Arge huazhongia Wei is a new pest on Kushui Rose in Lanzhou City of China, with two generations a year. The larvae duster together to feed on rose leaves. Female adults lay their eggs at the top of one-year-old branch...Arge huazhongia Wei is a new pest on Kushui Rose in Lanzhou City of China, with two generations a year. The larvae duster together to feed on rose leaves. Female adults lay their eggs at the top of one-year-old branches of Kushui Rose. The mature larvae survive the winter cocooning in the rhizosphere of rose fallen leaves and frass, and emerge into adults in middle or late May. The injury rate of rose plants reaches 81.4%, and that of one-year-old shoots reaches 30.6%.展开更多
PLENARY LECTURE A1 MOLECULAR BIOLOGY 60 YEARS AFTER THE DISCOVERY OF DNA STRUCTURE Kornblihtt AR.Facultad de Ciencias Exactas y Naturales,UBA and IFIBYNE-UBA-CONICET.Ciudad Universitaria,Pab.II,(1428)Buenos Aires.E-ma...PLENARY LECTURE A1 MOLECULAR BIOLOGY 60 YEARS AFTER THE DISCOVERY OF DNA STRUCTURE Kornblihtt AR.Facultad de Ciencias Exactas y Naturales,UBA and IFIBYNE-UBA-CONICET.Ciudad Universitaria,Pab.II,(1428)Buenos Aires.E-mail:ark@fbmc.fcen.uba.ar SYMPOSIA SATELLITE SYMPOSIUM“DEVELOPMENTAL BIOLOGY”A2 THE ROLE OF IHH/GLI CELL SIGNALING IN Xenopus laevis NEURAL CREST DEVELOPMENT .展开更多
December 1and 2,2011 Universidad Nacional de Rosario Rosario,Santa Fe,ARGENTINA Abstracts were revised by a Scientific CommitteeBoard of the Rosario Society Biology 2011 1.METFORMIN TOXICITY AND EFFECT ON TUMORGROWTH ...December 1and 2,2011 Universidad Nacional de Rosario Rosario,Santa Fe,ARGENTINA Abstracts were revised by a Scientific CommitteeBoard of the Rosario Society Biology 2011 1.METFORMIN TOXICITY AND EFFECT ON TUMORGROWTH IN CBi MICE CHALLENGED WITH M-406MAMMARY ADENOCARCINOMACapello Gardenal MC,Cáceres JM,Pagura L,Mainetti LE,RicoMJ,Rozados VR,Scharovsky OG1.Instituto de Genética Experimental,Facultad de Ciencias Médicas,U.N.R.;1C.I.U.N.R.Rosario,Argentina.展开更多
Antimicrobial resistance(AMR)has emerged as a significant challenge in human health.Wastewater treatment plants(WWTPs),acting as a link between human activities and the environment,create ideal conditions for the sele...Antimicrobial resistance(AMR)has emerged as a significant challenge in human health.Wastewater treatment plants(WWTPs),acting as a link between human activities and the environment,create ideal conditions for the selection and spread of antibiotic resistance genes(ARGs)and antibioticresistant bacteria(ARB).Unfortunately,current treatment processes are ineffective in removing ARGs,resulting in the release of large quantities of ARB and ARGs into the aquatic environment through WWTP effluents.This,in turn,leads to their dispersion and potential transmission to human through water and the food chain.To safeguard human and environmental health,it is crucial to comprehend the mechanisms by which WWTP effluent discharge influences the distribution and diffusion of ARGs in downstream waterbodies.In this study,we examine the latest researches on the antibiotic resistome in various waterbodies that have been exposed to WWTP effluent,highlighting the key influencing mechanisms.Furthermore,recommendations for future research and management strategies to control the dissemination of ARGs from WWTPs to the environment are provided,with the aim to achieve the“One Health”objective.展开更多
利用生物信息学方法筛选与宫颈癌发生、发展和预后相关的血管生成相关基因(angiogenesis related gene,ARG),并进行相关预后风险模型的构建与验证。首先,从TCGA数据库中检索宫颈癌患者的表达谱和临床特征,并提取差异表达的ARG;其次,采用...利用生物信息学方法筛选与宫颈癌发生、发展和预后相关的血管生成相关基因(angiogenesis related gene,ARG),并进行相关预后风险模型的构建与验证。首先,从TCGA数据库中检索宫颈癌患者的表达谱和临床特征,并提取差异表达的ARG;其次,采用Lasso Cox回归筛选预后ARG,构建相关预后模型;再次,使用GSE52903和GSE44001数据集进行外部验证;最后,利用基因集富集分析(gene set enrichment analysis,GSEA)探讨宫颈癌预后机制。筛选结果显示,共获得15个预后ARG,分别为EFNA1、ITGA5、EPHB4、NRP1、CDH5、PLAU、BMP6、DLL4、JUN、CA9、MMP1、BAIAP2L1、SERPINF1、F2RL1和FGFR2。GSE52903和GSE44001数据集的Kaplan-Meier生存曲线显示,高风险组的总生存期(overall survival,OS)(P=0.005)和无病生存期(disease-free survival,DFS)(P<0.001)显著低于低风险组。受试者操作特征(receiver operating characteristic,ROC)曲线分析结果显示,GSE52903验证集在1年、3年和5年的曲线下面积(area under the curve,AUC)值分别为0.84、0.77和0.73,C-指数为0.72;GSE44001验证集在1年、3年和5年的AUC值分别为0.71、0.72和0.70,C-指数为0.70,说明该模型对患者预后具有很强的预测效能。GSEA分析富集的通路主要涉及DNA复制、细胞外基质(extracellular matrix,ECM)受体相互作用、补体和凝血级联等,这些过程与宫颈癌发生、发展紧密相关。以上结果表明,这15个关键ARG可能是宫颈癌预后潜在的生物标志物。展开更多
基金Supported by Agricultural Science and Technology Research Projects of Lanzhou Science and Technology Bureau(2008-1-46)
文摘Arge huazhongia Wei is a new pest on Kushui Rose in Lanzhou City of China, with two generations a year. The larvae duster together to feed on rose leaves. Female adults lay their eggs at the top of one-year-old branches of Kushui Rose. The mature larvae survive the winter cocooning in the rhizosphere of rose fallen leaves and frass, and emerge into adults in middle or late May. The injury rate of rose plants reaches 81.4%, and that of one-year-old shoots reaches 30.6%.
文摘PLENARY LECTURE A1 MOLECULAR BIOLOGY 60 YEARS AFTER THE DISCOVERY OF DNA STRUCTURE Kornblihtt AR.Facultad de Ciencias Exactas y Naturales,UBA and IFIBYNE-UBA-CONICET.Ciudad Universitaria,Pab.II,(1428)Buenos Aires.E-mail:ark@fbmc.fcen.uba.ar SYMPOSIA SATELLITE SYMPOSIUM“DEVELOPMENTAL BIOLOGY”A2 THE ROLE OF IHH/GLI CELL SIGNALING IN Xenopus laevis NEURAL CREST DEVELOPMENT .
文摘December 1and 2,2011 Universidad Nacional de Rosario Rosario,Santa Fe,ARGENTINA Abstracts were revised by a Scientific CommitteeBoard of the Rosario Society Biology 2011 1.METFORMIN TOXICITY AND EFFECT ON TUMORGROWTH IN CBi MICE CHALLENGED WITH M-406MAMMARY ADENOCARCINOMACapello Gardenal MC,Cáceres JM,Pagura L,Mainetti LE,RicoMJ,Rozados VR,Scharovsky OG1.Instituto de Genética Experimental,Facultad de Ciencias Médicas,U.N.R.;1C.I.U.N.R.Rosario,Argentina.
基金supported by the National Natural Science Foundation of China(Grant Nos.51938001,52170185 and 52070111)the China Postdoctoral Science Foundation(No.2022M721815)。
文摘Antimicrobial resistance(AMR)has emerged as a significant challenge in human health.Wastewater treatment plants(WWTPs),acting as a link between human activities and the environment,create ideal conditions for the selection and spread of antibiotic resistance genes(ARGs)and antibioticresistant bacteria(ARB).Unfortunately,current treatment processes are ineffective in removing ARGs,resulting in the release of large quantities of ARB and ARGs into the aquatic environment through WWTP effluents.This,in turn,leads to their dispersion and potential transmission to human through water and the food chain.To safeguard human and environmental health,it is crucial to comprehend the mechanisms by which WWTP effluent discharge influences the distribution and diffusion of ARGs in downstream waterbodies.In this study,we examine the latest researches on the antibiotic resistome in various waterbodies that have been exposed to WWTP effluent,highlighting the key influencing mechanisms.Furthermore,recommendations for future research and management strategies to control the dissemination of ARGs from WWTPs to the environment are provided,with the aim to achieve the“One Health”objective.
文摘利用生物信息学方法筛选与宫颈癌发生、发展和预后相关的血管生成相关基因(angiogenesis related gene,ARG),并进行相关预后风险模型的构建与验证。首先,从TCGA数据库中检索宫颈癌患者的表达谱和临床特征,并提取差异表达的ARG;其次,采用Lasso Cox回归筛选预后ARG,构建相关预后模型;再次,使用GSE52903和GSE44001数据集进行外部验证;最后,利用基因集富集分析(gene set enrichment analysis,GSEA)探讨宫颈癌预后机制。筛选结果显示,共获得15个预后ARG,分别为EFNA1、ITGA5、EPHB4、NRP1、CDH5、PLAU、BMP6、DLL4、JUN、CA9、MMP1、BAIAP2L1、SERPINF1、F2RL1和FGFR2。GSE52903和GSE44001数据集的Kaplan-Meier生存曲线显示,高风险组的总生存期(overall survival,OS)(P=0.005)和无病生存期(disease-free survival,DFS)(P<0.001)显著低于低风险组。受试者操作特征(receiver operating characteristic,ROC)曲线分析结果显示,GSE52903验证集在1年、3年和5年的曲线下面积(area under the curve,AUC)值分别为0.84、0.77和0.73,C-指数为0.72;GSE44001验证集在1年、3年和5年的AUC值分别为0.71、0.72和0.70,C-指数为0.70,说明该模型对患者预后具有很强的预测效能。GSEA分析富集的通路主要涉及DNA复制、细胞外基质(extracellular matrix,ECM)受体相互作用、补体和凝血级联等,这些过程与宫颈癌发生、发展紧密相关。以上结果表明,这15个关键ARG可能是宫颈癌预后潜在的生物标志物。
