Short-term(up to 30 days)predictions of Earth Rotation Parameters(ERPs)such as Polar Motion(PM:PMX and PMY)play an essential role in real-time applications related to high-precision reference frame conversion.Currentl...Short-term(up to 30 days)predictions of Earth Rotation Parameters(ERPs)such as Polar Motion(PM:PMX and PMY)play an essential role in real-time applications related to high-precision reference frame conversion.Currently,least squares(LS)+auto-regressive(AR)hybrid method is one of the main techniques of PM prediction.Besides,the weighted LS+AR hybrid method performs well for PM short-term prediction.However,the corresponding covariance information of LS fitting residuals deserves further exploration in the AR model.In this study,we have derived a modified stochastic model for the LS+AR hybrid method,namely the weighted LS+weighted AR hybrid method.By using the PM data products of IERS EOP 14 C04,the numerical results indicate that for PM short-term forecasting,the proposed weighted LS+weighted AR hybrid method shows an advantage over both the LS+AR hybrid method and the weighted LS+AR hybrid method.Compared to the mean absolute errors(MAEs)of PMX/PMY sho rt-term prediction of the LS+AR hybrid method and the weighted LS+AR hybrid method,the weighted LS+weighted AR hybrid method shows average improvements of 6.61%/12.08%and 0.24%/11.65%,respectively.Besides,for the slopes of the linear regression lines fitted to the errors of each method,the growth of the prediction error of the proposed method is slower than that of the other two methods.展开更多
Conventional f-x prediction filtering methods are based on an autoregressive model. The error section is first computed as a source noise but is removed as additive noise to obtain the signal, which results in an assu...Conventional f-x prediction filtering methods are based on an autoregressive model. The error section is first computed as a source noise but is removed as additive noise to obtain the signal, which results in an assumption inconsistency before and after filtering. In this paper, an autoregressive, moving-average model is employed to avoid the model inconsistency. Based on the ARMA model, a noncasual prediction filter is computed and a self-deconvolved projection filter is used for estimating additive noise in order to suppress random noise. The 1-D ARMA model is also extended to the 2-D spatial domain, which is the basis for noncasual spatial prediction filtering for random noise attenuation on 3-D seismic data. Synthetic and field data processing indicate this method can suppress random noise more effectively and preserve the signal simultaneously and does much better than other conventional prediction filtering methods.展开更多
The identification of the inter-electrode gap size in the high frequency group pulse micro-electrochemical machining (HGPECM) is mainly discussed. The auto-regressive(AR) model of group pulse current flowing acros...The identification of the inter-electrode gap size in the high frequency group pulse micro-electrochemical machining (HGPECM) is mainly discussed. The auto-regressive(AR) model of group pulse current flowing across the cathode and the anode are created under different situations with different processing parameters and inter-electrode gap size. The AR model based on the current signals indicates that the order of the AR model is obviously different relating to the different processing conditions and the inter-electrode gap size; Moreover, it is different about the stability of the dynamic system, i.e. the white noise response of the Green's function of the dynamic system is diverse. In addition, power spectrum method is used in the analysis of the dynamic time series about the current signals with different inter-electrode gap size, the results show that there exists a strongest power spectrum peak, characteristic power spectrum(CPS), to the current signals related to the different inter-electrode gap size in the range of 0~5 kHz. Therefore, the CPS of current signals can implement the identification of the inter-electrode gap.展开更多
Based on the weekly closing price of Shenzhen Integrated Index, this article studies the volatility of Shenzhen Stock Market using three different models: Logistic, AR(1) and AR(2). The time-variable parameters o...Based on the weekly closing price of Shenzhen Integrated Index, this article studies the volatility of Shenzhen Stock Market using three different models: Logistic, AR(1) and AR(2). The time-variable parameters of Logistic regression model is estimated by using both the index smoothing method and the time-variable parameter estimation method. And both the AR(1) model and the AR(2) model of zero-mean series of the weekly dosing price and its zero-mean series of volatility rate are established based on the analysis results of zero-mean series of the weekly closing price, Six common statistical methods for error prediction are used to test the predicting results. These methods are: mean error (ME), mean absolute error (MAE), root mean squared error (RMSE), mean absolute percentage error (MAPE), Akaike's information criterion (AIC), and Bayesian information criterion (BIC). The investigation shows that AR(1) model exhibits the best predicting result, whereas AR(2) model exhibits predicting results that is intermediate between AR(1) model and the Logistic regression model.展开更多
A new algorithm for the detection of sleep spindles from human sleep EEG with surrogate data approach is presented. Surrogate data ap-proach is the state of the art technique for nonlinear spectral analysis. In this p...A new algorithm for the detection of sleep spindles from human sleep EEG with surrogate data approach is presented. Surrogate data ap-proach is the state of the art technique for nonlinear spectral analysis. In this paper, by developing autoregressive (AR) models on short segment of the EEG is described as a superposition of harmonic oscillating with damping and frequency in time. Sleep spindle events are detected, whenever the damping of one or more frequencies falls below a prede-fined threshold. Based on a surrogate data, a method was proposed to test the hypothesis that the original data were generated by a linear Gaussian process. This method was tested on human sleep EEG signal. The algorithm work well for the detection of sleep spindles and in addition the analysis reveals the alpha and beta band activities in EEG. The rigorous statistical framework proves essential in establishing these results.展开更多
The Autoregressive Moving Average (ARMA) model for whispered speech is proposed. with normal speech, whispered speech has no fundamental frequency because of the glottis being semi-opened and turbulent flow being cr...The Autoregressive Moving Average (ARMA) model for whispered speech is proposed. with normal speech, whispered speech has no fundamental frequency because of the glottis being semi-opened and turbulent flow being created, and formant shifting exists in the lower frequency region due to the narrowing of the tract in the false vocal fold regions and weak acoustic coupling with the aubglottal system. Analysis shows that the effect of the subglottal system is to introduce additional pole-zero pairs into the vocal tract transfer function. Theoretically, the method based on an ARMA process is superior to that based on an AR process in the spectral analysis of the whispered speech. Two methods, the least squared modified Yule-Walker likelihood estimate (LSMY) algorithm and the Frequency-Domain Steiglitz-Mcbide (FDSM) algorithm, are applied to the ARMA mfldel for the whispered speech. The performance evaluation shows that the ARMA model is much more appropriate for representing the whispered speech than the AR model, and the FDSM algorithm provides a name acorate estimation of the whispered speech spectral envelope than the LSMY algorithm with higher conputational complexity.展开更多
We previously found that the K141N mutation in heat shock protein B8 (HSPB8) was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a tr...We previously found that the K141N mutation in heat shock protein B8 (HSPB8) was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene, and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L, and consequently be suitable for use in studies of disease pathogenesis. Transgenic mice overexpressing K141N HSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system. PCR and western blot analysis confirmed integration of the KI41NHSPB8 gene and widespread expression in tissues of the transgenic mice. The K141N HSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination, but no obvious sensory disturbance at 6 months of age by behavioral assessment. Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was significantly decreased, but motor nerve conduction velocity remained normal at 6 months of age. Pathological analysis of the sciatic nerve showed reduced myelinated fiber density, notable axonal edema and vacuolar degeneration in K141N HSPB8 transgenic mice, suggesting axonal involvement in the peripheral nerve damage in these animals. These findings indicate that the KI4mHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease.展开更多
Eggs,as a meat consumer product in China,are closely related to the vegetable basket project.Exploring and predicting the future trend of egg market price is of great significance for stabilizing egg price and market ...Eggs,as a meat consumer product in China,are closely related to the vegetable basket project.Exploring and predicting the future trend of egg market price is of great significance for stabilizing egg price and market supply.In this study,the time series AR model was used for fitting the egg market prices in the 66 d from January 1 to March 7,2021,and the delay operator nlag18 was used for white noise test,giving pr>probability of chisq<0.005.The time series was not a white noise series,and then the stationary series was used for modeling.The optimal model was selected as the AR series(BIC(3,0)),and finally,the egg market price model AM was obtained as X_(t)=9.0556+(1+0.8926)ε_(t),which was the optimal model.The model showed that the egg price fluctuations in 2021 will be clustered,and the later price will be significantly affected by external factors in the previous period.The dynamic prediction results of the model showed that the egg price would stop falling in March 2020,and the egg price would continue to slow down in March.展开更多
To describe the current aging population in China and globally,especially as it applies to age-related macular degeneration(AMD).To review the current standards of care for treating both wet(exudative)eAMD and dry(atr...To describe the current aging population in China and globally,especially as it applies to age-related macular degeneration(AMD).To review the current standards of care for treating both wet(exudative)eAMD and dry(atrophic)aAMD.And to introduce a model for experimentation that is based on the Age-Related Eye Disease Study(AREDS)using eye bank tissue.A literature search that outlines current aging populations,standards of clinical treatment as defined by large,multicenter,randomized clinical trials that present level-I data with a low risk for bias.An experimental model system of AMD is presented that enables scientific analysis of AMD pathogenesis by applying grading criteria from the AREDS to human eye bank eyes.Analysis includes proteomic,cellular,and functional genomics.The standard of care for the treatment of eAMD is currently defined by the use of several anti-vascular endothelial growth(anti-VEGF)agents alone or in combination with photodynamic therapy.Monotherapy treatment intervals may be monthly,as needed,or by using a treat-and-extend(TAE)protocol.There are no proven therapies for aAMD.AMD that is phenotypically defined at AREDS level 3,should be managed with the use of anti-oxidant vitamins,lutein/zeaxanthin and zinc(AREDS-2 formulation).By understanding the multiple etiologies in the pathogenesis of AMD(i.e.,oxidative stress,inflammation,and genetics),the use of human eye bank tissues graded according to the Minnesota Grading System(MGS)will enable future insights into the pathogenesis of AMD.Initial AMD management is with lifestyle modification such as avoiding smoking,eating a healthy diet and using appropriate vitamin supplements(AREDS-2).For eAMD,anti-VEGF therapies using either pro re nata(PRN)or TAE protocols are recommended,with photodynamic therapy in appropriate cases.New cellular information will direct future,potential therapies and these will originate from experimental models,such as the proposed eye bank model using the MGS,that leverages the prospective AREDS database.展开更多
With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as ...With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as aggregation agents, the detailed components like catapult, landing gears, and disturbances are considered as meta-agents, which belong to their aggregation agent. Thus, the model with two layers is formed i.e. the aggregation agent layer and the meta-agent layer. The information communication among all agents is described. The meta-agents within one aggregation agent communicate with each other directly by information sharing, but the meta-agents, which belong to different aggregation agents exchange their information through the aggregation layer first, and then perceive it from the sharing environment, that is the aggregation agent. Thus, not only the hierarchy model is built, but also the environment perceived by each agent is specified. Meanwhile, the problem of balancing the independency of agent and the resource consumption brought by real-time communication within multi-agent system (MAS) is resolved. Each agent involved in carrier-based aircraft catapult launch is depicted, with considering the interaction within disturbed atmospheric environment and multiple motion bodies including carrier, aircraft, and landing gears. The models of reactive agents among them are derived based on tensors, and the perceived messages and inner frameworks of each agent are characterized. Finally, some results of a simulation instance are given. The simulation and modeling of dynamic system based on multi-agent system is of benefit to express physical concepts and logical hierarchy clearly and precisely. The system model can easily draw in kinds of other agents to achieve a precise simulation of more complex system. This modeling technique makes the complex integral dynamic equations of multibodies decompose into parallel operations of single agent, and it is convenient to expand, maintain, and reuse the program codes.展开更多
A multi-agent based manufacturing execution system (MES) model is presented. It is open, modula-rized, distributed, configurable, integratable and maintainable. By analyzing the MES domain in manufacturing systems, th...A multi-agent based manufacturing execution system (MES) model is presented. It is open, modula-rized, distributed, configurable, integratable and maintainable. By analyzing the MES domain in manufacturing systems, this paper proposes a multi-agent based MES model and analyzes the partitioned functions of MES in the model using unified modeling language (UML) diagrams, and establishes the ongoing implemented MES architecture. This MES can be facilely integrated with the enterprise resource planning (ERP), the floor control system (FCS), and the other manufacturing applications.展开更多
By using the simulative results of more than 20 climate system models which were provided by the fourth assessment report of the Intergovernmental Panel on Climate Change(IPCC),the climate change in Dalian area in the...By using the simulative results of more than 20 climate system models which were provided by the fourth assessment report of the Intergovernmental Panel on Climate Change(IPCC),the climate change in Dalian area in the 21st century under the different scenarios(SRES A2,SRES A1B and SRES B1) were analyzed and predicted with the multi-model's aggregative simulative results via the interpolation downscaling calculation.The results showed that the climate in Dalian would have the obvious warming and wetting tendency in the 21st century as a whole.The annual average warming tendency of air temperature would be 2.45-3.46 ℃/100 years,and the annual precipitation increase trend would be 5.8%-16.3% per 100 years.The warming in winter would be the most obvious,and the precipitation increase would be comparatively obvious in winter and spring.The precipitation decrease would be comparatively obvious in autumn in the previous period of 21st century.In A2,A1B and B1 scenarios,the air temperatures in the late period of 21st century would respectively be 3.46,3.44 and 2.45 ℃ higher than in the ordinary years,and the annual precipitation would respectively be 16.3%,11.8% and 5.79% more than in the ordinary years.展开更多
基金supported by National Natural Science Foundation of China,China(No.42004016)HuBei Natural Science Fund,China(No.2020CFB329)+1 种基金HuNan Natural Science Fund,China(No.2023JJ60559,2023JJ60560)the State Key Laboratory of Geodesy and Earth’s Dynamics self-deployment project,China(No.S21L6101)。
文摘Short-term(up to 30 days)predictions of Earth Rotation Parameters(ERPs)such as Polar Motion(PM:PMX and PMY)play an essential role in real-time applications related to high-precision reference frame conversion.Currently,least squares(LS)+auto-regressive(AR)hybrid method is one of the main techniques of PM prediction.Besides,the weighted LS+AR hybrid method performs well for PM short-term prediction.However,the corresponding covariance information of LS fitting residuals deserves further exploration in the AR model.In this study,we have derived a modified stochastic model for the LS+AR hybrid method,namely the weighted LS+weighted AR hybrid method.By using the PM data products of IERS EOP 14 C04,the numerical results indicate that for PM short-term forecasting,the proposed weighted LS+weighted AR hybrid method shows an advantage over both the LS+AR hybrid method and the weighted LS+AR hybrid method.Compared to the mean absolute errors(MAEs)of PMX/PMY sho rt-term prediction of the LS+AR hybrid method and the weighted LS+AR hybrid method,the weighted LS+weighted AR hybrid method shows average improvements of 6.61%/12.08%and 0.24%/11.65%,respectively.Besides,for the slopes of the linear regression lines fitted to the errors of each method,the growth of the prediction error of the proposed method is slower than that of the other two methods.
基金This research was financially supported by National Natural Science Foundation of China (Grant No. 40604016) and the National Hi-Tech Research and Development Program (863 Program) (Grants No. 2006AA09A102-09 and No. 2007AA06Z229).
文摘Conventional f-x prediction filtering methods are based on an autoregressive model. The error section is first computed as a source noise but is removed as additive noise to obtain the signal, which results in an assumption inconsistency before and after filtering. In this paper, an autoregressive, moving-average model is employed to avoid the model inconsistency. Based on the ARMA model, a noncasual prediction filter is computed and a self-deconvolved projection filter is used for estimating additive noise in order to suppress random noise. The 1-D ARMA model is also extended to the 2-D spatial domain, which is the basis for noncasual spatial prediction filtering for random noise attenuation on 3-D seismic data. Synthetic and field data processing indicate this method can suppress random noise more effectively and preserve the signal simultaneously and does much better than other conventional prediction filtering methods.
基金This project is supported by the 10th Five-year Plan Pre-research Project Foundation of China Weapon Industry Company, China(No.42001080701).
文摘The identification of the inter-electrode gap size in the high frequency group pulse micro-electrochemical machining (HGPECM) is mainly discussed. The auto-regressive(AR) model of group pulse current flowing across the cathode and the anode are created under different situations with different processing parameters and inter-electrode gap size. The AR model based on the current signals indicates that the order of the AR model is obviously different relating to the different processing conditions and the inter-electrode gap size; Moreover, it is different about the stability of the dynamic system, i.e. the white noise response of the Green's function of the dynamic system is diverse. In addition, power spectrum method is used in the analysis of the dynamic time series about the current signals with different inter-electrode gap size, the results show that there exists a strongest power spectrum peak, characteristic power spectrum(CPS), to the current signals related to the different inter-electrode gap size in the range of 0~5 kHz. Therefore, the CPS of current signals can implement the identification of the inter-electrode gap.
基金The research is supported by the National Natural Science Foundation of China (60574069)the Soft Science Foundation of Guangdong Province (2005B70101044)
文摘Based on the weekly closing price of Shenzhen Integrated Index, this article studies the volatility of Shenzhen Stock Market using three different models: Logistic, AR(1) and AR(2). The time-variable parameters of Logistic regression model is estimated by using both the index smoothing method and the time-variable parameter estimation method. And both the AR(1) model and the AR(2) model of zero-mean series of the weekly dosing price and its zero-mean series of volatility rate are established based on the analysis results of zero-mean series of the weekly closing price, Six common statistical methods for error prediction are used to test the predicting results. These methods are: mean error (ME), mean absolute error (MAE), root mean squared error (RMSE), mean absolute percentage error (MAPE), Akaike's information criterion (AIC), and Bayesian information criterion (BIC). The investigation shows that AR(1) model exhibits the best predicting result, whereas AR(2) model exhibits predicting results that is intermediate between AR(1) model and the Logistic regression model.
文摘A new algorithm for the detection of sleep spindles from human sleep EEG with surrogate data approach is presented. Surrogate data ap-proach is the state of the art technique for nonlinear spectral analysis. In this paper, by developing autoregressive (AR) models on short segment of the EEG is described as a superposition of harmonic oscillating with damping and frequency in time. Sleep spindle events are detected, whenever the damping of one or more frequencies falls below a prede-fined threshold. Based on a surrogate data, a method was proposed to test the hypothesis that the original data were generated by a linear Gaussian process. This method was tested on human sleep EEG signal. The algorithm work well for the detection of sleep spindles and in addition the analysis reveals the alpha and beta band activities in EEG. The rigorous statistical framework proves essential in establishing these results.
基金supported by the Independent Innovation Foundation of Shandong University(No.2009JC004)the Natural Science Foundation of Shandong Province(No.Y2007G31)
文摘The Autoregressive Moving Average (ARMA) model for whispered speech is proposed. with normal speech, whispered speech has no fundamental frequency because of the glottis being semi-opened and turbulent flow being created, and formant shifting exists in the lower frequency region due to the narrowing of the tract in the false vocal fold regions and weak acoustic coupling with the aubglottal system. Analysis shows that the effect of the subglottal system is to introduce additional pole-zero pairs into the vocal tract transfer function. Theoretically, the method based on an ARMA process is superior to that based on an AR process in the spectral analysis of the whispered speech. Two methods, the least squared modified Yule-Walker likelihood estimate (LSMY) algorithm and the Frequency-Domain Steiglitz-Mcbide (FDSM) algorithm, are applied to the ARMA mfldel for the whispered speech. The performance evaluation shows that the ARMA model is much more appropriate for representing the whispered speech than the AR model, and the FDSM algorithm provides a name acorate estimation of the whispered speech spectral envelope than the LSMY algorithm with higher conputational complexity.
基金funded by the National Natural Science Foundation of China,No.81071001,30900805
文摘We previously found that the K141N mutation in heat shock protein B8 (HSPB8) was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family. The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene, and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L, and consequently be suitable for use in studies of disease pathogenesis. Transgenic mice overexpressing K141N HSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system. PCR and western blot analysis confirmed integration of the KI41NHSPB8 gene and widespread expression in tissues of the transgenic mice. The K141N HSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination, but no obvious sensory disturbance at 6 months of age by behavioral assessment. Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was significantly decreased, but motor nerve conduction velocity remained normal at 6 months of age. Pathological analysis of the sciatic nerve showed reduced myelinated fiber density, notable axonal edema and vacuolar degeneration in K141N HSPB8 transgenic mice, suggesting axonal involvement in the peripheral nerve damage in these animals. These findings indicate that the KI4mHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease.
基金Construction of Guizhou breeding livestock and poultry genetic resources testing platform[QKZYD(2018)4015]Science and Technology Innovation Talent Team of Guizhou Province s Major Livestock and Poultry Genome Big Data Analysis and Application Research(QKHPTRC[2019]5615)Guizhou Provincial Poultry Industry Joint Research Project.
文摘Eggs,as a meat consumer product in China,are closely related to the vegetable basket project.Exploring and predicting the future trend of egg market price is of great significance for stabilizing egg price and market supply.In this study,the time series AR model was used for fitting the egg market prices in the 66 d from January 1 to March 7,2021,and the delay operator nlag18 was used for white noise test,giving pr>probability of chisq<0.005.The time series was not a white noise series,and then the stationary series was used for modeling.The optimal model was selected as the AR series(BIC(3,0)),and finally,the egg market price model AM was obtained as X_(t)=9.0556+(1+0.8926)ε_(t),which was the optimal model.The model showed that the egg price fluctuations in 2021 will be clustered,and the later price will be significantly affected by external factors in the previous period.The dynamic prediction results of the model showed that the egg price would stop falling in March 2020,and the egg price would continue to slow down in March.
基金This work was supported by the National Natural Science Foundation of China (51507015, 61773402, 61540037, 71271215, 61233008, 51425701, 70921001, 51577014), the Natural Science Foundation of Hunan Province (2015JJ3008), the Key Laboratory of Renewable Energy Electric-Technology of Hunan Province (2014ZNDL002), and Hunan Province Science and Technology Program(2015NK3035).
基金This work was supported in part by NIH/NIA RO1 AG025392 NIH/NEI:RO1 EY022097,JoAnne Smith and Delta Airlines Charitable Donation,and an unrestricted grant from Research to Prevent Blindness to the Mayo Clinic,Department of Ophthalmology,Rochester,MN,USA.
文摘To describe the current aging population in China and globally,especially as it applies to age-related macular degeneration(AMD).To review the current standards of care for treating both wet(exudative)eAMD and dry(atrophic)aAMD.And to introduce a model for experimentation that is based on the Age-Related Eye Disease Study(AREDS)using eye bank tissue.A literature search that outlines current aging populations,standards of clinical treatment as defined by large,multicenter,randomized clinical trials that present level-I data with a low risk for bias.An experimental model system of AMD is presented that enables scientific analysis of AMD pathogenesis by applying grading criteria from the AREDS to human eye bank eyes.Analysis includes proteomic,cellular,and functional genomics.The standard of care for the treatment of eAMD is currently defined by the use of several anti-vascular endothelial growth(anti-VEGF)agents alone or in combination with photodynamic therapy.Monotherapy treatment intervals may be monthly,as needed,or by using a treat-and-extend(TAE)protocol.There are no proven therapies for aAMD.AMD that is phenotypically defined at AREDS level 3,should be managed with the use of anti-oxidant vitamins,lutein/zeaxanthin and zinc(AREDS-2 formulation).By understanding the multiple etiologies in the pathogenesis of AMD(i.e.,oxidative stress,inflammation,and genetics),the use of human eye bank tissues graded according to the Minnesota Grading System(MGS)will enable future insights into the pathogenesis of AMD.Initial AMD management is with lifestyle modification such as avoiding smoking,eating a healthy diet and using appropriate vitamin supplements(AREDS-2).For eAMD,anti-VEGF therapies using either pro re nata(PRN)or TAE protocols are recommended,with photodynamic therapy in appropriate cases.New cellular information will direct future,potential therapies and these will originate from experimental models,such as the proposed eye bank model using the MGS,that leverages the prospective AREDS database.
基金Aeronautical Science Foundation of China (2006ZA51004)
文摘With the aid of multi-agent based modeling approach to complex systems, the hierarchy simulation models of carrier-based aircraft catapult launch are developed. Ocean, carrier, aircraft, and atmosphere are treated as aggregation agents, the detailed components like catapult, landing gears, and disturbances are considered as meta-agents, which belong to their aggregation agent. Thus, the model with two layers is formed i.e. the aggregation agent layer and the meta-agent layer. The information communication among all agents is described. The meta-agents within one aggregation agent communicate with each other directly by information sharing, but the meta-agents, which belong to different aggregation agents exchange their information through the aggregation layer first, and then perceive it from the sharing environment, that is the aggregation agent. Thus, not only the hierarchy model is built, but also the environment perceived by each agent is specified. Meanwhile, the problem of balancing the independency of agent and the resource consumption brought by real-time communication within multi-agent system (MAS) is resolved. Each agent involved in carrier-based aircraft catapult launch is depicted, with considering the interaction within disturbed atmospheric environment and multiple motion bodies including carrier, aircraft, and landing gears. The models of reactive agents among them are derived based on tensors, and the perceived messages and inner frameworks of each agent are characterized. Finally, some results of a simulation instance are given. The simulation and modeling of dynamic system based on multi-agent system is of benefit to express physical concepts and logical hierarchy clearly and precisely. The system model can easily draw in kinds of other agents to achieve a precise simulation of more complex system. This modeling technique makes the complex integral dynamic equations of multibodies decompose into parallel operations of single agent, and it is convenient to expand, maintain, and reuse the program codes.
文摘A multi-agent based manufacturing execution system (MES) model is presented. It is open, modula-rized, distributed, configurable, integratable and maintainable. By analyzing the MES domain in manufacturing systems, this paper proposes a multi-agent based MES model and analyzes the partitioned functions of MES in the model using unified modeling language (UML) diagrams, and establishes the ongoing implemented MES architecture. This MES can be facilely integrated with the enterprise resource planning (ERP), the floor control system (FCS), and the other manufacturing applications.
基金Supported by The National Natural Science Fund(40971294)The General Project of Humanities and Social Sciences in Liaoning Education Department(2009A405)The Science and Technology Plan Project of Dalian Technology Bureau(2008E13SF189,2009E11SF230)
文摘By using the simulative results of more than 20 climate system models which were provided by the fourth assessment report of the Intergovernmental Panel on Climate Change(IPCC),the climate change in Dalian area in the 21st century under the different scenarios(SRES A2,SRES A1B and SRES B1) were analyzed and predicted with the multi-model's aggregative simulative results via the interpolation downscaling calculation.The results showed that the climate in Dalian would have the obvious warming and wetting tendency in the 21st century as a whole.The annual average warming tendency of air temperature would be 2.45-3.46 ℃/100 years,and the annual precipitation increase trend would be 5.8%-16.3% per 100 years.The warming in winter would be the most obvious,and the precipitation increase would be comparatively obvious in winter and spring.The precipitation decrease would be comparatively obvious in autumn in the previous period of 21st century.In A2,A1B and B1 scenarios,the air temperatures in the late period of 21st century would respectively be 3.46,3.44 and 2.45 ℃ higher than in the ordinary years,and the annual precipitation would respectively be 16.3%,11.8% and 5.79% more than in the ordinary years.