Recent rapid rise of indoor location based services for smartphones has further increased the importance of precise localization of Wi-Fi Access Point(AP).However,most existing AP localization algorithms either exhibi...Recent rapid rise of indoor location based services for smartphones has further increased the importance of precise localization of Wi-Fi Access Point(AP).However,most existing AP localization algorithms either exhibit high errors or need specialized hardware in practical scenarios.In this paper,we propose a novel RSSI gradient-based AP localization algorithm.It consists of the following three major steps:firstly,it uses the local received signal strength variations to estimate the direction(minus gradient) of AP,then employs a direction clustering method to identify and filter measurement outliers,and finally adopts triangulation method to localize AP with the selected gradient directions.Experimental results demonstrate that the average localization error of our proposed algorithm is less than 2meters,far outperforming that of the weighted centroid approach.展开更多
目的研究尼古丁抑制DNA损伤后修复的分子机制。方法 Western blot检测蛋白表达水平,同位素方法检测Ref-1磷酸化和其核酸内切酶活性,试剂盒定量检测AP位点。结果尼古丁可以诱导Ref-1磷酸化,下调其核酸内切酶活性,抑制AP位点的修复,星状...目的研究尼古丁抑制DNA损伤后修复的分子机制。方法 Western blot检测蛋白表达水平,同位素方法检测Ref-1磷酸化和其核酸内切酶活性,试剂盒定量检测AP位点。结果尼古丁可以诱导Ref-1磷酸化,下调其核酸内切酶活性,抑制AP位点的修复,星状孢子素(Staurospo rine)和2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮(PD98059)可以抑制尼古丁诱导的Ref-1磷酸化。结论尼古丁通过诱导Ref-1磷酸化,下调其核酸内切酶活性,抑制DNA损伤的修复。展开更多
基金This work was supported in part by the National Natural Science Foundation of China，the Major Projects of Ministry of Industry and Information Technology，the National High Technology Research and Development Program of China
文摘Recent rapid rise of indoor location based services for smartphones has further increased the importance of precise localization of Wi-Fi Access Point(AP).However,most existing AP localization algorithms either exhibit high errors or need specialized hardware in practical scenarios.In this paper,we propose a novel RSSI gradient-based AP localization algorithm.It consists of the following three major steps:firstly,it uses the local received signal strength variations to estimate the direction(minus gradient) of AP,then employs a direction clustering method to identify and filter measurement outliers,and finally adopts triangulation method to localize AP with the selected gradient directions.Experimental results demonstrate that the average localization error of our proposed algorithm is less than 2meters,far outperforming that of the weighted centroid approach.
文摘目的研究尼古丁抑制DNA损伤后修复的分子机制。方法 Western blot检测蛋白表达水平,同位素方法检测Ref-1磷酸化和其核酸内切酶活性,试剂盒定量检测AP位点。结果尼古丁可以诱导Ref-1磷酸化,下调其核酸内切酶活性,抑制AP位点的修复,星状孢子素(Staurospo rine)和2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮(PD98059)可以抑制尼古丁诱导的Ref-1磷酸化。结论尼古丁通过诱导Ref-1磷酸化,下调其核酸内切酶活性,抑制DNA损伤的修复。
