Once a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the decision to discontinue AED should be balanced against continuation of AED therapy indefinitely. Studies...Once a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the decision to discontinue AED should be balanced against continuation of AED therapy indefinitely. Studies show that the rate of seizure recurrence after AED withdrawal is about two to three times the rate in patients who continue AEDs. However, there are many benefits to AED withdrawal that should be evaluated on an individualized basis. AED discontinuation may be considered in patients whose seizures have been completely controlled for a prolonged period. There are several factors that would increase risk of recurrences which will be reviewed and discussed. As a consequence, the decision to withdraw or withhold treatment must be still individualized. In any patient, the decision to discontinue treatment should also take into effect the social aspects like driving license, job and leisure activities as well as emotional and personal factors and patients with adverse effects or drug interactions. Patients will ultimately have to decide themselves whether they wish to discontinue drug treatment.展开更多
抗癫痫药物(antiepileptic drugs,AEDs)是癫痫最主要的治疗手段,与此同时与AEDs相关的不良反应也受到广泛关注。对骨代谢的影响主要表现为骨代谢指标异常、骨密度(bone mineral density,BMD)降低,进而引起骨质疏松、骨折等。据统计,癫...抗癫痫药物(antiepileptic drugs,AEDs)是癫痫最主要的治疗手段,与此同时与AEDs相关的不良反应也受到广泛关注。对骨代谢的影响主要表现为骨代谢指标异常、骨密度(bone mineral density,BMD)降低,进而引起骨质疏松、骨折等。据统计,癫痫患者的骨折率是普通人群的2~6倍[1],且超过50%服用抗癫痫药物的癫痫患者报告有骨骼异常[2]。由于早期骨代谢异常往往没有明确的症状,常被人们忽视。展开更多
生酮饮食（ketogenic diet,KD）是一种高脂肪、适量蛋白质、低碳水化合物的饮食组合,通过模拟饥饿状态下机体主要分解脂肪产生能量,进而利用脂肪代谢产物—酮体（乙酰乙酸、β-羟丁酸和丙酮）而抑制癫痫发作。1921年Wilder R M博士[1]...生酮饮食（ketogenic diet,KD）是一种高脂肪、适量蛋白质、低碳水化合物的饮食组合,通过模拟饥饿状态下机体主要分解脂肪产生能量,进而利用脂肪代谢产物—酮体（乙酰乙酸、β-羟丁酸和丙酮）而抑制癫痫发作。1921年Wilder R M博士[1]就曾提出禁食后通过改变饮食中营养素的比例可减少癫痫的发生,展开更多
文摘Once a patient has initiated an antiepileptic drug (AED) and achieved a sustained period of seizure freedom, the decision to discontinue AED should be balanced against continuation of AED therapy indefinitely. Studies show that the rate of seizure recurrence after AED withdrawal is about two to three times the rate in patients who continue AEDs. However, there are many benefits to AED withdrawal that should be evaluated on an individualized basis. AED discontinuation may be considered in patients whose seizures have been completely controlled for a prolonged period. There are several factors that would increase risk of recurrences which will be reviewed and discussed. As a consequence, the decision to withdraw or withhold treatment must be still individualized. In any patient, the decision to discontinue treatment should also take into effect the social aspects like driving license, job and leisure activities as well as emotional and personal factors and patients with adverse effects or drug interactions. Patients will ultimately have to decide themselves whether they wish to discontinue drug treatment.
文摘抗癫痫药物(antiepileptic drugs,AEDs)是癫痫最主要的治疗手段,与此同时与AEDs相关的不良反应也受到广泛关注。对骨代谢的影响主要表现为骨代谢指标异常、骨密度(bone mineral density,BMD)降低,进而引起骨质疏松、骨折等。据统计,癫痫患者的骨折率是普通人群的2~6倍[1],且超过50%服用抗癫痫药物的癫痫患者报告有骨骼异常[2]。由于早期骨代谢异常往往没有明确的症状,常被人们忽视。
文摘生酮饮食（ketogenic diet,KD）是一种高脂肪、适量蛋白质、低碳水化合物的饮食组合,通过模拟饥饿状态下机体主要分解脂肪产生能量,进而利用脂肪代谢产物—酮体（乙酰乙酸、β-羟丁酸和丙酮）而抑制癫痫发作。1921年Wilder R M博士[1]就曾提出禁食后通过改变饮食中营养素的比例可减少癫痫的发生,
