Purpose: Cotard’s syndrome, Alice in Wonderland Syndrome, and Catatonia are all rare psychiatric disorders that have relatively little research regarding their treatments. The aim of this article is to highlight any ...Purpose: Cotard’s syndrome, Alice in Wonderland Syndrome, and Catatonia are all rare psychiatric disorders that have relatively little research regarding their treatments. The aim of this article is to highlight any gaps in knowledge regarding represented demographics in these treatment studies, and to discuss the current and upcoming treatment options. Background: This literature review explores under-researched psychiatric conditions: Cotard’s syndrome, Alice in Wonderland syndrome, and Catatonic Schizophrenia. Understanding psychiatric disorders requires basic knowledge of brain anatomy. These conditions are often result of or associated with neurological issues, such as migraines or tumors. The brain has eight lobes, two of four kinds: frontal, parietal, occipital, and temporal lobes, which all govern different functions and abilities. Frontal lobes control judgment, decision-making, personality traits, and fine motor movements. Parietal lobes interpret pain and temperature, occipital lobes handle visual stimuli, and temporal lobes enable hearing. The pre-frontal cortex is associated with high intelligence, psychotic traits, and psychosis. The Broca’s Area in the frontal lobes controls expressive language. These areas and divisions of the brain contribute to the complexity of the psychiatric disorders discussed in this review. Introduction: Cotard’s syndrome is a psychiatric disorder characterized by delusions of being dead or not having certain limbs or organs. It is believed that there is a disconnect between their fusiform face area and the amygdala, causing a lack of familiarity between one’s mind and body. Alice in Wonderland Syndrome (AIWS) is another psychiatric disorder which is characterized by visual hallucinations, such as distorted perceptions of color, size, distance, and speed. The most common symptoms include micropsia and macropsia. Catatonia/Catatonic Schizophrenia is an uncommon type of schizophrenia. This type of schizophrenia is characterized by motor rigidity, verbal rigidity, the flat effect, psychomotor retardation, waxy flexibility, and overall negative symptoms. Thus, these people may come off as emotionally detached, and able to stay frozen in odd positions for periods on end. Treatments and Results: Cotard’s syndrome seemed to be most effectively treated by ECT (electroconvulsive therapy). Alice in Wonderland Syndrome (AIWS) had the highest positive responses to treatment by Valproate (an anti-epileptic drug), as well as intervention to treat the associated neurological conditions they had. Catatonia/Catatonic Schizophrenia seemed to be most effectively treated with a combination of benzodiazepines and ECT. Discussion and Demographics: In all 3 disorders, the Latino and African communities were underrepresented. There also seemed to be an underrepresentation of men in Cotard’s syndrome, and of women in Alice in Wonderland Syndrome. Japan and India seemed to have the highest density of treatment studies in all 3 disorders.展开更多
The warming of the Arctic Intermediate Water （AIW） is studied based on the analyses of hydro- graphic observations in the Canada Basin of the Arctic Ocean during 1985-2006. It is shown that how the anomalously warm ...The warming of the Arctic Intermediate Water （AIW） is studied based on the analyses of hydro- graphic observations in the Canada Basin of the Arctic Ocean during 1985-2006. It is shown that how the anomalously warm AIW spreads in the Canada Basin during the observation time through the analysis of the AIW temperature spatial distribution in different periods. The results indicate that by 2006, the entire Canada Basin has almost been covered by the warming AIW. In order to study interannual variability of the AIW in the Canada Basin, the Canada Basin is divided into five regions according to the bottom topography. From the interannual variation of AIW temperature in each region, it is shown that a cooling period follows after the warming event in upstream regions. At the Chukchi Abyssal Plain and Chukchi Plateau, upstream of the Arctic Circumpolar Boundary Current （ACBC） in the Canada Basin, the AIW temperature reached maximum and then started to fall respectively in 2000 and 2002. However, the AIW in the Canada Abyssal Plain and Beaufort Sea continues to warm monotonically until the year 2006. Furthermore, it is revealed that there is convergence of the AIW depth in the five different regions of the Canada Basin when the AIW warming occurs during observation time. The difference of AIW depth between the five regions of the Canada Basin is getting smaller and smaller, all approaching 410 m in recent years. The results show that depth convergence is related to the variation of AIW potential density in the Canada Basin.展开更多
文摘Purpose: Cotard’s syndrome, Alice in Wonderland Syndrome, and Catatonia are all rare psychiatric disorders that have relatively little research regarding their treatments. The aim of this article is to highlight any gaps in knowledge regarding represented demographics in these treatment studies, and to discuss the current and upcoming treatment options. Background: This literature review explores under-researched psychiatric conditions: Cotard’s syndrome, Alice in Wonderland syndrome, and Catatonic Schizophrenia. Understanding psychiatric disorders requires basic knowledge of brain anatomy. These conditions are often result of or associated with neurological issues, such as migraines or tumors. The brain has eight lobes, two of four kinds: frontal, parietal, occipital, and temporal lobes, which all govern different functions and abilities. Frontal lobes control judgment, decision-making, personality traits, and fine motor movements. Parietal lobes interpret pain and temperature, occipital lobes handle visual stimuli, and temporal lobes enable hearing. The pre-frontal cortex is associated with high intelligence, psychotic traits, and psychosis. The Broca’s Area in the frontal lobes controls expressive language. These areas and divisions of the brain contribute to the complexity of the psychiatric disorders discussed in this review. Introduction: Cotard’s syndrome is a psychiatric disorder characterized by delusions of being dead or not having certain limbs or organs. It is believed that there is a disconnect between their fusiform face area and the amygdala, causing a lack of familiarity between one’s mind and body. Alice in Wonderland Syndrome (AIWS) is another psychiatric disorder which is characterized by visual hallucinations, such as distorted perceptions of color, size, distance, and speed. The most common symptoms include micropsia and macropsia. Catatonia/Catatonic Schizophrenia is an uncommon type of schizophrenia. This type of schizophrenia is characterized by motor rigidity, verbal rigidity, the flat effect, psychomotor retardation, waxy flexibility, and overall negative symptoms. Thus, these people may come off as emotionally detached, and able to stay frozen in odd positions for periods on end. Treatments and Results: Cotard’s syndrome seemed to be most effectively treated by ECT (electroconvulsive therapy). Alice in Wonderland Syndrome (AIWS) had the highest positive responses to treatment by Valproate (an anti-epileptic drug), as well as intervention to treat the associated neurological conditions they had. Catatonia/Catatonic Schizophrenia seemed to be most effectively treated with a combination of benzodiazepines and ECT. Discussion and Demographics: In all 3 disorders, the Latino and African communities were underrepresented. There also seemed to be an underrepresentation of men in Cotard’s syndrome, and of women in Alice in Wonderland Syndrome. Japan and India seemed to have the highest density of treatment studies in all 3 disorders.
基金The National Natural Science Foundation of China under contract Nos 40631006 and 40876003the Polar Science Youth Innovational Foundation of China under contract No. 20080221the National Key Basic Research Program "973" of China under contract No. 2010CB950301
文摘The warming of the Arctic Intermediate Water （AIW） is studied based on the analyses of hydro- graphic observations in the Canada Basin of the Arctic Ocean during 1985-2006. It is shown that how the anomalously warm AIW spreads in the Canada Basin during the observation time through the analysis of the AIW temperature spatial distribution in different periods. The results indicate that by 2006, the entire Canada Basin has almost been covered by the warming AIW. In order to study interannual variability of the AIW in the Canada Basin, the Canada Basin is divided into five regions according to the bottom topography. From the interannual variation of AIW temperature in each region, it is shown that a cooling period follows after the warming event in upstream regions. At the Chukchi Abyssal Plain and Chukchi Plateau, upstream of the Arctic Circumpolar Boundary Current （ACBC） in the Canada Basin, the AIW temperature reached maximum and then started to fall respectively in 2000 and 2002. However, the AIW in the Canada Abyssal Plain and Beaufort Sea continues to warm monotonically until the year 2006. Furthermore, it is revealed that there is convergence of the AIW depth in the five different regions of the Canada Basin when the AIW warming occurs during observation time. The difference of AIW depth between the five regions of the Canada Basin is getting smaller and smaller, all approaching 410 m in recent years. The results show that depth convergence is related to the variation of AIW potential density in the Canada Basin.
