The discovery of a rearrangement reaction of 5-amino-1-arylaminocarbonyl-1,2,triazole(pyrszole)to 5-arylureylene-1,2,4-trazole and the mechanism for thisrearrangement reaction are presented. The rearrangement reaction...The discovery of a rearrangement reaction of 5-amino-1-arylaminocarbonyl-1,2,triazole(pyrszole)to 5-arylureylene-1,2,4-trazole and the mechanism for thisrearrangement reaction are presented. The rearrangement reaction could be attributed to athermodynamic energy preference leading to the predominant formation of 5-aryluretjlene1,2,4-triazole,as shown by molecular mechanics calculation with MMX Program.展开更多
α,β-Unsaturated primary amides are important intermediates and building blocks in organic synthesis.Herein,we report a ligand-free iron-catalyzed hydroaminocarbonylation of alkynes using NH_(4)HCO_(3)as the ammonia ...α,β-Unsaturated primary amides are important intermediates and building blocks in organic synthesis.Herein,we report a ligand-free iron-catalyzed hydroaminocarbonylation of alkynes using NH_(4)HCO_(3)as the ammonia source,enabling the highly efficient and regioselective synthesis of linearα,β-unsaturated primary amides.Various aromatic and aliphatic alkynes are transformed into the desired linearα,β-unsaturated primary amides in good to excellent yields.Further studies show that using NH_(4)HCO_(3)as the ammonia source is key to obtain good yields and selectivity.The utility of this route is demonstrated with the synthesis of linearα,β-unsaturated amides including vanilloid receptor-1 antagonist TRPV-1.展开更多
文摘The discovery of a rearrangement reaction of 5-amino-1-arylaminocarbonyl-1,2,triazole(pyrszole)to 5-arylureylene-1,2,4-trazole and the mechanism for thisrearrangement reaction are presented. The rearrangement reaction could be attributed to athermodynamic energy preference leading to the predominant formation of 5-aryluretjlene1,2,4-triazole,as shown by molecular mechanics calculation with MMX Program.
基金financial supports from the National Natural Science Foundation of China(Nos.21772035,22022204,22072167,21202206)Natural Science Foundation of Hunan Province(Nos.2021JJ40147)。
文摘α,β-Unsaturated primary amides are important intermediates and building blocks in organic synthesis.Herein,we report a ligand-free iron-catalyzed hydroaminocarbonylation of alkynes using NH_(4)HCO_(3)as the ammonia source,enabling the highly efficient and regioselective synthesis of linearα,β-unsaturated primary amides.Various aromatic and aliphatic alkynes are transformed into the desired linearα,β-unsaturated primary amides in good to excellent yields.Further studies show that using NH_(4)HCO_(3)as the ammonia source is key to obtain good yields and selectivity.The utility of this route is demonstrated with the synthesis of linearα,β-unsaturated amides including vanilloid receptor-1 antagonist TRPV-1.
