Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform （DOX@PEG-Ag2S） obtained by loading the anti-canc...Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform （DOX@PEG-Ag2S） obtained by loading the anti-cancer drug doxorubicin （DOX） into polyethylene glycol-coated silver sulfide quantum dots （PEG-Ag2S QDs） through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability （93 wt.% of DOX to Ag2S QDs）, long circulation in blood （t1/2 = 10.3 h）, and high passive tumor-targeting efficiency （8.9% ID/gram） in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose （ID） per gram of tissue. After targeting the tumor tissue, DOX from PEG-AgRS cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window （NIR-II）, the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.展开更多
Last two decades,with the rapid changes and development of nanotechnology and biological materials,diverse multi-functional nanomaterials emerging,which offers a novel way to treat and diagnose diseases,and therefore ...Last two decades,with the rapid changes and development of nanotechnology and biological materials,diverse multi-functional nanomaterials emerging,which offers a novel way to treat and diagnose diseases,and therefore spawned the new biomedical technology of theranostics,which integrates the treatment and diagnosis or monitoring of diseases into one.Ag2S as a bio-nanomaterial with low biotoxicity has attracted more and more attention due to its good photoluminescence properties and fluorescence imaging of small animals in the second near-infrared region(NIR-Ⅱ).Meanwhile,Ag2S has the ability to absorb near-infrared light strongly because of its local surface plasma resonance(LSPR)effect and had become a kind of photothermal conve rters with good photothermal conve rsion efficiency.More interestingly,both photothermal effect and fluorescence characteristics of Ag2S nanoparticles(NPs)are closely related to their particle sizes.However,the relationship between photothermal effect and fluorescence characteristics of Ag2S NPs and their sizes has not been reviewed so far.Herein,the synthesis methods and influencing factors of synthesize Ag2S NPs with different sizes were compared firstly,and then the photothermal effect and fluorescence characte ristics of Ag2S NPs with different sizes were summarized.Finally,the possibilities and challenges of using Ag2S NPs to construct theranostic agent were discussed in the end.展开更多
Highly ordered Ag2 S/ZnS/ZnO nanorod array film photoanodes were prepared on a Ti substrate for photocathodic cathodic protection.The results indicated that the photoresponse range of the Ag2S/ZnS/ZnO composite film w...Highly ordered Ag2 S/ZnS/ZnO nanorod array film photoanodes were prepared on a Ti substrate for photocathodic cathodic protection.The results indicated that the photoresponse range of the Ag2S/ZnS/ZnO composite film was extended compared to those of the ZnO and ZnS/ZnO films,indicating its higher light absorption capacity.When the Ag2S/ZnS/ZnO composite film served as a photoanode,the film can provide the best effective photocathodic protection for 304 stainless steel in a 3.5 wt%NaCl solution under white light illumination compared to the ZnO and ZnS/ZnO films.Additionally,in comparison to pure ZnO film,the photocurrent for the ZnS/ZnO film remained the same without noticeable fluctuation after illumination for 1 h,indicating that the ZnS functionalization improved the stability by overcoming the photocorrosion effect of the ZnO photoanode under light irradiation.展开更多
Localized surface plasmon resonance(LSPR)of nanostructures and the interfacial charge transfer(CT)of semiconductor materials play essential roles in the study of optical and photoelectronic properties.In this paper,a ...Localized surface plasmon resonance(LSPR)of nanostructures and the interfacial charge transfer(CT)of semiconductor materials play essential roles in the study of optical and photoelectronic properties.In this paper,a composite substrate of Ag2S quantum dots(QDs)coated plasmonic Au bowtie nanoantenna(BNA)arrays with a metalinsulator-metal(MIM)configuration was built to study the synergistic effect of LSPR and interfacial CT using surface-enhanced Raman scattering(SERS)in the near-infrared(NIR)region.The Au BNA array structure with a large enhancement of the localized electric field(E-field)strongly enhanced the Raman signal of adsorbed p-aminothiophenol(PATP)probe molecules.Meanwhile,the broad enhanced spectral region was achieved owing to the coupling of LSPR The as-prepared Au BNA array structure facilitated enhancements of the excitation as well as the emission of Raman signal simultaneously,which was established by finite-difference time-domain simulation.Moreover,Ag2S semiconductor QDs were introduced into the BNA/PATP system to further enhance Raman signals,which benefited from the interfacial CT resonance in the BNA/Ag2S-QDs/PATP system.As a result,the Raman signals of PATP in the BNA/Ag2S-QDs/PATP system were strongly enhanced under 785 nm laser excitation due to the synergistic effect of E-field enhancement and interfacial CT.Furthermore,the SERS polarization dependence effeas of the BNA/Ag2S-QDs/PATP system were also investigated.The SERS spectra indicated that the polarization dependence of the substrate increased with decreasing polarization angles(θpola)of excitation from p-polarized(θpola=90°)excitation to s-polarized(θpola=0°)excitation.This study provides a strategy using the synergistic effect of interfacial CT and E-field enhancement for SERS applications and provides a guidance for the development of SERS study on semiconductor QD-based plasmonic substrates,and can be farther extended to other material-nanostructure systems for various optoelectronic and sensing applications.展开更多
Hollow Ag2S spheres have been prepared via hydrolyze reaction of Ag2S2O3, which formed from the reaction of AgNO3 with Na2S2O3, in cyclohexane/water/polyglycol emulsion system. It was found that the component of the r...Hollow Ag2S spheres have been prepared via hydrolyze reaction of Ag2S2O3, which formed from the reaction of AgNO3 with Na2S2O3, in cyclohexane/water/polyglycol emulsion system. It was found that the component of the reaction system has a significant influence on the formation of hollow Ag2S spheres. The possible formation mechanism of the hollow Ag2S spheres in the emusion system was also discussed.展开更多
基金the Natural Science Foundation of Shaanxi Province，the Special Foundation of the Education Department of Shaanxi Province，the Special Research Fund of Xianyang Normal University for Talent Introduction
基金This work was financially supported by the Chinese Academy of Sciences ＂Strategic Priority Research Program＂ （No. XDA01030200）, the Ministry of Science and Technology of China （No. 2011CB965004）, the National Natural Science Foundation of China （Nos. 21303249, 21301187, and 81401464）, and the Natural Science Foundation of Jiangsu Province （Nos. BK2012007 and BK20130366）.
文摘Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag2S QD-based theranostic nanoplatform （DOX@PEG-Ag2S） obtained by loading the anti-cancer drug doxorubicin （DOX） into polyethylene glycol-coated silver sulfide quantum dots （PEG-Ag2S QDs） through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability （93 wt.% of DOX to Ag2S QDs）, long circulation in blood （t1/2 = 10.3 h）, and high passive tumor-targeting efficiency （8.9% ID/gram） in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose （ID） per gram of tissue. After targeting the tumor tissue, DOX from PEG-AgRS cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag2S QDs fluorescence in the second near-infrared window （NIR-II）, the DOX@PEG-Ag2S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag2S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.
基金financially supported by the National Natural Science Fund for Distinguished Young Scholar(No.31525009)The National Key Research and Development Program of China(No.2017YFC1103502)+1 种基金National Natural Science Foundation of China(Nos.31771096 and 31871008)1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(No.ZYGD18002)。
文摘Last two decades,with the rapid changes and development of nanotechnology and biological materials,diverse multi-functional nanomaterials emerging,which offers a novel way to treat and diagnose diseases,and therefore spawned the new biomedical technology of theranostics,which integrates the treatment and diagnosis or monitoring of diseases into one.Ag2S as a bio-nanomaterial with low biotoxicity has attracted more and more attention due to its good photoluminescence properties and fluorescence imaging of small animals in the second near-infrared region(NIR-Ⅱ).Meanwhile,Ag2S has the ability to absorb near-infrared light strongly because of its local surface plasma resonance(LSPR)effect and had become a kind of photothermal conve rters with good photothermal conve rsion efficiency.More interestingly,both photothermal effect and fluorescence characteristics of Ag2S nanoparticles(NPs)are closely related to their particle sizes.However,the relationship between photothermal effect and fluorescence characteristics of Ag2S NPs and their sizes has not been reviewed so far.Herein,the synthesis methods and influencing factors of synthesize Ag2S NPs with different sizes were compared firstly,and then the photothermal effect and fluorescence characte ristics of Ag2S NPs with different sizes were summarized.Finally,the possibilities and challenges of using Ag2S NPs to construct theranostic agent were discussed in the end.
基金This work was supported financially by the Funding from the Taishan Scholarship of Climbing Plan(No.tspd20161006)the National Natural Science Foundation of China(No.51772176)the Scientific Research Foundation of Shandong University of Science and Technology for Recruited Talents(No.2017RCJJ018).
文摘Highly ordered Ag2 S/ZnS/ZnO nanorod array film photoanodes were prepared on a Ti substrate for photocathodic cathodic protection.The results indicated that the photoresponse range of the Ag2S/ZnS/ZnO composite film was extended compared to those of the ZnO and ZnS/ZnO films,indicating its higher light absorption capacity.When the Ag2S/ZnS/ZnO composite film served as a photoanode,the film can provide the best effective photocathodic protection for 304 stainless steel in a 3.5 wt%NaCl solution under white light illumination compared to the ZnO and ZnS/ZnO films.Additionally,in comparison to pure ZnO film,the photocurrent for the ZnS/ZnO film remained the same without noticeable fluctuation after illumination for 1 h,indicating that the ZnS functionalization improved the stability by overcoming the photocorrosion effect of the ZnO photoanode under light irradiation.
基金Chinese Academy of Sciences(QYZDB-SSWSYS038)National Natural Science Foundation of China(11674178,11774340,91750205,61705227)+1 种基金K.C.Wong Education Foundation(GJTD-2018-08)Jilin Provincial Science&Technology Development Project(20180414019GH)。
文摘Localized surface plasmon resonance(LSPR)of nanostructures and the interfacial charge transfer(CT)of semiconductor materials play essential roles in the study of optical and photoelectronic properties.In this paper,a composite substrate of Ag2S quantum dots(QDs)coated plasmonic Au bowtie nanoantenna(BNA)arrays with a metalinsulator-metal(MIM)configuration was built to study the synergistic effect of LSPR and interfacial CT using surface-enhanced Raman scattering(SERS)in the near-infrared(NIR)region.The Au BNA array structure with a large enhancement of the localized electric field(E-field)strongly enhanced the Raman signal of adsorbed p-aminothiophenol(PATP)probe molecules.Meanwhile,the broad enhanced spectral region was achieved owing to the coupling of LSPR The as-prepared Au BNA array structure facilitated enhancements of the excitation as well as the emission of Raman signal simultaneously,which was established by finite-difference time-domain simulation.Moreover,Ag2S semiconductor QDs were introduced into the BNA/PATP system to further enhance Raman signals,which benefited from the interfacial CT resonance in the BNA/Ag2S-QDs/PATP system.As a result,the Raman signals of PATP in the BNA/Ag2S-QDs/PATP system were strongly enhanced under 785 nm laser excitation due to the synergistic effect of E-field enhancement and interfacial CT.Furthermore,the SERS polarization dependence effeas of the BNA/Ag2S-QDs/PATP system were also investigated.The SERS spectra indicated that the polarization dependence of the substrate increased with decreasing polarization angles(θpola)of excitation from p-polarized(θpola=90°)excitation to s-polarized(θpola=0°)excitation.This study provides a strategy using the synergistic effect of interfacial CT and E-field enhancement for SERS applications and provides a guidance for the development of SERS study on semiconductor QD-based plasmonic substrates,and can be farther extended to other material-nanostructure systems for various optoelectronic and sensing applications.
文摘Hollow Ag2S spheres have been prepared via hydrolyze reaction of Ag2S2O3, which formed from the reaction of AgNO3 with Na2S2O3, in cyclohexane/water/polyglycol emulsion system. It was found that the component of the reaction system has a significant influence on the formation of hollow Ag2S spheres. The possible formation mechanism of the hollow Ag2S spheres in the emusion system was also discussed.
