Systematic review of risk factors,prognosis,and management of colorectal signet-ring cell carcinoma

BACKGROUND Colorectal signet-ring cell carcinoma(CSRCC)is a rare clinical entity which accounts for approximately 1%of all colorectal cancers.Although multiple studies concerning this specific topic have been published in the past decades,the pathogenesis,associated risk factors,and potential implications on treatment are still poorly understood.Besides the low incidence,historically confusing histological criteria have resulted in confusing data.Nevertheless,the rising incidence of CSRCC along with relatively young age at presentation and associated dismal prognosis,highlight the actual interest to synthesize the known literature regarding CSRCC.AIM To provide an updated overview of risk factors,prognosis,and management of CSRCC.METHODS A literature search in the MEDLINE/PubMed database was conducted with the following search terms used:‘Signet ring cell carcinoma’and‘colorectal’.Studies in English language,published after January 1980,were included.Studies included in the qualitative synthesis were evaluated for content concerning epidemiology,risk factors,and clinical,diagnostic,histological,and molecular features,as well as metastatic pattern and therapeutic management.If possible,presented data was extracted in order to present a more detailed overview of the literature.RESULTS In total,67 articles were included for qualitative analysis,of which 54 were eligible for detailed data extraction.CSRCC has a reported incidence between 0.1%-2.4%and frequently presents with advanced disease stage at the time of diagnosis.CSRCC is associated with an impaired overall survival(5-year OS:0%-46%)and a worse stagecorrected outcome compared to mucinous and not otherwise specified adenocarcinoma.The systematic use of exploratory laparoscopy to determine the presence of peritoneal metastases has been advised.Surgery is the mainstay of treatment,although the rates of curative resection in CSRCC(21%-82%)are lower compared to those in other histological types.In case of peritoneal metastasis,cytoreductive surgery with hyperthermic intraperitoneal chemotherapy should only be proposed in selected patients.CONCLUSION CSRCC is a rare clinical entity most often characterized by young age and advanced disease at presentation.As such,diagnostic modalities and therapeutic approach should be tailored accordingly.

“ASP.NET应用开发技术”课程思政探索与实践

作为软件工程专业的核心技术课程,“ASP.NET应用开发技术”在2022年被立项为河南中医药大学(以下简称“我校”)的课程思政样板课。教学团队始终坚持“知识传授与价值引领”相结合的原则进行课程建设,分别从课程内容、课程资源、教学活动、日常管理等方面对思政元素进行了深入挖掘,以全面融入人文素养,进而引领学生树立科学的世界观和人生观。

Modeling of Intelligent Integrated Network Management System Using Object Oriented Approach *

The concept of intelligent integrated network management (IINM) is briefly introduced. In order to analyze, design and implement IINM successfully, object oriented approach is testified to be an effective and efficient way. In this paper, object oriented technique is applied to the structural model of IINM system, The Domain object class and the MU object class are used to represent the manager and the managed resources. Especially, NM IA is introduced which is a special object class with intelligent behaviors to manage the resources efficiently.

基于ASP.NET的在线音乐网站设计

拥有独立服务器的音乐网站,由于网络广告、版权等问题,增加了用户的开支成本。研究一种免费、方便使用的音乐分享网站显得十分必要。本文基于一种脚本语言(active server page.NET,ASP.NET)技术设计了在线音乐网站。首先分析了所用的关键技术和功能需求,其次完成了数据库的设计,最后实现了注册登录功能、界面设计、播放音乐、后台管理模块、测试模块等设计。经测试,该音乐分享网站设计基本达到了预期的目标。

Performance Optimization of Agricultural Machinery Monitoring WebGIS System Based on ASP.NET

ASP.NET-based agricultural machinery monitoring WEBGIS is flexible and dynamic,but this flexibility and dynamic characteristics reduce the performance of WEBGIS.Therefore,it is necessary to use built-in optimization features of.NET Framework,some performance optimization techniques in program design and ASP.NET cache technology to reduce the loading of server,and make the designed system work more efficiently.

基于ASP.NET技术、量子遗传算法的物流调度管理系统设计与实现

随着大数据及云计算技术、人工智能技术在国内的迅猛发展,物流行业也广泛应用ASP.NET软件开发技术、B/S(browser/server)系统结构、SQL Server数据库等软硬件开发出符合物流企业车辆运输调度、物流信息管理的数字化服务系统。基于此,利用Web应用程序的ASP.NET分布式框架、B/S结构、SQL Server关系型数据库、IIS8服务器、COM组件等软硬件工具,建构起可用于物流企业客户订单管理、出库/入库管理、车辆调度管理的信息化服务系统,运用量子遗传算法建立物流企业的配送车辆路径规划模型、车辆优化调度寻优方案,进而提升物流企业配送车辆调度、物流信息资源管理的效率与质量。

Etiology and management of urethral calculi:A systematic review of contemporary series

Objective:To conduct a systematic literature review on urethral calculi in a contemporary cohort describing etiology,investigation,and management patterns.Methods:A systematic search of MEDLINE and Cochrane Central Register of Controlled Trials(CENTRAL)databases was performed.Articles,including case reports and case series on urethral calculi published between January 2000 and December 2019,were included.Full-text manuscripts were reviewed for clinical parameters including symptomatology,etiology,medical history,investigations,treatment,and outcomes.Data were collated and analyzed with univariate methods.Results:Seventy-four publications met inclusion criteria,reporting on 95 cases.Voiding symptoms(41.1%),pain(40.0%),and acute urinary retention(32.6%)were common presenting features.Urethral calculi were most often initially investigated using plain X-ray(63.2%),with almost all radio-opaque(98.3%).Urethral calculi were frequently associated with coexistent bladder or upper urinary tract calculi(16.8%)and underlying urethral pathology(53.7%)including diverticulum(33.7%)or stricture(13.7%).Urethral calculi were most commonly managed with external urethrolithotomy(31.6%),retrograde manipulation(22.1%),and endoscopic in situ lithotripsy(17.9%).Conclusion:This unique systematic review of urethral calculi provided a summary of clinical features and treatment trends with a suggested treatment algorithm.Management in contemporary urological practice should be according to calculus size,shape,anatomical location,and presence of urethral pathology.

基于ASP.NET MVC架构在精炼炉RH二级客户端设计与实现

为了实现基于B/S框架的精炼炉RH二级客户端系统,采用基于.NET平台的ASP.NET MVC的Web开发框架,使用了MVC(Model-View-Controller)三层模式,利用基于ADO.NET为基础的Entity Framework对象关系映射器(简称ORM)框架技术,与数据库之间进行交互,Web界面采用Razor视图引擎,使得代码开发更加简洁、规范。基于MVC分层模式开发的精炼炉RH二级客户端系统,具有较好的可复用性、可扩展性,并且易于部署和维护。

CifNet Network Multi-Well Data Management System

The CifNet network multi-well data management system is developed for 100MB or 1000MB local network environments which are used in Chinese oil industry. The kernel techniques of CifNet system include: 1, establishing a high efficient and low cost network multi-well data management architecture based on the General Logging Curve Theory and the Cif data format; 2, implementing efficient visit and transmission of multi-well data in C/S local network based on TCP/IP protocol; 3,ensuring the safety of multi-well data in store, visit and application based on Unix operating system security. By using CifNet system, the researcher in office or at home can visit curves of any borehole in any working area of any oilfield. The application foreground of CifNet system is also commented.

基于ASP.NET的高校毕业论文管理系统设计与实现

针对高校毕业论文传统管理方法存在的问题,以昆明幼儿师范高等专科学校为例,分析了毕业论文管理上的难点,并提出了相应的解决方案。使用用例图设计了系统的主要功能,使用状态图设计了系统的主要流程,同时构建了系统数据库。使用ASP.NET语言实现了高校毕业论文管理系统中指导教师出题和学院审核模块、上传开题报告和论文模块、学院分配评审教师模块和教师审核论文模块。系统的应用能够规范高校毕业论文的管理,提高工作效率。

A Parking Management System Based on Wireless Sensor Network

This paper introduces a parking management system based on a wireless sensor network developed by our group. The system consists of a large amount of parking space monitoring nodes, a few parking guiding nodes, a sink node and a management station. All the nodes exchange information with each other through wireless communication. The prototype of the parking management system has been implemented and the preliminary test results show that the performance of the system can satisfy the requirements of the application.

Application Research and Implementation of the CORBA-Based Web Distributed Network Management System

The distributed management has become an important tendency of development for the NMS (Network Management System) with the development of Internet. Based on the analysis of CORBA (Conmon Object Request Broker Architecture) technique, we mainly discuss about the applicability of the approach by which CORBA combined with Java has been applied to the system model and Web architecture: and address the applied frame and the interface definitions that are the, key technologies for implementing the Distributed Object Computing (DOC). In addition, we also conduct the research on its advantages and disadvantages and further expected improvements. Key words distributed Web network management - CORBA - Java CLC number TP 393.07 Foundation item: Supported by the QTNG (Integrated Network Management System) Project Foundation and QT-NMS (SDH NMS) Project Foundation of Wuhan Qingtian Information Industry Co., LTD of Hubei of China (SDH.001)Biography: WANG Feng (1979-), male Master candidate, research direction: administration of network and software engineering.

Design and analysis of an advanced thermal management system for the solar close observations and proximity experiments spacecraft

In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.

Development of a Non-Pollution Orange Fruit Expert System Software Based on ASP.NET

Based on ASP.NET,a orange fruit tree fertilizer expert system software was developed.The system could simulate and decide an annual fertilization plan for young and mature trees in terms of geographical position and climate.This paper introduced the design conditions,framework,production,and deployment of the system.It exhibited characters of orange specialty and was a typical online agriculture expert system.The use of the system for orange fruit management could decrease production cost,guarantee orange quality and improve economical benefit at the same time.Farmer using the system saved N input by 41-238 g/plant,P2O5 input 3-24 g/plant,and K2O input 1-36 g/plant,and got higher yield by 6-17 kg/plant.

Ultra Reliable Load-Aware Connection Management(LACM)Algorithm in WIA-FA Systems

The increasing demand for industrial automation and intelligence has put forward higher requirements for the reliability of industrial wireless communication technology.As an international standard based on 802.11,Wireless networks for Industrial Automation-Factory Automation(WIA-FA)greatly improves the reliability in factory automation scenarios by Time Division Multiple Access(TDMA).However,in ultra-dense WIA-FA networks with mobile users,the basic connection management mechanism is inefficient.Most of the handover and resource management algorithms are all based on frequency division multiplexing,not suitable for the TDMA in the WIA-FA network.Therefore,we propose Load-aware Connection Management(LACM)algorithm to adjust the linkage and balance the load of access devices to avoid blocking and improve the reliability of the system.And then we simulate the algorithm to find the optimal settings of the parameters.After comparing with other existing algorithms,the result of the simulation proves that LACM is more efficient in reliability and maintains high reliability of more than 99.8%even in the ultra-dense moving scenario with 1500 field devices.Besides,this algorithm ensures that only a few signaling exchanges are required to ensure load bal-ancing,which is no more than 5 times,and less than half of the best state-of-the-art algorithm.

On Designs of Decentralized Reputation Management for Permissioned Blockchain Networks

In permissioned blockchain networks,the Proof of Authority(PoA)consensus,which uses the election of authorized nodes to validate transactions and blocks,has beenwidely advocated thanks to its high transaction throughput and fault tolerance.However,PoA suffers from the drawback of centralization dominated by a limited number of authorized nodes and the lack of anonymity due to the round-robin block proposal mechanism.As a result,traditional PoA is vulnerable to a single point of failure that compromises the security of the blockchain network.To address these issues,we propose a novel decentralized reputation management mechanism for permissioned blockchain networks to enhance security,promote liveness,and mitigate centralization while retaining the same throughput as traditional PoA.This paper aims to design an off-chain reputation evaluation and an on-chain reputation-aided consensus.First,we evaluate the nodes’reputation in the context of the blockchain networks and make the reputation globally verifiable through smart contracts.Second,building upon traditional PoA,we propose a reputation-aided PoA(rPoA)consensus to enhance securitywithout sacrificing throughput.In particular,rPoA can incentivize nodes to autonomously form committees based on reputation authority,which prevents block generation from being tracked through the randomness of reputation variation.Moreover,we develop a reputation-aided fork-choice rule for rPoA to promote the network’s liveness.Finally,experimental results show that the proposed rPoA achieves higher security performance while retaining transaction throughput compared to traditional PoA.

A Neural Network-Based Trust Management System for Edge Devices in Peer-to-Peer Networks

Edge devices in Internet of Things(IoT)applications can form peers to communicate in peer-to-peer(P2P)networks over P2P protocols.Using P2P networks ensures scalability and removes the need for centralized management.However,due to the open nature of P2P networks,they often suffer from the existence of malicious peers,especially malicious peers that unite in groups to raise each other’s ratings.This compromises users’safety and makes them lose their confidence about the files or services they are receiving.To address these challenges,we propose a neural networkbased algorithm,which uses the advantages of a machine learning algorithm to identify whether or not a peer is malicious.In this paper,a neural network(NN)was chosen as the machine learning algorithm due to its efficiency in classification.The experiments showed that the NNTrust algorithm is more effective and has a higher potential of reducing the number of invalid files and increasing success rates than other well-known trust management systems.

Management of Acute Malnutrition in Children Aged 0 to 24 Months Boulbinet Health Center

Introduction: Malnutrition is a pathological state resulting from the relative deficiency or excess of one or more essential nutrients, whether manifested clinically or detected only by biochemical, anthropometric or physiological analyses. The overall objective was to assess the quality of management of acute malnutrition in children aged 0 - 24 months at the Boulbinet health center. Methodology: This was a prospective descriptive study lasting six (06) months from May 5 to October 5, 2018. The study included all children aged 0 to 24 months. Results: Acute malnutrition in children aged 0 - 24 months accounted for 2.11% of cases. The sex ratio was 1.41 in favor of males. The mean age of our patients was 5 months 7 days, with extremes of 1 month and 6 months. The majority came from Ra toma (40.24%). Exclusive breastfeeding was most common (54.02%). The main clinical signs were: pallor 49.42%, diarrhea 46.67, oral lesions37.96%. SAM represented 89.66% and MAM 10.34%. Most associated pathologies: anemia 49.42% and oral candidiasis 37.93%. In terms of outcome, we recorded 56.32% cures, 20.69% deaths, 18.39% dropouts and 4.60% cures. Conclusion: Improving the quality of care for malnourished children aged 0 - 24 months requires raising awareness among mothers and the general public of the consequences of malnutrition.

Resource management at the network edge for federated learning

Federated learning has been explored as a promising solution for training machine learning models at the network edge,without sharing private user data.With limited resources at the edge,new solutions must be developed to leverage the software and hardware resources as the existing solutions did not focus on resource management for network edge,specially for federated learning.In this paper,we describe the recent work on resource manage-ment at the edge and explore the challenges and future directions to allow the execution of federated learning at the edge.Problems such as the discovery of resources,deployment,load balancing,migration,and energy effi-ciency are discussed in the paper.

A Self-Attention Based Dynamic Resource Management for Satellite-Terrestrial Networks

The satellite-terrestrial networks possess the ability to transcend geographical constraints inherent in traditional communication networks,enabling global coverage and offering users ubiquitous computing power support,which is an important development direction of future communications.In this paper,we take into account a multi-scenario network model under the coverage of low earth orbit(LEO)satellite,which can provide computing resources to users in faraway areas to improve task processing efficiency.However,LEO satellites experience limitations in computing and communication resources and the channels are time-varying and complex,which makes the extraction of state information a daunting task.Therefore,we explore the dynamic resource management issue pertaining to joint computing,communication resource allocation and power control for multi-access edge computing(MEC).In order to tackle this formidable issue,we undertake the task of transforming the issue into a Markov decision process(MDP)problem and propose the self-attention based dynamic resource management(SABDRM)algorithm,which effectively extracts state information features to enhance the training process.Simulation results show that the proposed algorithm is capable of effectively reducing the long-term average delay and energy consumption of the tasks.