS:This retrospective cohort study included 45 patients with pathologically confirmed LGACC between January 2008 and June 2022.Tumor(T)classification(P=0.005),nodal metastasis(N)classification(P=0.018)and positive margin(P=0.008)were independent risk factors of recurrence;T(P=0.013)and N(P=0.003)classification and the basaloid tumor type(P=0.032)were independent risk factors for metastasis;T classification(P<0.001)was an independent factor of death of disease.In the further analysis,the durations from first surgery to radiotherapy is correlated with metastatic risk in LGACC patients with basaloid component(P=0.022).CONCLUSION:Histological subtype should be emphasized when evaluating prognosis and guiding treatment.Timely radiotherapy may reduce the risk of metastasis in patients with basaloid component. 展开更多
关键词 lacrimal gland adenoid cystic carcinoma risk factors prognostic analysis histological subtypes
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Optimizing surgical approaches for lacrimal gland adenoid cystic carcinoma to minimize cross-organ invasion
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作者 Ming-Shen Ma Ting-Ting Ren +4 位作者 Fu-Xiao Luan Jing Li Nan Wang Yong Tao Jian-Min Ma 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第10期1949-1952,共4页
AIM:To evaluate the outcomes of eye-sparing surgery for lacrimal gland adenoid cystic carcinoma and the impact on tumor recurrence and orbital integrity.METHODS:The study enrolled four patients with recurrent lacrimal... AIM:To evaluate the outcomes of eye-sparing surgery for lacrimal gland adenoid cystic carcinoma and the impact on tumor recurrence and orbital integrity.METHODS:The study enrolled four patients with recurrent lacrimal gland adenoid cystic carcinoma.The outcome focused on the relevance of the integrity of the lateral orbital wall to the occurrence of extraorbital metastasis in the local recurrence of lacrimal gland adenoid cystic carcinoma.RESULTS:Three patients underwent eye-sparing surgery via lateral orbitotomy without postoperative radiotherapy,and one patient who underwent eye-sparing surgery via sub-brow approach.These four patients all demonstrated a recurrence involving the invasion of extraorbital tissues as metastatic form through surgical bone seams.CONCLUSION:Preserving intact orbital bone tissue is crucial for mitigating direct cross-organ metastasis of lacrimal gland adenoid cystic carcinoma.The findings suggest avoiding the lateral orbitotomy approach with no or limited orbital bone wall invasion. 展开更多
关键词 lacrimal gland adenoid cystic carcinoma RECURRENCE eye-sparing surgery
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Rare esophageal carcinoma-primary adenoid cystic carcinoma of the esophagus: A case report
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作者 Li-Dan Geng Jie Li +1 位作者 Li Yuan Xiao-Bo Du 《World Journal of Clinical Cases》 SCIE 2024年第3期630-636,共7页
BACKGROUND Esophageal adenoid cystic carcinoma(EACC)is an exceedingly rare malignant tumor of the esophagus,posing significant challenges in the clinic.CASE SUMMARY This report detailed the case of a 72-year-old male ... BACKGROUND Esophageal adenoid cystic carcinoma(EACC)is an exceedingly rare malignant tumor of the esophagus,posing significant challenges in the clinic.CASE SUMMARY This report detailed the case of a 72-year-old male whose diagnosis of EACC was confirmed through postoperative histopathological examination.The patient underwent thoracoscopy-assisted radical resection of the esophageal tumor,coupled with lymph node dissection.Pathological findings revealed an adenoid cystic carcinoma infiltrating the entire layer of the muscularis propria,locally extending into the outer membrane of the esophageal fiber,involving the cardia and exhibiting no lymph node metastasis.The patient’s condition was classified as primary EACC,T3N0M0,per the American Joint Committee on Cancer(2017;8th edition).One month after surgery,the patient received postoperative adjuvant radiation therapy.CONCLUSION In addressing the rarity and high potential for biopsy misdiagnosis of EACC,this study delved into its diagnostic methods and treatment. 展开更多
关键词 Esophageal adenoid cystic carcinoma Malignant tumor Lymph node dissection Adjuvant radiation therapy MISDIAGNOSIS Case report
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Anal metastasis in esophageal cancer:A case report
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作者 Lu Xu Rui Xu Jing Sun 《World Journal of Clinical Cases》 SCIE 2024年第19期3925-3930,共6页
BACKGROUND Esophageal cancer is the sixth leading cause of cancer-related death and eighth most common cancer,affecting>450000 people worldwide.Esophageal squamous cell carcinoma is the most common histological typ... BACKGROUND Esophageal cancer is the sixth leading cause of cancer-related death and eighth most common cancer,affecting>450000 people worldwide.Esophageal squamous cell carcinoma is the most common histological type,whereas esophageal adenoid cystic carcinoma(EACC)is rare.The liver is the most common distant metastatic site in esophageal cancer.Anal metastasis is rare and has not been reported in clinical practice before.Here,we report anal metastases in a patient with EACC after regular chemotherapy and surgical resection.CASE SUMMARY A 61-year-old esophageal cancer patient was found to have lung and brain metastases during standardized treatment.The patient’s treatment plan was continuously adjusted according to the latest treatment guidelines.However,the patient subsequently noticed rectal bleeding and itching,and after obtaining pathology results at the local hospital,anal metastasis of esophageal cancer was diagnosed.CONCLUSION Postoperative pathology and immunohistochemistry confirmed EACC with rare anal metastasis.More exploration of EACC diagnosis and treatment is needed. 展开更多
关键词 Esophageal cancer Esophageal adenoid cystic carcinoma METASTASIS Anus metastasis Treatment Case report
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Ethmoidal Polyposis, Adenoid Hypertrophy and Tympanic Membrane Perforation—A Case Report
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作者 Ahmad Mahmud Mohammed Bello Fufore +4 位作者 Abubakar Umar Hamisu Abdullahi Thomas Musa Samdi Auwal Adamu Onyekwere George B. Nwaorgu 《International Journal of Otolaryngology and Head & Neck Surgery》 2024年第3期178-186,共9页
Background: Ethmoidal polyposis coexisting with adenoid enlargement and tympanic membrane perforation is a rare condition in otolaryngological practice. Evidences have shown that antrochoanal polyp often times coexist... Background: Ethmoidal polyposis coexisting with adenoid enlargement and tympanic membrane perforation is a rare condition in otolaryngological practice. Evidences have shown that antrochoanal polyp often times coexists with adenoid enlargement especially in the young which was in sharp contrast to ethmoidal polyposis occurring in the presence of adenoid enlargement. Moreover, the hidden location of nasopharynx housing the adenoids, coupled with the masking effect of bilateral sinonasal polyps, leads to inadvertent misdiagnosis of this complex pathology with subsequent difficulty in providing effective management. Case Presentation: A 24 year-old lady presented with recurrent bilateral nasal obstruction that became persistent associated with nasal discharge and anosmia. She also had recurrent right otorrhoea with associated hearing loss. Diagnostic rigid nasal endoscopy revealed mucoid discharge with bilateral polypoid masses filling both nasal cavities. Otoendoscopic finding revealed a small (about 5%) central tympanic membrane perforation. A clinical assessment of chronic rhinosinusitis with nasal polyposis complicated by chronic suppurative otitis media (CSOM) was made. A non-contrast CT scan of the paranasal sinuses showed isodense lesions in the nasal cavities, all paranasal sinuses and the entire nasopharynx. She had endoscopic sinus surgery and a nasopharyngeal clearance biopsy. The nasal, paranasal and nasopharyngeal masses had histologic confirmation of inflammatory nasal polyps and lymphoid (adenoid) hyperplasia respectively. Her condition improved remarkably with subsequent medical treatment. She was followed up for 8 months and no recurrence was observed. Conclusion: Sinonasal polyposis can coexist with adenoid hypertrophy and middle ear disease as a single pathological condition. Hence, a high index of suspicion and thorough evaluation become necessary for making timely diagnoses and instituting effective management. 展开更多
关键词 Sino-Nasal Polyps Adenoid Enlargement RHINOSINUSITIS Otitis Media Endoscopic Sinus Surgery
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Development patterns of adenoids in Chinese children without sleep-disordered breathing: a retrospective magnetic resonance imaging study with consecutive age groups 被引量:1
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作者 Xiao-Li Yi Un-Yin Yao +2 位作者 Peng-Fei Zhao Xin-Yu Yuan Zhen-Chang Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2021年第12期1500-1502,共3页
To the Editor:Sleep-disordered breathing(SDB)is a health problem affecting approximately 12%of children in China,[1]characterized by habitual loud snoring and increased respiratory effort.Increased upper airway resist... To the Editor:Sleep-disordered breathing(SDB)is a health problem affecting approximately 12%of children in China,[1]characterized by habitual loud snoring and increased respiratory effort.Increased upper airway resistance related to enlarged adenoids has been identified as the most common cause in children with obstructive SDB,and adenoidectomy is the standard treatment for the disorder.Similar to lymphoid tissues,adenoids show a unique natural growth pattern,which incorporates both overgrowth and involution.However,the development patterns of adenoids have not been clearly elucidated.Since the adenoids are located in the nasopharynx roof,direct evaluation of their size and proportion to the upper airway area is difficult.Thus,radiological methods have been employed widely for such purposes,including traditional plain cranial radiographs,computed tomography(CT),cone-beam CT,and magnetic resonance imaging(MRI).MRI can reveal the accurate size of adenoids by differentiating them from other soft tissue structures without any ionizing radiation;therefore,it can effectively study the adenoids’developmental pattern in normal children.Previous studies have evaluated age-associated changes in adenoid size by MRI.Arens et al[2]indicated that adenoids grow proportionally to the skeletal structures in children aged 1 to 11 years.Papaioannou et al[3]reported that head MRI examinations demonstrated increased adenoid size during the first 7–8 years of life and then decreased gradually in children without snoring signs.Variabilities of the above-reported adenoids’development pattern exist due to the limitations associated with the small sample size.Furthermore,none of the above-mentioned studies on normal children used a strict method to exclude SDB.Additionally,for adenoid hypertrophy,the adenoid/nasopharyngeal(A/N)ratio was found to be a useful,tolerable,and confident diagnostic method in pediatric patients,with emphasis on the correlation of the adenoid size and upper airway lumen to variable degrees.Therefore,the A/N ratio can be considered a useful objective tool in evaluating adenoid development in children.We aimed to investigate the growth and involution patterns of adenoids in consecutive age groups from birth to 16 years in Chinese children without SDB using MRI data,which may benefit the study of diseases associated with the development of adenoids. 展开更多
关键词 ADENOID RESONANCE CHILDREN
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Comparison of biological behavior of lacrimal gland adenoid cystic carcinoma with high-grade transformation cells 被引量:2
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作者 Chuan-Li Zhang Li-Min Zhu +3 位作者 Xun Liu Mei-Xia Jiang Ting-Ting Lin Yan-Jin He 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第2期163-171,共9页
AIM:To evaluate the differences between human lacrimal gland adenoid cystic carcinoma with high-grade transformation(LACC-HGT)primar y cells cultured by high-grade transformation tissue and non-high-grade transformati... AIM:To evaluate the differences between human lacrimal gland adenoid cystic carcinoma with high-grade transformation(LACC-HGT)primar y cells cultured by high-grade transformation tissue and non-high-grade transformation(non-HGT)primary cells cultured by non-highgrade transformation tissue in proliferation,metastasis,drug susceptibility,and genes.METHODS:LACC-HGT primary cells were established by tissue block culture,and the 4^(th)to 10^(th)generation primary cells were selected as research objects.The cells were preliminarily identified by immunofluorescent staining.The differences between non-HGT and LACC-HGT primary cells in terms of proliferation,metastasis,and drug susceptibility were compared by cell counting kit-8(CCK-8)assay,wound healing,and drug sensitivity experiments.Differentially expressed genes were screened using mRNA array.Gene expression was analyzed using real-time quantitative polymerase chain reaction(RT-qPCR).RESULTS:LACC-HGT primary cells were successfully cultured by tissue block culture.Immunofluorescence staining results showed that cytokeratin(CK)and CK7 expression levels were positive in LACC-HGT primary cells.CCK-8 results showed that the proliferation ability of LACCHGT cells was significantly higher than that of non-HGT cells.Wound healing experiment showed that the migration ability of LACC-HGT cells was significantly higher than that of non-HGT cells.LACC-HGT cells were also less sensitive to cisplatin and paclitaxel than non-HGT cells.Compared with non-HGT cells,9566 differentially expressed genes were found in LACC-HGT primary cells,of which 5162 were upregulated and 4404 were down-regulated.The expression of N-acetylneuraminate pyruvate lyase(NPL),MARVEL domain containing 3(MARVELD3),syntabulin(SYBU),and allograft inflammatory factor 1(AIF1)was higher in LACCHGT cells than in non-HGT cells,whereas that of periostin(POSTN)was lower.CONCLUSION:LACC-HGT primary cells have faster proliferation,stronger migration ability,and poorer sensitivity to chemotherapy drugs than non-HGT primary cells.The expression of mRNAs in non-HGT and LACC-HGT primary cells are significantly different.These features are speculated to be the reasons why high-grade transformation tissues exhibit higher malignant degree and poorer prognosis than their counterparts. 展开更多
关键词 lacrimal gland lacrimal gland adenoid cystic carcinoma high-grade transformation primary cell culture biological behavior mRNA array
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Preliminary proteomic analysis of human tears in lacrimal adenoid cystic carcinoma and pleomorphic adenoma 被引量:1
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作者 Han Yue Feng-Xi Meng +1 位作者 Rui Zhang Jiang Qian 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第6期841-848,共8页
·AIM: To detect proteomic differences in tears between adenoid cystic carcinoma(ACC) and pleomorphic adenoma(PA).·METHODS: Tear samples were collected from 4 patients with ACC, 5 with PA, and 4 control cases... ·AIM: To detect proteomic differences in tears between adenoid cystic carcinoma(ACC) and pleomorphic adenoma(PA).·METHODS: Tear samples were collected from 4 patients with ACC, 5 with PA, and 4 control cases. Label-free analysis and parallel reaction monitoring(PRM) were used to screen and validate the tear proteome. Gene Ontology(GO) annotation and Kyoto Encyclopedia of Genes and Genomes(KEGG) were conducted for bioinformatics analysis.·RESULTS: In total, 1059 proteins in tear samples were identified by label-free analysis. Between ACC and PA, 415 differentially expressed proteins were detected. Based on the GO annotation, enzyme regulator activity and serinetype endopeptidase inhibitor activity in the molecular function category, blood microparticle and extracellular matrix in the cellular component category, and response to nutrient levels in the biological process category were most predominant. By KEGG pathway annotation, the different proteins between ACC and PA mainly par ticipated in complement and coagulation cascades, amoebiasis, African trypanosomiasis and cholesterol metabolism. Eight proteins with mostly significant differences were verified by PRM, and five proteins with more than 10-fold increases in ACC compared with PA, including integrin β, α-2-macroglobulin, epididymal secretory sperm binding protein Li 78p, RAB5C, and complement C5, were identified.·CONCLUSION: The combined tools of label-free analysis and PRM are very effective and efficient, especially for samples such as tears. Some proteomic dif ferences in tears between ACC and PA are identified and these protein candidates may be specific biomarkers for future exploration. 展开更多
关键词 adenoid cystic carcinoma pleomorphic adenoma TEAR PROTEOME
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TACC diagnosed by transoesophageal endoscopic ultrasonography:A case report
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作者 Xiao-Xin Pu Qin-Wei Xu Bao-Yi Liu 《World Journal of Clinical Cases》 SCIE 2023年第16期3847-3851,共5页
BACKGROUND Primary adenoid cystic carcinoma in the trachea(TACC)is a rare tumour.Tracheal bronchoscopy is always chosen as a routine approach to obtain a pathological diagnosis,but it can be associated with an increas... BACKGROUND Primary adenoid cystic carcinoma in the trachea(TACC)is a rare tumour.Tracheal bronchoscopy is always chosen as a routine approach to obtain a pathological diagnosis,but it can be associated with an increased risk of asphyxia.CASE SUMMARY We describe a case of TACC in a patient evaluated by chest computed tomography(CT)with three-dimensional reconstruction imaging and diagnosed by transoesophageal endoscopic ultrasonography.The pathological diagnosis confirmed tracheal adenoid cystic carcinoma.CONCLUSION We highlight the importance of CT and provide a successful exploration of transoesophageal biopsy as a safe alternative approach. 展开更多
关键词 Adenoid cystic carcinoma Tracheal obstruction Transoesophageal endoscopic ultrasonography Three-dimensional computed tomography reconstruction Case report
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腺样体肥大儿童伴变应性鼻炎与分泌性中耳炎的相关性 被引量:9
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作者 闫宏岭 田佳新 +2 位作者 葛玥铭 陈丽君 周雪冰 《中国耳鼻咽喉头颈外科》 CSCD 2015年第2期103-104,共2页
分泌性中耳炎影响患儿听力,甚至影响语言、交流能力发育[1],若不能进行合理治疗,可能会造成儿童听力障碍以及言语与治疗发育不良。近几年临床研究显示,该疾病与儿童腺样体肥大以及变应性鼻炎存在一定关系。本文选择我院曾接收的存在腺... 分泌性中耳炎影响患儿听力,甚至影响语言、交流能力发育[1],若不能进行合理治疗,可能会造成儿童听力障碍以及言语与治疗发育不良。近几年临床研究显示,该疾病与儿童腺样体肥大以及变应性鼻炎存在一定关系。本文选择我院曾接收的存在腺样体肥大病史的患儿500例,对其变应性鼻炎、咽鼓管功能不良以及分泌性中耳炎相关性进行分析。1.1资料来源。2012年1月~2012年12月我院住院的腺样体肥大患儿500例,腺样体肥大程度为3~4度阻塞。 展开更多
关键词 增殖腺(adenoids) 儿童(Child) 鼻炎 变应性 常年性(Rhinitis Allergic Perennial) 中耳炎 伴渗出液(Otitis Media with Effusion)
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上颌窦气化程度与腺样体肥大相关性分析 被引量:5
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作者 闫宏岭 田佳新 +2 位作者 葛玥铭 周雪冰 李光民 《中国耳鼻咽喉头颈外科》 CSCD 2015年第1期49-50,共2页
上颌窦(maxillary sinus)是颌面部的重要解剖结构。很多研究表明成人上颌窦形态与睡眠呼吸暂停综合征密切相关[1]。一般认为其气化程度受遗传因素影响,也有学者研究同卵双生的双胞胎其上颌窦容积亦有差别,说明后天因素在气化过程中亦有... 上颌窦(maxillary sinus)是颌面部的重要解剖结构。很多研究表明成人上颌窦形态与睡眠呼吸暂停综合征密切相关[1]。一般认为其气化程度受遗传因素影响,也有学者研究同卵双生的双胞胎其上颌窦容积亦有差别,说明后天因素在气化过程中亦有重要作用。上颌窦形态异常造成的睡眠呼吸暂停综合征很难通过手术或其他方式来改善,因此发现影响上颌窦气化的因素并早期加以干预,具有重要临床意义。在临床工作中, 展开更多
关键词 上颌窦(Maxillary Sinus) 增殖腺(adenoids) 儿童(Child)
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腺样体肥大患儿机体免疫功能变化研究 被引量:15
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作者 王娟 苏金柱 +1 位作者 温鑫 王登茂 《中国耳鼻咽喉头颈外科》 CSCD 2015年第12期635-636,共2页
<正>腺样体也称咽扁桃体或增殖体,属于淋巴组织,表面呈桔瓣样。正常生理情况下,儿童6~7岁时腺样体发育至最大,青春期后逐渐萎缩,成人后基本消失~[1]。腺样体位于鼻咽顶后壁处,病理性肥大易引起鼻堵、张口呼吸、耳闷、听力下降等症... <正>腺样体也称咽扁桃体或增殖体,属于淋巴组织,表面呈桔瓣样。正常生理情况下,儿童6~7岁时腺样体发育至最大,青春期后逐渐萎缩,成人后基本消失~[1]。腺样体位于鼻咽顶后壁处,病理性肥大易引起鼻堵、张口呼吸、耳闷、听力下降等症状,最终造成慢性鼻-鼻窦炎、阻塞性睡眠呼吸暂停低通气综合征及分泌性中耳炎等疾病,给儿童的颌面骨发育、智力发育造成严重影响。 展开更多
关键词 儿童(Child) 免疫球蛋白类(Immunoglobulins) T淋巴细胞亚群(T-Lymphocyte Subsets) 腺样体肥大(adenoid vegetation)
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阻塞性腺样体和扁桃体肥大与胰岛素样生长因子系统 被引量:1
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作者 陈敏 刘立中 《国外医学(耳鼻咽喉科学分册)》 2005年第5期269-271,共3页
阻塞性腺样体和扁桃体肥大可能引起儿童生长发育异常,其病理生理机制尚不明确。本文就血清胰岛素样生长因子-1(insulin-likegrowthfactorI,IGF-1)/胰岛素样生长因子结合蛋白-3(insulin-likegrowthfactor-bindingprotein3,IGFBP-3)概况... 阻塞性腺样体和扁桃体肥大可能引起儿童生长发育异常,其病理生理机制尚不明确。本文就血清胰岛素样生长因子-1(insulin-likegrowthfactorI,IGF-1)/胰岛素样生长因子结合蛋白-3(insulin-likegrowthfactor-bindingprotein3,IGFBP-3)概况及其在阻塞性腺样体和扁桃体肥大患儿生长激素分泌异常诊断和疗效判断方面的意义进行综述。 展开更多
关键词 胰岛素样生长因子1(Insulin-Like GROWTH FACTOR Ⅰ) 胰岛素样生长因子结合蛋白质3(Insulin-Like GROWTH FACTOR Binding Protein 3) 增殖腺(adenoids) 肥大(Hypertrophy) 胰岛素样生长因子系统
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鼻内镜下腺样体刮除术60例临床观察 被引量:1
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作者 王海妹 周学军 《海南医学》 CAS 2006年第5期123-123,共1页
关键词 腺样体(Adenoid) 内窥镜(Endoseopes)
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头颈部腺样囊性癌48例
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作者 黄光武 农辉图 +3 位作者 邝国乾 陈陵 庆建纲 欧子民 《广西医科大学学报》 CAS 1993年第1期80-82,共3页
腺样囊性癌(adenoid cystic carcinoma简称ACC)是涎腺常见的恶性肿瘤之一,多见于涎腺,也可发生于头颈其他部位。为了提高对本病的认识,根据我院治疗的病例,结合近年文献,对其临床特征、诊断和治疗等方面进行讨论。
关键词 腺样囊性癌 涎腺 ADENOID 复发灶 术前放疗 根治性手术 口底 肿瘤复发 肿瘤分类 鼻咽部
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抑癌基因与腺样囊性癌关系的研究进展
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作者 唐黎黎 农晓琳 《广东医学》 CAS CSCD 北大核心 2014年第21期3424-3426,共3页
腺样囊性癌(adenoid cystic carcinoma,ACC)可发生于涎腺、泪腺、汗腺、乳腺以及上颌窦内、气管支气管等部位内壁的腺体等全身各部外分泌腺组织,因好发于大小涎腺中较小腺体,近年对涎腺来源的腺样囊性癌研究较为深入。腺样囊性癌生长... 腺样囊性癌(adenoid cystic carcinoma,ACC)可发生于涎腺、泪腺、汗腺、乳腺以及上颌窦内、气管支气管等部位内壁的腺体等全身各部外分泌腺组织,因好发于大小涎腺中较小腺体,近年对涎腺来源的腺样囊性癌研究较为深入。腺样囊性癌生长速度缓慢,但由于其嗜神经血管生长及易远处转移的特点,使得腺样囊性癌易复发、早期转移率高,需要随访的周期较长。 展开更多
关键词 腺样囊性癌 涎腺组织 抑癌基因 ADENOID 小涎腺 气管支 外分泌腺 细胞周期 肿瘤血管生成 细胞凋亡
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