THE β-like globin gene cluster in human is very homologous to that in mouse. The locuscontrol region (LCR) which is contained in 20 kb upstream of the E-globin gene consists offour erythrold-specif1c DNaseⅠhypersens...THE β-like globin gene cluster in human is very homologous to that in mouse. The locuscontrol region (LCR) which is contained in 20 kb upstream of the E-globin gene consists offour erythrold-specif1c DNaseⅠhypersensitive sites (HS1-HS4) (flg. 1 ). It has beenknown that LCR is critical for the high-level expression of globin genes; its deletion might re-sult in disorder of globin gene expression, even induce severe anemia. Recently,展开更多
文摘THE β-like globin gene cluster in human is very homologous to that in mouse. The locuscontrol region (LCR) which is contained in 20 kb upstream of the E-globin gene consists offour erythrold-specif1c DNaseⅠhypersensitive sites (HS1-HS4) (flg. 1 ). It has beenknown that LCR is critical for the high-level expression of globin genes; its deletion might re-sult in disorder of globin gene expression, even induce severe anemia. Recently,
