A novel series of 5-（（5-substituted-1H-1,2,4-triazol-3-yl）methyl）-4,5,6,7-tetrahydrothieno[3,2-c]pyr- idines 5（a-i） has been synthesized from thienopyridine hydrazide, substituted aromatic nitriles using 4- dime...A novel series of 5-（（5-substituted-1H-1,2,4-triazol-3-yl）methyl）-4,5,6,7-tetrahydrothieno[3,2-c]pyr- idines 5（a-i） has been synthesized from thienopyridine hydrazide, substituted aromatic nitriles using 4- dimethylaminopyridine （DMAP） as a catalyst under microwave irradiation and evaluated for their in vitro antifungal activity. Compound 5g is found to be more potent against Candida albicans when compared with miconazole. Docking study of the newly synthesized compounds was performed, and results showed good binding mode in the active site of fungal enzyme P450 cytochrome lanosterol 14α- demethylase. ADMET properties of synthesized compounds were also analyzed and showed good drug like properties. The results of in vitro antifungal activity, docking study and ADMET prediction revealed that the synthesized compounds have potential antifungal activity and can be further optimized and developed as a lead compound.展开更多
文摘A novel series of 5-（（5-substituted-1H-1,2,4-triazol-3-yl）methyl）-4,5,6,7-tetrahydrothieno[3,2-c]pyr- idines 5（a-i） has been synthesized from thienopyridine hydrazide, substituted aromatic nitriles using 4- dimethylaminopyridine （DMAP） as a catalyst under microwave irradiation and evaluated for their in vitro antifungal activity. Compound 5g is found to be more potent against Candida albicans when compared with miconazole. Docking study of the newly synthesized compounds was performed, and results showed good binding mode in the active site of fungal enzyme P450 cytochrome lanosterol 14α- demethylase. ADMET properties of synthesized compounds were also analyzed and showed good drug like properties. The results of in vitro antifungal activity, docking study and ADMET prediction revealed that the synthesized compounds have potential antifungal activity and can be further optimized and developed as a lead compound.
