Highly sensitive fluorescence quantification of irinotecan in biological fluids with the aid of second-order advantage

A rapid,green and highly sensitive excitation-emission matrix（EEM） fluorescence method was proposed for analysis of irinotecan（CPT-11） in biological fluids including human plasma and urine samples of uncalibrated interferences with the aid of second-order advantage.Due to the serious spectral overlapping from biological matrices,the parallel factor analysis（PARAFAC） and the alternating normalization-weighted error（ANWE） have been recommended to perform directly calibration and overcome the problem which makes the traditional fluorospectrophotometer in trouble.Satisfactory results can be achieved.Furthermore, performance of the proposed method was evaluated based on figures of merit and some statistical parameters.The accuracy of both algorithms was validated by the elliptical joint confidence region（EJCR） test.The precision and repeatability were also investigated by the relative standard deviations（RSDs） of intra-day and inter-day.

Second-order calibration applied to quantification of two active components of Schisandra chinensis in complex matrix

The effectiveness of traditional Chinese medicine (TCM) against various diseases urges more low cost, speed and sensitive analytical methods for investigating the phamacology of TCM and providing a theoretical basis for clinical use. The potential of second-order calibration method was validated for the quantification of two effective ingredients of Schisandra chinensis in human plasma using spectrofluorimetry. The results obtained in the present study demonstrate the advantages of this strategy for multi-target determination in complex matrices. Although the spectra of the analytes are similar and a large number of interferences also exist, second-order calibration method could predict the accurate concentrations together with reasonable resolution of spectral profiles for analytes of interest owing to its ‘second-order advantage’. Moreover, the method presented in this work allows one to simply experimental procedure as well as reduces the use of harmful chemical solvents.

基于遗传算法的虹膜卷缩轮提取方法

卷缩轮(Autonomic Nerve Wreath,ANW)是虹膜诊断学中一个重要的诊断标志.而如何提取易受光斑、色素斑及睫毛等干扰影响的卷缩轮在目前仍是一个难题.本文提出了一种基于遗传算法的虹膜卷缩轮提取方法.该方法以区域点密度作为适应度,并通过轮盘赌来选择最优个体,比较相邻两染色体间基因适应度来进行父本的选择.实验结果表明提出的方法能有效避免光斑、色素斑及睫毛等信息的干扰,提高了算法的搜索效率和准确率,提取出的卷缩轮与实际的卷缩轮较一致.

飞利浦S220E2ANW 智能体验应用随心玩

智能化已经成为近些年来广泛使用的流行词了,小到智能手机、智能平板,大到智能家电、智能家居,都被冠以了智能化的代名词,传统PC显示器生产大厂飞利浦在去年推出智能Android一体机的基础之上,再次推陈出新,推出全新的纯白色智能安卓一体机S220E2ANW,这款S220E2ANW可一机多用：即是安卓一体机又是全高清显示器,不仅让智能平板大屏化,更是成为了传统意义PC显示器实现智能化理念的又一次时代助推器。

激发-发射矩阵荧光结合二阶校正法测定人体血浆样和牛蒡子药材中的牛蒡苷含量

本文利用激发-发射矩阵荧光与二阶校正算法相结合,实现快速测定人体血浆样和牛蒡子对照药材中的牛蒡苷含量。采用二阶校正方法的平行因子分析(PARAFAC)和交替归一加权残差(ANWE)两种算法进行解析,所得血浆基体干扰下牛蒡苷的回收率分别为(98.7±1.4)%和(99.7±1.6)%,实现了对血浆样中的牛蒡苷含量的直接快速定量测定。此外,用上述两种方法对牛蒡子药材中的牛蒡苷含量进行快速测定,所得结果与液相色谱方法结果进行比较,结果令人满意。实验结果表明,此方法方便快捷,可用于复杂试样中未知干扰共存下牛蒡苷含量的测定。