AILI Tower is famous in Haikou, Hainan Province, because it was built when the real estate market was at its most depressed. The completion of the Western-style building not only added another edifice to the landscape...AILI Tower is famous in Haikou, Hainan Province, because it was built when the real estate market was at its most depressed. The completion of the Western-style building not only added another edifice to the landscape of this once-isolated island, but served to bolster people’s confidence and strengthen their resolve to build China’s second largest island into展开更多
In many affluent nations,acetaminophen(APAP)overdose is the leading cause of drug-induced acute liver failure.The process of APAP-induced liver injury(AILI)is intimately tied to inflammation,including hepatocyte necro...In many affluent nations,acetaminophen(APAP)overdose is the leading cause of drug-induced acute liver failure.The process of APAP-induced liver injury(AILI)is intimately tied to inflammation,including hepatocyte necrosis-caused initiation of inflammation,inflammation amplification that exacerbates liver injury,and the resolution of inflammation that triggers liver regeneration and repair.Excessive APAP metabolism in the liver eventually leads to hepatocyte necrosis and inflammation.Innate immune cells,such as neutrophils,eosinophils,monocytes,and gammadelta T cells,are recruited into the injured liver and release various cytokines.These immune cells and cytokines have been found to serve two purposes in AILI.In this review,we highlighted the dual role of inflammation,including inflammatory cytokines and inflammatory immune cells in AILI,and discussed possible explanations for contradictory findings.展开更多
This study investigated the effect of annealing temperature on the mechanical properties of an as-rolled Mg-9.26wt.%Li-3,03wt,%Al-1,10wt.%Zn （LAZ931） alloy sheet. The dual-phase （a ＋ 13） LAZ931 alloy plate of 3 m...This study investigated the effect of annealing temperature on the mechanical properties of an as-rolled Mg-9.26wt.%Li-3,03wt,%Al-1,10wt.%Zn （LAZ931） alloy sheet. The dual-phase （a ＋ 13） LAZ931 alloy plate of 3 mm in thickness were roiled （67% reduction） and then annealed at temperatures at 100℃-350℃. The alloy＇s ductility showed a sharp concave downward tendency as a function of annealing temperature, The elongation of the LAZ931 alloy sheet increased with annealing temperature up to 150℃, followed by a sharp decrease of the alloy＇s ductility as the annealing temperature higher than 150℃. The specimen exhibited an extremely low elongation （only -0,5%） at annealing temperature around 300℃. Formation of brittle AILi particles on boundary resulted in Li depletion zone near by grain boundary, transforming the Li depletion zone into a （hcp） layer. The combined effects including brittle AILi particles on boundary and the hcp α layer on boundary resulted in the brittlement of the high-temperature-annealing sample.展开更多
文摘AILI Tower is famous in Haikou, Hainan Province, because it was built when the real estate market was at its most depressed. The completion of the Western-style building not only added another edifice to the landscape of this once-isolated island, but served to bolster people’s confidence and strengthen their resolve to build China’s second largest island into
基金supported by National Natural Science Foundation of China(82270640,81873570).
文摘In many affluent nations,acetaminophen(APAP)overdose is the leading cause of drug-induced acute liver failure.The process of APAP-induced liver injury(AILI)is intimately tied to inflammation,including hepatocyte necrosis-caused initiation of inflammation,inflammation amplification that exacerbates liver injury,and the resolution of inflammation that triggers liver regeneration and repair.Excessive APAP metabolism in the liver eventually leads to hepatocyte necrosis and inflammation.Innate immune cells,such as neutrophils,eosinophils,monocytes,and gammadelta T cells,are recruited into the injured liver and release various cytokines.These immune cells and cytokines have been found to serve two purposes in AILI.In this review,we highlighted the dual role of inflammation,including inflammatory cytokines and inflammatory immune cells in AILI,and discussed possible explanations for contradictory findings.
文摘This study investigated the effect of annealing temperature on the mechanical properties of an as-rolled Mg-9.26wt.%Li-3,03wt,%Al-1,10wt.%Zn （LAZ931） alloy sheet. The dual-phase （a ＋ 13） LAZ931 alloy plate of 3 mm in thickness were roiled （67% reduction） and then annealed at temperatures at 100℃-350℃. The alloy＇s ductility showed a sharp concave downward tendency as a function of annealing temperature, The elongation of the LAZ931 alloy sheet increased with annealing temperature up to 150℃, followed by a sharp decrease of the alloy＇s ductility as the annealing temperature higher than 150℃. The specimen exhibited an extremely low elongation （only -0,5%） at annealing temperature around 300℃. Formation of brittle AILi particles on boundary resulted in Li depletion zone near by grain boundary, transforming the Li depletion zone into a （hcp） layer. The combined effects including brittle AILi particles on boundary and the hcp α layer on boundary resulted in the brittlement of the high-temperature-annealing sample.
