For investigating the biological function of ADPR, four novel analogues （compounds 2-5） in which the pyrophosphate linkage was replaced by the aspartic acid dipeptide were synthesized. 5＇-Amino adenosine or its ana...For investigating the biological function of ADPR, four novel analogues （compounds 2-5） in which the pyrophosphate linkage was replaced by the aspartic acid dipeptide were synthesized. 5＇-Amino adenosine or its analogues was used as the starting material, liquid phase peptide synthesis strategy was used to construct these ADPR analogues. The structures were characterized by 1H NMR and HRMS spectra. This study provides a versatile synthesis of peptide modified ADPR analogues and helps to understand the structure-activity relationship of ADPR.展开更多
Glia-neuron interaction is an integral part of signaling networks in the brain. Abundant evidence has suggested a pivotal role for glia in neuronal survival and activity [1-3], yet the mechanisms that lead to neurogli...Glia-neuron interaction is an integral part of signaling networks in the brain. Abundant evidence has suggested a pivotal role for glia in neuronal survival and activity [1-3], yet the mechanisms that lead to neuroglial crosstalk have not been well elucidated, nor has the diverse function of the exchange and transfer for materials between the two types of cells. Intriguingly, glia have been demonstrated as the recipients of axonal mitochondria from retinal ganglion cells [4]. This transcellular degradation of mitochondria provides an excellent example of how glia and neurons communicate, and prompts us to reconsider the importance and implications of how dysfunctional neuroglial crosstalk might underlie possible causes of brain diseases.展开更多
基金National Natural Science Foundation of China(Grant No.20472007)the Research Found for the DocroralProgram of Higher Education
文摘For investigating the biological function of ADPR, four novel analogues （compounds 2-5） in which the pyrophosphate linkage was replaced by the aspartic acid dipeptide were synthesized. 5＇-Amino adenosine or its analogues was used as the starting material, liquid phase peptide synthesis strategy was used to construct these ADPR analogues. The structures were characterized by 1H NMR and HRMS spectra. This study provides a versatile synthesis of peptide modified ADPR analogues and helps to understand the structure-activity relationship of ADPR.
文摘Glia-neuron interaction is an integral part of signaling networks in the brain. Abundant evidence has suggested a pivotal role for glia in neuronal survival and activity [1-3], yet the mechanisms that lead to neuroglial crosstalk have not been well elucidated, nor has the diverse function of the exchange and transfer for materials between the two types of cells. Intriguingly, glia have been demonstrated as the recipients of axonal mitochondria from retinal ganglion cells [4]. This transcellular degradation of mitochondria provides an excellent example of how glia and neurons communicate, and prompts us to reconsider the importance and implications of how dysfunctional neuroglial crosstalk might underlie possible causes of brain diseases.
