In this review,the databases searched were PubMed and Web of Science.It is believed that the main causes of acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are inflammatory response disorders,excess...In this review,the databases searched were PubMed and Web of Science.It is believed that the main causes of acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are inflammatory response disorders,excessive oxidative stress,cell death,endoplasmic reticulum stress,coagulation dysfunction,and weakened aquaporin function.展开更多
This review outlines the effects of different types of cells with immune function on acute lung injury(ALI)inflammation and the regulation of inflammatory responses between these cells via cell-cell interactions.It is...This review outlines the effects of different types of cells with immune function on acute lung injury(ALI)inflammation and the regulation of inflammatory responses between these cells via cell-cell interactions.It is expected to provide some possible strategies for the research and treatment of ALI and acute respiratory distress syndrome(ARDS).展开更多
Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary disease typically caused bymicrobial infections, trauma, inhalation of harmful gases, and other factors. It is characterized by an inflammatio...Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary disease typically caused bymicrobial infections, trauma, inhalation of harmful gases, and other factors. It is characterized by an inflammation inthe lungs and increased alveolar permeability, leading to pulmonary edema and consequently, a low oxygen supply orhypoxemia. ARDS is responsible for 1 in 10 admissions to intensive care units, and the mortality rate for patientswith severe ARDS is as high as 46%. Extensive efforts have been devoted to investigating the pathological mechanismsof ARDS to develop new effective clinical strategies. Recent studies have reported that receptor-interacting serine/threonine kinase 1 (RIPK1) is involved in the pathogenesis of ARDS. RIPK1 is a critical mediator of programmed celldeath and inflammation. Growing evidence suggests that RIPK1 plays a role in the pathogenesis of differentinflammatory diseases and serves as a promising pharmaceutical target. This review summarizes and sheds some lighton the recent findings regarding the role of RIPK1 and related molecules in the pathogenesis of ARDS.展开更多
Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are common life-threatening lung diseases associated with acute and severe inflammation.Both have high mortality rates,and despite decades of research...Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are common life-threatening lung diseases associated with acute and severe inflammation.Both have high mortality rates,and despite decades of research on clinical ALI/ARDS,there are no effective therapeutic strategies.Disruption of alveolar-capillary barrier integrity or activation of inflammatory responses leads to lung inflammation and injury.Recently,studies on the role of extracellular vesicles(EVs)in regulating normal and pathophysiologic cell activities,including inflammation and injury responses,have attracted attention.Injured and dysfunctional cells often secrete EVs into serum or bronchoalveolar lavage fluid with altered cargoes,which can be used to diagnose and predict the development of ALI/ARDS.EVs secreted by mesenchymal stem cells can also attenuate inflammatory reactions associated with cell dysfunction and injury to preserve or restore cell function,and thereby promote cell proliferation and tissue regeneration.This review focuses on the roles of EVs in the pathogenesis of pulmonary inflammation,particularly ALI/ARDS.展开更多
The article presents the physicochemical properties of soil from six different areas in Qalay Abdul Ali,Kabul,Afghanistan.The authors collected dissimilar samples from six diverse areas,each with a unique profile iden...The article presents the physicochemical properties of soil from six different areas in Qalay Abdul Ali,Kabul,Afghanistan.The authors collected dissimilar samples from six diverse areas,each with a unique profile identifier,and transported them to the research laboratory.The key objectives of this study are to recognize and profile such areas in terms of their physical and chemical characteristics and correlate them with the earlier geological periods of the Qalay Abdul Ali Region.Due to regional conflicts in the region,such quantifications are necessary as very limited data for this region existed.From the analysis,the authors assess that the soil type is gravely soil,and silt with gravels with mostly neutral pH of the soil,although,in specific regions,it was near-acidic.The amounts of CaCO_(3),EC(electroconductivity),and pH are dissimilar according to the locations,the values of EC,and pH within a normal range at whole locations,and the remnants of plants in various quantities.These observations recommend that the soil limitations can be used accordingly for the utilization of soil factors in the regions of the study sites and extra washbasins in the country.As the population continues to grow,such data will be critical to the future sustainability of this region.展开更多
基金Yunnan Fundamental Research Projects(202201AU070167,202301AT070258)Yunnan Key Laboratory of Formulated Granules(202105AG070014).
文摘In this review,the databases searched were PubMed and Web of Science.It is believed that the main causes of acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are inflammatory response disorders,excessive oxidative stress,cell death,endoplasmic reticulum stress,coagulation dysfunction,and weakened aquaporin function.
基金Yunnan Fundamental Research Projects(202201AU070167&202301AT070258),and the Yunnan Key Laboratory of Formulated Granules(202105AG070014).
文摘This review outlines the effects of different types of cells with immune function on acute lung injury(ALI)inflammation and the regulation of inflammatory responses between these cells via cell-cell interactions.It is expected to provide some possible strategies for the research and treatment of ALI and acute respiratory distress syndrome(ARDS).
基金supported by the National Natural Science Foundation of China under Grant 31970897Outstanding Youth Foundation of Jiangsu Province(BK20190069,China)+1 种基金the Fundamental Research Funds for the Central Universities No.30919011102(China)Qing Lan Project of Jiangsu Province,China.
文摘Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary disease typically caused bymicrobial infections, trauma, inhalation of harmful gases, and other factors. It is characterized by an inflammation inthe lungs and increased alveolar permeability, leading to pulmonary edema and consequently, a low oxygen supply orhypoxemia. ARDS is responsible for 1 in 10 admissions to intensive care units, and the mortality rate for patientswith severe ARDS is as high as 46%. Extensive efforts have been devoted to investigating the pathological mechanismsof ARDS to develop new effective clinical strategies. Recent studies have reported that receptor-interacting serine/threonine kinase 1 (RIPK1) is involved in the pathogenesis of ARDS. RIPK1 is a critical mediator of programmed celldeath and inflammation. Growing evidence suggests that RIPK1 plays a role in the pathogenesis of differentinflammatory diseases and serves as a promising pharmaceutical target. This review summarizes and sheds some lighton the recent findings regarding the role of RIPK1 and related molecules in the pathogenesis of ARDS.
基金This work was supported by the Weatherhead Endowment Fund
文摘Acute lung injury(ALI)and acute respiratory distress syndrome(ARDS)are common life-threatening lung diseases associated with acute and severe inflammation.Both have high mortality rates,and despite decades of research on clinical ALI/ARDS,there are no effective therapeutic strategies.Disruption of alveolar-capillary barrier integrity or activation of inflammatory responses leads to lung inflammation and injury.Recently,studies on the role of extracellular vesicles(EVs)in regulating normal and pathophysiologic cell activities,including inflammation and injury responses,have attracted attention.Injured and dysfunctional cells often secrete EVs into serum or bronchoalveolar lavage fluid with altered cargoes,which can be used to diagnose and predict the development of ALI/ARDS.EVs secreted by mesenchymal stem cells can also attenuate inflammatory reactions associated with cell dysfunction and injury to preserve or restore cell function,and thereby promote cell proliferation and tissue regeneration.This review focuses on the roles of EVs in the pathogenesis of pulmonary inflammation,particularly ALI/ARDS.
文摘The article presents the physicochemical properties of soil from six different areas in Qalay Abdul Ali,Kabul,Afghanistan.The authors collected dissimilar samples from six diverse areas,each with a unique profile identifier,and transported them to the research laboratory.The key objectives of this study are to recognize and profile such areas in terms of their physical and chemical characteristics and correlate them with the earlier geological periods of the Qalay Abdul Ali Region.Due to regional conflicts in the region,such quantifications are necessary as very limited data for this region existed.From the analysis,the authors assess that the soil type is gravely soil,and silt with gravels with mostly neutral pH of the soil,although,in specific regions,it was near-acidic.The amounts of CaCO_(3),EC(electroconductivity),and pH are dissimilar according to the locations,the values of EC,and pH within a normal range at whole locations,and the remnants of plants in various quantities.These observations recommend that the soil limitations can be used accordingly for the utilization of soil factors in the regions of the study sites and extra washbasins in the country.As the population continues to grow,such data will be critical to the future sustainability of this region.
