为解决在空间狭小、条件简陋的平台上使用DGPS和AHRS不便的问题,提出了一种基于ARM9的手持式DGPS/AHRS组合导航系统设计方案。采用S3C2440AARM芯片作为主控芯片,选用DGPS模块和AHRS模块进行硬件设计。在Windows CE 6.0平台上采用Visual ...为解决在空间狭小、条件简陋的平台上使用DGPS和AHRS不便的问题,提出了一种基于ARM9的手持式DGPS/AHRS组合导航系统设计方案。采用S3C2440AARM芯片作为主控芯片,选用DGPS模块和AHRS模块进行硬件设计。在Windows CE 6.0平台上采用Visual Studio2008开发导航软件,通过RS232串口读取DGPS模块和AHRS模块输出的数据信息,解析后用于实时显示和导航参数计算。实验结果表明,该系统能准确采集各种导航信息,运行稳定可靠,具有重要的实用价值。展开更多
Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving mechanism.Previous studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor risk....Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving mechanism.Previous studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor risk.Currently,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular mechanisms.In the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics analysis.We then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target gene.Biologically,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate cancer.The current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors.展开更多
针对一种下肢柔性助力机器人,开发了一种基于航姿参考模块(attitude and heading reference system,AHRS)设计的人体下肢运动学信息采集系统.该系统的AHRS具有体积小、功耗低的特点,便于通过绑带与人体保持紧致连接,并且能够长时间穿戴,...针对一种下肢柔性助力机器人,开发了一种基于航姿参考模块(attitude and heading reference system,AHRS)设计的人体下肢运动学信息采集系统.该系统的AHRS具有体积小、功耗低的特点,便于通过绑带与人体保持紧致连接,并且能够长时间穿戴,AHRS的设计融合了卡尔曼滤波算法(Kalman filter,KF)以提高数据的精度,多通道的数据通过ZigBee技术组建的无线传感器网络进行通信,并传输至上位机.然后,建立人体下肢运动学模型,推出AHRS测量角度和人体下肢姿态角度转换关系.同时,考虑在人体不同的步态活动下机器人助力的情况不同,设计了决策树分类器以对不同的步态活动进行识别分类,进一步地协助下肢柔性助力机器人对人体进行有效助力.在多种步态活动下,通过将该系统所采集的数据与Vicon系统采集的数据进行对比可知,该系统所采数据具有较高的精度,也验证了系统具有良好的稳定性及可靠性,另外利用大量的步态数据训练决策树分类器,并通过对未知步态活动进行的分类实验验证了步态识别的准确性.展开更多
文摘为解决在空间狭小、条件简陋的平台上使用DGPS和AHRS不便的问题,提出了一种基于ARM9的手持式DGPS/AHRS组合导航系统设计方案。采用S3C2440AARM芯片作为主控芯片,选用DGPS模块和AHRS模块进行硬件设计。在Windows CE 6.0平台上采用Visual Studio2008开发导航软件,通过RS232串口读取DGPS模块和AHRS模块输出的数据信息,解析后用于实时显示和导航参数计算。实验结果表明,该系统能准确采集各种导航信息,运行稳定可靠,具有重要的实用价值。
文摘Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving mechanism.Previous studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor risk.Currently,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular mechanisms.In the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics analysis.We then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target gene.Biologically,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate cancer.The current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors.
